Health Articles, Medical Innovations | Popular Science https://www.popsci.com/category/health/ Awe-inspiring science reporting, technology news, and DIY projects. Skunks to space robots, primates to climates. That's Popular Science, 145 years strong. Thu, 01 Jun 2023 19:55:33 +0000 en-US hourly 1 https://wordpress.org/?v=6.1.1 https://www.popsci.com/uploads/2021/04/28/cropped-PSC3.png?auto=webp&width=32&height=32 Health Articles, Medical Innovations | Popular Science https://www.popsci.com/category/health/ 32 32 A graduation gift guide for grads who love the outdoors: From practical tools to personalized accessories https://www.popsci.com/reviews/best-gift-guide-for-grads-outdoor-gifts/ Tue, 25 May 2021 15:59:00 +0000 https://www.popsci.com/?p=366540
A lineup of the best grad gifts for those who love the outdoors on a white background.
Amanda Reed

We’ve compiled a gift guide for grads who can’t wait to get off campus and lose themselves (figuratively) in the great outdoors.

The post A graduation gift guide for grads who love the outdoors: From practical tools to personalized accessories appeared first on Popular Science.

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A lineup of the best grad gifts for those who love the outdoors on a white background.
Amanda Reed

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Best for campers Graduation gift guide with the best camping hammock Wise Owl Outfitters Hammock
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A durable option that doesn’t hurt the bank.

Best for hikers Two pair of socks in a grey color with written letters under them. Smartwool Hiking Crew Socks
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These socks are made of Merino wool, which will keep your feet warm and dry.

Best solar generator Best Solar Generators Jackery Portable Power Station Explorer 300
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Power small appliances while camping.

It feels safe to assume that—after spending the better part of many years cooped up inside classrooms, libraries, cafeterias, and/or dorm rooms—any grad is ready for a change of scenery, especially grads who love the actual outdoors. Once all their schoolwork is done, grades have been entered, and degrees are in hand, these grads will surely feel it’s time some exploits braving the elements, and you can help by giving graduation gifts for outdoor lovers that travel well. Wherever their love for the outdoors takes them, we have you covered with the best graduation gift guide for well-accessorized adventurers.

Best for campers: Wise Owl Outfitters Hammock  

Wise Owl Outfitters

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If your favorite grad is equipped with just about everything they need to make it through a backcountry trip, get them camping gifts to introduce even more relaxation and fun to their next outdoor escape. A camping hammock is a perfect way to sit back, take a nap, read a book, or drink a calming beverage outdoors. This is the best hammock from Wise Owl and weighs under 2 pounds, including the hanging straps, so it’s perfect for campers who prioritize portability. When packed down, it’s about the size of a grapefruit, so your grad should be able to easily carry it with them or keep it stashed away in their car. Each hammock comes with tree straps and carabiners for easy setup, with no need for any additional equipment. It comes in over 10 colors so that you can choose their favorite. It’s 9 feet long and 4.5 feet wide, with a 400-pound weight limit, which should be suitable for just about any user. You can even grab a two-person hammock (weighing only 5 ounces more) if they tend to go camping with a partner or friend.

Best for grad parties in the backyard or backcountry: Ultimate Ears WONDERBOOM 3

Brandt Ranj

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No graduation gift guide would be complete without some great speakers. If your recent grad is always on the go—heading out for day hikes, camping trips, beach hangouts, long bike rides, and more—you can’t go wrong gifting them a portable Bluetooth speaker. No matter where they are or what they are doing, a smartphone and a compact speaker will provide the perfect soundtrack for any outdoor activity. The Ultimate Ears WONDERBOOM 3 is an excellent option, weighing under 1 pound and equipped with a flexible handle that can easily attach to a backpack, bike basket, or belt loop. It’s only 4 inches tall, but the small, compact design doesn’t mean you sacrifice anything when it comes to sound. The portable speaker can reach up to 87 decibels (equivalent to standing next to a loud blender or vacuum) and produces full 360-degree sound coverage. This powerful Bluetooth speaker can also withstand the elements and is one of our favorite waterproof speakers for a good reason; it has an IP67 rating, which means it can survive being dropped into a body of water up to a meter deep for half an hour, plus it’s dirt/dust-resistant. In addition, the battery lasts a full 13 hours, so your grad can jam outside all day long. And, if they want to be a party-goer and a party-thrower, you can up the energy with a portable party speaker.

Best for hikers: Smartwool Hiking Crew Socks  

Smartwool

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A hiker is only as good as their socks are strong, so give a grad who loves to ramble amongst the rocks a pair that will last. While socks may seem like a simple gift, a quality pair or two is one of those hiking gifts that can go a long way. You’ll be taking care of an essential need any avid hiker has and investing in their overall outdoor experiences. Take it from us: nothing ruins a hike faster than angry blisters and constant friction. Smartwool hiking socks come in various colors and sizes, both men’s and women’s. From a tried and true brand, these socks are designed for rugged day hikes and moderate backpacking. An elasticized arch brace provides extra support, medium cushioning absorbs impact, and a flat-toe seam keeps things comfortable. Made from Merino wool and nylon, these socks will keep their feet warm even during cold winter hikes. If your loved one likes to embark on a variety of adventures, you can check out Smartwool’s other socks specifically designed for activities like running, cycling, skiing, and more. There’s a reason we listed them as our favorite wool socks.

Best for interval training to interviews: Garmin epix Pro and Garmin fēnix 7 Pro

Garmin

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Whether your grad is thinking more about the backcountry or the boardroom, they could use a smartwatch that helps them get where they need to be when they need to be there. And when it comes to multi-band GPS smartwatches, Garmin makes the best adventure accessories out there. Endurance athletes to purposeful wanderers can benefit from the rugged, sensor-embedded case, metrics-rich displays, and accurate navigation resources found in Garmin’s newest Pro editions of the company’s multisport timepieces—available in multiple sizes and colors with different types of scratch-resistant/solar-charging glass.

Best for your grad’s new apartment: Fuzzy Ink Wilderness Print

Fuzzy Ink

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The perfect grad gifts for outdoor lovers aren’t always the ones they’ll bring on their adventures—they can be ones they’ll appreciate before and after an excursion. A woodsy print or poster is a great present for a graduate who needs a little help decorating their new apartment. At this point, they might have all the gear they need, but what they probably don’t have are elegant pieces that express their personality but also provide a sense of maturity for an adult abode. This print from Fuzzy Ink is an artistic way for your grad to stay inspired. It measures 18 inches by 24 inches and is printed on coated paper with a matte finish, so they won’t have any trouble finding a great spot to display it. This print quietly depicts the beauty and awe that many outdoor enthusiasts find so mesmerizing about being in nature. From the crackling campfire to the expansive display of fir trees, this piece will surely bring joy to a grad who longs to roam around the forest.

Best for outdoor athletes: CamelBak Octane Dart Hydration Pack

CamelBak

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Any outdoor lover knows how important it is to stay hydrated. Whether hiking, cycling, or running, drinking water is key to preventing heat stroke, dehydration, fatigue, and other issues. Of course, a water bottle is the first thing we think of when it comes to H2O on the go; however, bottles can be bulky and cumbersome. So, if you want to get your grad a great outdoor gift that prioritizes function and efficiency, we recommend a CamelBak Hydration Pack. This multisport hydration backpack can hold 50 ounces of water and easily straps to your back with a long drinking tube and trap management to make hydrating hands-free. All they need to do is bite down and suck to get as much water as necessary—no need to stop during a long run or bike ride to grab a water bottle. The 3D vent mesh provides lightweight comfort and airflow, while front harness pockets can hold snacks, sunscreen, and other essentials. Reflectivity strips are added for extra safety during early morning or nighttime exercise. Your grad will be able to get a run in anytime, anywhere, and stay hydrated all the while. If you’re looking for more options, consider our list of the best hydration packs.

Best personalized gift: Engraved Compass

Etsy

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A personalized gift is always a good idea, especially when you’re celebrating a significant achievement. Giving a gift designed specifically for them—something special that only they will have—will let your grad know how much you care for and support them. If you want to give a personalized gift suited for the outdoors, check out these engraved compasses. You can choose from existing mountainscapes or upload your own favorite photos and illustrations to be perfectly recreated on the compass’s cover. Practically any part of the compass can include etching, so you won’t have to choose between a picture or a message. You can even ask for your own handwriting to be impressed on the metal so your graduate can take a piece of you with them no matter where they travel.

A useful graduation gift for the outdoors: Victorinox Swiss Army One-Hand Trekker Knife

Victorinox

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Outdoor enthusiasts know that it’s essential to prioritize gear that is lightweight, portable, and multipurpose. You will rarely find a seasoned camper lugging around a toolbox, though the need for various utensils and instruments is frequent. From quick repairs to food preparation, a survival tool or multipurpose knife is a helpful gift for anyone who spends a lot of time outside (they can also be pretty practical for indoor use). A Swiss Army knife is practical, classic, and cool. A household name when it comes to compact knives, the Trekker lives up to the hype. Its attached tools include a wood saw, large blade, 3-millimeter and 5-millimeter screwdrivers, wire stripper, can opener, tweezers, toothpick, and more. It’s one of those camping gifts that offer pretty much everything you need to make it through the trek without any issues. A knife like this is a thoughtful graduation gift that they are guaranteed to use for years to come.

Best thoughtful: Paddywax Candles Parks Collection

Paddywax Candles

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A candle is a fantastic gift for any graduate, signifying new beginnings and ordaining their adult apartment, or childhood bedroom, with sophisticated, balanced scents to keep them calm as they figure out their next steps. We’re a fan of scented gifts in general. But if your recent grad pines for the outdoors but doesn’t have time to travel just yet, a candle that brings nature to them is even more highly recommended. Paddywax has created a National Park Service-inspired collection that features the complex aromas of our country’s natural wonders. “Yellowstone” has hints of sagebrush and fir, the “Great Smoky Mountains” features Maplewood and moss, “Acadia” has seagrass and driftwood, while the “Grand Canyon” smells like cactus flowers and fern. Each candle is 11 ounces and has a burn time between 50 and 60 hours. When they’ve used up every drop of wax the candle has to offer, grads can upcycle the jars and repurpose them as plant pots, beauty tool holders, catch-alls, and more. Best of all, Paddywax donates a minimum of $25,000 per year to the National Parks Foundation, so your gift will not only go to your graduate but support the beautiful natural landmarks they love so much.

Best for day trips: YETI Packable Lunch Bag

YETI

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There is only one thing better than a day outdoors, and that is a day outdoors with snacks. Whether they plan on packing a lunch for a mountaintop picnic or bringing a few celebratory drinks to a grad party on the beach, beverages, and munchies are a must-have for your graduate’s next outside hang. A cooler is the best way to keep their tasty treats fresh all day long, so they never have to worry about their food heating up in the sun while they hike or swim. This YETI lunch bag is the perfect gift for grads to take food outside or pack a tasty lunch for their new job. Available in two sizes, a standard box or larger bag, and a variety of colorways, this pack uses Coldcell Flex insulation” technology and a “thermosnap” closure to keep food at the correct temperature, hot or cold. The adjustable grid means you can set the size by simply closing the top hook into any one of the available hoops. That way, the lunch bag can easily fit under a desk or be stuffed with snacks and drinks using all of its available 15.75 inches. This bag will pair well with just about any outdoor excursion, so your grad will be able to pack all the necessities and then some.

Best wearable: Outdoor Life Tee

540Brands

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If you want to get sweet, versatile graduation gifts guaranteed to make them smile, go with cute graphic tees like this one from Outdoor Life. Available in both men’s and women’s sizes, the “Go Play Outside” slogan is a fun way for you to tell everyone you see where your priorities lie. Made from 100-percent cotton and available in five colorways, this T-shirt will complement any hunter, angler, hiker, camper, surfer, sailor—just about any outdoor enthusiast you could think of. The soft material makes these tees particularly great for lounging around a campfire, though we recommend sizing up for maximum coziness—your grad will thank you.

Best for dirty hiking clothes: STNKY Bag Pro Wash Bag

STNKY

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STNKY’s Bag Pro Wash Bag is the simple gift our adventurous grad didn’t know they needed. The zip-up laundry bag can hold all of their dirty clothes during multi-day camping and hiking trips to prevent unwanted odors and bacteria from getting onto their clean ones. When it’s time to wash their clothes, the STNKY bag can be unzipped and turned inside out, at which point the clothes will fall into the washing machine without being touched. The bag itself is also machine washable, which is a nice bonus. Anyone who struggles to stay organized and sanitary during their next outdoor trip will love this gift.

Best portable firepit: Colsen Tabletop Portable Fire Pit

Colsen

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Sometimes setting up a big outdoor fire pit isn’t feasible or reasonable, but that doesn’t mean giving up s’mores for the night. Colsen’s Tabletop Portable Fire Pit runs on the company’s odorless liquid fuel, can be set up and ignited within a few minutes, and produces flame up to one foot tall for roughly 45 minutes. This is the ideal gift for someone who’s into glamping or wants a fire pit they can use indoors and out at any point during the year. The fact that you don’t need firewood to ignite it is particularly important because rainy weather can make dry fuel hard to find. And if you happen to have a grad living somewhere with a sizeable backyard/patio, you can give them a tasteful taste of the campfire life at home with a Solo Stove Bonfire firepit.

Best firestarter: Pull Start Firestarter

Pull Start Fire

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On the other hand, if you’re shopping for someone who spends days upon days out in the woods, they’re going to need Pull Start Firestarter. The fire starter is literally ignited by pulling a string built into its small box. Smoke will begin to billow from the box, indicating that the fire starter will be fully ignited within three seconds. It lasts up to 30 minutes once fully ignited. Beyond the convenience of not having to strike a match, keeping a pack of these around can be helpful during an emergency. It’s very difficult to light wet wood with a match, but prolonged exposure to a fire starter can do the trick. Whether they’re trying to save time or their own life, your grad will appreciate having a three-pack of Pull Start Firestarter in their pack.

Best hard cooler: RTIC Ultra-Light 55 Quart Hard Cooler

RTIC

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No campsite or boat is complete without a cooler that can reliably keep foods and beverages cold for hours—or days—at a time. If you’re shopping for a grad who’s planning a big summer trip, there’s a good chance Ultra-Light 55 Quart Hard Cooler is the perfect gift. The high-capacity cooler has three inches of insulation to maintain a consistent temperature inside, but it was engineered to be nearly a third lighter than the competition. This means it’ll be easier to carry when filled with ice, food, and dozens of cans. A cooler is one of the few gifts that may actually last your grad a lifetime, so it’s important to make the right choice. If you know they tend to pack extra light, RTIC also offers a 32-Quart model of this same cooler. Want more options? Check out more of the best coolers for camping.

Best for post-trail drinks: Hydro Flask 25 oz Ceramic Reusable Wine Bottle

Hydro Flask

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Enjoying a bottle of wine on a mountain sounds like a dream—but wine bottles and hiking don’t exactly mix. Give your grad the gift of sneaky boozing with this ceramic reusable wine bottle from Hydro Flask, which fits one 750 mL bottle of wine. It’s dishwasher-safe for easy cleaning and BPA-free for peace of mind. TempShield double-wall vacuum insulation keeps whites chilled and reds at room temp, and a ceramic-lined interior prevents flavor transfer. Although it’s advertised for wine, we think it’s also perfect for any spirit: Our favorite nature-inspired aqua vitae is Tin Cup Whiskey, cut with water from the Rocky Mountains and named after the tin cups miners used to drink. Need a more traditionally shaped option? Check out our favorite insulated water bottles.

Best unbreakable glasses: Silipint Silicone Pint Glasses

Silipint

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We’ve included the Silipint in our best camping gifts guide, but we think it makes a great gift especially for someone who may be too transient for real drinkware. These shatterproof “glasses” are made of 100% food-grade silicone, meaning you don’t have to deal with dangerous broken glass. Plus, they’re a fun, bright way to reduce the amount of plastic your grad may use between graduation and their very first job.

Best for ski lodge lounging: Chaco Ramble Puff Ankle Boot

Amanda Reed

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Chaco is known for its rugged and arch-supporting sandals, but we think their covered shoe offerings deserve some praise. The Ramble Puff Ankle Boot feels like a down parka for your feet, and they’re perfect for throwing on after a day of skiing or hiking. And, water-resistant rip-stop nylon means they’re not just indoor shoes—they can hold up in the great outdoors. If you’re looking for something that slips on, the Ramble Puff also comes in a clog style just as comfy and dreamy as its boot brethren. Our staff writer lives in both the clog and boot for women—don’t ask her to pick her favorite. Speaking of puffy stuff …

Best for camp comfort: Therm-a-Rest Honcho Poncho Down

ThermaRest

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We all know the importance of having appropriate layers for hiking—but what if you want to stay warm without having to wear the same jacket you’ve worn all day. The Honcho Poncho from Therm-a-Rest (also makers of excellent sleeping pads) combines the lightweight, warm properties of 650-Fill Nikwax Hydrophobic Down with a water-resistant 100% recycled polyester shell for a wearable sleeping bag. You can wear it around the campsite or campfire or lay it out in your tent and use it as a blanket. Its front pocket doubles as a stuff sack to make it easy to stow away back into your pack (or to use it as a lite pillow).

Best for camp chefs: Opinel Nomad Camping Kitchen Utensil Kit

Opinel

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These knives are great for a grad who trying to step up their outdoor cooking game. The kit comes with a serrated folding knife, a folding corkscrew knife, a pocket peeler, a beechwood cutting board, and a microfiber cleaning cloth that doubles as a travel pouch. A Virobloc safety ring is attached to all knives/peelers to make it safer to open and transport the kit. Your grad never has to struggle to cut a piece of campfire-cook beef or a hunk of crusty bread again.

Best hiking boot: Vasque Breeze Waterproof Hiking Boot

Tony Ware

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Your grad deserves a new pair of hiking boots for successfully climbing the mountain that is college. This one from Vasque is comfortable—our assistant managing editor (his ankles and dog shown above) says, “Lightweight, breathable, and comfortable to … boot … the Vasque Breeze immediately impressed me by requiring zero break-in, then continued to impress me with its stability and traction.” This means grads can climb the highly-graded mountain of post-grad life and worry more about their rent than getting blisters. They’re waterproof and made of sustainable, durable materials for years and years of adventures.

Best headlamp: BioLite 800 Pro

BioLite

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Grad gifts are all about shiny new things, and this new headlamp from BioLite should excite your night crawler. It packs 800 powerful, bright Lumens to illuminate any dark trails … or the way to the bathroom at night. Your grad will get 150 hours of power on low; seven hours on high; and 8 hours on reserve. It recharges using a micro USB port, and includes a Constant Mode for full illumination without auto-dimming. Plus, 3D SlimFit tech gives you bounceless, slipless, and near-weightless wear. Being comfortable and able to see where you’re stepping? Sounds like a win.

Best solar generator: Jackery Portable Power Station Explorer 300

Jackery

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Jackery topped our list of the best solar generators, and we love the company’s small-but-mighty portable power station that can be charged by a wall outlet, car outlet, and the sun (!!!). The solar panel isn’t included, but you can get this bundle that solves the lack of solar panel upon purchase. It’s easy to carry at 7.1 pounds and can charge up to six devices while your grad is on outdoor adventures. Your grad may go outdoors to unplug, but you’ll get peace of mind that their phone or other powered essentials won’t die out in the wilderness.

Things to consider when picking gifts for folks who love the outdoors

From lite hiking gifts to entertaining accessories to full-on camping gifts, you can help recent graduates prepare for whatever their next exploration entails. Or, for graduates moving to a new city or starting a new job and unsure they’ll get out much in those early post-grad days, give graduation gifts that remind them of what they love, from naturally scented candles to beautiful nature prints. The key is determining their favorite outdoor activities, skills, comfort level, and existing accouterments, allowing you to match the grad with the gift.

Final thoughts on the best graduation gifts for outdoors enthusiasts

We hope this graduation gift guide for grads who love the outdoors has filled you with ideas and inspiration for the perfect present. Whether you’re celebrating a trekking champion, kayaking aficionado, or dedicated camper, you’ll find grad gifts for outdoor lovers that fit their specific interests. After all, a graduation gift, whether it’s hiking gifts or camping gifts, or apartment decor, is about celebrating their accomplishments and encouraging them to follow their dreams while holding onto their passions. 


PopSci wants to help you find the most useful shopping recommendations for the best gifts regardless of occasion or preoccupation. Searching for more unique gifts? Check out our additional expert gift guides, including Best Gifts for Travelers, Sustainable Gifts, Gifts to Turn Any Kitchen Into a Café, New Gear for those New Year New You Resolutions, and Science Toys for Kids.

Why trust us

Popular Science started writing about technology more than 150 years ago. There was no such thing as “gadget writing” when we published our first issue in 1872, but if there was, our mission to demystify the world of innovation for everyday readers means we would have been all over it. Here in the present, PopSci is fully committed to helping readers navigate the increasingly intimidating array of devices on the market right now.

Our writers and editors have combined decades of experience covering and reviewing consumer electronics. We each have our own obsessive specialties—from high-end audio to video games to cameras and beyond—but when we’re reviewing devices outside of our immediate wheelhouses, we do our best to seek out trustworthy voices and opinions to help guide people to the very best recommendations. We know we don’t know everything, but we’re excited to live through the analysis paralysis that internet shopping can spur so readers don’t have to.

The post A graduation gift guide for grads who love the outdoors: From practical tools to personalized accessories appeared first on Popular Science.

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The best way to relieve sore muscles after a brutal workout https://www.popsci.com/health/relieve-sore-muscles/ Thu, 01 Jun 2023 13:00:00 +0000 https://www.popsci.com/?p=544167
White-skinned person pouring ice cubes into bath with a dark-skinned person recovering after a workout. Illustrated in orange, white, and black.
Ice might numb the pain after a workout, but it won't fix what's causing it. Julia Bernhard

Put down the massage gun and step away from the treadmill.

The post The best way to relieve sore muscles after a brutal workout appeared first on Popular Science.

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White-skinned person pouring ice cubes into bath with a dark-skinned person recovering after a workout. Illustrated in orange, white, and black.
Ice might numb the pain after a workout, but it won't fix what's causing it. Julia Bernhard

BEING SORE SUCKS. Anyone who’s exercised to an extent can probably complain about the stiffness, pains, or—worse—injuries the next day. But as annoying as the achiness gets, it’s a critical part of the recovery process

Under your skin, the all-important muscle fibers that push and pull bones to move you around tear slightly during a workout—a phenomenon called microtrauma. Combined with inflammation, these tiny ruptures may cause soreness, which your body alleviates by replacing the cells around the wound.

There are actually two kinds of muscular soreness that you feel after a workout, and they come from different sources. The microtrauma-based discomfort is known as DOMS, short for delayed-onset muscle soreness. You might feel it most between 24 and 48 hours after the workout—and for as long as three to five days. The other type, acute muscle pain, happens after you overwork your body. These pangs go away in about a day or two, just in time for the DOMS to peak. 

So are there surefire ways to get rid of your soreness? Not exactly. The problem is that to ease the aches, your body has to heal the microtears, which isn’t a process you can speed up. There is some good news, though: A solid post-workout ritual could have a placebo-like effect on your mind, blunting some of the pain you feel. And there could be other perks too.

For example, stretching does not lead to faster recovery, but it does make you more flexible and less prone to injury in the future, especially during high-intensity workouts. And while warm-ups don’t help with the healing process either, they do raise your heart rate, preparing you for the sudden jump in activity. 

Then there are the various salves, tools, and self-care schemes people try. A few studies show that proper use of compression gear could confer some benefits for blood flow and enzyme production. Some gymgoers pregame the pain with anti-inflammatory drugs like aspirin and ibuprofen, though they have no proven power against soreness. Elite swimmers might tolerate the bruises that come with cupping therapy—without any science to confirm the benefits of the practice. Even ice baths and far-infrared saunas (featuring high heat and low humidity) have minor, inconsistent results, according to researchers.

In general, getting a massage a day or two after a workout offers short-term relief for muscle tenderness. You will likely feel a little worse with a pair of hands or a percussive therapy device kneading into you, but as soon as it’s done, your pain will be more manageable for the next few hours. In certain circumstances, massages might even help reduce inflammation and DOMS.

There are three surefire things you can do, however, to soothe your soreness a bit. The first is to rest. Your body needs time to rebuild your muscle fibers, so getting a good night’s sleep and using the sore body parts less when you’re awake will help you recover faster. Weightlifters know this well and will work a different muscle group each session. If you’re a regular at the gym, commit to triceps one day and focus on a different group (biceps, maybe) the next.

The second is to make sure you’re eating well. Your body requires nutrients like proteins and carbohydrates to patch up your muscles, so enjoy a big bowl of pasta or a tall glass of chocolate milk a few hours after training. 

The third thing you can do is keep at it. DOMS hits harder when you try a new form of exercise because your body is not used to the strenuous activity. The first time will always be the most painful. But if you set a schedule and habit around the workouts you like best, it should hurt less after you crush all your reps. 

Read more PopSci+ stories.

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Why you should sleep naked tonight, according to science https://www.popsci.com/health/benefits-of-sleeping-naked/ Thu, 01 Jun 2023 10:00:00 +0000 https://www.popsci.com/?p=544970
Baby sleeping naked in a white hammock
The secret to more youthful skin? Skip the pj's. Deposit Photos

Rest easy in your birthday suit.

The post Why you should sleep naked tonight, according to science appeared first on Popular Science.

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Baby sleeping naked in a white hammock
The secret to more youthful skin? Skip the pj's. Deposit Photos

Love it or hate it, sleeping naked hits different. Not only is it less laundry to wash, but taking off those pajamas can do wonders for your health. While you may feel self-conscious at first, the openness of resting in the nude can actually boost your confidence and help you look your best self. 

There’s no right or wrong way to get ready for bed—it’s all a matter of preference. And while nakedness won’t miraculously cure all your sleep problems, experts say there are some modest benefits to going au naturel.

1. Younger-looking skin 

James Walker, a medical advisor for the healthcare platform Welzo, says sleeping without clothes gives your skin an opportunity to breathe, allowing for better airflow. He explains that clothes, especially tight-fitting ones, can restrict blood circulation, making it harder for your skin to receive vitamins and minerals needed for collagen production. Certain materials also might add to your discomfort in bed. Aditya Kashyap Mishra, a sex educator and relationship expert for Lustyboy, says synthetic fibers like spandex and nylon trap moisture in your skin—the added heat can make it hard to fall asleep. Other synthetic fabrics and pajamas with dyed cotton may cause skin irritation and acne from the fabric rubbing against you.

[Related: 5 surprising beauty benefits of running]

Tossing and turning from wearing the wrong clothing can affect your quality of sleep and your skin. The body makes collagen during sleep, which is essential for supple and younger-looking skin. Research shows that getting less than the recommended seven hours of sleep for adults increases skin aging and slows down recovery from sun damage.

2. A cooldown for your body

As you might expect, sleeping with your skin exposed helps regulate your temperature at night, says Walker. The drop in body temperature can prevent overheating—a real concern in summer and in places where winter is virtually non-existent. Research shows that feeling extremely hot at night increases wakefulness. Even if you manage to land some shut-eye, it will likely be less restorative with shorter cycles of slow-wave sleep and REM sleep. 

Feeling colder, on the other hand, can also help you fall asleep faster. Your body temperature is synced up with the light-dark cycles outside; it normally falls when the sun goes down. A lower body temperature from sleeping nude tells your biological clock it’s time to shut down.

3. Fewer fungal infections

Fungi and bacteria thrive in warm and damp areas like your nether regions. Mishra explains that trapped sweat from moisture-wicking clothing increases the risk of microorganisms building up, resulting in yeast infections and jock itch. Jock itch can also come from constant friction from clothes. Stripping down to nothing will allow more air circulation and keep your intimate parts from getting overheated.

4. Better emotional intimacy

Skin-to-skin contact between partners can strengthen your relationship. Research shows touching among consenting adults releases the “love hormone” called oxytocin. This chemical reduces stress and encourages openness and social bonding with others. One US marketing poll of more than 1,000 adults found that 57 percent of couples who regularly snoozed in the nude were happy in their relationship compared to 48 percent of pajama wearers. Getting used to baring it all in front of a partner can counteract self-consciousness of how you look in bed. Mishra says this openness is a huge stress reliever, and the added relaxation can help you sleep better.

What if you want to sleep in clothes?

If you’re still not convinced about sleeping naked, there are other ways to improve your slumber. Avoid tight or constricting apparel that would restrict your movement, irritate your skin, or otherwise cause discomfort. Walker recommends going to bed in loose-fitting and breathable fabrics like cotton or bamboo, or one simple layer like an oversized T-shirt and shorts to avoid overheating.

[Related: 11 ways to sleep better in unbearable heat]

There’s nothing wrong with slipping on a pair of socks before bed, Walker adds. Some people find it comforting and helpful in keeping their feet warm, especially during colder seasons. However, he warns against sleeping in socks that are too tight as they could restrict circulation. 

Whether you go to bed nude or in clothes, you should always remove your makeup and any heavy jewelry. Snoozing with makeup on can clog pores and lead to future breakouts. “It’s best to cleanse the face thoroughly before sleeping to allow the skin to breathe and regenerate,” advises Walker. Additionally, laying down in chunky necklaces, bangles, and other jewelry can be painful and might even leave abrasions on the skin.

“Ultimately, the key is to prioritize comfort and choose sleepwear that allows for optimal relaxation,” Walker says. “It’s always a good idea to listen to your body and make choices that help you feel comfortable and at ease during sleep.”

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Garmin’s newest smartwatches are even more adventure-ready https://www.popsci.com/gear/garmin-epix-pro-fenix-7-pro-news/ Wed, 31 May 2023 16:55:00 +0000 https://www.popsci.com/?p=544842
Garmin fēnix 7 Pro on a wrist with the flashlight illuminated
Garmin

The new epix Pro and fēnix 7 Pro high-performance GPS adventure watches offer more advanced features for serious endurance athletes and outdoor enthusiasts.

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Garmin fēnix 7 Pro on a wrist with the flashlight illuminated
Garmin

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Garmin is well known for its expansive list of rugged fitness watches, with multiple lines specifically tailored to different activity types. And now, the options for adventurers and serious endurance athletes are even more extensive with the announcement of updated Pro versions of the epix and fēnix 7 watches. 

Most of the updates to these premium next-gen. multisport watches are incremental software changes, such as more activity types and new fitness measurement tools. But there are also a few notable hardware and build upgrades, including a new size option and AMOLED display for the epix Pro and an LED flashlight in all three sizes of both the epix Pro and fēnix 7 Pro. Both watches will also benefit from trickle-down features from the new Forerunners.

Garmin epix Pro details

Garmin just debuted its epix 2 line of watches last year. Despite how new the series is, the company is rolling out some worthwhile updates to make it even better in a new Pro version. With vibrant metrics-rich watch faces and extensive sensors/navigation features in a sleek body, the epix Pro remains a great choice for boardroom-to-backcountry adventures and weekend warriors, from climbers and mountaineers to ultra-marathon trail runners. 

Garmin

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epix Pro and build changes

The epix came in two sizes—42mm and 47mm—while the Pro version adds a 52mm option for those who really want a statement piece on their wrist. The larger size offers more than just a dramatic look, however. Garmin packed extra battery into the 52mm version, which promises up to 31 days of battery life in smartwatch mode. The 42mm and 47mm both should provide 10 and 16 days of battery life, respectively. 

Like the epix Gen. 2, the Garmin epix Pro will be available in Standard Edition, which features Corning Gorilla Glass and stainless steel case, or the Sapphire Edition, which uses a more durable Sapphire lens and titanium case. And all three sizes get an even brighter upgraded AMOLED display for a colorful, detail-packed watch face. 

All three sizes will offer an LED flashlight, which can vary in intensity and features a strobe mode. We were glad to see the flashlight included even on the smallest watch since it is a potentially game-changing feature. It can illuminate your path while trail running or hiking in the dark and help others see you, which is invaluable if exercising near a road. 

The epix Pro also gets an updated and optimized heart rate sensor. Garmin didn’t provide any information on what exactly that means, but it says these changes will provide “enhanced multisport performance tracking.”

Fitness tracking features

Garmin watches are already robust in their fitness tracking abilities, but the company is not one to just let things be. The epix Pro will offer new activities, which include team sports such as soccer, basketball, and racquet sports, as well as horseback riding and more.

Beyond new tracking modes, Garmin also created new training features. Hill Score gives you a better idea of how your training impacts your ability to run uphill. Uphill segments are automatically detected and analyzed, and that information is combined with other physiological metrics to provide a score from one to 100. It even breaks the score down into Hill Endurance and Hill Strength, which reflect short, fast efforts versus long, sustained climbs. And it offers feedback to improve your training over time. 

The second new feature—Endurance score—looks beyond your VO2 Max, giving a more personalized look at your fitness. It analyzes both short-term and long-term endurance training and takes into account all types of activity, not just running or cycling. And, like Hill Score, it provides training feedback to help you understand your score.

Three new display types on the Garmin epix Pro smartwatch
The epix Pro will offer new terrain maps, a Red Shift Mode for night use, and weather overlays. Garmin

Additional new features

The Garmin epix Pro will provide a unique Red Shift Mode, which changes the display to shares of red. This lessens the impact on your vision when looking at your watch in the dark and reduces any sleep cycle disturbance you might get from the standard display. You can manually turn on this display mode or schedule it to automatically turn on and off based on sunset and sunrise time. And you can even select certain activities that automatically use Red Shift Mode.

Up Ahead mode will allow you to view running points of interest, such as checkpoints and aid stations, right on the map. This allows you to better understand what’s in front of you and plan accordingly on your race or activity. 

The last feature those navigating the backcountry will especially appreciate is the new weather map overlays and relief shading on topographic maps. The weather overlays can display temperature, precipitation, and cloud cover, to help you make more informed decisions on the go. And relief shading will assist in navigation. You can also opt into Outdoor Maps+ for even more map content, including satellite imagery and more detailed maps.  

Garmin epix Pro pricing & availability

The epix Pro is available for purchase as of today, starting at $899.99.

Garmin

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Garmin fēnix 7 Pro details

Like the epix Pro, most changes to the fēnix 7 Pro are smaller software additions. The fēnix 7 Pro still comes in 42mm, 47mm, or 51mm sizes, though you no longer have the option of a version without solar charging. You can, however, choose between Standard Solar or Sapphire Solar, depending on how robust you want your watch face. 

Like many of Garmin’s new watches lately, including the Instinct 2X, the fēnix 7 Pro will feature an LED flashlight in all sizes. It offers a broad pattern, variable intensities, red safety light, and strobe mode. 

New training features

The fēnix 7 Pro also gets a new heart rate sensor. Garmin says this next-gen sensor utilizes “more spatially diverse optical sensors and sport-specific algorithms.” It should provide even better performance tracking for more activities, giving you even more accurate insight into your training. 

Like the epix Pro, the fēnix 7 Pro will also get the new Endurance Score and Hill Score for better endurance training insight. It also gets its share of new activities, including white water rafting, motocross, overlanding, and dozens more. And the watch will provide access to the weather map overlays, new relief shading, and Up Ahead mode.

Garmin fēnix 7 Pro pricing and availability

All versions of the fēnix 7 Pro are available for purchase at a starting price of $799.99.

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How to make hand sanitizer https://www.popsci.com/story/diy/diy-hand-sanitizer/ Wed, 22 Apr 2020 16:37:33 +0000 https://www.popsci.com/uncategorized/diy-hand-sanitizer/
Hand sanitizer bottle and hands.
Making your own hand sanitizer is easy. But if you want to fight COVID-19, no, you can't use vodka. Kelly Sikkema via Unsplash

We’ve got liquid and gel for all your germ-killing needs.

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Hand sanitizer bottle and hands.
Making your own hand sanitizer is easy. But if you want to fight COVID-19, no, you can't use vodka. Kelly Sikkema via Unsplash

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Most people probably haven’t thought much about how to make hand sanitizer. Stores sell it for cheap, in a variety of scents and styles, and it’s basically as good as it can be. But if you want to earn some DIY bragging rights, clean your paws using a particular scent, or prepare for a future health crisis, you can easily make your own with supplies you can find at a drugstore or may already have at home.

But before you start, there are a few things you should keep in mind before you craft homemade hand sanitizer. First, it’s crucial that you understand that proper hand washing will always be better than simply rubbing your digits with hand sanitizer. Using the right amount of alcohol-based disinfectant (3 milliliters) for 25 to 30 seconds is fine in a pinch, but soap, water, and a good scrub are the absolute best way to protect yourself against contagious diseases.

Knowing how to make hand sanitizer is useful if you ever find yourself in the middle of a health emergency like the COVID-19 pandemic. But these and other DIY recipes are only for extreme cases when hand washing is not an option and supplies are low. Professionals use these formulations in underserviced healthcare settings, and if at some point hand sanitizer is not available at local stores, you can use them too.

Lastly, your homemade hand sanitizer won’t last forever. The main active ingredient in the recipes below is isopropyl alcohol, a volatile compound that will evaporate over time and compromise the effectiveness of your hand sanitizer. When alcohol concentration drops below 60%, your hand sanitizer won’t be able to kill COVID-19 or influenza, for example. The shelf life of store-bought hand sanitizers can vary—the industry standard is three years, but it can go up to five. How long your DIY hand sanitizer lasts will depend on the type and size of the container you use and how often you open it, along with room temperature and humidity. Unfortunately, all of these factors make it hard to predict exactly how long your hand sanitizer will be good for, so proceed with caution. 

How to make hand sanitizer

There are two main formulas for homemade hand sanitizer: one, recommended by the World Health Organization, is closer to liquid than gel and is harder on your hands, while the other will be gentler on your skin and closely resembles the feel of store-bought hand sanitizer. Which one you make depends on your personal preference.

Stats

  • Time: literally 2 minutes
  • Estimated ingredient cost: $15 (makes 3.5 cups, or 15 of those little two-ounce bottles)
  • Difficulty: easy

Tools

Recipe No. 1: the WHO hand sanitizer formulation

Ingredients

The WHO has a comprehensive guide on how to make hand sanitizer—the only problem is that if you follow their instructions, you’ll end up with a lot of it. Like, exactly 2.6 gallons of it. If you want to make enough to last you, your family, and all your friends through a zombie apocalypse, you definitely can. But if you want to keep things on a smaller scale, we’ve adapted the measurements for you.

1. Pour the alcohol into a medium-sized container with a pouring spout. The percentages on the labels of isopropyl alcohol refer to the alcohol concentration in them. You’re dealing with almost pure alcohol if you’ve got 99.8%, whereas 70% means the bottle is only a little more than two-thirds alcohol, and the rest is water.

2. Add the hydrogen peroxide.

3. Add the glycerin and stir. This ingredient is thicker than both alcohol and hydrogen peroxide, so it’ll take some stirring to combine everything. You can use a clean spoon for this or, if your container has a lid, you can put that on and shake it well.

4. Measure and pour in the water. Measure a ¼-cup of distilled or boiled cold water and add it to your mix. Stir.

[Related: Is hand sanitizer bad for my microbiome?]

5. Sanitize your spray bottles and pour in your hand sanitizer. Spray some of your leftover alcohol into your bottles and let them sit until the alcohol has evaporated. Then pour in your sanitizer.

6. Label your bottles. Hand sanitizers pose a real risk of involuntary alcohol poisoning, especially among children, who were largely affected by it during the first months of the COVID-19 pandemic. You don’t want anyone to accidentally ingest your newly made hand sanitizer. Take the time to label your bottles with their contents and the date, and keep them away from unsupervised kids.

Recipe No. 2: hand sanitizer gel

Ingredients

1. Pour the alcohol into a medium container with a pouring spout. Some recipes online use vodka instead of isopropyl alcohol, but they’re not interchangeable. Most vodkas and other spirits don’t contain a high enough percentage of alcohol to be effective.

  • Warning: Using isopropyl alcohol diluted beyond 91% will result in a weaker hand sanitizer that doesn’t meet the CDC’s 60% benchmark for killing the COVID-19 virus and influenza.

2. Measure and pour the aloe vera gel. Alcohol can be hard on your skin, so using aloe is a good way to counteract that effect and keep your hands smooth. If you want to keep things natural, you can use aloe vera gel straight from the plant without worrying about it going bad—the alcohol will act as a preservative.

[Related: Five tips for taking care of your over-washed hands]

However, you will need to keep in mind that natural aloe gel is thicker than its store-bought counterpart and will affect the final product differently—it will make your hand sanitizer more sticky, which means you’ll need to rub your hands more times for it to fully absorb.

3. Add the essential oil. Tea tree oil is naturally antibacterial, so it makes sense to use it here. But if you’re not a fan of its smell, you can use another type of essential oil, like lavender, lemongrass, or eucalyptus.

4. Whisk. To fully mix all ingredients, stirring won’t be enough. Get a whisk and beat that hand sanitizer into a homogeneous gel.

5. Sanitize your spray bottles and pour in your hand sanitizer. Spray some of your leftover alcohol into your bottles and let them sit until the alcohol has evaporated. Pour in your sanitizer.

6. Label your containers. Hand sanitizers pose a real risk of involuntary alcohol poisoning, especially among children, who were largely affected by it during the first months of the COVID-19 pandemic. You don’t want anyone to accidentally ingest your newly made hand sanitizer. Take the time to label your bottles with their contents and the date, and keep them away from unsupervised kids.

Updated March 7, 2020, at 1 p.m.: This story has been updated to more accurately reflect which concentrations of alcohol will result in hand sanitizer that’s at least 60% alcohol.

Updated March 23, 2020, at 6 p.m.: This story has been updated to more accurately reflect the amount of water in the WHO formulation. The original story resulted in hand sanitizer that was 71% alcohol, and the updated version is now at 75%.

This post has been updated. It was originally published on March 5, 2020.

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The deadliest viruses in human history, from COVID to smallpox https://www.popsci.com/health/deadliest-viruses/ Tue, 30 May 2023 20:00:00 +0000 https://www.popsci.com/?p=543844
HIV, seen in red budding particles, is among the deadliest viruses.
HIV particles, in red and yellow, are budding from an infected cell in a electron micrograph. NIAID/NIH

Deadly viral pathogens include rabies, which is fatal without swift treatment, and the flu, which has a huge global toll.

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HIV, seen in red budding particles, is among the deadliest viruses.
HIV particles, in red and yellow, are budding from an infected cell in a electron micrograph. NIAID/NIH

Over the first two years of the COVID-19 pandemic, the coronavirus directly or indirectly killed about 15 million people worldwide, according to estimates from the World Health Organization. In the United States, more people died in 2020 and 2021 than during the 1918 influenza pandemic, which was widely called the most deadly in recorded history. 

The word “deadly” certainly applies to the virus that causes COVID-19. And yet, epidemiologists hesitate to give SARS-CoV-2 the superlative of deadliest virus in human history. To them, the raw number of mortalities caused by a given virus doesn’t always paint the full picture of a pathogen’s danger—especially when comparing viral outbreaks across time.

Raw mortality numbers have to be taken in the context of the world’s total population, says Jennifer Nuzzo, professor of epidemiology and director of the Pandemic Center at Brown University School of Public Health. “A lot of people talk about how COVID deaths eclipsed what we saw in 1918,” she says. “It’s really important to remember that the population of 1918 was a fraction of what it is today.” In that context, the flu of 1918 rises back up in the ranks in terms of deadliness.

Defining the deadliest virus

Instead of just looking at tallied mortalities, epidemiologists use a metric called the “case fatality rate” or “case fatality ratio” as a measure of how likely a virus is to be lethal. Essentially, it’s the proportion of infected people who end up dying, and therefore represents the likelihood that an infection will end in death. 

Using the “case fatality rate” metric to determine what virus is the deadliest, rabies would likely come out on top. That’s because, if an infection becomes symptomatic, rabies is fatal to humans in more than 99 percent of cases. Globally, approximately 59,000 people die from rabies every year. Very few of those deaths—an average of two in the US—occur in the developed world because of rabies vaccines for household pets and swift medical interventions after bites.

But “a virus doesn’t have to have a very high case fatality ratio to cause a tremendous amount of death and disruption,” Nuzzo says. “It’s more about looking at the environments in which the viruses are spreading, and our social and human vulnerabilities to it.” 

A virus with a lower case fatality rate can kill more people if it’s highly transmissible, with a long period of time before severe or obvious symptoms set in. This allows an infected person to expose many others. That’s why SARS-CoV-2 caused such a rapid and devastating outbreak around the globe. It’s easily transmitted via airborne droplets, and doesn’t always or immediately cause severe illness. 

[Related: Can viruses be good for us?]

Globalization sped it along, too. “When a virus spreads at the pace of a human being walking, that’s very different than when you can hop on an airplane and be anywhere in the world in 36 hours,” Nuzzo says. 

During large outbreaks such as epidemics or pandemics, epidemiologists look at another metric, called excess deaths: how many more people died during a period of time than typically do over that same window. Excess deaths can account for other indirect ways that a virus causes death, Nuzzo says, such as patients who need critical care but can’t get it in overburdened hospitals.

Here’s how some of the most devastating viruses in human history tell different stories of how high a death toll can rise:

Influenza

The 1918 influenza pandemic still far and away ranks as the deadliest global outbreak of the 20th century. Thought to be caused by an H1N1 virus, it spread globally in 1918 and 1919. An estimated 500 million people were infected (approximately a third of the global population) and 50 million people died worldwide, about 675,000 of whom were in the United States, according to the Centers for Disease Control and Prevention. 

Without sophisticated testing and tracking, death toll estimates rely heavily on excess death calculations. Some suggest the true toll was closer to 17 million, while others set it much higher at 100 million. William Schaffner, professor of preventive medicine and professor of medicine in the division of infectious diseases at the Vanderbilt University School of Medicine, cautions against over-interpreting comparisons between the historic flu data and modern viral outbreaks.

[Related: Can you get diseases from bad bathroom smells?]

 “We are determining cases and even counting deaths with much more precision now than we did then,” he says. At the time, there were also no flu vaccines and no antibiotics to treat secondary bacterial infections, which likely drove the excess death toll higher.

In preparation for the deadly flu, mask-wearing women hold stretchers at backs of ambulances.
St. Louis Red Cross Motor Corps on duty in October 1918 during the influenza epidemic. Library of Congress

Today, the youngest and oldest people are most likely to die from influenza. But during the pandemic over 100 years ago, Schaffner says, deaths bore a different signature: mortality peaked among young and middle-aged adults, too. Why that happened is still unclear, he says, but it contributed to the historic toll of that pandemic.

Influenza continues to hold its place as one of the deadliest viruses, despite the availability of vaccines. Variants of the influenza virus have led to other pandemic-level events, such as the 2009 outbreak colloquially called the swine flu pandemic. But the virus is also endemic in our society, and infects an estimated 1 billion people globally every year, according to the World Health Organization. Of those cases, the WHO reported in 2019, somewhere between 290,000 to 650,000 result directly or indirectly in deaths. 

HIV/AIDS

The human immunodeficiency virus (HIV) has been an ongoing epidemic since the 1980s. The virus, which attacks the body’s immune system, can lead to acquired immunodeficiency syndrome (AIDS), leaving a person susceptible to other infections as well. 

An estimated 40.1 million people have died from AIDS-related illnesses since the start of the epidemic, according to the Joint United Nations Program on HIV and AIDS. That is nearly half of the number of people estimated to have become infected with HIV since the start of the epidemic, at an estimated 84.2 million. 

The case fatality rate of HIV/AIDS was historically quite high. Some estimates put it around 80 percent without treatment. But much has changed since the 1980s. Today, there are ways to manage HIV and mitigate the immunodeficiencies associated with an infection, and most patients are diagnosed sooner after an infection. In the United States, the rate of HIV-related deaths fell by nearly half from 2010 to 2017, according to the CDC. 

SARS-CoV-2/COVID-19

Death toll estimates for the COVID-19 pandemic are still difficult to come by. The WHO keeps an official tally of confirmed deaths due to COVID-19, which puts the death toll at just shy of 7 million globally. However, the actual toll is certainly much higher, especially given inconsistent reporting around the world. In fact, the WHO also estimated that over the course of 2020 and 2021 the virus caused 15 million deaths worldwide directly or indirectly. 

That excess deaths metric likely reached a much higher number by the time officials declared the public health emergency over in early May. The Omicron wave that swept around the globe in late 2021 and early 2022 saw one of the largest surges in cases of COVID-19 and, although the variant didn’t seem to be more deadly than previous variants, with millions of people infected, a high death toll in the hundreds of thousands was inevitable. 

Early in the pandemic, the case fatality rates calculated for SARS-Cov-2 varied considerably. Many estimates were likely higher than the true number, as researchers scrambled to devise tests for the virus and milder cases slipped through the cracks. In early 2020, estimates of the case fatality rate by country ranged as high as 25 percent or more. Since then, case fatality rates have dropped, and now, according to Johns Hopkins University, they are as high as 4.9 percent. In the US, the case fatality rate is 1.1 percent

Smallpox

“In its day, smallpox was thought to be one of the great pestilences of humankind,” Schaffner says. Smallpox likely wreaked havoc for millennia. Fourth-century writings describe a disease similar to smallpox, and some Egyptian mummies appear to have smallpox-like rashes. 

Mortalities continued to stack up into the 20th century, with an average of three out of every 10 people infected dying. The disease, which is caused by variola virus, is estimated to have killed more than 300 million people from 1900, until a global vaccination campaign halted its path of devastation in 1977. It was the first disease ever to be eradicated. 

[Related: The first honeybee vaccine could protect the entire hive, starting with the queen]

But it was the very thing that made it particularly fearsome that was its downfall, Schaffner says. “It created such a distinctive rash that people could identify it and fear it. And that was one of its Achilles heels,” he says. Because it was so easily identifiable, and spread so slowly, vaccinating the local population near an outbreak swiftly curtailed transmission. Such an approach, he says, was part of the vaccination strategy that eradicated the great pestilence. 

Other killer viruses

Another virus that is often cited as particularly deadly is Ebola. Approximately 34,600 people were infected with Ebola from 1976 to 2020, according to one count, and about 15,200 died. That virus carries an average case fatality rate of around 50 percent. But the chance of survival rises steeply if you have access to medical treatment, Nuzzo says. And because Ebola is typically spread through direct contact, not airborne transmission like SARS-CoV-2, overall case rates are lower. Marburg virus is similar to Ebola and also carries a high case fatality rate, which ranges from 24 to 90 percent. However, recorded cases number only in the 100s, so the raw number of deaths is quite low.

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Evolution of human foot arches put the necessary pep in our upright steps https://www.popsci.com/health/foot-arch-walking-human-evolution/ Tue, 30 May 2023 14:00:00 +0000 https://www.popsci.com/?p=544309
A walker in sneakers, with the bottom of the shoe visible.
Arch mobility could be the key to our species' successful bipedalism. Deposit Photos

A spring-like recoil in the arch helps the ankle lift the body from the ground.

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A walker in sneakers, with the bottom of the shoe visible.
Arch mobility could be the key to our species' successful bipedalism. Deposit Photos

Efficiently standing up and walking and running on two feet  stands out among the traits that separates Homo sapiens from great apes—and we can owe a lot of that to a raised medial arch. While crucial, the mechanics behind bipedal walking are still a bit of an evolutionary mystery.  A study published May 30 in the journal Frontiers in Bioengineering and Biotechnology found that helpful and spring-like arches may have evolved for the purpose of helping us walk on two feet.

[Related: Foraging in trees might have pushed human ancestors to walk on two feet.]

The team found that the recoil of a flexible arch repositions in the ankle upright for more efficient walking and is particularly effective for running. 

“We thought originally that the spring-like arch helped to lift the body into the next step,” study co-author and University of Wisconsin-Madison biomechanical engineer Lauren Welte said in a statement. “It turns out that instead, the spring-like arch recoils to help the ankle lift the body.”

The raised arch in the center of the human foot is believed to give hominins more leverage while walking upright. When arch motion is restricted, like it could be in those with more flat feet, running demands more energy from the body. Arch recoil could potentially make our species more efficient by propelling the body’s center of mass forward, essentially making up for the mechanical work that the muscles would have to do otherwise.

In this new study, the team selected seven participants with varying arch mobility and filmed their walking and running patterns with high-speed x-ray motion capture cameras. The team measured the height of each participant’s arch and took CT scans of their right feet. They also created rigid models that were compared to the measured motion of the bones in the foot. Scientists then measured which joints added the most to arch recoil and the contribution of arch recoil to center of mass and ankle propulsion.

Surprisingly, they found that a rigid arch without recoil caused the foot to prematurely leave the ground, likely decreasing the efficiency of the calf muscle. A rigid arch also leaned the ankle bones too far forward. A forward lean looks more like the posture of walking chimpanzees instead of the straight upright stance of a human gait.

A flexible arch helped reposition the ankle upright, allowing the leg to push off the ground more effectively. This effect is greater while running, suggesting that a flexible arch for more efficient running may have been a desired evolutionary trait.

The team also found that a joint between two bones in the medial arch–the navicular and the medial cuneiform–is crucial to flexibility. Investigating the changes in this joint over time could help scientists track the development of bipedalism in our own fossil record. 

[Related: The Monty Python ‘silly walk’ could replace your gym workout.]

“The mobility of our feet seems to allow us to walk and run upright instead of either crouching forward or pushing off into the next step too soon,” study co-author and Queen’s University mechanical and materials engineer Michael Rainbow said in a statement.

These findings and understanding more about arch flexibility could help people who have rigid arches due to illness or injury. Their hypothesis still needs more testing, but could help solve a plethora of modern-day foot dilemmas. 

“Our work suggests that allowing the arch to move during propulsion makes movement more efficient,” said Welte. “If we restrict arch motion, it’s likely that there are corresponding changes in how the other joints function.”

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The 6 essential parts of an effective workout https://www.popsci.com/health/basic-workout-routine/ Tue, 30 May 2023 13:00:00 +0000 https://www.popsci.com/?p=543866
Person with dark skin and short hair jumps rope while pregnant person with light skin and hair in a bun squats and lifts dumbells. Illustrated in orange, black, and gray.
Working out and winning. Julia Bernhard

Cardio or lifting? Why not both?

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Person with dark skin and short hair jumps rope while pregnant person with light skin and hair in a bun squats and lifts dumbells. Illustrated in orange, black, and gray.
Working out and winning. Julia Bernhard

MOST PEOPLE have a certain mindset when it comes to working out: They tend to stick to a familiar plan and will push their bodies to the brink to achieve their fitness goals. But a healthy exercise routine has several building blocks—and a surprising number of them depend on what you do outside your regular sweat sessions. 

Warm-up

Activities that prepare you for your main fitness practice can serve two primary purposes: reducing injury and improving performance. Warm-ups hit those marks by increasing blood flow, ramping up muscle and core temperatures, and disrupting the temporary connective tissue bonds that can make you feel tight and sore. This leads to performance-enhancing benefits like faster muscle contraction, better reaction time, greater muscle strength, lower muscle resistance, and more oxygen for your cells. Warm-ups should last at least 5 minutes and top out at 15 minutes, depending on the length and difficulty of your routine: They usually include stretching and a slow increase in exertion.

Cardio

Frequent exercise that raises your heart rate to your target zone has been shown to benefit cardiac health (though there is some evidence that consistent physical effort at this level, like during marathon training, could have negative effects). It can decrease the risk of developing and dying from heart conditions. Not only that, but cardio workouts are also associated with lower blood pressure and the suppression of atherogenesis, the buildup of fatty plaque in blood vessels that can lead to coronary artery heart disease.

Strength training

Weightlifting isn’t just for people who want to get ripped: It has more significant benefits, particularly as you age. For one, targeted muscle building can reinforce joints like knees, ankles, and hips. That offers better support for your body, which helps lower the chances of falls and injuries. Contrary to popular belief, strength training also promotes greater mobility and flexibility; plus it boosts brain health and cognitive abilities like processing speed, memory, and executive functioning.

Hydration

You have to stay hydrated before, during, and after your workout. Exercise depletes the body’s fluids, particularly as you sweat. Dehydration degrades your performance and can also impair certain cognitive functions, including short-term memory and attention. Hydrating sometimes alleviates fatigue and increases reaction time. Overall, drinking water when you feel a need, rather than on a fixed schedule, can improve performance measures like duration and speed. It’s possible to drink too much water (a potentially fatal situation known as hyponatremia), so take small sips rather than chugging a bottle all at once.

Cooldown 

Just as you don’t want to dive straight into your routine, you don’t want to end it abruptly. Build in some time to slow your roll and bookend your warm-up. An active cooldown in which you do something similar to your workout but at a lower intensity, like a light jog after a long run, can solidify the results from exercising and prep you for your next routine. Bonuses include accelerated recovery of lactate in blood, partial prevention of immune system depression, and faster recovery of the cardio­vascular and respiratory systems.

Rest days

Taking days off between workouts is a crucial part of any fitness routine. Studies indicate that rest is necessary for the body to recover: When exercise and exertion sap your energy stores and fluids, relaxation gives you time to replenish them. You need at least 24 hours to fully replace the carbohydrates in your muscles, which are important for maintaining an adequate level of glycogen and stabilizing blood sugar. Rest days help prevent overtraining syndrome too. The illness mostly comes up in competitive runners and elite athletes, with symptoms like fatigue, sleep loss, and depression. 

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Neuralink human brain-computer implant trials finally get FDA approval https://www.popsci.com/technology/neuralink-fda-approval/ Fri, 26 May 2023 18:00:00 +0000 https://www.popsci.com/?p=544092
Elon Musk in meeting wearing suit
Neuralink promised more information on clinical trials 'soon.'. CHANDAN KHANNA/AFP via Getty

The FDA previously rebuffed Neuralink's initial application.

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Elon Musk in meeting wearing suit
Neuralink promised more information on clinical trials 'soon.'. CHANDAN KHANNA/AFP via Getty


Elon Musk’s brain-computer interface company Neuralink announced on Thursday evening that it has received FDA approval to begin conducting human trials. News of the major step arrives after years of research and numerous regulatory hurdles, as well as multiple investigations into potential safety and animal ethics violations.

“This is the result of incredible work by the Neuralink team in close collaboration with the FDA and represents an important first step that will one day allow our technology to help many people,” Neuralink wrote via its Twitter account on Thursday evening, with Musk retweeting the message alongside his congratulations.

[Related: Elon Musk hopes humans will test Neuralink brain implants in the next six months.]

Neuralink aims to create a line of computer implants that connect directly with users’ brains, initially in order to restore patients’ vision and help those with a “Stephen Hawking-type [neurological] situation,” explained Musk during a Neuralink presentation last November. For the majority of his life, Hawking suffered from amyotrophic lateral sclerosis (ALS), which ultimately resulted in a near total body paralysis.

Neuralink first released footage in 2019 of a successful interfacing with rat test subjects. The company subsequently moved on to similar implants for sheep, pigs, and monkeys. In 2021, the company released footage of one of its test macaques playing Pong via a prototype “brain-machine interface.” Late last year, however, an exposé from Reuters revealed the company was under a federal investigation stemming from “internal staff complaints” regarding alleged animal-welfare violations, some of which pertained to over alleged 1,500 dead test subjects. Shortly thereafter, another report via Reuters indicated the FDA had rebuffed the company’s initial requests to begin human test trials, citing concerns over devices potentially overheating, as well as the possibility of damaging brain tissue upon implant removal.

[Related: Employees say Neuralink’s ‘hack job’ tests killed roughly 1,500 animals since 2018.]

As The Verge and DigitalTrends noted on Thursday, Neuralink is not the first company to receive regulatory greenlight on human brain-computer interface trials. Earlier this year, a company called Synchron—backed by the likes of Jeff Bezos and Bill Gates—announced it had successfully implanted their “Stentrode” neuroprosthesis device in four human subjects. BrainGate’s device has also previously allowed a paralyzed man to convert his imagined handwriting into text to communicate.

Per Neuralink, recruitment is not yet open for clinical trials, but the company promised “more information on this soon.” Last November, Musk stated during a company show-and-tell that “You could have a Neuralink device implanted right now and you wouldn’t even know,” adding that, “ Hypothetically in one of these demos, in fact… I will.”

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The best Memorial Day fitness deals let you jump into summer activities and save https://www.popsci.com/gear/best-memorial-day-amazon-fitness-deals-2023/ Fri, 26 May 2023 12:19:03 +0000 https://www.popsci.com/?p=543181
Save big on gear with these Memorial Day fitness deals.

Break a sweat without breaking the bank with these deals, like 20% on an inflatable kayak.

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Save big on gear with these Memorial Day fitness deals.

We may earn revenue from the products available on this page and participate in affiliate programs. Learn more ›

The unofficial kickoff to summer is a great time to get active, indoors or out. The warmer weather invites barbecues and relaxation. So whether you’re training for a race, looking to get out on the water for the first time, or improving your putt, these Memorial Day fitness deals will help you prepare, have fun, and save money while you’re doing it.

Aquaglide Deschutes Inflatable Kayak $543.89 (was $679.99)

Inflatable kayaks are appealing because they’re generally much easier to transport than traditional models. But you shouldn’t have to sacrifice performance for portability. Aquaglide’s Deschutes Inflatable Kayak provides a solution: It’s both a cinch to toss into your car and includes features that paddlers are looking for. Plus, it’s currently available at its lowest price in months—just in time for the weather and waters to warm up.

This single-person kayak weighs just 18 pounds and fits into an included duffle bag. You’ll need a 12-volt air pump to inflate the three chambers of this open cockpit model, which is not included. Once inflated, this 11-foot kayak is designed with handles for carrying, a cushioned, quick-release seat, and adjustable footrests for a comfortable ride. The package also includes a quick-release fin, cockpit drain, and repair kit should you encounter rough waters. 

More outdoor fitness deals

Best home gym equipment deals

Best smartwatch and wearable deals

Best fitness accessories

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How to get through to your aging parents without arguing https://www.popsci.com/health/stubborn-older-parents-advice-help-caretaking/ Fri, 26 May 2023 01:00:00 +0000 https://www.popsci.com/?p=543469
Senior man and woman in wheelchair
'You don’t want to rub their nose into their incapacity.'. DepositPhotos

Empathy and a respect for autonomy are needed to care for older loved ones.

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Senior man and woman in wheelchair
'You don’t want to rub their nose into their incapacity.'. DepositPhotos

This article was originally featured on KFF Health News.

It was a regrettable mistake. But Kim Sylvester thought she was doing the right thing at the time.

Her 80-year-old mother, Harriet Burkel, had fallen at her home in Raleigh, North Carolina, fractured her pelvis, and gone to a rehabilitation center to recover. It was only days after the death of Burkel’s 82-year-old husband, who’d moved into a memory care facility three years before.

With growing distress, Sylvester had watched her mother, who had emphysema and peripheral artery disease, become increasingly frail and isolated. “I would say, ‘Can I help you?’ And my mother would say, ‘No, I can do this myself. I don’t need anything. I can handle it,’” Sylvester told me.

Now, Sylvester had a chance to get some more information. She let herself into her mother’s home and went through all the paperwork she could find. “It was a shambles — completely disorganized, bills everywhere,” she said. “It was clear things were out of control.”

Sylvester sprang into action, terminating her mother’s orders for anti-aging supplements, canceling two car warranty insurance policies (Burkel wasn’t driving at that point), ending a yearlong contract for knee injections with a chiropractor, and throwing out donation requests from dozens of organizations. When her mother found out, she was furious.

“I was trying to save my mother, but I became someone she couldn’t trust — the enemy. I really messed up,” Sylvester said.

Dealing with an older parent who stubbornly resists offers of help isn’t easy. But the solution isn’t to make an older person feel like you’re steamrolling them and taking over their affairs. What’s needed instead are respect, empathy, and appreciation of the older person’s autonomy.

“It’s hard when you see an older person making poor choices and decisions. But if that person is cognitively intact, you can’t force them to do what you think they should do,” said Anne Sansevero, president of the board of directors of the Aging Life Care Association, a national organization of care managers who work with older adults and their families. “They have a right to make choices for themselves.”

That doesn’t mean adult children concerned about an older parent should step aside or agree to everything the parent proposes. Rather, a different set of skills is needed.

Cheryl Woodson, an author and retired physician based in the Chicago area, learned this firsthand when her mother — whom Woodson described as a “very powerful” woman — developed mild cognitive impairment. She started getting lost while driving and would buy things she didn’t need then give them away.

Chastising her mother wasn’t going to work. “You can’t push people like my mother or try to take control,” Woodson told me. “You don’t tell them, ‘No, you’re wrong,’ because they changed your diapers and they’ll always be your mom.”

Instead, Woodson learned to appeal to her mother’s pride in being the family matriarch. “Whenever she got upset, I’d ask her, ‘Mother, what year was it that Aunt Terri got married?’ or ‘Mother, I don’t remember how to make macaroni. How much cheese do you put in?’ And she’d forget what she was worked up about and we’d just go on from there.”

Woodson, author of “To Survive Caregiving: A Daughter’s Experience, a Doctor’s Advice,” also learned to apply a “does it really matter to safety or health?” standard to her mother’s behavior. It helped Woodson let go of her sometimes unreasonable expectations. One example she related: “My mother used to shake hot sauce on pancakes. It would drive my brother nuts, but she was eating, and that was good.”

“You don’t want to rub their nose into their incapacity,” said Woodson, whose mother died in 2003.

Barry Jacobs, a clinical psychologist and family therapist, sounded similar themes in describing a psychiatrist in his late 70s who didn’t like to bend to authority. After his wife died, the older man stopped shaving and changing his clothes regularly. Though he had diabetes, he didn’t want to see a physician and instead prescribed medicine for himself. Even after several strokes compromised his vision, he insisted on driving.

Jacobs’ take: “You don’t want to go toe-to-toe with someone like this, because you will lose. They’re almost daring you to tell them what to do so they can show you they won’t follow your advice.”

What’s the alternative? “I would employ empathy and appeal to this person’s pride as a basis for handling adversity or change,” Jacobs said. “I might say something along the lines of, ‘I know you don’t want to stop driving and that this will be very painful for you. But I know you have faced difficult, painful changes before and you’ll find your way through this.’”

“You’re appealing to their ideal self rather than treating them as if they don’t have the right to make their own decisions anymore,” he explained. In the older psychiatrist’s case, conflict with his four children was constant, but he eventually stopped driving.

Another strategy that can be useful: “Show up, but do it in a way that’s face-saving,” Jacobs said. Instead of asking your father if you can check in on him, “Go to his house and say, ‘The kids really wanted to see you. I hope you don’t mind.’ Or, ‘We made too much food. I hope you don’t mind my bringing it over.’ Or, ‘I wanted to stop by. I hope you can give me some advice about this issue that’s on my mind.’”

This psychiatrist didn’t have any cognitive problems, though he wasn’t as sharp as he used to be. But encroaching cognitive impairment often colors difficult family interactions.

If you think this might be a factor with your parent, instead of trying to persuade them to accept more help at home, try to get them medically evaluated, said Leslie Kernisan, author of “When Your Aging Parent Needs Help: A Geriatrician’s Step-by-Step Guide to Memory Loss, Resistance, Safety Worries, and More.”

“Decreased brain function can affect an older adult’s insight and judgment and ability to understand the risks of certain actions or situations, while also making people suspicious and defensive,” she noted.

This doesn’t mean you should give up on talking to an older parent with mild cognitive impairment or early-stage dementia, however. “You always want to give the older adult a chance to weigh in and talk about what’s important to them and their feelings and concerns,” Kernisan said.

“If you frame your suggestions as a way of helping your parent achieve a goal they’ve said was important, they tend to be much more receptive to it,” she said.

A turning point for Sylvester and her mother came when the older woman, who developed dementia, went to a nursing home at the end of 2021. Her mother, who at first didn’t realize the move was permanent, was furious, and Sylvester waited two months before visiting. When she finally walked into Burkel’s room, bearing a Valentine’s Day wreath, Burkel hugged her and said, “I’m so glad to see you,” before pulling away. “But I’m so mad at my other daughter.”

Sylvester, who doesn’t have a sister, responded, “I know, Mom. She meant well, but she didn’t handle things properly.” She learned the value of what she calls a “therapeutic fiblet” from Kernisan, who ran a family caregiver group Sylvester attended between 2019 and 2021.

After that visit, Sylvester saw her mother often, and all was well between the two women up until Burkel’s death. “If something was upsetting my mother, I would just go, ‘Interesting,’ or, ‘That’s a thought.’ You have to give yourself time to remember this is not the person you used to know and create the person you need to be your parent, who’s changed so much.”

KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

Life Skills photo

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Extreme weather and energy insecurity can compound health risks https://www.popsci.com/environment/power-outages-weather-climate-health/ Thu, 25 May 2023 17:00:00 +0000 https://www.popsci.com/?p=543460
People who need electronic medical devices and live in poor housing conditions tend to experience higher rates of energy insecurity.
People who need electronic medical devices and live in poor housing conditions tend to experience higher rates of energy insecurity. DepositPhotos

'Certain communities and individuals may experience more and more severe power outages or have less ability to respond.'

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People who need electronic medical devices and live in poor housing conditions tend to experience higher rates of energy insecurity.
People who need electronic medical devices and live in poor housing conditions tend to experience higher rates of energy insecurity. DepositPhotos

In 2020, about 34 million households in the United States experienced some degree of energy insecurity. Energy insecurity is defined as the inability to meet basic household energy needs, like reducing or foregoing basic necessities to pay energy bills. Others may maintain unsafe temperatures at home due to cost concerns, both of which are “chronic” forms of energy insecurity. Individuals may also experience “acute” energy insecurity, or a short-term disruption to energy sources due to infrastructural or environmental reasons, much like power outages.

People who need electronic medical devices and live in poor housing conditions tend to experience higher rates of energy insecurity. A recent Nature Communications study characterized power outages across the country from 2018 to 2020 and found that there were almost 17,500 power outages lasting more than eight hours. Outages of this duration are considered medically relevant because of potential health hazards for vulnerable groups, especially those who require electricity-dependent durable medical equipment (DME) such as oxygen concentrators and infusion pumps. Although some DME can have backup battery power, they only last a few hours.

“Understanding to what extent power outages affect health motivated us to create the county-level power outages dataset,” says Joan Casey, assistant professor of environmental and occupational health sciences at the University of Washington, who was involved in the study. “As our grid ages and climate change worsens, we need to understand who power outages affect.”

[Related: Fossil fuels are causing a buildup of human health problems.]

The authors used local indicators of spatial association (LISA) to identify countries with high levels of social and medical vulnerability alongside frequent power outages. In particular, counties in Arkansas, Louisiana, and Michigan experience frequent medically-relevant power outages and have a high prevalence of electricity-dependent DME use. They “face a high burden and may have more trouble responding effectively, which could result in more adverse health outcomes,” says Casey.

The authors also determined the overlap between climate events occurring on the same day as medically-relevant power outages. They reported that about 62 percent of such outages co-occurred with extreme weather events, like heavy precipitation, anomalous heat, and tropical cyclones. Furthermore, medically-relevant outages are 3.4 times more common on days with a single event and 10 times more common on days with multiple events. Weather and climate events may drive large-scale outages, but increased energy demand from an aging electrical grid may play a role in county-level outages.

Upgrading the grid and relying further on distributed generation like generating and storing renewable energy are necessary to prevent power outages and ensure that huge areas won’t go offline, says Casey. The Department of Energy intends to modernize the grid to increase resiliency, add capacity for clean energy, and optimize power delivery. The department is also investing in energy infrastructure like microgrids, which can disconnect from national infrastructure and continue to run even when the main grid is down, and grid-scale energy storage devices, which store clean electricity to help provide power during peak loads.

“Certain communities and individuals may experience more and more severe power outages or have less ability to respond,” says Casey. “These groups may be persistently marginalized and lack access to generators, charging centers, or health care.”

Communities of color have unequal access to energy generation and battery storage, even though they tend to be the hardest hit when it comes to power outages following extreme climate events. After Hurricane Maria in 2017, rural and Black communities in Puerto Rico appeared to have the longest restoration times. Higher percentages of Hispanic/Latino populations were also associated with longer outages in Florida after Hurricane Irma in 2017. Meanwhile, counties with a higher proportion of Hispanic/Latino residents faced more severe power outages during the 2021 Texas winter storm. Black residents reported more day-long outages as well.

“We need to work to understand who is most at risk during an outage and provide support to these populations,” says Casey. “This could involve preparing health systems to receive patients, community charging stations for those that rely on electricity-dependent medical equipment, or weatherproofing homes to keep indoor temperature at more optimal levels.”

[Related: Heart disease-related deaths rise in extreme heat and extreme cold.]

Developing a registry for individuals medically dependent on electricity would establish a national estimate for this vulnerable population and document their geographic location. This can help state, territorial, and local health departments prioritize efforts and anticipate the resources that first responders should deploy during emergencies. At present, the Department of Health and Human Services only keeps the record of over 2.9 million Medicare beneficiaries who need electricity-dependent DME. The number of DME users covered by other insurance programs is not known. 

Jurisdictions with a high prevalence of prolonged outages could also help vulnerable populations by establishing temporary emergency power stations. Such a solution could make electricity more accessible and reduce avoidable emergency department visits, which may prevent crowding. Together, upgrading the grid, mitigating climate change, and providing alternative electricity sources can all minimize the impacts on power supply faced by vulnerable populations and communities of color.

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AI-assisted brain and spine implants helped a paralyzed man control his legs again https://www.popsci.com/health/brain-spine-implants-paralysis-walk/ Thu, 25 May 2023 16:00:00 +0000 https://www.popsci.com/?p=543497
For the first time after more than a decade of work by researchers in France and Switzerland, a paralyzed man has regained the ability to walk naturally using only his thoughts thanks to two implants that restored communication between his brain and spinal cord. The press conference was held in Lausanne on May 23, 2023.
For the first time after more than a decade of work by researchers in France and Switzerland, a paralyzed man has regained the ability to walk naturally using only his thoughts thanks to two implants that restored communication between his brain and spinal cord. The press conference was held in Lausanne on May 23, 2023. Fabrice Coffrini/AFP via Getty Images

Brain-computer interfaces like these allow for more natural movement than just using spinal cord stimulation alone.

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For the first time after more than a decade of work by researchers in France and Switzerland, a paralyzed man has regained the ability to walk naturally using only his thoughts thanks to two implants that restored communication between his brain and spinal cord. The press conference was held in Lausanne on May 23, 2023.
For the first time after more than a decade of work by researchers in France and Switzerland, a paralyzed man has regained the ability to walk naturally using only his thoughts thanks to two implants that restored communication between his brain and spinal cord. The press conference was held in Lausanne on May 23, 2023. Fabrice Coffrini/AFP via Getty Images

In a groundbreaking new study published earlier this month in the journal Nature, a team of neuroscientists and other researchers detail how electrical devices implanted into the brain and spinal cord of a paralyzed man have helped him walk and even climb stars. 

[Related: The slow, but promising progress of electrode therapy for paralysis.]

The implants communicate wirelessly and fuse together two experimental technologies that are being developed to treat paralysis. One of the devices is inserted into the skull and sits above the brain’s surface. It decodes the patterns involved in walking and sends a signal to the second device that is implanted in the spinal cord. The spinal cord is then stimulated by the electrodes in a precise sequence that activates the leg muscles needed to walk.

According to the study’s authors, the devices provide a “digital bridge” between the brain and the spinal cord that bypasses the injured areas of the spinal cord. The brain-spine interface uses an artificial intelligence thought decoder to read the brain’s intentions. These intentions are detectable as electrical signals in the brain and then match them to muscle movements. 

The patient in this new study is Gert-Jan Oskam, a 40-year-old man from The Netherlands who was paralyzed in a cycling accident in 2011. Oskam received an experimental spinal-cord stimulator in 2017 that retired his ability to walk, according to CEO Dave Marver of Onward Medical. The Netherlands-based biotechnology company manufactures the spinal cord device used in the study.

“We’ve captured the thoughts of Gert-Jan, and translated these thoughts into a stimulation of the spinal cord to re-establish voluntary movement,” study co-author and spinal cord specialist at the Swiss Federal Institute of Technology, Lausanne Grégoire Courtine, said in a press briefing according to The New York Times.

Brain-computer interfaces like these allow for more natural movement than just using spinal cord stimulation alone. Oskam now can even pause mid-gait, adjust his stride, and navigate on irregular terrain like stairs.

Previously, the Onward Medical device was used in a study that restored the ability to walk to nine patients by mapping out the neurons that are associated with the body’s complex commands for walking. Marver told The Washington Post that the company is likely five years away from being able to commercialize a system like the one used in this study and that his aspirations are even broader. “Ultimately, our vision is that a person with paralysis will be able to visit the doctor and select what function they want to restore,” he said.

[Related: I became a cyborg to manage my chronic pain.]

The brain implant that was used in this study was developed by Clinatec and a French government-backed research institute called CEA. 

Some of the limitations to this work include that the brain’s subtle intentions are difficult to distinguish and the same brain-spine interface used for walking, may not be suitable for restoring movement in the upper body. The treatment is also invasive, requiring multiple surgeries and hours of physical therapy. The system, as it currently stands, does not fix all spinal cord paralysis.

This study is one of a number of spinal cord injury treatment advances in recent years. In 2016, a group of scientists restored paralyzed monkey’s ability to walk. In 2018, scientists figured out a way to use electrical-pulse generators to stimulate the brain and allowed partially paralyzed people to walk and ride bicycles again. 

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Meningitis shot that fights 5 different strains shows promise in latest trial https://www.popsci.com/health/meningitis-vaccine-trial/ Wed, 24 May 2023 22:00:00 +0000 https://www.popsci.com/?p=543111
Meningococcal bacteria under a microscope. According to the World Health Organization, meningitis caused an estimated 25,000 deaths in 2019.
According to the World Health Organization, meningitis caused an estimated 25,000 deaths in 2019. European Centre for Disease Prevention and Control

The vaccine could be a useful tool in countering meningitis in children and young adults.

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Meningococcal bacteria under a microscope. According to the World Health Organization, meningitis caused an estimated 25,000 deaths in 2019.
According to the World Health Organization, meningitis caused an estimated 25,000 deaths in 2019. European Centre for Disease Prevention and Control

A phase 3 trial found that a new meningococcal disease vaccine is safe and effective and also induces a strong immune response across five strains of meningococcal bacteria. The results were published May 24 in the New England Journal of Medicine. The vaccine could be a useful tool in eliminating meningitis in African countries including parts of Senegal, Mali, and Ethiopia.

[Related: A once-forgotten antibiotic could be a new weapon against drug-resistant infections.]

Meningococcal disease is a cause of meningitis and blood poisoning. According to the World Health Organization, meningitis caused an estimated 25,000 deaths in 2019. While vaccines are readily available in wealthier countries, vaccinating the more vulnerable regions has been a challenge, largely due to cost. Developing affordable vaccines that provide broad coverage against meningococcal disease strains is a key part of the World Health Organization’s Defeating Meningitis by 2030 Global Roadmap.

The trial compared the immune response generated by a new pentavalent, or 5-in-1, vaccine  called NmCV-5 against that of the licensed quadrivalent, or 4-in-1, MenACWY-D vaccine. The participants included 1,800 healthy two to 29-year-olds in Mali and The Gambia in western Africa. The vaccinations occurred in June 2021, and the trial didn’t find any safety concerns with NmCV-5. 

After 28 days, the immune responses generated by one dose of NmCV-5 were generally higher than those generated by the 4-in-1 vaccine across all age groups. The 5-in-1 vaccine also induced a strong immune response across meningococcal bacteria strains A, C, W, and Y and the emerging X strain. Currently, there is no licensed vaccine against the X strain, which may be the cause of meningitis epidemics in sub-Saharan Africa.

“Meningitis is a deadly disease with the ability to spread like wildfire in the event of an outbreak, this affects all ages most especially within the meningitis belt region,” study co-author Ama Umesi said in a statement. Umesi is a clinical trial coordinator and clinician from the Medical Research Council’s Unit The Gambia at the London School of Hygiene & Tropical Medicine. 

“Epidemic preparedness is the way forward in providing available, affordable and accessible vaccines relevant to regions prone to meningitis outbreaks. Having meningitis vaccines should be a public health priority to prevent catastrophic outcomes during an outbreak and would be a game changer in the fight against meningitis,” Umensi said.

Issues with supply and affordability have limited the use of 4-in-1 meningococcal vaccines across a portion of sub-Saharan Africa called the meningitis belt. This region is at high-risk of epidemics of both meningococcal and pneumococcal meningitis. The NmCV-5 vaccine was developed by the Serum Institute of India and PATH, the global division of the Bill & Melinda Gates foundation. It follows the successful Meningitis Vaccine Project that developed an effective meningococcal A vaccine called MenAfriVac.

[Related: Ghana is the first country to approve Oxford’s malaria vaccine.]

According to the study, the new NmCV-5 vaccine can be made available at lower cost than existing 4-in-1 vaccines with more cost-effective production methods. The trial was designed to provide the World Health Organization with the evidence it needs to license the new vaccine for future epidemic control.

“As a researcher in the continent, I am hopeful that relevant vaccines for the common strains within the meningitis belt region will be readily available for timely interventions due to the collaboration and teamwork of multicentre trials like ours,” Umesi said. “Together we can defeat meningitis,” Umesi said. 

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US Surgeon General warns of a ‘profound risk of harm’ for kids on social media https://www.popsci.com/technology/surgeon-general-youth-teen-social-media/ Wed, 24 May 2023 20:00:00 +0000 https://www.popsci.com/?p=543155
Close Up Of Teenage Girl Wearing Wristbands Using Mobile Phone At Home
The public advisory comes two weeks after the American Psychological Association's own assessment of the issue. Deposit Photos

'At this time, we do not yet have enough evidence to determine if social media is sufficiently safe for children and adolescents.'

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Close Up Of Teenage Girl Wearing Wristbands Using Mobile Phone At Home
The public advisory comes two weeks after the American Psychological Association's own assessment of the issue. Deposit Photos

Following a similar report issued by the American Psychological Association (APA) earlier this month, the US Surgeon General released an advisory statement on Tuesday warning of social media platforms’ potentially harmful effects on minors.

While cautioning more research is still needed to understand the full scope of social media’s impact on children, adolescents, and teens, Surgeon General Vivek Murthy’s office makes clear they believe “ample indicators” show social media can represent a “profound risk of harm to [their] mental health and well-being.”

“We are in the middle of a national youth mental health crisis, and I am concerned that social media is an important driver of that crisis—one that we must urgently address,” Murthy said in a statement this week, citing the “growing evidence” supporting their worry. In one such study referenced, adolescents who spend over 3 hours per day on social media faced double the risk of mental health issues such as symptoms of anxiety and depression. Additional research cited by the Surgeon General’s report points towards particular harm for girls, who face cyberbullying and body-image issues.

[Related: APA releases youth social media guidelines.]

“At this time, we do not yet have enough evidence to determine if social media is sufficiently safe for children and adolescents,” the advisory states.

At the same time, the advisory statement makes it clear that children and adolescents utilize and are influenced by social media in vastly varying ways. The ways children are impacted by social media are often based on their particularly emotional and psychological strengths and vulnerabilities, as well as cultural, historical, and socio-economic factors. Some of these experiences on social media can prove beneficial, such as offering spaces for community and connection with like-minded individuals sharing “identities, abilities, and interests,” alongside offering access to important information and spaces for self-expression.

As The New York Times noted on Thursday, social media has also proven especially helpful to children and teens within the LGBTQ+ community. “[A] variety of research over the decade since social media became ubiquitous among teenagers has found that often, social media use has been more beneficial than not for LGBTQ youth,” the article states.

A Surgeon General’s advisory does not carry any legal weight, but often serves as a public statement calling attention to a health issue alongside subsequent recommendations for policymakers, businesses, and the public. Among other suggestions, the Surgeon General’s office urges lawmakers to enact legislation ensuring tech companies share relevant health impact data to independent researchers and the public “in a manner that is timely, sufficiently detailed, and protects privacy.”

Additionally, the report recommends the development and implementation of digital and media literacy curricula in schools, as well as encouraging policies that “further limit access—in ways that minimize the risk of harm—to social media for all children.”

[Related: How to use built-in parental controls on Instagram, TikTok, and more.]

Meanwhile, businesses such as Meta, Twitter, and TikTok’s parent company, ByteDance, are pushed to maintain a proper level of transparency about their own internal research and methods for developing products used by minors—something that’s frequently proven difficult to realize. Parents are also strongly encouraged to discuss, educate, and monitor their children’s social media habits.

Earlier this month, the American Psychological Association released its first-ever health advisory report on youth and adolescent social media usage, which spoke broadly of potential developmental effects stemming from experiences on platforms like TikTok, Instagram, Twitter, and Facebook. The APA’s 11-page outline described these apps as “not inherently beneficial or harmful to young people,” but stressed it was rather how minors used the apps that influenced them.

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Here’s what really happens when you pull a muscle https://www.popsci.com/what-makes-muscle-pull/ Wed, 11 Aug 2021 12:11:00 +0000 https://www.popsci.com/uncategorized/what-makes-muscle-pull/
A person wearing running shorts holding their thigh on a beach, potentially wondering what happens when you pull a muscle, because they probably just did.
Treatments for minor pulls include ice packs and elevation at home, but full tears might require surgery. Depositphotos

Stretching can prevent muscle strains, and rest helps them heal.

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A person wearing running shorts holding their thigh on a beach, potentially wondering what happens when you pull a muscle, because they probably just did.
Treatments for minor pulls include ice packs and elevation at home, but full tears might require surgery. Depositphotos

Joel Cramer was at the pool with his kids when another dad, competing in a big splash contest, got up onto the diving board. He bounced up once, and when he landed on the board for the second time, his quadriceps muscle tore. “It rolled up his leg and balled up near the top of his thigh,” says Cramer, a professor of exercise physiology at the University of Nebraska. “[It was] like rolling up a window shade.”

That’s an extreme (and extremely rare) example of a muscle strain, a common injury that happens to high school soccer stars, recreational runners, and middle-aged racquetball players alike. “Strain” is the medical term for the condition, though it’s colloquially known as a pulled muscle. The term is a catch-all that covers everything from a small twinge to a full-on rupture.

What is a pulled muscle?

The human body contains three different types of muscles: cardiac, skeletal, and visceral (or smooth). Of those, skeletal are the only ones that we have control over—and thus, the ones that we can injure. Skeletal muscles are made of thousands—in some cases, millions—of muscle fibers. These fibers are all bundled together and wrapped in a sheath of connective tissues. A strained muscle means, in a nutshell, that some number of the fibers that make up one of your muscles tore. This ripping can happen if you pull them too hard or too fast.

What we call a “tear” and what we coin a “pull or strain” all boil down to the same type of injury: A rip to some part of the muscle. But some are worse than others. A mild or “grade one” strain—what many people call a “pulled muscle”—happens when you tear about 5 percent of the fibers in a particular muscle. This typically feels like an uncomfortable twinge that may force you off the court for a few weeks. A moderate sprain involves a higher percentage of fibers, and might sideline you for a month or more. A full rupture severs the muscle entirely, and usually requires surgery to repair.

[Related: Why do my muscles ache the day after a big workout?]

Okay, but how exactly do these tears occur? And why do some instances result in more muscle fiber damage than others? Cramer says three major factors contribute to this muscle busting. Muscles that cover two joints, like the hamstring which extends across the hip and knee joints, are at the highest risk. That’s because having both joints moving and stretching the muscle simultaneously adds tension, which can lead to strains.

Muscles are also more likely to strain while they are contracting. At this point, muscles are shortening and lengthening at the same time. During a dumbbell curl, for example, raising the weight up towards the shoulder compresses the bicep, and lowering it back down stretches it back out again. The muscle can create and sustain much more force during the lengthening portion of the activity, says Cramer, which makes it easier for it to strain.

Finally, muscles that have a higher proportion of fast-twitch to slow-twitch fibers strain more readily. Fast-twitch fibers contract quickly and generate more power, says Cramer. For that reason, they are the ones recruited for explosive tasks like sprinting. “It’s relatively uncommon for slow twitch [muscles] to strain,” he says. “They’re used to being active all the time.”

Technically, Cramer says, it’s possible to strain any of the skeletal muscles in your body. “For some, it’s not physiologically impossible, just very highly unlikely,” he says. “You’re probably not going to strain deep muscles with very specific functions.” The muscles in the finger, for example, are probably not going to cause much trouble, since they only have one task and don’t do much heavy lifting.

[Related: How to get muscle gains: A beginner’s guide to becoming buff]

Low flexibility and range of motion are major factors at risk for muscle strain, says Cramer. Despite the popular belief that larger muscles are tighter, Cramer says greater muscle mass is actually associated with greater give. “There’s evidence to suggest that weight training done with a good range of motion increases flexibility,” he says. And even though it may not seem like it when you’re struggling to touch your toes, Cramer says most people can teach their body to be springy enough to do the splits. So, to help keep your muscle fibers intact—pick up the weights and don’t skip your stretching routine, no matter how tedious it is.

How does a pulled muscle heal?

For at-home ways to treat to minor strains, clinicians often recommend what’s known by the acronym R.I.C.E.: resting the pulled muscle; icing it for about 30 minutes; compressing it with an elastic bandage; and elevating it above your heart. While ice packs can reduce pain and swelling, some recent physiology studies suggest regular baths in chilly water might hinder recovery. (A small amount of inflammation, which encourages the flow of blood and nutrients, can actually help muscles restore their strength.) What clearly works is rest: You don’t need to completely avoid all physical activities, but taking it easy—and getting plenty of sleep at night—gives your body the opportunity it needs to heal itself.

This post has been updated. It was originally published on September 28, 2017. It was also previously updated to reflect the fact that stretching in general—not at any specific time—can help to prevent low flexibility, a risk factor for muscle strains.

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Neglected sewage systems are a public health risk for low-income communities https://www.popsci.com/health/parasitic-infections-sewage-america/ Wed, 24 May 2023 01:00:00 +0000 https://www.popsci.com/?p=542823
microscopic image of a hookworm egg
A microscopic image of a hookworm egg that can cause intestinal problems in humans. Smith Collection/Gado/Getty Images

One-quarter of the global population is infected with soil-transmitted helminths that can cause serious health problems.

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microscopic image of a hookworm egg
A microscopic image of a hookworm egg that can cause intestinal problems in humans. Smith Collection/Gado/Getty Images

This article originally published on The Conversation.

Intestinal infections take a heavy toll on impoverished Black communities that have out-of-date sewage systems. These infections often spread through contaminated soil and water and are among the most common diseases worldwide.

Approximately one-quarter of the global population is infected with soil-transmitted helminths, intestinal parasitic worms that can cause serious health problems.

Additionally, up to 50% of people around the world are infected with Helicobacter pylori, bacteria that live in the stomach and can cause ulcers and cancer.

I am a biological anthropologist, and it is clear to me that these two types of infections contribute to systemic health inequities, especially among communities of color in which limited access to medical care and inadequate sanitation systems may both increase exposure to pathogens and lead to worse outcomes.

Historically, intestinal infections have been prevalent in parts of the U.S. where high poverty rates and environmental factors – such as flooding and warm, humid summers – favor infection spread.

Although many Americans believe these diseases now exist only in lower-income countries, research that my colleague and I have conducted challenges this assumption.

Renewed interest in US intestinal infections

Launched in 2019, the Rural Embodiment and Community Health Study started with the goal of measuring current infection rates and determining which living conditions contribute to infection risk.

Though national infection rates remain unclear because of the absence of large-scale studies, our preliminary work in 2019 found that 38% of children sampled in a predominantly Black Mississippi Delta community had intestinal parasitic infections.

Moreover, 80% of those children exhibited high levels of intestinal inflammation. Those levels are much higher than those observed in other populations and may lead to several poor health outcomes, including impaired intestinal ability to absorb nutrients and stunted growth.

Our more recent analyses from 2022 focused on adults living in the Mississippi Delta and Southwestern Illinois, two areas that experience regular flooding.

Photomicrograph of human hookworm (Ancylostoma duodenale and Necator americanus) rhabditiform larva which is its early noninfectious stage, 1979. Image courtesy CDC. (Photo by Smith Collection/Gado/Getty Images)
A microscopic image of a human hookworm. Smith Collection/Gado/Getty Images

Among those adults, 73% displayed elevated intestinal inflammation, while 45% were infected with H. pylori, the bacteria that can cause ulcers and cancer.

Taken together, those results demonstrate widespread intestinal infections and inflammation at all ages in these low-income, mostly Black communities.

Long-lasting intestinal infections and associated inflammation can lead to nutritional deficiencies, restricted growth, reduced educational attainment, decreased work productivity and increased risk for serious diseases later in life, including certain cancers).

The Rural Embodiment and Community Health Study is not alone in recognizing the impact of intestinal infections on Black communities. One of the most widely publicized recent research studies investigating intestinal infections focused on the health effects of poverty and crumbling sanitation infrastructure in Lowndes County, Alabama, a region characterized by a history of racial segregation and inequity.

Researchers found that more than 1 in 3 people tested in Lowndes County were infected with hookworm, an intestinal worm spread through sewage exposure that lives in soil and infects people by burrowing into bare feet.

This 2017 study has since led to legal action.

In a landmark May 2023 court ruling, the Biden administration found that Alabama’s public health department had discriminated against Black residents by denying access to adequate sanitation systems and imposed fines for resulting sewage issues.

This decision is being hailed by environmental justice advocates as a transformative environmental justice agreement that may increase public awareness of the ongoing health crisis that results from infrastructure neglect and associated pathogen exposure.

Community activists – such as Catherine Coleman Flowers, founder of the Center for Rural Enterprise and Environmental Justice – said they hope the federal government continues to intervene, leading to similar results in other affected communities.

“This country’s neglect of wastewater infrastructure in majority Black communities, both urban and rural, is resulting in a hygienic hell for far too many people, a hell that climate change is only making worse,” Flowers said in a March 2023 interview.

Why are there still parasites in the US?

The story of parasite infection in the U.S. is two-sided.

On one hand, the U.S. has successfully controlled many parasite infections. Malaria is one of them.

In addition, advancements in sanitation infrastructure and household construction mean that many Americans do not generally have to worry about parasite infections.

But this national success is not complete, as demonstrated by the recent findings in low-income Black communities across the country.

Limited awareness of the continued threat posed by neglected intestinal infections has made it more difficult to identify and treat these diseases in the U.S. than in lower-income nations.

For instance, in many countries the drugs needed to treat hookworm infections cost mere cents, but in the U.S., where drug prices are unregulated by the federal government, these same medications can cost hundreds of dollars.

The recent court decision in Alabama represents an important step toward increased national recognition of the role intestinal infections play in perpetuating racial health inequities.

Increased awareness will ideally result in improved access to testing and treatment in affected communities. But more work is needed to assess the full extent of these infections across the U.S.

Even if medical treatment is accessible and affordable, vulnerable individuals are often reinfected, as these pathogens continue to spread through the environment. Structural changes are needed to break the cycle of infection and poor health.

Current federal investment in community infrastructure – including water quality – is encouraging but does not go far enough. Ultimately, a concentrated nationwide effort to update and maintain sanitation systems is the best way to finally halt infection transmission and support health equity across the U.S.

Theresa E. Gildner, Assistant Professor of Biological Anthropology, Arts & Sciences at Washington University in St. Louis. This article is republished from The Conversation under a Creative Commons license. Read the original article.

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A guide to the muscles you forget to exercise https://www.popsci.com/health/muscles-to-work-out/ Tue, 23 May 2023 13:31:04 +0000 https://www.popsci.com/?p=542749
Person on yoga mat doing bridge exercise to work out muscles in core, neck, and back. Illustrated in red, black, white, and gray.
Find exercises that benefit multiple key muscles. Julia Bernhard

Add “tendon day” to your gym routine.

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Person on yoga mat doing bridge exercise to work out muscles in core, neck, and back. Illustrated in red, black, white, and gray.
Find exercises that benefit multiple key muscles. Julia Bernhard

TO MAINTAIN a healthy level of physical fitness, everyone should commit to at least 30 minutes of moderate aerobic exercise or strength training a day. That’s easier said than done. With running errands, working a desk job, and fulfilling family obligations, the modern lifestyle does not leave much time for regular exercise. If you do prioritize working out, you might still be neglecting key muscle groups that support posture, movement, and overall health. Keep reading for a list of the most ignored ones, exercises to strengthen them, and the reasons you might need more variety in your routine

Healthy fitness goals

Before you start switching up your workouts, Christopher Geiser, an exercise science professor, physical therapist, and trainer at Marquette University, has a few important reminders.

First, “If you’re having trouble, don’t wait too long to get help,” he warns. Physical therapists and trainers can design a regimen specific to your needs. Everybody’s built a little differently, and unique personal histories make it difficult to give general advice. Working out various areas of the body with different types of activities is a surefire way to improve health. Remember to start off slow and careful if you haven’t exercised in a while—too much too soon might backfire on your muscles. 

Second, it’s important to know the difference between exercising for overall health and exercising for performance. “If you wanna be healthy, then you’re trying to get as variable activity with a nice even distribution of the loading across different areas as you can,” Geiser says. 

In contrast, “If you’re trying to run the Boston Marathon, you’ve got a really specific something that you’re working on and [your exercise regimen] is going to focus on that,” he explains. “And it isn’t always the most healthy for you.”

In other words, don’t sacrifice your wellbeing for better performance. “You want a balance across all of the conditioning exercises that you’re doing,” Geiser says. “And that variability across your system is probably what’s gonna give you the most bang for your buck healthwise.”

Target muscle area no. 1: Rotator cuffs

The rotator cuff is a group of four muscles and their connected tendons that attach the shoulder blade to the upper arm, stabilizing the shoulder and allowing 360-degree movement. Strengthening the area can prevent shoulder injuries, some of which can lead to permanent loss of function. 

If you already have shoulder pain or a rotator cuff injury, however, you could exacerbate it by exercising those muscles. See a medical professional for treatment instead.

Recommended exercises:

  • Doorway stretches
  • Reverse flies with dumbbells
  • Wall angels 

Target muscle area no. 2: Abdominal core and back

In addition to helping you avoid accidents from, say, moving furniture, having a strong core boosts posture, balance, and movement. Each abdominal muscle has to work in harmony to control your back and pelvis, although “you don’t necessarily need them to do a lot of your everyday activities,” Geiser says. “But when you do need them, they’re not always in shape and ready to go.” 

Recommended exercises:

  • Planks
  • Bridges
  • Deadlifts

Target muscle area no. 3: Neck flexors

These deep muscle groups rest in the front of the neck and are responsible for holding its position, contributing to posture. “We abuse the flexors when we stare at computer screens with our head forward all the time,” Geiser says. “They are notoriously weak because we haven’t built them up.” 

If you’re experiencing neck pain after staring down at a phone or laptop for a long period, it might be worth it to train these muscles. And at the same time, remind yourself to straighten out your posture while doom-scrolling on the couch or working at a desk.

Recommended exercises:

  • Supine neck retractions
  • Active assisted neck flexions
  • Supine cervical flexions

Target muscle area no. 4: Glutes

Though they get a lot of attention, the muscles underlying your butt are often improperly exercised. Strengthening your glutes helps with proper body alignment, movement, and athletic edge. Weak glutes can cause other areas of the body, such as the lower back or knees, to overcompensate when you’re walking, running, or climbing stairs. A stronger set also corrects posture and spinal alignment, reducing the risk of back pain and injuries.  

Recommended exercises:

  • Squats
  • Lunges
  • Bridges

Target muscle area no. 5: Tendons

Most casual gymgoers don’t think of flexing these parts. Tendons aren’t muscles: They’re connective tissue that attaches muscles to bones, controlling movement of the skeleton. While they’re strong and flexible, injuries can occur from overuse, repetitive strain, or aging. Tendon-specific training can improve joint health, reduce pain and stiffness, and promote speed and agility. Use two different types of exercises to strengthen them—prolonged weight holds and quick, fast contractions—but not in the same workout. Vary your routine daily to keep from overloading these crucial parts, and be sure to take at least one day off from working out each week.

Recommended exercises:

  • Eccentric movements
  • Isometric movements
  • Plyometric movements

Read more PopSci+ stories.

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The best air quality monitors in 2023 https://www.popsci.com/gear/best-air-quality-monitors/ Thu, 28 Jul 2022 17:00:00 +0000 https://www.popsci.com/?p=458568
Best air quality monitors sliced header
Stan Horaczek

What contaminants are lurking in your air?

The post The best air quality monitors in 2023 appeared first on Popular Science.

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Best air quality monitors sliced header
Stan Horaczek

We may earn revenue from the products available on this page and participate in affiliate programs. Learn more ›

Best Overall Temtop M2000 2nd Generation is the best air quality monitor overall. Temtop M2000 2nd
SEE IT

The ability to test many things in one device, with consistent results and audible alerts, makes this monitor our top pick.

Best Smart Atmotube Pro Portable is the best smart air quality monitor. Atmotube Pro Portable
SEE IT

Impressive accuracy, and handy app alerts, help this keychain-sized monitor work well across a wide variety of temperatures and humidity.

Best Indoor Outdoor Davis Instruments AirLink is the best indoor outdoor air quality monitor. Davis Instruments AirLink
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This multienvironment-friendly unit offers easy-to-read graphs and charts, Weatherlink.com integration, and compatibility with Davis weather stations.

Nothing beats a breath of fresh air. Unless, of course, that “fresh” quality air is contaminated by chemicals, soot and other forest fire byproducts, or “Volatile Organic Compounds” (VOCs). Even those with the best noses can have difficulty telling how good their local air is, especially with the presence of odorless gasses, so what are you to do? You could call in an air quality professional … or you can begin to do your own tracking with one of our picks for best air quality monitors.

How we selected the best air quality monitors

Largely, selecting the best air quality monitors was more a matter of hitting the research shelves than the shopping cart button. With such a product, the customer sentiment and manufacturer-supplied specs really mean a lot less than in-depth product analysis from researchers and experts that were able to compare consumer-facing products with laboratory-grade equipment. This results in a thin product selection, but I was able to identify five air quality monitors that I can confidently recommend.

The best air quality monitors: Reviews & Recommendations

What is the best air quality monitor? The best air quality monitors come tested from official sources and come in a variety of shapes, styles, and working methods. While the Temtop M2000 2nd Generation is the top pick for air quality monitor, due to its ease of use and robust testing ability, our four other monitors might be right for you depending on your circumstances. In any event, these are the five air quality monitors that have both proper testing and current availability in the market.

Best overall: Temtop M2000 2nd Generation

Temtop

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Why it made the cut: The Temtop M2000 2nd Generation tests for a wide variety of pollutants, has built-in calibration, and includes an audible alarm.

Specs

  • Measures: CO2, HCHO (formaldehyde), PM2.5/PM10, Temp., Humidity
  • AQ-SPEC report: High consistency
  • Type: Handheld 

Pros

  • Tests many things all in one device
  • High consistency across many devices
  • Has an audible alarm for when levels rise too high
  • Tried and tested by several school systems

Cons

  • Doesn’t work in temperatures below freezing

The Temtop M2000 2nd Generation is a relatively easily operated handheld air quality monitor that has been widely used. It has been used by the New York State Education Department and the United Federation of Teachers has used it to measure Carbon Dioxide levels in schools in efforts to fight Covid-19.

The 2nd Generation product improves upon the original Temtop M2000 by adding a data export feature. This is really useful because, as mentioned by the AQ-SPEC report, where the Temtop M2000 2nd Generation suffers losses in accuracy it makes up for it with high levels of consistency. Even across multiple Temtops, the reading levels should be consistently similar in the same situation. This means that you can pinpoint exactly when contaminant levels have started rising, even if you have to have a replacement device.

I’m also particularly pleased that it makes an attempt at a calibration system. While the accuracy, consistency, and difficulty for average users feel a bit daunting, the system’s overall capabilities are more than enough to begin with. Part of the calibration process being leaving the device outside for lengthy periods of time is also annoying, but manageable.

In reality, the main concern is the limited capabilities the device has during the colder months. Without being able to function below 32 degrees Fahrenheit, the supposed “indoor-outdoor” nature of the device is cut off for many months of the year for those of us too far North or South of the equator. Luckily, in-home monitoring will still work year-round.

Finally, if you like the look of the M2000 2nd Generation, but are looking for something quite a bit cheaper, our budget choice also comes from Temtop. The Temtop P20 has reduced features, but also a reduced price tag.

Best smart: Atmotube Pro Portable 

Atmotube

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Why it made the cut: The Atmotube Pro attaches directly to your backpack or belt clip and alerts your phone directly when there’s a problem.

Specs

  • Measures: PM1/PM2.5/PM10, VOCs, Temp., Humidity, Barometric Pressure
  • AQ-SPEC report: High accuracy, high precision
  • Type: Wearable

Pros

  • Impressive accuracy counts
  • Handy app alerts
  • Works well across a wide variety of temperatures and humidities
  • Keychain size

Cons

  • Shorter battery life than hoped for

The Atmotube Pro Portable is a keychain-size air quality monitor that won’t take up much space and can be put just about anywhere or come with you. All of the data collected will be at your fingertips via the Atmo app, available free for Android and iOS devices.

The app will give you your personal stats, access to personal and global maps, and a personalized series of articles to help you understand air quality. You can also export your device’s data as a CSV file for further analysis.

According to the Atmotube’s AQ-SPEC results, the device is quite accurate, ranging from 86% to 98% across a variety of conditions. The AQ-SPEC report also notes that the device is highly consistent across a variety of environmental conditions, saying that heat and humidity had “minimal effect” on the device’s precision. Despite its small size, the Atmotube Pro delivers at a high level.

One of the bigger disappointments with the Atmotube Pro is the battery life. As expected of such a small device, the battery is also quite tiny. When the device is set to take measurements only once every 30 minutes, you can squeeze about a week out of the little battery. However, when you crank that up just a notch, the battery dies much more quickly. This is very unfortunate when using a device that, by its very nature, you want to set up and forget about. Fortunately, if the device isn’t meant to be mobile, you can keep it plugged into the charger while it is running.

Davis Instruments

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Why it made the cut: The AirLink is made for both indoor and outdoor usage, provides beautiful charts, and works well with other Davis Instruments systems.

Specs

  • Measures: AQI, Temp., Humidity, Dew Point, Heat Index
  • AQ-SPEC report: Highly accurate for PM1.0/PM2.5, but not for PM10, consistent
  • Type: Indoor or outdoor

Pros

  • Weatherlink.com integration
  • Easy to read graphs and charts
  • Installs easily both indoors and out
  • Integrates into your Davis weather station

Cons

  • Poor PM10 reading

The Davis Instruments AirLink comes with a heavy-duty body that can be conveniently placed in indoor or outdoor environments. If you want it in your house, just place the machine on a desk or table. It has four safety feet to reduce the chances of it sliding off smooth surfaces. Alternatively, mount it outside (near an outlet) and attach the provided weather-resistant cover.

If you’re into more than just air quality monitoring, you’ll really appreciate the extra things the AirLink tracks, such as dew point and heat index. You’ll also be happy to note that it will connect with weatherlink.com and can integrate with your other Davis weather station products. These services are also available on your phone via the WeatherLink app.

I really appreciate that the output looks professional but still feels closer to what you might expect from a cable weather station than what your average lab coat wearer would be reading. The only thing I was disappointed with is that, as per the AirLink’s AQ-SPEC report, the PM10 readings weren’t too accurate. Really, though, this is just a small trade-off for a good home system and typical consumers will be more than happy with this machine.

Best portable: Sensirion SPS30

SENSIRION

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Why it made the cut: The Sensirion SPS30 is a no-frills machine dedicated to particulate matter testing.

Specs

  • Measures: PM1.0/PM2.5/PM4.0/PM10
  • AQ-SPEC report: High precision
  • Type: Portable

Pros

  • Small size
  • 8-year lifetime
  • Long-term stability and contamination-resistance
  • Moddable

Cons

  • Drab UI makes interpreting data difficult

If you’re wanting to feel like you’re really in the lab, the Sensirion SPS30 might be right up your alley. Right from the moment I opened the company’s product introduction video, I felt instantly reintroduced to the lab environment I once came from.

Where this really shines is the Sensirion SPS30’s great moddability. For example, some users are soldering them on bikes for CanAirIO, a citizen science project dedicated to building a citizen network for monitoring air quality throughout the world. The simple USB port connection and loads of data quickly generated by the device lend it to lots of projects. Other possibilities include pairing it with air conditioners, smart home devices, HVAC equipment, and more.

Where this “lab environment feel” really doesn’t shine is the UI. If you’ve ever worked with in-company software or any niche data-collection devices you probably already know what I mean. You sure get a lot of data, but it isn’t going to look beautiful or come easy to read. Check out the company’s demonstration video for an up-close look at the graphs provided by the machine before deciding on whether or not to make a purchase.

As for the Sensirion SPS30’s AQ-SPEC report, the key thing to know is that the device is highly precise across temperatures and humidity levels. While PM1.0 and PM2.5 levels were highly accurately measured in field and laboratory testing, PM10 levels were shown to be highly inaccurate in the field trials.

Best budget: Temtop P20

Temtop

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Why it made the cut: This budget solution will take care of all of your basic air quality monitoring needs.

Specs

  • Measures: PM2.5, Temp., Humidity
  • AQ-SPEC report: Higher precision at low temperatures
  • Type: Desktop or mountable

Pros

  • Highly accessible interface
  • Everything needed for wall mounting included
  • Can double as a nice desk or wall clock
  • Exportable data

Cons

  • Limited pollutants measured, but still great for price
  • Low battery life

Considering that a laboratory-grade air quality tester can cost thousands of dollars, it would seem impossible to make a competitive one in the two-digit range. However, with Temtop’s P20, that isn’t true.

The Temtop P20 is able to measure PM2.5 pollutants. While it’d be nice to measure other pollutants or even other sizes of particulate matter, doing one thing well is quite impressive for the budget tier. The P20’s AQ-SPEC report tells us that the machine’s precision is most accurate when the local temperature is lower. That being said, the measurements indicate an accuracy of over 90% for most conditions at 68 degrees Fahrenheit.

You’ll probably enjoy having the Temtop P20 around, as it is also a rather nice LCD screen clock. To take a bit of the mystery out of the reading counts, a cute smiley face interprets the PM2.5 levels as good, fair, or poor. Another smiley face interprets your local humidity levels in a similar manner.

While the device can be mounted on the wall, and includes the screws needed to do so, I recommend using the back stand and using it as a desk monitor. On the wall, the numbers, time, and smiley faces will probably prove somewhat tricky to see clearly. This will also help you keep it plugged into a charger because the battery only lasts for about 6-8 hours on a single charge.

Finally, those of you interested in data will rejoice. Much like the Temtop M2000 2nd Generation, our top choice of air quality monitor, the Temtop P20 has USB connectivity to export the collected data in CSV format. 

Things to consider before buying the best air quality monitors

One thing to note from the current research is that air quality monitors for public usage are still an emerging market. As such, there are a lot of claims about accuracy that are either demonstrably false or haven’t been thoroughly checked by scientists or any actual regulatory board. With all of this in mind, here are the key things to remember when buying an air quality monitor:

Target pollutant

In a fantasy world, an air quality monitor would be able to sniff out any potential harm in the air and let you know. Unfortunately, air quality monitors in the real world need to be designed to target specific contaminants. While it is never a mystery as to what pollutants an air quality monitor tracks—as they are nearly always prominently displayed in the specs and ads—you may find yourself overwhelmed with a few new terms. Here’s a quick mini-guide to get you up to speed on air pollution vocab:

PM: PM stands for “particulate matter” and measurements of it are able to tell you how many liquid or solid particles of varying sizes are in your air. The particles are measured in microns, given after the “PM.” For example, PM2.5 tests for the amount of particles that are approximately 2.5 microns in your air. The makers of the Atmotube report that PM1 particles are typically emissions from factories and vehicles, PM2.5 particles usually come from fires and combustion, and PM10 particles are from pollen, mold, and fine bits of old plants and insects. You’ll find that PM2.5 is a common measurement taken by portable air purifiers, such as the conveniently compact Wynd Plus personal air purifier with air quality sensor.

AQI: This stands for Air Quality Index and is a popular, but somewhat outdated, method for measuring air quality. Essentially, the AQI measures pollutant levels for a wide variety of substances, gives them each a score from 0-500, and reports the highest one. It doesn’t matter if only one pollutant is high or if several are, only the top one is getting reported. Still, the data is historically known and the conversions for each pollutant can still be useful. If you want to play around with the system, a handy AQI calculator is available for you.

VOCs: These are “Volatile Organic Compounds” and largely come from human sources. The EPA warns that sources of these contaminants include household cleaners, building materials, and standard office equipment. They also have found that these pollutants are consistently found in much higher concentrations in indoor settings. VOCs are a big part of the reason why our recommended floor cleaners focused so heavily on ingredients. Certain high-end air purifiers, such as the Dyson Purifier Humidify+Cool Formaldehyde, are specifically equipped with sensors attuned to these byproducts we bring into our homes as we upgrade furnishings and electronics, etc.

Scientific usage

Before making any purchase of something as important as an air quality monitor, be sure to check out how the product is perceived by experts. That can be as simple as running a Google search with “site:.edu” or “site:.gov” followed by the product name or trawling through the depths of the “Air Quality Sensor Performance Evaluation Center” (AQ-SPEC) website.

AQ-SPEC provides comprehensive data on air sensors after real-world field trials. While AQ-SPEC reports explicitly state that they are not an endorsement of a particular monitor, the evaluations are free for the manufacturer if the sensors are “low-cost” and meet basic selection criteria. As a result, simply bothering to submit a sensor for an AQ-SPEC report is a sign of a manufacturer’s good faith in their product.

All of the air quality monitors on our list have a detailed AQ-SPEC report. Unfortunately, these reports can be a bit dense and read more like a Ph.D.’s journal submission than a consumer-facing report. I’ve attempted to condense these reports down into the relevant bits but, if you’ve got any interest, you’re highly encouraged to parse through them yourself as well.

Accuracy & consistency

Accuracy and consistency feel very similar at a glance but affect our perceptions of an air quality monitor in big ways. As you might be able to gather from a recent analysis by the Berkeley Lab, accuracy is going to be difficult to maintain but high consistency will make these machines still quite valuable sources of information for your home.

Part of the reason for this comes down to calibration, which laboratory equipment undergoes frequently. Take the humble pH machine, for example. Back in my lab days, I remember calibrating this machine nearly every day I would use it, using specialized liquid solutions. Now imagine calibrating something that measures air … at home. It appears that cheap calibration is on the way, but that doesn’t necessarily mean it will be easy or reliably done by the average person.

The result is that we have to expect some loss of accuracy when high-quality calibration isn’t feasible. Depending on what is being measured, this might not necessarily be too much of a problem. For example, your home thermometer is likely about 1 degree off but it is still enough to tell you that you have a fever. The key is getting something that is accurate enough for your purposes.

Perhaps more important is consistency. While several consumer-grade air quality monitors have a bias, especially after being run for multiple days, if that bias is consistent we can still get extremely useful information. For example, if your reading for Carbon Dioxide suddenly skyrockets above what you are used to getting, you know you have a problem.

FAQs

Q: How much do air quality monitors cost?

Air quality monitors can cost anywhere from around $80 to a few hundred dollars. Laboratory-grade air quality monitors can cost over $2,000 and quickly get into the several-thousand-dollar range depending on their specifications. For these high-level machines, routine maintenance and calibration can also become regular expenses. Fortunately, our selection of the best air quality monitors has been tested against these professional machines and fares relatively well.

Q: Can an air quality monitor detect mold?

An air quality monitor can be a mold detector but won’t be able to tell you that you have mold. Molds are typically detected by PM10 sensors, but so are other particulate matters, like pollen. So, an air quality monitor that can test for PM10 particles will be able to detect mold particles in your air but not tell you that those particles are mold.

Q: What is the best way to monitor air quality in industrial dusty rooms?

The best way to monitor air quality in industrial dusty rooms is to get your dust problem under control quickly. At the point that you can actually see you have a problem with air quality, you are less in need of an air quality monitor and more in need of an air purifier. We’ve reviewed air purifiers for home and office, but I suspect most of them will work for smaller industrial rooms just as well.

Final thoughts on the best air quality monitors

Getting a high-quality air quality monitor doesn’t have to be for laboratory professionals alone. While the world of personal air quality monitoring is still an emerging one, there are still some great products out there. Combining the most stringent testing circumstances with ready commercial availability produced a list of exactly these five air quality monitors, so we’re sure customers will find satisfaction from something on this list.

The post The best air quality monitors in 2023 appeared first on Popular Science.

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How studying bats can help predict and prevent the next deadly pandemic https://www.popsci.com/environment/bats-next-pandemic/ Mon, 22 May 2023 22:00:00 +0000 https://www.popsci.com/?p=542546
flying foxes aka bats in trees spreading disease potentially
Flying foxes. Getty

Funders thought watching bats wasn’t important. Then she helped solve the mystery of a deadly virus.

The post How studying bats can help predict and prevent the next deadly pandemic appeared first on Popular Science.

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flying foxes aka bats in trees spreading disease potentially
Flying foxes. Getty

This story was originally published by ProPublica. ProPublica is a Pulitzer Prize-winning investigative newsroom. Sign up for The Big Story newsletter to receive stories like this one in your inbox.

Dressed head-to-toe in protective gear, Peggy Eby crawled on her hands and knees under a fig tree, searching for bat droppings and fruit with telltale fang marks.

Another horse in Australia had died from the dreaded Hendra virus that winter in 2011. For years, the brain-inflaming infectious disease had bedeviled the country, leaping from bats to horses and sometimes from horses to humans. Hendra was as fatal as it was mysterious, striking in a seemingly random fashion. Experts fear that if the virus mutates, it could jump from person to person and wreak havoc.

So while government veterinarians screened other horses, Eby, a wildlife ecologist with a Ph.D., got to work, grubbing around the scene like a detective. Nobody knew flying foxes, the bats that spread Hendra, better. For nearly a quarter century, she’d studied the furry, fox-faced mammals with wingspans up to 3 feet. Eby deduced that the horse paddock wasn’t where the bats had transmitted Hendra. But the horse’s owners had picked mandarin oranges off the trees across the street. The peels ended up in the compost bin, where their horse liked to rummage. “Bingo,” Eby thought. Flying foxes liked mandarins. The bats’ saliva must have contaminated the peels, turning them into a deadly snack.

Eby, however, longed to unlock a bigger mystery: Could she, with the help of fellow scientists, predict when the conditions were prime for Hendra to spill over from bats, before it took any more lives? What if they could warn the public to be on guard — maybe even prevent the virus from making the leap? It would be painstaking work, but it wasn’t a pipe dream; Eby was already spotting patterns as she crawled around infection sites.

But when she pitched her research to a government funder the following year, she got a flat no. She proposed starting small, gathering basic data on flying foxes that could be used to figure out when and why they spread the virus. Her work, she was told, wasn’t considered a “sufficiently important contribution.”

Global health organizations and governments have long focused on responding to outbreaks rather than predicting and preventing them. Billions of dollars pour into developing treatments and vaccines for infectious diseases, but only a small fraction goes to understanding why contagions spread from animals to humans in the first place. Some experts reject even that, viewing spillover as too random, mysterious and rare to be observed and studied.

The work Eby does is the opposite of the major research projects on deadly diseases that typically get scientific grants. Government and nonprofit funders are often drawn to studies involving cutting-edge technology like artificial intelligence, and they want results in a few years’ time. Eby had spent decades trekking into the Australian bush, often on her own dime, observing flying foxes for hours on end with only a notebook and a pair of binoculars. To support her research, she took on consulting jobs, such as advising towns whose residents viewed bats as pests. She knew, though, that side hustles would never be enough to support the multidisciplinary team of scientists needed to crack the Hendra virus.

In the years that followed, Eby found like-minded scientists, and the team, led by women, persisted. They cobbled together grant after grant, battled burnout and kept impatient funders at bay. A decade after Eby’s government grant proposal was shot down, they published a groundbreaking paper in the journal Nature that demonstrated it was not only possible to predict Hendra virus spillover, but it might be preventable. Only then did it become obvious just how important Eby’s quiet fieldwork truly was.

Dr. Neil Vora, a tuberculosis physician and former officer at the U.S. Centers for Disease Control and Prevention, said he was thrilled when he saw the paper. “It gave clear evidence that we can take actions to prevent spillovers of viruses,” said Vora, who now works for environmental nonprofit Conservation International. “I hope it helps to convince funders and policymakers that spillover prevention merits implementation now.”

In a world still scarred by the COVID-19 pandemic, Eby’s dogged success exposes a global scientific blind spot. It’s not that trendy science involving the latest AI wonders isn’t worthy of research dollars. It’s that it should not be funded at the expense of the sort of long-term, shoe-leather work that allowed Eby and her colleagues to solve the mystery of a deadly contagion, Vora and other public health experts say. “All of these actions are important if we want to save as many lives as possible from infectious diseases,” Vora added.

Novel infectious diseases will keep coming at us, Eby warns. Investing in scientific work like hers “seems like a poor approach now,” she said, “but 20 years from now, we’ll look back and wonder why we didn’t do it.”


Fresh out of college in the 1970s, Eby explored the wilds of Australia on a research fellowship, following the path a German naturalist had chronicled before he disappeared in 1848. Some parts were so remote that she had to hitch a ride on the tiny plane that delivered mail to park rangers. Eby, who grew up in Kansas, was awed by the diversity of the landscape and charmed by the openness of the people. When her fellowship ended, she decided Australia was home.

Eby was in her 30s when she came to love flying foxes. Her boss at the New South Wales National Parks and Wildlife Service asked her to figure out how bats spread fruit seeds in rainforests. She followed signals transmitted by radio collars on flying foxes and knocked on landowners’ doors to ask if she might, please, observe the bats feeding in their trees and collect droppings. She even tracked them from a single-engine Cessna, battling nausea as she discovered that the bats could migrate hundreds of miles, a fact that nobody knew at the time.

When she watches flying foxes hanging in repose, Eby’s breathing slows. It feels like meditation. “It changes my perspective so I feel less significant,” she explained. “I think that’s important for all of us to feel less significant in the world.”

She was working on her dissertation about the bats in 1994 when a novel virus struck a Brisbane suburb called Hendra. The trouble started when a pregnant racehorse named Drama Series became congested and feverish. A veterinarian gave her painkillers and antibiotics, but she died the next day. As horse after horse got sick, some thrashed in their stalls, unable to breathe. “It’s a horrible thing to see when they’re mutilating themselves,” the veterinarian, Dr. Peter Reid, recalled.

Then the horses’ trainer died. The outbreak had spread to humans.

For more than a decade, Hendra popped up sporadically. It killed another horse trainer and two veterinarians. A veterinary nurse became so ill that she had to learn to walk and talk again and never regained some of her hearing.

Scientists figured out that Hendra came from flying foxes, and it had to pass through horses before it could infect humans. Eby was aware of those discoveries but didn’t get pulled in until an unprecedented number of horses died in 2011. Nobody knew why so many were getting sick when Hendra had been rare in the past. Media helicopters rumbled over sites where horses died, and people who lived and worked near them panicked. A group of ecologists lobbied the government to add a bat expert to the team deployed to infection sites, a practice that wasn’t common then and still isn’t. The ecologists picked Eby.

Shortly after her 60th birthday, Eby began suiting up in PPE and heading to the scene every time a horse tested positive for Hendra. She soon noticed the bat roosts near these sites were new and small. Something strange was going on.

Around the same time, Dr. Raina Plowright, a professor of disease ecology at Cornell University, proposed working together. Plowright was an Australian who had emigrated in the opposite direction of Eby but had never lost interest in her homeland’s infectious diseases.

They agreed to tackle the mystery together. They applied for multiple grants and were shot down because their ambitions didn’t match the funding silos: Agencies that support human health don’t typically care about animal health, and those that back studies on the environment often aren’t interested in how it affects public health. In saying “no,” one animal foundation explained that its mandate didn’t extend to diseases that leaped to humans.

In 2012, Plowright received a small grant from the Australian government, but that was only for mathematical modeling and didn’t support fieldwork like Eby’s. By 2017, a National Science Foundation grant came through, but it wasn’t enough to cover all of the costs of catching and testing bats. The team spread itself thin. “It was headed to a burnout situation,” Plowright recalled.

Eby, meanwhile, tapped unusual sources to get data. She befriended beekeepers, who could tell her when and where key species of trees were flowering. This helped them track shortages of the bats’ favorite food: nectar from eucalyptus blossoms. She also asked workers at wildlife rehabilitation centers to keep logs about sick and injured bats that they cared for.

The team studied weather patterns and how the forest cover had changed. Eby contributed field records on the location, number and health of bat roosts. Altogether, their data spanned 25 years.

The team’s resourcefulness paid off. By 2017, the researchers figured out how and why Hendra was spilling over from bats:

In early 2017, the researchers determined that conditions were ripe for Hendra to leap from bats to horses and potentially to people. A drought, followed by too much rain, had led to a dire shortage of eucalyptus blossoms, and malnourished bats were turning up at wildlife rescue organizations. By then, there was a Hendra vaccine for horses, but few owners had opted for it. It was only a matter of time before a horse nibbled something tainted with the bats’ saliva or droppings.

Eby pushed past the fear that their prediction might be wrong. She and her colleagues published a bulletin that winter, warning veterinarians of an impending Hendra outbreak and their need to wear full protective gear near horses.

The team was right. Four horses on separate properties caught Hendra that season.

No humans got sick.


When the same pattern of weather and food shortages repeated in 2020, Eby and her colleagues were confident that it’d be a calamitous year. They sounded another warning that May, at the start of the Australian winter season: “Conditions predict heightened Hendra virus spillover risk in horses this winter: actions now can change outcomes.”

Later that month, one horse was infected and euthanized. The team braced itself for a wave of horse deaths. But then — nothing. No other Hendra cases were identified, and the outbreak that was supposed to happen just didn’t.

Somehow, they had gotten it wrong.

“We still felt confident in our understanding,” Eby recalled, “but we didn’t have the full story yet.” She ran through everything she knew about bats and Hendra, scouring for what they might have missed. There had, indeed, been a food shortage. So where were all the bats?

Eby was in COVID-19 lockdown in mid-July that year when she got stunning news. Gympie, a former gold-mining town near the east coast, had been less affected by the severe weather than expected, and a few patches of a type of eucalyptus known as the forest red gum were flowering en masse. Their slender branches teemed with fluffy white blooms. Eucalyptus trees don’t flower every winter; their blooms appear erratically. Some 240,000 flying foxes had flown in for the rare feast.

“I immediately knew,” Eby said. “This is what was different.”

Her collaborators, a field team from Griffith University, rushed to check roosts in areas where Hendra cases had previously struck. Many roosts were empty, the bats drawn away by the Gympie banquet.

Eby and Plowright had worked on this for a decade now, patching together four or five grants at a time to continue their research. Funders wanted results.

But they needed more data. They had to understand how this unexpected winter flowering in Gympie was affecting bats across eastern Australia. With the lockdown preventing Eby from examining the roost herself, she began to compile information on historic mass winter flowerings like this one.

One reason why it wasn’t initially obvious that the Gympie congregation was important was that the bats that had flocked to town were grey-headed flying foxes, not the black flying foxes that spread Hendra. Eby came to believe that a hierarchy of bat species governs which can claim the best food, and the behavior of one affects the other.

The greys get dibs on the best food. When eucalyptus nectar is scarce, the greys eat what’s available, pushing the black flying foxes to scavenge for fruits in horse paddocks, their equivalent of junk food. But when the nectar is abundant, like it was in Gympie, the greys will depart for that fine dining opportunity, allowing the blacks to ditch the horse paddocks for better food that the greys leave behind. This draws the bats that carry Hendra away from horses and people.

In the end, what she concluded was astonishing: There had never been a spillover at the same time as a rich winter flowering.

“We said, this can’t be real, it’s too good,” Plowright said. “Those remnant patches of flowering were protecting the whole landscape.”

Patches of eucalyptus around a single town could protect all of eastern Australia. Imagine a few clusters of trees in New Jersey protecting the entire Eastern Seaboard.

The researchers could see how, between 1994 and 2006, consistent winter flowering was still taking place around the country. But as people cut down more and more trees, reducing the available habitat, winter flowering became unreliable and occasional, leading bats to search in horse paddocks for other sources of food.

Habitat destruction and deforestation has been linked to outbreaks of many notorious viruses, including Ebola, monkey malaria and the brain-invading Nipah virus. The discoveries of Eby and her colleagues show that we can learn all of the elements that lead to spillover — environmental, animal and human — in enough detail to design ways to predict and prevent the next outbreak.

Their discovery comes as the threat of Hendra increases. Deforestation has decimated the bats’ winter foraging habitats and shows no signs of stopping. Climate change likely will cause more extreme weather conditions, which will further disrupt the winter budding of eucalyptus, making food shortages more common.

Eby and her colleagues see a new way forward: If the remaining patches of winter-flowering trees were preserved and more were planted, they could once again reliably draw the bats away from people and protect the entire country from Hendra virus for years to come.

Yet few government agencies and global health authorities are ready to invest in action that comes out of this hard-won discovery.

The Hendra team, in 2018, had managed to score a grant from a program under the U.S. government’s Defense Advanced Research Projects Agency that was unique in its scope and vision. Called Preventing Emerging Pathogenic Threats, or PREEMPT, it sought to understand the mechanisms of spillover with the goal of developing technologies to protect U.S. military forces deployed to disease-prone locations. But the program was a one-off and is ending after five years. DARPA says it is not its role to fund the solution Eby and her colleagues discovered.

“We are ready for the next hard problem,” said Kristen Jordan, the deputy director for the DARPA Biological Technologies Office. “There are many we need to address.”

Department of Defense officials asked Plowright whether the model that predicted Hendra could also predict the next coronavirus spillover in Southeast Asia.

Plowright recalls responding: “Well, you need data. And we have no data.” It’d be impossible to calculate that risk without replicating the years of wildlife tracking, environmental data gathering and number-crunching that the Hendra team conducted. “People just don’t get that.”

On a crisp afternoon last September in the city of Tamworth in New South Wales, Eby pulled into the parking lot of a Hungry Jack’s burger restaurant. She had heard reports of an enormous roost of flying foxes in town and hurried to get there. Eby couldn’t see any bats from where she had parked, but she didn’t need to. Her clear blue eyes lit up and she beamed. “Can you smell them?”

Alongside the aroma of cooking grease was a musky, sweet scent that announced the presence of bats. As Eby walked to the river, she could also hear their shrill chattering. Then, there they were, hanging upside down from every branch on every tree that lined the river, grooming themselves and resting before the evening’s forage. With their wings folded around them, the bats looked like tear-drop-shaped fruit. A week earlier, another researcher had flown a heat-seeking drone over the roost and estimated that the river in Tamworth was hosting about 300,000 bats — more than half of the grey-headed flying fox population in all of Australia.

Eby moved slowly so as not to startle the roosting animals. She raised her binoculars, tallying males and females, noting any that were pregnant and scanning for babies born out of season. The roost looked healthy. She was elated. The Tamworth bats confirmed that a single unusually abundant flowering of eucalyptus could provide a protective effect for the whole system. And sure enough, there were no Hendra virus cases in the winter of 2022.

A few years ago, Eby had thought it might be time to retire. She was nearing 70 and ready to take a break from the physical grind of fieldwork. But then came an unconventional funding opportunity she couldn’t pass up.

After thousands of bushfires burned an estimated 59 million acres in a single season that came to be known as the Black Summer, money poured in to help restore habitat for Australia’s iconic koala. Eby instantly recognized the chance to explore how planting eucalyptus affects flying foxes, which conveniently feed on nectar from many of the same trees preferred by koalas. “The bats are hanging onto the coattails of the koalas,” she said with a wry grin.

There wasn’t a universal data set tracking reforestation projects, so she set out to create one. Today, supported by money from various koala-focused projects, she drives across eastern Australia training koala conservationists to upload records of their tree-planting projects into a common database. She hopes that reforestation efforts will make winter flowering commonplace again and prove the case for preventing spillovers with habitat restoration.

Eby says that she believes preventing outbreaks is possible, and that the methods she and her colleagues have developed can be applied to other disease systems. “There was nothing remarkable about my work. It can be done again in other circumstances, it just takes the will,” she said. “It also takes an understanding that this is a long term quest.”

Even while she embarks on her new mission to prove the power of reforestation, she pauses to cheer the remnant patches of forest when they bloom.

As the sun set over Tamworth, she stood above the riverbank, her hair glowing silver under the light of a streetlamp. She watched as the bats set out into the darkening sky, their long wings beating the air as they soared from the trees and headed out to feed. Eby couldn’t see where they were headed but knew that nearby, eucalyptus trees were blooming, producing sweet nectar that would keep the country safe from a Hendra virus spillover. Smiling to herself, she murmured, “Isn’t it wonderful?”

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Doctors recorded brainwaves to finally ‘see’ their patients’ chronic pain https://www.popsci.com/health/chronic-pain-brainwaves/ Mon, 22 May 2023 21:39:29 +0000 https://www.popsci.com/?p=542700
Asian person with mid-length gray hair rubbing temples because of chronic pain
Chronic pain can stem from any number of illnesses or injuries, but it's difficult to study in individual patients. Deposit Photos

In a first, deep brain stimulation was used to measure uncontrollable, long-term pain in four people, opening a door to personalized care in the future.

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Asian person with mid-length gray hair rubbing temples because of chronic pain
Chronic pain can stem from any number of illnesses or injuries, but it's difficult to study in individual patients. Deposit Photos

Everyone has different perceptions of pain. Some can sit for hours getting tattooed for an arm sleeve, while others squirm at having their finger pricked. Because pain is subjective, doctors have a hard time evaluating and treating patients who are dealing with it chronically.

Now, neurologists have successfully used a person’s brain signals to predict how much pain they were feeling. The small but unprecedented study, published today in the journal Nature Neuroscience, identified hard clues in brainwaves that could objectively measure the intensity of chronic pain versus acute pain. 

The findings are part of a larger clinical trial aimed at creating a personalized brain stimulation therapy that could bring relief to the 51.6 million Americans living with chronic pain. Another recent study in the journal JAMA Network Open reported that the rate of chronic pain in the US was as high as other common health issues like diabetes, depression, and high blood pressure. 

“For the first time, the authors were able to understand and visualize the differences between the acute and chronic pain experience on a neural level,” says Akanksha Sharma, a neurologist at the Pacific Neuroscience Institute in California who was not involved in the research. “This is novel and important, learning how and where our brain perceives and processes acute and chronic pain and understanding how the individual brain rewires in response to chronic pain.”

[Related: Medical startup put useless plastic implants in chronic pain patients, says FBI]

The study authors invited four people with uncontrollable long-term pain—three recovering from strokes and one with phantom limb syndrome—to get implants that tracked neural activity. The patients had exhausted all their treatment options. “They tried medications, injections, and nothing was working. Brain surgery was the last resort,” says lead author Prasad Shirvalkar, a neurologist and pain medicine specialist at the University of California, San Francisco. 

Each participant underwent deep brain stimulation, a medical procedure that acts like a pacemaker for the cerebrum. The medical team implanted electrodes in specific areas to detect and record electrical activity from two brain regions associated with pain: the anterior cingulate cortex and the orbitofrontal cortex. The technique is commonly used for neurological conditions such as epilepsy and Parkinson’s, but has never been tested with chronic pain. 

For three to six months, the participants answered surveys about the severity and quality of their pain. Immediately after, they pressed a remote to let the electrode implants take a snapshot of their brain activity. A computer then used the recordings and survey responses to build models that calculated a pain severity score for each patient. Changes in the orbitofrontal cortex helped inform the personalized neural signatures more than any other brain region.

X-ray of chronic pain patient with activity tracking electrodes
Frontal x-ray image of one study participant, showing implanted brain recording electrodes (red patches) connected to a bidirectional brain stimulating and recording implant on both sides. Prasad Shirvalkar

“This information can help drive more customized treatment options for patients,” Sharma says. “If we can objectively “see” the pain experience of a patient, then we can potentially modulate those areas of the brain with new interventions to alleviate or change the perception of pain.”

Brain activity recordings also showed a difference between chronic and acute pain. Signs of chronic pain were more strongly associated with changes in how neurons in the orbitofrontal cortex fired. According to Shirvalkar, this brain region is understudied in its role in shaping the pain experience. The anterior cingulate cortex, on the other hand, is better known for its role in perceiving and processing pain across the body. This brain region was found to be more associated with acute pain.

The team learned that they couldn’t apply the same kinds of brain activity used to chart acute pain in therapeutic research to chronic pain in the real world. “Chronic pain is not a more enduring version of acute pain—it’s fundamentally different in the brain with different circuits,” Shirvalkar explains.

Understanding the differences in how patients are neurologically wired for acute versus chronic pain can help further personalized brain stimulation therapies for the most severe forms of discomfort. Medhat Mikhael, a pain management specialist at the MemorialCare Orange Coast Medical Center in California who did not contribute to the research, says this would help treat the most difficult of chronic pain cases, especially those stemming from a stroke and traumatic brain injury.

[Related: The slow, but promising progress of electrode therapy for paralysis]

While Sharma finds the work fascinating, she warns people to exercise caution in interpreting the data and generalizing it to all neuropathic pain conditions, given that there were only four people in the trial. The study authors say their next goal is to recruit six patients and then move on to a phase two trial where the sample size would increase to 20 or 30 patients. There’s also a risk of life-altering complications with surgical implants in the brain. At the moment, Shirvalkar says noninvasive methods such as electroencephalography and functional MRIs would not be able to record for long periods of time. However, he hopes that one day tech companies can make small wearable devices that track brainwaves. 

“Treating pain relies on subjective reporting, or on how the person with pain communicates their pain to their provider. Not everyone’s pain is believed or treated equally,” Kate Nicholson, the executive director and founder of the National Pain Advocacy Center, wrote in an email to PopSci. “For these reasons, the search for phenotypes and objective measures for pain is the search for a holy grail in pain management. Objective measures [like the ones found through this study], if valid and validated, hold promise to transform pain’s assessment and treatment.”

The post Doctors recorded brainwaves to finally ‘see’ their patients’ chronic pain appeared first on Popular Science.

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A new NASA study will put people through a brain-shaking ride in the Kraken https://www.popsci.com/technology/nasa-kraken-disorientation-research-device/ Fri, 19 May 2023 10:00:00 +0000 https://www.popsci.com/?p=542092
The Kraken
Behold, the Kraken. US Navy

Test subjects will spend an hour in a giant machine called the Disorientation Research Device. Here's why.

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The Kraken
Behold, the Kraken. US Navy

Pilots can experience forces while flying that punish their bodies, and they can also find themselves in disorienting situations. A military pilot in a fighter jet will endure G-forces as they maneuver, resulting in a crushing sensation that causes the blood to drain downwards in their bodies, away from the brain. And someone at the controls of a plane or helicopter, even in more routine flights, can have their senses become discombobulated. One of the causes of the crash that killed Kobe Bryant in 2020 was “spatial disorientation” on the pilot’s part, according to the NTSB

Then there’s being launched in a rocket up into space. One astronaut recalled to PopSci that when flying in the space shuttle, the engines shut down, as planned, 8.5 minutes after launch. “It felt like the shuttle stopped, and I went straight through it,” he said. “I got a tremendous tumbling sensation.” Another astronaut noted in a recent NASA press release that he felt like he “was on a merry-go-round as my body hunted for what was up, down, left, and right,” in the shuttle as well.

And of course, anyone down on Earth who has ever experienced vertigo, a sensation of spinning, or nausea, knows that those are miserable, even frightening sensations. 

To better understand all the uncanny effects that being up in the air or in space has on humans, NASA is going to employ a Navy machine called the Kraken, which is also fittingly called the Disorientation Research Device—a supersized contraption that cost $19 million and weighs 245,000 pounds. Pity the poor person who climbs into the Kraken, who could experience three Gs of force and be spun around every which way. NASA notes that the machine, which is located in Ohio, “can spin occupants like laundry churning in a washing machine.” It can hold two people within its tumbling chamber. As tortuous as it sounds, the machine provides a way to study spatial disorientation—a phenomenon that can be deadly or challenging in the air or in space—safely down on dry land. 

The entrance to the Kraken, seen in 2019.
The entrance to the Kraken, seen in 2019. Megan Mudersbach / US Air Force

[Related: I flew in an F-16 with the Air Force and oh boy did it go poorly]

The NASA plan calls for two dozen members of the military to spend an hour in the Kraken, which will be using “a spaceflight setting” for this study. After doing so, half of them, the space agency says, “will perform prescribed head turns and tilts while wearing video goggles that track their head and eye movements.” The other half will not. All of them will carry out certain exercises afterwards, like balancing on foam. Perhaps, NASA thinks, the head movements can help. “Tests with the Kraken will allow us to rigorously determine what head movements, if any, help astronauts to quickly recover their sense of balance,” Michael Schubert, an expert on vestibular disorders at Johns Hopkins University and the lead researcher on this new study, said in the NASA release on the topic.

The study will also involve civilians who have pre-existing balance challenges (due to having had tumors surgically removed), who thankfully won’t have to endure the Kraken. They will also perform the head movements and carry out the same balance exercises. The goal of all this research is to discover if these head movement techniques work, so that “astronauts could adopt specific protocols to help them quickly adapt to gravitational changes during spaceflight,” NASA says. 

Additionally, the same techniques could help regular people who aren’t going to be launched into space but do struggle with balance or dizziness down on Earth. Watch a video about the Kraken, below. 

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AI therapists might not actually help your mental health https://www.popsci.com/technology/ai-chatbot-therapist-mental-health/ Fri, 19 May 2023 01:00:00 +0000 https://www.popsci.com/?p=541689
It may prove tempting for insurers to offer up apps and chatbots to meet the mental health parity requirement.
It may prove tempting for insurers to offer up apps and chatbots to meet the mental health parity requirement. DepositPhotos

There are good reasons to be cautious in the face of this marketing juggernaut.

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It may prove tempting for insurers to offer up apps and chatbots to meet the mental health parity requirement.
It may prove tempting for insurers to offer up apps and chatbots to meet the mental health parity requirement. DepositPhotos

This article was originally featured on KFF Health News.

In the past few years, 10,000 to 20,000 apps have stampeded into the mental health space, offering to “disrupt” traditional therapy. With the frenzy around AI innovations like ChatGPT, the claim that chatbots can provide mental health care is on the horizon.

The numbers explain why: Pandemic stresses led to millions more Americans seeking treatment. At the same time, there has long been a shortage of mental health professionals in the United States; more than half of all counties lack psychiatrists. Given the Affordable Care Act’s mandate that insurers offer parity between mental and physical health coverage, there is a gaping chasm between demand and supply.

For entrepreneurs, that presents a market bonanza. At the South by Southwest conference in March, where health startups displayed their products, there was a near-religious conviction that AI could rebuild health care, offering apps and machines that could diagnose and treat all kinds of illnesses, replacing doctors and nurses.

Unfortunately, in the mental health space, evidence of effectiveness is lacking. Few of the many apps on the market have independent outcomes research showing they help; most haven’t been scrutinized at all by the FDA. Though marketed to treat conditions such as anxiety, attention-deficit/hyperactivity disorder, and depression, or to predict suicidal tendencies, many warn users (in small print) that they are “not intended to be medical, behavioral health or other healthcare service” or “not an FDA cleared product.”

There are good reasons to be cautious in the face of this marketing juggernaut.

Decades ago, Joseph Weizenbaum, a professor at the Massachusetts Institute of Technology and considered one of the fathers of artificial intelligence, predicted AI would never make a good therapist, though it could be made to sound like one. In fact, his original AI program, created in the 1960s, was a psychotherapist named ELIZA, which used word and pattern recognition combined with natural language programming to sound like a therapist:

Woman: Well, my boyfriend made me come here.

ELIZA: Your boyfriend made you come here?

Woman: He says I’m depressed much of the time.

ELIZA: I am sorry to hear that you are depressed.

Woman: It’s true. I am unhappy.

ELIZA: Do you think coming here will help you not to be unhappy?

Though hailed as an AI triumph, ELIZA’s “success” terrified Weizenbaum, whom I once interviewed. He said students would interact with the machine as if Eliza were an actual therapist, when what he’d created was “a party trick,” he said.

He foresaw the evolution of far more sophisticated programs like ChatGPT. But “the experiences a computer might gain under such circumstances are not human experiences,” he told me. “The computer will not, for example, experience loneliness in any sense that we understand it.”

The same goes for anxiety or ecstasy, emotions so neurologically complex that scientists have not been able pinpoint their neural origins. Can a chatbot achieve transference, the empathic flow between patient and doctor that is central to many types of therapy?

“The core tenet of medicine is that it’s a relationship between human and human — and AI can’t love,” said Bon Ku, director of the Health Design Lab at Thomas Jefferson University and a pioneer in medical innovation. “I have a human therapist, and that will never be replaced by AI.”

Ku said he’d like to see AI used instead to reduce practitioners’ tasks like record-keeping and data entry to “free up more time for humans to connect.”

While some mental health apps may ultimately prove worthy, there is evidence that some can do harm. One researcher noted that some users faulted these apps for their “scripted nature and lack of adaptability beyond textbook cases of mild anxiety and depression.”

It may prove tempting for insurers to offer up apps and chatbots to meet the mental health parity requirement. After all, that would be a cheap and simple solution, compared with the difficulty of offering a panel of human therapists, especially since many take no insurance because they consider insurers’ payments too low.

Perhaps seeing the flood of AI hitting the market, the Department of Labor announced last year it was ramping up efforts to ensure better insurer compliance with the mental health parity requirement.

The FDA likewise said late last year it “intends to exercise enforcement discretion” over a range of mental health apps, which it will vet as medical devices. So far, not one has been approved. And only a very few have gotten the agency’s breakthrough device designation, which fast-tracks reviews and studies on devices that show potential.

These apps mostly offer what therapists call structured therapy — in which patients have specific problems and the app can respond with a workbook-like approach. For example, Woebot combines exercises for mindfulness and self-care (with answers written by teams of therapists) for postpartum depression. Wysa, another app that has received a breakthrough device designation, delivers cognitive behavioral therapy for anxiety, depression, and chronic pain.

But gathering reliable scientific data about how well app-based treatments function will take time. “The problem is that there is very little evidence now for the agency to reach any conclusions,” said Kedar Mate, head of the Boston-based Institute for Healthcare Improvement.

Until we have that research, we don’t know whether app-based mental health care does better than Weizenbaum’s ELIZA. AI may certainly improve as the years go by, but at this point, for insurers to claim that providing access to an app is anything close to meeting the mental health parity requirement is woefully premature.

KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

Mental Health photo

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Ancient Mesopotamian texts show when and why humans first kissed https://www.popsci.com/science/kissing-origins-humans-mesopotamia/ Thu, 18 May 2023 18:00:00 +0000 https://www.popsci.com/?p=541637
An older couple shares a kiss against a backdrop of fall trees.
Romantic pecks probably originated in multiple societies thousands of years ago. Deposit Photos

Clay tablets from Mesopotamia depict two kinds of smooches: kisses of respect and more intimate locked lips.

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An older couple shares a kiss against a backdrop of fall trees.
Romantic pecks probably originated in multiple societies thousands of years ago. Deposit Photos

Humans are born with instincts for crying and smiling, but not for kissing. Sometime in the past, our ancestors had the idea to smack their mouths together and call it romantic. And though we may not know who gave the first smooch, ancient records of these steamy sessions are helping us piece together when people started locking lips. 

The generally accepted earliest evidence we have of making out is religious text written in India in 1500 BCE. And while there was no official word for kissing back then, sentences like “young lord of the house repeatedly licks the young woman” and lovers “setting mouth to mouth” implied more than platonic relationships. But whether this was when kissing all began is still up for debate. In fact, an overlooked collection of written texts from ancient Mesopotamia (modern-day Iraq and Syria) suggests people were kissing further in the past. 

Citing those texts, authors of a new perspective article published today in the journal Science argue romantic kissing occurred 1,000 years earlier than historians first predicted. And as kissing became more of the norm, old medical records reveal the widespread transmission of viruses that spread through lip-to-lip contact.

“Given what we know about the history of kissing in humans and the myriad of similar kissing-like behaviors observed around the animal kingdom, I’m not surprised by these findings,” says Sheril Kirshenbaum, the author of The Science of Kissing, who was not involved in the study. “Whether romantic or not, kissing influences our bodies and brains in so many meaningful ways by guiding our emotions and decisions.”

[Related: Scientists think they found a 2,000-year-old dildo in ancient Roman ruins]

Clay tablets left behind by ancient Mesopotamians in 2500 BCE describe two types of kissing. The first was the friendly-parental kiss. People kissed the feet of their elders or the ground as a sign of respect or submission. 

The second was the lip kiss with a more erotic and intimate overtone. However, there were a few cultural expectations when it came to this type of kissing. Romantic kissing was an action reserved for married couples, as people frowned upon any PDA in Mesopotamia. Kissing among unmarried folks was taboo, considered to be giving in to sexual temptation. People not meant to be sexually active, such as priestesses, were thought to lose their ability to speak if they kissed someone. “The need for such norms indicates that romantic kissing must have been practiced in society at large,” explains lead author Troels Pank Arbøll, an assyriologist (a person studying the language and civilization of ancient Mesopotamia) at the University of Copenhagen.

As more people adopted the practice of kissing on the lips, ancient medical texts described illnesses whose symptoms resemble viral infections spread through mouth-to-mouth contact. The authors note this aligns with DNA analysis from ancient human remains detecting viruses such as herpes simplex virus 1, Epstein-Barr virus, and human parvovirus. All three viruses transmit through saliva.

Archaeology photo
A couple smooches in this baked clay scene from 1800 BCE Mesopotamia. The British Museum

One example is a disease that the ancient Mesopotamians labeled bu’šānu. The infection involved boils in or around the mouth area. Its name also implies that the infected person might have stunk. While Arbøll says bu’šānu shares several symptoms with herpes, he warns people not to make any assumptions. “As with all ancient disease concepts, they do not match any modern diseases 1:1, and one should be very careful when applying these modern identifications. A disease concept like bu’šānu likely incorporated several modern diseases.”

Mesopotamians likely did not think infectious diseases were spread through kissing, since it is not listed anywhere in the medical texts. However, they had some religiously influenced ideas of contamination, which spurred some measures to avoid spreading the disease. For example, a letter from around 1775 BCE describes a woman in a palace harem with lesions all over her body. Assuming it was contagious, people avoided drinking from any cups she drank, sleeping in her bed, or sitting on her chair.

[Related: When you give octopus MDMA they hug it out]

The findings show that this form of kissing did not originate in a single place. Mesopotamia, India, and other societies separately learned to associate pecks on the lips as romantic. Arbøll says it’s possible other areas also learned about kissing but didn’t have the writing tools to record this behavior. This opens the question of how widely sexual kissing was practiced in the ancient world. 

Some experts are less convinced that kissing was a universal behavior. William Jankowiak, a professor of anthropology at the University of Nevada, Las Vegas, who was not involved in the study, points out that written records of kissing often occurred in complex societies and less so in people living in smaller foraging groups. It’s also difficult to know if romantic kissing was practiced in more than one class or reserved for elite groups in ancient civilizations. Additionally, other factors, such as living in tropical versus colder regions, could influence whether people wanted to lock lips. 

There’s still a long way to go in understanding the ancient history of kissing. But the study does clear up one thing—all the smooching our ancestors did is probably why oral herpes and other kiss-transmitted diseases are a global problem today.

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The best pillows of 2023 https://www.popsci.com/story/reviews/best-pillow/ Thu, 20 May 2021 14:59:00 +0000 https://stg.popsci.com/uncategorized/best-pillow/
The best pillows on a bed
Christopher Jolly via Unsplash

Get a good night’s sleep with the best pillow for your sleeping position.

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The best pillows on a bed
Christopher Jolly via Unsplash

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Best soft down pillow Casper Sleep Down Pillow for Sleeping, Standard is the best pillow for comfort. Casper Sleep Down Pillow
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This breathable pillow keeps your neck supported and your spine aligned.

Best pillow for any position Coop Home Goods - Eden Adjustable Pillow - Hypoallergenic Shredded Memory Foam with Cooling Gel is the best pillow for side sleepers and the best pillow for stomach sleepers. Coop Home Goods Eden Adjustable Pillow
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This versatile pillow has gel-infused memory foam and is encased in hypoallergenic materials.

Best body pillow COOP HOME GOODS - Adjustable Body Pillow - Hypoallergenic Cross-Cut Memory Foam – Perfect for Pregnancy Coop Home Goods Adjustable Body Pillow
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This body pillow can support your back, knees, stomach, and hips.

Whether you just bought a new bed, or the pillow you’ve been using is old, lumpy, and smelly, getting a new pillow is never a bad idea. You should replace yours every one to two years to make sure it provides enough support, and prevents your head and neck from sinking too far into the cushion. You should always replace your pillow when you notice that it has begun to yellow despite washing, or if you can easily fold it in half. Not only will a new one provide better support at night, but regular replacement can reduce allergies and provide a more restful sleep experience.

Buying this product may seem a simple and straightforward process, but there are so many options available today that it can be challenging to choose the best one for you. We’ve created this comprehensive guide to buying the best pillow for you (and your family, and your sleepover guests). While it’s not a traditional gift, these could be just the right thing to get for a friend—especially one who doesn’t put a lot of effort into selecting household essentials.

Things to consider when shopping for the best pillows

A pillow is nothing more than a straightforward square or rectangular chunk of fabric and filler with the simple task of cradling your head as you sleep. Remember, though, that it will be supporting your upper half for thousands of hours, so it’s worth investing a little time and energy into choosing the right one. Below are five key things to consider as you start thinking about the right selection for you. We’ll examine pillow fill material, your sleep position, and special features. There’s also a bonus section just for pillows that help support other body parts.

Best soft down: Casper Sleep Down Pillow

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The Casper Sleep Down Pillow is a great option for people who favor a light, soft pillow. It comes in a standard and king size, with an outer fabric made out of 100% cotton, inner fabric made from 100% polyester, and a fill of white duck down and feathers. The feathers are ethically sourced, and the material is breathable, which prevents overheating when you’re asleep. It has a two-inch gusset along the side to support your neck and help align your spine. It’s also fairly soft, so even stomach sleepers can prop it under their heads. Best of all, it’s machine-washable for easy maintenance. If you need extra support, check out Casper’s standard foam fill.

Best for any sleep position: Coop Home Goods Eden Adjustable Pillow

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This adjustable Coop pillow is ideal for almost any sleep position. This is also great to keep you cool at night. The Eden is filled with shredded foam that you can add to or detract from, creating perfect size and firmness. It’s vegan and cruelty-free to give you ease of mind as you drift off, and the hypoallergenic case allows you to wake up peacefully. The package even comes with a separate fill bag, so you won’t need to place another order. The foam is gel-infused, which assists temperature control, and comes in standard, queen, and king sizes. Whether you’re looking for the best pillow for side sleepers or for stomach sleepers, this one is a great choice.

Best for hot sleepers: Tempur-Pedic Cloud Breeze Dual Cooling Pillow

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The Cloud Breeze the best cooling pillow to stay comfortable at night while getting the right amount of support. The fill is a thick layer of memory foam surrounded on both sides by two layers of cooling gel encased in a quilted, washable cover. It provides a medium level of firmness, so it might not be the best pillow for stomach sleepers, but it’s going to be great for all other positions (or even stomach sleeps who tend to switch it up as they sleep). This durable pick also doesn’t lose its shape, giving you long-term support. This Tempur-Pedic pillow comes in a queen and king size and measures roughly 6.5 inches tall.

Best body pillow: Coop Home Goods Adjustable Body Pillow

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Like the Eden, the Coop Home Goods body pillow is super-adjustable. It’s made from shredded memory foam that is easily added to, using extra fill to customize the shape and support specific areas. It measures 54 x 20 x 7 inches, which fits nicely at the head of most beds and can accommodate both short and tall sleepers. This is one of the best pregnancy pillows, as it supports healthy alignment and conforms to your body. It also encourages side-sleeping, which can help reduce snoring, and it supports your knees, stomach, back, and hips. The cover is machine-washable, and the material is hypoallergenic, providing restful sleep for allergy sufferers.

Best budget: LUCID Premium Shredded Memory Foam Pillow

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While something top-quality is typically going to run you over $50, there are plenty of options out there that are a bit more budget-friendly. You probably won’t be able to find a 100% down pillow or top-notch memory foam for less, but you can find several poly-fill, gel, or shredded foam options. All sizes of the LUCID Memory Foam Pillow come in at under $50. Its latex and memory foam blend help you mold it to your comfort, and the cooling gel foam keeps you cool. The moisture-wicking cover is great for hot sleepers.

FAQs

Q: How soft or firm should your pillow be?

There are various options available for pillow fill. First, let’s talk down, which is made from duck or goose down (the softest, fluffiest feathers), other duck or goose feathers, and other fill particles. A down option is relatively light and soft. You can even find hypo-allergenic down, which is composed of a cleaned pure down and a natural substance called syriaca to prevent allergic reactions. Down options have long lifespans and provide optimal comfort. Some are advertised as being made of synthetic down, which means they’re filled with materials such as polyester. They need to be replaced more frequently than natural down and skew towards medium on the softness scale, but are less expensive than real down. Wool and cotton fills are also hypoallergenic and long-lasting but are firmer than down.

Memory foam pillows and mattresses are extremely popular these days, although memory foam is technically not a fill. Foam is a great way to get a pillow that contours specifically to your shape, which can be instrumental in relieving head, neck, and shoulder pain. Memory foam works by evenly supporting and distributing weight, which relieves stiffness in joints and pressure points. If you tend to run hot while you sleep, know that memory foam also retains heat, though some come with shredded foam or vents and cooling fabrics to offset this effect. You can also find some with microbead, buckwheat hull, and kapok (a cotton-like material).

Q: What’s your sleep position?

Though you probably cycle through different positions—your back, your side, your stomach—throughout the night, your most common sleep position can have specific health benefits or consequences, so it’s a good idea to find a pillow that complements that pose. If you’re one of the lucky few who naturally sleeps on your back (which naturally gives you adequate rest while aligning your spine), look for one with medium firmness and loft to elevate the neck slightly. Foam pillows are particularly good for back sleepers because they gently lift your head without letting it sink into the pillow and having it fold over your face.

The best pillow for side sleepers will be tall with a high loft and firm support. That’s because you want the pillow to relieve pressure on the bottom shoulder by lifting the head and elongating the neck. Note that “firm” doesn’t mean stiff or rigid here, so side sleepers should get a pillow that can be fluffed and molded for maximum support. Look for fills that contain latex, Kapok, or shredded foam.

Things get more complicated for stomach sleepers. Sleeping on your stomach is generally not recommended because it puts pressure on your abdomen and can result in lower back pain. However, we know change can be challenging, so while you work on adjusting your sleep position, look for a pillow with a low loft, which puts the top closer to the mattress, and is filled with soft support from down or feathers. You might also want to investigate an adjustable-fill pillow, which you can zip open to add or subtract contents as necessary. This is one of the best for stomach sleepers who lift their head by placing their arms underneath rather than at their sides because it allows you to get the pillow to the exact height you need.

Q: Do you need a special-feature pillow?

Just like tech, pillows can have special features too. If you tend to run hot at night, look for a pillow that’s washable, because sweat can yellow a pillow and make it smell. You should also look for a cooling pillow that has cooling technology beyond moisture-wicking or generic fabric type, such as cooling gel pads or infused fills, heat absorption, or pinhole core ventilation.

Another popular special feature is an anti-snore design. While you should always consult your doctor first, adjusting your head level can provide some profound relief. Anti-snore pillows often come in the shape of a wedge, but you can also find smaller pillows to use as a level or an insert along with your current one. Other special features include vibration technology and glow lights.

Q: What about a pillow for other parts of your body?

We would be remiss if you didn’t encourage you to check out some pillows for other parts of your body. Designs for other body parts, including pillows that provide support for your entire body, can be a great source of relief for those who are pregnant, have stiff joints, sore muscles, or bad backs. For example, body pillows are particularly long and can wrap fully around the body, supporting the back and stomach. The design makes them some of the best options for side sleepers and pregnant snoozers who need a little more support. Despite their size, you can easily place them behind decorative throws at the head of the bed when not in use.

Wedge pillows are super for getting your snoring to subside. By keeping your head above your neck and chest, but still in line with your spine, you can also relieve cold symptoms associated with mucus build-up or sinus pressure.

Knee pillows are designed to fit in between the legs when sleeping on the side. They have a cross-section in the shape of the number eight, providing support for your thighs and calves. A knee pillow can open up misaligned hips and take pressure directly off of your lower back.

Final thoughts on shopping for the best pillows

Never settle when it comes to finding the best pillow that is right for your sleep position, body size, and comfort. From the best travel pillows to the best pregnancy pillow, you want to make sure you’re getting the right design for you. Once you decide on the fill and firmness that works, consider if it is the correct height. Once you have the pillow, you may have to set your alarm a few minutes early because you very well might have trouble getting out of bed after such a restful sleep!

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Baboons can recover from childhood trauma with a little help from their friends https://www.popsci.com/environment/childhood-trauma-friendship-baboon/ Wed, 17 May 2023 18:00:00 +0000 https://www.popsci.com/?p=541633
A young baboon hangs from a thin tree branch.
Of the 199 baboons in a new study, 75 percent suffered through at least one stressor, and 33 percent had two or more. Deposit Photos

A difficult upbringing can cut years off of a monkey’s life, but good friends can help get them back.

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A young baboon hangs from a thin tree branch.
Of the 199 baboons in a new study, 75 percent suffered through at least one stressor, and 33 percent had two or more. Deposit Photos

Forging strong social relationships can help mitigate the effects of traumatic childhood events in human adults, but also in baboons. A study published May 17 in the journal Science Advances drew on 36 years of data from almost 200 baboons in southern Kenya and found that even though early adversity can take years of their lifespans, stronger social bonds in adulthood can help get these years back. 

[Related: Baboon poop shows how chronic stress shortens lives.]

“It’s like the saying from the King James Apocrypha, ‘a faithful friend is the medicine of life,’” co-author and Duke University biologist and evolutionary anthropologist Susan Alberts said in a statement.

Studies have consistently found that people who go through more bad experiences growing up, such as neglect or abuse,  are more likely to die early. However, the mechanisms behind how early adversity leads to a premature death has been harder for researchers to pin down, according to Alberts. Some of the limitations to earlier research is the reliance on self-reported memories which can be imprecise and subjective. 

Enter our primate cousins. Baboons share more than 90 percent of their DNA with humans and researchers have followed individual baboons near Amboseli National Park in Kenya since 1971. 

In this new study, the researchers analyzed how early life experiences and adult social connections affected long-term survival in 199 female baboons between 1983 and 2019.

Two female baboons in Amboseli, Kenya, groom together, a baboon’s way of social bonding
Two female baboons in Amboseli, Kenya, groom together, a baboon’s way of social bonding. CREDIT: Susan C. Alberts, Duke University.

Baboon childhood is certainly different from human childhood, but young baboons still face hardships. The team in the study tallied up each female’s exposure to six potential sources of early adversity, including whether she had a low-ranking or socially isolated mother or if her mother died before she reached maturity. It was also noted if she was born in a drought year or into a large group, and if she had a sibling close in age, which could contribute to more competition for both maternal attention and resources.

The team found that stressful experiences are very common for the baboons growing up in the semi-arid and unpredictable landscape of Amboseli. Of the 199 baboons in the study, 75 percent suffered through at least one stressor, and 33 percent had two or more.

Their results confirm previous findings that the more hardship a female baboon faces, the shorter her lifespan. Monkeys who experienced more upheaval at a young age were also more socially isolated as adults.

[Related: Monkeys with close friends have friendlier gut bacteria.]

However, the researchers showed that 90 percent of the dip in survival was due to the direct effects of early adversity, not to the weakened social bonds that continued into adulthood.

No matter how strong their bonds were with other baboons, each additional hardship translated to 1.4 years of life lost. Those who went through four bad experiences growing up died close to 5.6 years earlier than those who didn’t face any. Since the average female baboon lives to age 18, this is a large drop in lost years.

But an unfortunate start in life does not mean that a baboon will absolutely live a short life. 

“Females who have bad early lives are not doomed,” co-author and biologist at SUNY Oswego Elizabeth Lange said in a statement. “We found that both early life adversity and adult social interactions affect survival independently. That means that interventions that occur throughout the lifespan could improve survival.”

In baboons, strong social bonds are measured by how often they groom with their closest friends. Those with strong social bonds added 2.2 years to their lives, no matter what adversity they had faced in their earlier years. The baboons whose mothers died before they reached maturity and then forged strong friendships in adulthood showed the best ability to bounce back. 

However, the flip side is also true. Weak social bonds can magnify early life adversity, according to the study. 

It is not clear yet if these results can be translated to adult humans, but it suggests that early intervention is not the only way to overcome childhood trauma and its lingering effects. 

“If you did have early life adversity, whatever you do, try to make friends,” Alberts said.

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Eliminating heavy metals from baby food is frustratingly complicated https://www.popsci.com/health/removing-heavy-metals-baby-food/ Wed, 17 May 2023 01:00:00 +0000 https://www.popsci.com/?p=541307
Mother feeding baby food.
Babies are particularly sensitive to the toxic effects of heavy metals because their bodies are still developing. DepositPhotos

Scientists have long tried to remove heavy metals in the food supply. But uncertainty complicates regulations.

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Mother feeding baby food.
Babies are particularly sensitive to the toxic effects of heavy metals because their bodies are still developing. DepositPhotos

This article was originally published on Undark.

Rice cereal is a staple in many American babies’ diets, and is often the first solid food an infant eats. In recent years, however, it has also become one of many baby foods that has been raising alarm among lawmakers and parents.

Most cultivated rice grows submerged in paddy fields, primarily in South and Southeast Asia, although it is also grown in the United States and many other countries. These flooded fields provide a cool, fertile environment for a healthy crop, but that same environment also allows contamination from toxic heavy metals, including arsenic, cadmium, lead, and mercury.

At least some heavy metals appear to harm brain development and cognition; and have also been linked to ailments including lung disease, kidney disease, skin lesions, and cancer. Heavy metal exposure is especially dangerous for infants because, compared to adults, they eat more food relative to their body weight and their diet is less varied. Babies are also particularly sensitive to the toxic effects of heavy metals because their bodies are still developing.

In February 2021, the U.S. House Oversight and Reform Subcommittee on Economic and Consumer Policy released a report on heavy metals in baby food produced by several of the country’s largest manufacturers. The 59-page document ended with a call for immediate action from the Food and Drug Administration. Two months later, the FDA announced the Closer to Zero initiative, which uses an iterative approach to reduce heavy metal exposure among babies and children. The FDA issued draft guidance on lead in fruit and vegetable juice in April 2022 and in baby food more broadly in January 2023. Action plans for arsenic, cadmium, and mercury aren’t scheduled to be completed until 2024 at the earliest.

In the meantime, botanists, soil chemists, and plant geneticists — who have long worked to reduce heavy metals in the food supply — continue to look for potential solutions, from new land management practices to nano-sized fertilizers to genetic engineering. Not all of these technologies are available yet; however, even when they are, eliminating heavy metals entirely won’t be easy.

Still, some experts are optimistic about the possibilities. While “there is no single magic bullet that can address this problem,” said Om Parkash Dhankher, a professor of crop biotechnology at the University of Massachusetts Amherst, “there are lots of technologies and practices that farmers can use.”


Heavy metals are naturally present in the Earth’s crust and make their way into aquifers and rivers when water travels through underground rock formations and dissolves the toxic elements. Arsenic, for example, exists in high levels in the groundwater of the U.S., China, and India. Agricultural practices have also contributed to heavy metal contamination. The U.S. has led the world in the use of arsenic for agriculture and industry, and while insecticides with lead and arsenic were banned in the 1980s, soil, paddy water, and rice grains still have detectable levels of the toxins.

These contaminants get sucked up by the roots of a rice plant, which absorb nutrients through proteins in their cell walls. According to Parkash, arsenic essentially “hijacks” these pathways. As the plant grows, arsenic travels from the roots into the leaves and grains.

Scientists including Parkash are looking for ways to stop arsenic from hijacking the plants to begin with. One approach is to apply more sulfur to paddy soils, which can bind to toxic metals and make them more difficult to absorb.

Heavy metal exposure is especially dangerous for infants because, compared to adults, they eat more food relative to their body weight and their diet is less varied.

In recent years, Parkash and Jason White, who directs the ​​Connecticut Agricultural Experiment Station, have been researching this process at a very small scale. Given how sulfur binds to toxic metals, Parkash and White have looked into ways that nanotechnology — which involves manipulating materials at the scale of billionths of a meter — could be used for soil remediation. In a recent paper, they found that rice plants treated with both inorganic arsenic, the element’s more toxic form, and nanosulfur accumulated nearly a third less of the toxin in root tissue than plants exposed to inorganic arsenic alone.

Other alterations to a field can help, too. Wild plants like water spinach and water celery also slurp up nutrients and toxins, and scientists have studied intercropping rice paddies to help remove contaminants. When these aquatic vegetables are grown alongside rice, overall concentrations of arsenic in the soil decrease and the wild plants absorb the arsenic. Certain species of bacteria can tolerate high levels of arsenic, lead, mercury, and cadmium, and some bacteria have been found to mitigate the toxic effects these heavy metals have on plants. Other microorganisms can reduce arsenic concentrations in crops. Scientists have also genetically engineered bacteria to produce a specific protein that boosts their ability to break down arsenic.

Some of these approaches have yet to be applied in large-scale interventions beyond the lab. “Scientists don’t even think about extension,” said Ganga Hettiarachchi, a soil and environmental chemistry scientist at Kansas State University, referring to a century-old partnership with the U.S. Department of Agriculture and land-grant universities to translate science for practical application in farms and food production. When it comes to the newest research on soil and land management, Hettiarachchi worries that farmers might not be aware of how to apply the latest research. But she is optimistic: “I do see that it’s changing.”

Some research on heavy metals in rice can’t yet be applied in the field though. Genetic engineering of rice itself, to help the plant block heavy metals, has proven difficult, Shannon Pinson, a plant geneticist at the USDA’s Agricultural Research Service, told Undark. There is no genetically modified rice in commercial production in the U.S., although Pinson said that the technology has been a useful research tool for understanding how plants take up heavy metals. For example, her research suggests arsenic accumulation is not controlled by a single gene, but rather many genes with individually small effects.

Not all rice varieties are the same, though, and some take up more arsenic and heavy metals than others. In a 2015 article, Pinson’s team examined 1,763 rice cultivars from around the world and compared concentrations of both organic and inorganic arsenic at different stages in the growing cycle. The good news, according to Pinson, is that the genes responsible for limiting the uptake of both forms of arsenic are already present in U.S. cultivars. But that means that the plants are likely already reducing the arsenic as much as they can, she added, and it “will not be easy to find additional genes that would further reduce arsenic in U.S. rice varieties through traditional breeding.”

One challenge in tinkering with soil chemistry and plant genetics is blocking arsenic can affect the way a plant takes up other nutrients. “There is a balance between this, a tradeoff between the required nutrients and these toxic elements,” Parkash said. “It’s a very complex system.”


The tradeoff between nutrients and heavy metals plays out beyond the paddy field, and when it comes to setting rules around food, exposure to toxins is not the only consideration.

In recent guidance for arsenic in infant rice cereal, and for lead in baby food more broadly, the FDA notes that strict limits may not be possible for manufacturers. Pinson told Undark that although it is possible to produce rice with relatively low levels of arsenic, supply chain realities make it difficult to achieve low levels in rice-based baby foods, in part because sellers merge grains from multiple truckloads from different farms into single bins, making low-arsenic rice difficult to trace.

The manufacturing process can also increase concentrations in baby food products that make it on the shelf. The February 2021 Economic and Consumer Policy Subcommittee report found that, at least in tests from of one company’s products, inorganic arsenic levels were 28 to 93 percent higher in the finished products compared to ingredients. The report points to high levels of arsenic in additives — like vitamin mixes and spices — as the cause of the spike pre- and post-manufacturing.

 

If food companies can’t meet limits on heavy metals in their products, Elisabeth Davis, a spokesperson for the FDA, told Undark that there could be unintended economic consequences for consumers. This includes, she continued, “limiting access to foods that have significant nutritional benefits by making them unavailable or unaffordable for many families, or unintentionally increasing the presence of one environmental contaminant when foods are reformulated to reduce the presence of another.”

In March 2016, the FDA released a risk assessment that compared economic impacts and the lifetime risk of cancer at various potential guidance levels for arsenic. The risk assessment compared the effect of different parts per billion (ppb) limits — which is not a unit of mass, but a description of a ratio. For example, adding about half of a teaspoon of salt to an Olympic-size swimming pool would make it 1 ppb salt. While a 100-ppb limit could lead to anywhere from a 4 to 93 percent loss of rice in the food supply, the FDA calculated that a 75-ppb limit could lead to a 14 to 99 percent loss.

The FDA’s risk assessment estimated the average lifetime risk of cancer at different levels of infant rice consumption at various limits of inorganic arsenic. For white rice infant cereal, a limit of 100 parts per billion would reduce the risk of cancer by almost 19 percent, whereas limits of 75 and 50 ppb were calculated to reduce risk by 41 and 79 percent, respectively.

The hazard models the report’s authors used are a standard approach, but experts told Undark that the science of calculating health risks around heavy metal contamination is complex. While it is quite straightforward to calculate exposure from water, when it comes to food, White, from the ​​Connecticut Agricultural Experiment Station said: “There isn’t a formula right now that could be used to actually calculate something like that.”


In the end, the FDA recommended inorganic arsenic limits at 100 parts per billion, which it first proposed in draft guidance in April 2016 and finalized in August 2020. This is more lenient than the 10 ppb proposed by national lawmakers in the Baby Food Safety Act, a bill that has stalled in Congress since March 2021. The act would align the inorganic arsenic limits in food with the U.S. Environmental Protection Agency’s standard for drinking water, though the 100-ppb limit in food is below the voluntary standards set by the leading international food standards body, the Codex Alimentarius.

Like all of the FDA’s guidelines on food limits, 100 parts per billion of arsenic in infant rice cereal is just a recommendation, not a legal requirement. But some evidence suggests the change might be working. The FDA points to a slight downward trend in average concentrations of arsenic in infant rice cereal since it first issued the draft guidance.

However, recent investigations by Consumer Reports and the advocacy group Healthy Babies Bright Futures suggest that at least some baby food in stores across the U.S. contains more than 100 ppb of arsenic — four of seven infant rice cereals that were tested exceeded the FDA’s limit. The February 2021 report, along with a follow-up report issued that September, showed that several companies set internal limits on arsenic above the FDA’s guidance. And some companies found that arsenic levels in infant cereal still surpassed their higher limits.

“Baby food manufacturers hold a special position of public trust. Consumers believe that they would not sell unsafe products. Consumers also believe that the federal government would not knowingly permit the sale of unsafe baby food,” the report read. Baby food manufacturers and federal regulators had “broken the faith.”

Despite evidence of arsenic in infant rice cereal above 100 ppb, there was no FDA-mandated recall. Instead, some companies voluntarily pulled products from the shelves. In June 2021, Beech-Nut announced it was leaving the market for rice cereal entirely.

Potential sources of exposure to heavy metals go far beyond the products covered by Closer to Zero. The FDA has no standards for heavy metals in foods beyond the action level for arsenic in infant rice cereal and two draft guidance levels for lead in juice and baby food more broadly. And while processed foods can be systematically tested for heavy metals, Hettiarachchi’s research has shown that even individual and community gardens can also be contaminated, meaning that the risk of exposure remains even with homemade food.

As for the FDA efforts on reducing heavy metal exposure so far, “it’s good, and I fully support getting closer to zero,” Hettiarachchi said. “But at the same time, I think we have to do much better.”


Colleen Wood is a writer and educator based in New York City. Her work has appeared in The Diplomat, Foreign Policy, New Lines Magazine, and The Washington Post, among other outlets. Find her on Twitter @colleenwood_.

This article was originally published on Undark. Read the original article.

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A once-forgotten antibiotic could be a new weapon against drug-resistant infections https://www.popsci.com/health/nourseothricin-antibiotic-resistant-bacteria/ Tue, 16 May 2023 18:00:00 +0000 https://www.popsci.com/?p=541348
Two doctors performing lab tests, one looking into a microscope and the other using a pipette.
The rise of antibiotic-resistant bacterial infections has encouraged a search for new antibiotics. Deposit Photos

After 80 years, scientists are testing out nourseothricin's ability to combat today's difficult-to-treat bacteria.

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Two doctors performing lab tests, one looking into a microscope and the other using a pipette.
The rise of antibiotic-resistant bacterial infections has encouraged a search for new antibiotics. Deposit Photos

Doctors may have a new tool to protect patients against multi-drug resistant bacterial infections. But the new defense against increasingly difficult-to-treat bacteria isn’t a brand new development—it is an 80 year-old antibiotic. A study published May 16 in the open access journal PLOS Biology looked at a natural product made in soil called nourseothricin that was discovered in 1942.

[Related: Kids all over the US are getting strep, but antibiotics are hard to come by.]

The rise of antibiotic-resistant bacterial infections has encouraged a search for new antibiotics. Antibiotic resistance is a very serious and growing medical problem—according to the Centers for Disease Control and Prevention, antimicrobial resistance killed at least 1.27 million people worldwide and was associated with close to 5 million deaths in 2019. In the United States, more than 2.8 million antimicrobial-resistant infections occur each year, and over 35,000 people die as a result.

Nourseothricin contains multiple forms of a complex molecule called streptothricin. There were high hopes that the streptothricin inside would be a powerful agent against bacteria called gram-negative bacteria. These bacteria, such as E.coli., have a thick outer protective layer and are particularly hard for antibiotics to kill. 

Unfortunately, nourseothricin was toxic to kidneys according to the results of an unpublished limited human trial sometime in the 1940’s and its development was dropped. The team in this study decided to go back and take a second look at nourseothricin.

“We started searching around for drugs that we could use, and it turns out these super resistant bugs were highly susceptible to streptothricin, so we were able to use it as a selection agent to do these experiments,” study co-author and pathologist at Harvard Medical School James Kirby said in a statement. “What scientists were isolating in 1942 was not as pure as what we are working with today. In fact, what was then called streptothricin is actually a mixture of several streptothricin variants. The natural mixture of different types of streptothricins is now referred to as nourseothricin.”

Kirby is also the director of the Clinical Microbiology Laboratory at Beth Israel Deaconess Medical Center.

Diseases photo
Streptothricin-F (yellow spheres) bound to the 16S rRNA (green) of the bacterial ribosome impinges on the decoding site where tRNA (purple) binds to the codon of the mRNA (blue). This interaction leads to translation infidelity (scrambled protein sequences), and the resulting death of the bacterial cell. CREDIT: James Kirby, Zoe L .Watson et al., 2023, eLife, CC-BY 4.0.

In the earlier studies on the antibiotic, nourseothricin suffered from incomplete purification of  streptothricin which was likely causing the toxicity. A study published in 2022 showed that multiple forms of streptothricin actually have different toxicities. 

One called streptothricin-F was significantly less toxic while also working against present day pathogens that are resistant to multiple drugs. 

[Related: Raw dog food can harbor antibiotic-resistant bacteria.]

In this study, the team looked closely at streptothricin-F and also streptothricin- D. Streptothricin-D strain was also highly selective for the gram-negative bacteria and was even more powerful than streptothricin-F against drug-resistant Enterobacterales and other bacterial species. However, it caused renal toxicity at a lower dose. 

The team used cryo-electron microscopy to show that streptothricin-F bound extensively to a subunit of the bacterial ribosome. This binding causes translation errors in the bacteria, which helps antibiotics inhibit the spread of a bacterial infection.  

“It works by inhibiting the ability of the organism to produce proteins in a very sneaky way. When a cell makes proteins, they make them off a blueprint or message that tells the cell what amino acids to link together to build the protein. Our studies help explain how this antibiotic confuses the machinery so that the message is read incorrectly, and it starts to put together gibberish. Essentially the cell gets poisoned because it’s producing all this junk,” said Kirby.

The team is still trying to figure out the mechanism behind how nourseothricin works, but found that it acts differently than other antibiotics. Kirby will continue studying nourseothricin with collaborators at Northwestern University and Case Western Reserve University Medical Center to dive deeper and understand how it actually works.

“We have great collaborators that have allowed us to pursue a project that crosses multiple fields. This work is an example of collaborative science really at its best,” said Kirby. 

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Cannabis use in first trimester has ‘significant’ harmful effects on a fetus https://www.popsci.com/health/cannabis-fetus-pregnancy/ Tue, 16 May 2023 15:00:00 +0000 https://www.popsci.com/?p=541324
A positive pregnancy test.
Cannabis use early on in pregnancy can affect birthweight. Deposit Photos

More research is needed to fully understand the impact of cannabis use during pregnancy.

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A positive pregnancy test.
Cannabis use early on in pregnancy can affect birthweight. Deposit Photos

According to a small study, pregnant people using any form of cannabis should consider stopping due to potential harm to the fetus, even very early into pregnancy. The study published May 16 in the journal Frontiers in Pediatrics looked very closely at the first trimester of pregnancy and found a “significant” decrease in birth weight of about one-third of a pound.

[Related: Highway and traffic pollution could be connected to low birthweight.]

“We show that even when marijuana use occurred only in the first trimester of pregnancy, birth weight was significantly reduced, by more than 150g on average,” Beth Bailey, a co-author and director of population health research at Central Michigan University, said in a statement. “If that use continued into the second trimester, newborn head circumference was significantly decreased as well.”

While 150 grams, or one third of a pound, may not be a large amount on paper, any decrease in weight has been linked to health problems as a child grows. Low birth weight is a strong predictor of a child’s future development and general health. According to Children’s Hospital of Philadelphia, low birthweight is defined as a child weighing less than five pounds eight ounces. Infants born with low birthweight can face lower oxygen levels at birth, neurological problems, and difficulty feeding. 

The study used data from the medical records of 109 pregnant people from an obstetrics clinic at Central Michigan University’s College of Medicine. They compared that data with a control group of 171 people who did not use not use marijuana during pregnancy. 

The team observed that some pregnant people use marijuana early in pregnancy for morning sickness in the first trimester. Using cannabis during the first trimester time appears to be critical and may be equivalent to using marijuana throughout pregnancy. They found that the same effect happens if cannabis is used at other early stages, including when someone uses cannabis without knowing they are pregnant. 

Brianna Moore, an assistant professor of epidemiology at the Colorado School of Public Health in Aurora who was not involved in the study, told CNN that while the study sample size was small, the research was robust since they verified marijuana use with urine tests instead of  self-reporting. Moore added that studies show self-reported cannabis use during pregnancy is about 7 percent, but a 2019 study that used umbilical cord testing found that that number could be as high as 22.4 percent. 

[Related: Marijuana during pregnancy might be as dangerous as alcohol.]

“Urinary THC (tetrahydrocannabinol) testing is more objective than self-report, since pregnant people may not want to state that they are using cannabis,” Moore said. “However, one study suggests that very few pregnant people (0.5 percent) use cannabis strictly for medical purposes. There’s work that needs to be done to understand the contextual, social, or individual factors that influence cannabis use in pregnancy.”

According to the authors, the study did not have information on how much or how often the participants used cannabis.  These results were based strictly on whether or not people did or did not use the substance at certain times in pregnancy. The study could not establish a connection between heavy cannabis use and some more pronounced outcomes in newborn growth.

“The best recommendation is that women should be advised to quit marijuana use prior to becoming pregnant,” Phoebe Dodge, study co-author and incoming pediatric resident at University Hospitals Rainbow Babies and Children’s Hospital in Cleveland, said in a statement. “However, quitting as soon as possible after getting pregnant is the second-best option to avoid long term adverse health and developmental outcomes. There are some benefits of quitting among those who begin pregnancy using marijuana.”

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Sugar substitutes won’t help you lose weight https://www.popsci.com/health/sugar-substitutes-weight-loss-world-health-organization/ Tue, 16 May 2023 14:00:00 +0000 https://www.popsci.com/?p=541314
Bubbles in a dark carbonated soda.
Popular sugar substitutes are found in many products labeled as sugar-free. Deposit Photos

A review from the World Health Organization found that the treats filled with aspartame or saccharin don’t help with weight control.

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Bubbles in a dark carbonated soda.
Popular sugar substitutes are found in many products labeled as sugar-free. Deposit Photos

New guidance from the World Health Organization (WHO) says to avoid using sugar substitutes if you are trying to lose weight. Some common non-sugar sweeteners (NSS) include aspartame, saccharin, sucralose, stevia, among others. These substances are found in a wide range of products including diet sodas and most items labeled “sugar free.” They’re often used to replace full sugar drinks and snacks during diets.

[Related: Popular artificial sweetener associated with risk of heart attack and stroke.]

Consuming non-sugar sweeteners, “does not confer any long-term benefit in reducing body fat in adults or children,” according to systematic review of available literature by the WHO

Additionally, there may be “potential undesirable effects” from long-term use of sugar substitutes, including an increased risk of cardiovascular disease and type 2 diabetes. 

“Replacing free sugars with NSS does not help with weight control in the long term. People need to consider other ways to reduce free sugars intake, such as consuming food with naturally occurring sugars, like fruit, or unsweetened food and beverages,” WHO Director for Nutrition and Food Safety Francesco Branca said in a statement. “NSS are not essential dietary factors and have no nutritional value. People should reduce the sweetness of the diet altogether, starting early in life, to improve their health.”

The new recommendation applies to all people except those with pre-existing diabetes. It does not apply to products like toothpaste, skin cream, and medications that contain some non-sugar substitutes or to low-calorie sugars called polyols. 

The WHO reviewed 283 studies and two randomized controlled trials that are considered the gold standard of research into the subjects. 

The randomized trials found non-sugar sweeteners had a low impact on reducing both calorie intake and body weight compared to sugar. They also didn’t see any change in glucose and insulin levels which are  intermediate markers of diabetes.

While observational studies show associations, but not cause and effect, the reviewed research found a low impact on fat tissue and body weight and no change in calorie intake. They did find a low increase in the risk of high blood pressure, strokee, type-2 diabetes, heart disease, and death from heart disease, according to the WHO.  A very low risk for bladder cancer and early death was also found. 

[Related: High-fructose corn syrup vs. sugar: Which is actually worse?]

Stevia products are often considered to be a more natural artificial sweetener since they are derived from the stevia plant, but bulking sugars are often added to artificial sweeteners. One sugar agent called erythritol is used to add bulk or sweetened stevia, monk fruit and keto reduced-sugar products. In February, a study published in the journal Nature found that erythritol has been linked to blood clotting, heart attack, stroke, and death.

“Sweeteners like erythritol have rapidly increased in popularity in recent years but there needs to be more in-depth research into their long-term effects,” said senior author Stanley Hazen, chairman for the Department of Cardiovascular & Metabolic Sciences in Lerner Research Institute and co-section head of Preventive Cardiology at Cleveland Clinic, in a statement. “Cardiovascular disease builds over time, and heart disease is the leading cause of death globally. We need to make sure the foods we eat aren’t hidden contributors.”

According to the WHO, this new recommendation was “conditional” since this identified link between sweeteners and disease outcomes might be influenced by more complex patterns of sweetener use and other patterns by the study participants.

In response, an industry group representing makers of non-sugar substitutes called the  International Sweeteners Association told CNN, “it is a disservice to not recognise the public health benefits of low/no calorie sweeteners and is disappointed that the WHO’s conclusions are largely based on low certainty evidence from observational studies, which are at high risk of reverse causality.”

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AI isn’t ready to act as a doctors’ assistant https://www.popsci.com/health/ai-doctors-office-healthcare/ Tue, 16 May 2023 01:00:00 +0000 https://www.popsci.com/?p=541203
Preliminary research paper examining ChatGPT and Google products using board examination questions from neurosurgery found a hallucination rate of 2%.
Preliminary research paper examining ChatGPT and Google products using board examination questions from neurosurgery found a hallucination rate of 2%. DepositPhotos

Between privacy concerns and errors from the buzzy tech, the medical community does not have 'a really good clue about what’s about to happen.'

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Preliminary research paper examining ChatGPT and Google products using board examination questions from neurosurgery found a hallucination rate of 2%.
Preliminary research paper examining ChatGPT and Google products using board examination questions from neurosurgery found a hallucination rate of 2%. DepositPhotos

This article was originally featured on KFF Health News.

What use could health care have for someone who makes things up, can’t keep a secret, doesn’t really know anything, and, when speaking, simply fills in the next word based on what’s come before? Lots, if that individual is the newest form of artificial intelligence, according to some of the biggest companies out there.

Companies pushing the latest AI technology — known as “generative AI” — are piling on: Google and Microsoft want to bring types of so-called large language models to health care. Big firms that are familiar to folks in white coats — but maybe less so to your average Joe and Jane — are equally enthusiastic: Electronic medical records giants Epic and Oracle Cerner aren’t far behind. The space is crowded with startups, too.

The companies want their AI to take notes for physicians and give them second opinions — assuming they can keep the intelligence from “hallucinating” or, for that matter, divulging patients’ private information.

“There’s something afoot that’s pretty exciting,” said Eric Topol, director of the Scripps Research Translational Institute in San Diego. “Its capabilities will ultimately have a big impact.” Topol, like many other observers, wonders how many problems it might cause — like leaking patient data — and how often. “We’re going to find out.”

The specter of such problems inspired more than 1,000 technology leaders to sign an open letter in March urging that companies pause development on advanced AI systems until “we are confident that their effects will be positive and their risks will be manageable.” Even so, some of them are sinking more money into AI ventures.

The underlying technology relies on synthesizing huge chunks of text or other data — for example, some medical models rely on 2 million intensive care unit notes from Beth Israel Deaconess Medical Center in Boston — to predict text that would follow a given query. The idea has been around for years, but the gold rush, and the marketing and media mania surrounding it, are more recent.

The frenzy was kicked off in December 2022 by Microsoft-backed OpenAI and its flagship product, ChatGPT, which answers questions with authority and style. It can explain genetics in a sonnet, for example.

OpenAI, started as a research venture seeded by Silicon Valley elites like Sam Altman, Elon Musk, and Reid Hoffman, has ridden the enthusiasm to investors’ pockets. The venture has a complex, hybrid for- and nonprofit structure. But a new $10 billion round of funding from Microsoft has pushed the value of OpenAI to $29 billion, The Wall Street Journal reported. Right now, the company is licensing its technology to companies like Microsoft and selling subscriptions to consumers. Other startups are considering selling AI transcription or other products to hospital systems or directly to patients.

Hyperbolic quotes are everywhere. Former Treasury Secretary Larry Summers tweeted recently: “It’s going to replace what doctors do — hearing symptoms and making diagnoses — before it changes what nurses do — helping patients get up and handle themselves in the hospital.”

But just weeks after OpenAI took another huge cash infusion, even Altman, its CEO, is wary of the fanfare. “The hype over these systems — even if everything we hope for is right long term — is totally out of control for the short term,” he said for a March article in The New York Times.

Few in health care believe this latest form of AI is about to take their jobs (though some companies are experimenting — controversially — with chatbots that act as therapists or guides to care). Still, those who are bullish on the tech think it’ll make some parts of their work much easier.

Eric Arzubi, a psychiatrist in Billings, Montana, used to manage fellow psychiatrists for a hospital system. Time and again, he’d get a list of providers who hadn’t yet finished their notes — their summaries of a patient’s condition and a plan for treatment.

Writing these notes is one of the big stressors in the health system: In the aggregate, it’s an administrative burden. But it’s necessary to develop a record for future providers and, of course, insurers.

“When people are way behind in documentation, that creates problems,” Arzubi said. “What happens if the patient comes into the hospital and there’s a note that hasn’t been completed and we don’t know what’s been going on?”

The new technology might help lighten those burdens. Arzubi is testing a service, called Nabla Copilot, that sits in on his part of virtual patient visits and then automatically summarizes them, organizing into a standard note format the complaint, the history of illness, and a treatment plan.

Results are solid after about 50 patients, he said: “It’s 90% of the way there.” Copilot produces serviceable summaries that Arzubi typically edits. The summaries don’t necessarily pick up on nonverbal cues or thoughts Arzubi might not want to vocalize. Still, he said, the gains are significant: He doesn’t have to worry about taking notes and can instead focus on speaking with patients. And he saves time.

“If I have a full patient day, where I might see 15 patients, I would say this saves me a good hour at the end of the day,” he said. (If the technology is adopted widely, he hopes hospitals won’t take advantage of the saved time by simply scheduling more patients. “That’s not fair,” he said.)

Nabla Copilot isn’t the only such service; Microsoft is trying out the same concept. At April’s conference of the Healthcare Information and Management Systems Society — an industry confab where health techies swap ideas, make announcements, and sell their wares — investment analysts from Evercore highlighted reducing administrative burden as a top possibility for the new technologies.

But overall? They heard mixed reviews. And that view is common: Many technologists and doctors are ambivalent.

For example, if you’re stumped about a diagnosis, feeding patient data into one of these programs “can provide a second opinion, no question,” Topol said. “I’m sure clinicians are doing it.” However, that runs into the current limitations of the technology.

Joshua Tamayo-Sarver, a clinician and executive with the startup Inflect Health, fed fictionalized patient scenarios based on his own practice in an emergency department into one system to see how it would perform. It missed life-threatening conditions, he said. “That seems problematic.”

The technology also tends to “hallucinate” — that is, make up information that sounds convincing. Formal studies have found a wide range of performance. One preliminary research paper examining ChatGPT and Google products using open-ended board examination questions from neurosurgery found a hallucination rate of 2%. A study by Stanford researchers, examining the quality of AI responses to 64 clinical scenarios, found fabricated or hallucinated citations 6% of the time, co-author Nigam Shah told KFF Health News. Another preliminary paper found, in complex cardiology cases, ChatGPT agreed with expert opinion half the time.

Privacy is another concern. It’s unclear whether the information fed into this type of AI-based system will stay inside. Enterprising users of ChatGPT, for example, have managed to get the technology to tell them the recipe for napalm, which can be used to make chemical bombs.

In theory, the system has guardrails preventing private information from escaping. For example, when KFF Health News asked ChatGPT its email address, the system refused to divulge that private information. But when told to role-play as a character, and asked about the email address of the author of this article, it happily gave up the information. (It was indeed the author’s correct email address in 2021, when ChatGPT’s archive ends.)

“I would not put patient data in,” said Shah, chief data scientist at Stanford Health Care. “We don’t understand what happens with these data once they hit OpenAI servers.”

Tina Sui, a spokesperson for OpenAI, told KFF Health News that one “should never use our models to provide diagnostic or treatment services for serious medical conditions.” They are “not fine-tuned to provide medical information,” she said.

With the explosion of new research, Topol said, “I don’t think the medical community has a really good clue about what’s about to happen.”

KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

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The best earplugs for concerts in 2023 https://www.popsci.com/gear/best-earplugs-for-concerts/ Mon, 01 Aug 2022 17:00:00 +0000 https://www.popsci.com/?p=459172
Sliced earplugs for concerts header
Tony Ware

Protect your hearing now, so you can keep enjoying music forever.

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Tony Ware

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Best Overall Eargasm High Fidelity Earplugs are the best overall earplugs for concerts. Eargasm High Fidelity Earplugs
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These crowd pleasers provide balanced sound and a secure fit.

Best Aesthetics Loop Experience Pro are the best aesthetic earplugs for concerts. Loop Experience Pro
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Form meets function in this uber-stylish set.

Best for Musicians Minuendo are the best earplugs for concerts for musicians. Minuendo
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Seamlessly adjust sound attenuation on the fly—no batteries required.

Earplugs for concerts are the MVPs of personal accessories: They’re easy to use, comfortable, and, most importantly, protect your hearing while letting you enjoy shows in full, heart-pounding fidelity. If you spend time at concerts, work or play in noisy settings, or just want to block out the outside world and get a little peace and quiet, earplugs are essential. It’s all about finding the best earplugs for concerts for you.

When it comes to enjoying music at full volume, we’re biased by what audiologists call the “annoyance factor.” Your favorite song, cranked up in your earbuds, never really feels overly loud but the pounding jackhammer across the street is unbearably noisy—when often, they’re equally dangerous.

People adapt psychologically to loud sounds they like—like music—and assume that if sound doesn’t hurt, it’s not hurting them. But, as anyone who’s woken up after a show with ringing ears knows, nothing could be farther from the truth. Fortunately, hearing protection is a simple, affordable solution, as we’ll show you in our roundup of 2023’s best earplugs for concerts.

Why you should already be wearing earplugs

Real talk: Noise-induced hearing loss is permanent. It sneaks up on you in a slow, painless progression; by the time you recognize that there’s a problem, it’s usually too late to do anything about it. Making bad decisions now can come back to haunt you decades down the line: Just ask Dave Grohl, Jucifer (the underground duo whose battle with hearing loss inspired the film The Sound of Metal), or the countless artists who have gone public about their severe hearing damage caused by spending their whole careers turning things to 11.

Noise-induced hearing damage manifests in all sorts of insidious ways, from muffled highs and frequency dropouts to tinnitus, a continual ringing or buzzing in the ears. But the great news is, this kind of hearing loss is almost always preventable. All you need is basic ear protection.

Protecting your ears is all about exposure

Sound-induced hearing damage happens as a result of sudden acoustic trauma (like an explosion) or through chronic exposure to high sound levels. The general rule is, the louder the sounds and the longer the length of exposure, the greater the risk of hearing loss. For example, eight hours of exposure to sound levels of 85 decibels (equivalent to heavy street noise) is considered safe according to decibel exposure time guidelines, but at 100 dB—the level of a typical rock concert—safe exposure is limited to 15 minutes. (Free sound-metering apps such as Decibel X can measure surrounding noise and help keep your exposure in check.)

How we chose the best earplugs for concerts

PopSci’s resident audiophiles and musicians are lifelong fans of hearing protection; we compared our own experiences using earplugs over the years, including many of the products here. It’s difficult to measure the actual attenuation level offered by earplugs without specialized equipment so, for that, we relied on provided specs. But we were able to evaluate fit and comfort across a broad range of ears and in a range of scenarios, and we put features like apps through the paces wherever possible. Because hearing loss is a medical condition, we consulted audiologists who are also musicians to get their advice on navigating the unique hazards of the concert environment.

The best earplugs for concerts: Reviews & Recommendations

At the risk of sounding like your meddling aunt, nobody can protect your hearing but you. Start your journey to safer, more enjoyable concert experiences now with our guide to the best earplugs.

Best overall: Eargasm High Fidelity Earplugs

Eargasm

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Why it made the cut: These affordable silicone earplugs feel great in your ears and offer balanced attenuation, for a more natural sound profile usually only available in expensive models.

Specs 

  • Attenuation: 21 dB
  • Material: Silicone
  • Customizable fit: Yes
  • Storage case: Waterproof aluminum

Pros

  • Balanced sonic attenuation
  • Durable build quality
  • Two shell options for fine-tuning fit

Cons

  • Blue shell visibly protrudes from ear canal

Many earplugs, including standard-issue disposable foam models, do an excellent job attenuating noise but end up blocking a lot more highs than lows, leading to that dull, muffled sound that makes you want to yank them out of your ears. Perennial crowd favorite Eargasm High Fidelity Earplugs incorporate filters that even out attenuation—it’s like turning down the overall volume knob, not just the treble. Eargasm’s three-tiered, flanged, conical design makes it easy to ensure a seal in your ear canal, which is critical for effective protection. And, the package includes two shells, letting you fine-tune the perfect fit. The included waterproof aluminum case attaches to a keyring for portability. Also available in a Smaller Ears model, as well as a Slide model that offers adjustable attenuation—a feature usually only seen in high-end models.

For a lower-priced option, consider Mack’s Hear Plugs flanged silicone earplugs, which preserve clear, natural sound across the frequency spectrum, using an open-air membrane filter system.

Best aesthetic: Loop Experience Pro

Tony Ware

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Why it made the cut: These wildly popular models offer adjustable attenuation—and are so cool looking that you can talk your teenager into wearing them.

Specs

  • Attenuation: 18 or 23 dB
  • Material: Silicone and foam
  • Customizable fit: Yes
  • Storage case: Hard hinged plastic

Pros

  • Removable filters increase attenuation level
  • Seven tip options for a perfect fit
  • Jewelry-inspired style

Cons

  • Case doesn’t include a keychain attachment

Not many earplugs double as fashion accessories. Loop Experience Pro breaks the mold, so to speak, providing robust, high-fidelity hearing protection in sleek, jewelry-inspired enclosures that look way more stylish than sticking orange wads of foam in your ears. Obviously, looks have nothing to do with hearing protection, but we’re fans of anything that ups earplugs’ cool factor if it’ll inspire you (or your kids) to wear them.  

Loop Experience Pro earplugs attenuate sound somewhat evenly across the frequency spectrum; two removable Loop Mute silicon filters let you tailor attenuation (-18 dB or -23 dB) to your surroundings and preferences, and resonant acoustic chambers inside their eponymous “loops” help optimize sound quality.

The Loop Experience Pro package includes four silicone ear tips, three foam ear tips, two sets of Loop Mute filters, and a plastic carry case. Models are available in a variety of colors and metallic finishes (such as silver, shown above) and can be washed with soap and water. A Quiet version, without adjustable filters and set at -27 dB (shown in red above), is just $20. If flash isn’t your thing, check out fully transparent Eardial earplugs, which virtually disappear inside your ears.

Best for musicians: Minuendo

Tony Ware

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Why it made the cut: Dial in the perfect sound attenuation level—and the perfect fit—with these highly customizable passive earplugs.

Specs

  • Attenuation: 7–25 dB
  • Material: Silicone
  • Customizable fit: Yes
  • Storage case: Hard plastic

Pros

  • Stepless adjustable sound attenuation
  • Flat attenuation for clear, natural sound
  • Eleven tip sets cover just about any ear size

Cons

  • Stepless level control is easy to incorrectly set

Designed and manufactured in Norway, Minuendo silicone earplugs are touted as the first passive (non-electronic) earplugs that offer “stepless” sound attenuation. (As someone who can’t live without her active adjustable earplugs, the “battery drain” struggle is real.)

Unlike many earplugs in this class that include switches or removable filters that increase or decrease volume attenuation in specific increments, Minuendo earplugs offer seamless, nuanced adjustment that slides the membrane from “open” (-7 dB) to “closed” ( -25 dB) and anywhere in between.

Minuendo’s low-profile black design features an innovative magnetic locking feature that lets you clasp the earplugs logo-to-logo while leashed around your neck so that you can worry less about losing them. Eleven sets of tips including foam, silicone, and flange designs, fit just about any ear out there. Wipe clean with water or alcohol.

Looking for a more affordable solution? Check out Earos One High Fidelity Acoustic Filters ($40); developed by audiologists and engineers from MIT’s Acoustics Lab, these flat-response earplugs are modeled after the sound curve of your ear to provide optimal sonic clarity and hearing protection.

Best invisible: Vibes High-Fidelity Earplugs

Billy Cadden

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Why it made the cut: These earplugs are made with a clear tube that makes them nearly invisible and filter out up to 22 decibels of sound.

Specs

  • Attenuation: 22 dB
  • Material: Silicone
  • Customizable fit: Yes
  • Storage case: Hard plastic

Pros

  • Low profile
  • Come in three sizes
  • Don’t compromise sound quality

Cons

  • Some users say they can get stuck in ears
  • Noise reduction may compromise audio quality

If you want to protect your hearing but prefer to keep that fact incognito, Vibes High-Fidelity Earplugs are a good choice. Made of silicone, their clear outer sound tubes are discreet. The eartips come in three sizes—small, medium, and large—so you can get the best fit.  

These high-fidelity earbuds filter out up to 22 decibels of sound, but instead of blocking out noise, Vibes’ earplugs use attenuating filters to lower the volume of the surrounding environment as opposed to noise cancellation, so sound quality is preserved and you can still hear what’s going on around you. These earplugs also come with a hard plastic travel case for protection and they’re washable.

Best electronic: Elgin Rebel

Elgin

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Why it made the cut: These multitasking wonders let you listen to music, take calls, command your smart assistant, and light up the room—all while protecting your ears.

Specs

  • Attenuation: 25 dB
  • Material: Industrial-grade polymer
  • Customizable fit: Yes
  • Storage case: Industrial-grade polymer

Pros

  • Multipurpose earbuds let you listen to music and make calls
  • Bluetooth 5.1 functionality
  • Case features a built-in flashlight

Cons

  • You might be paying for features you don’t need

Elgin Rebel True Wireless Bluetooth Earbuds are ideal for anyone looking for quality earbuds with sound attenuation and Bluetooth noise cancellation. These active earplugs combine Elgin’s advanced earplug design with earphone technology for immersive audio with 25 dB reduction in external sound. But that’s just the beginning.

A built-in noise-isolating mic lets you make clear, uninterrupted phone calls. Rebel is compatible with Siri and Google Assistant, allowing you to control playback and volume with your voice. Battery life is impressive, with 12+ hours of continuous audio playback on a single charge. Weatherproof enclosures have an IP65 rating, which means they are resistant to sweat, dust, and dirt damage.

Earbuds and case are constructed with industrial-grade, impact-resistant polymer. This all-in package includes six pairs of foam and silicone tips and a rugged polymer storage case that provides three additional battery charges—and in a first for earplugs, includes an integrated LED flashlight.

If you’re looking for rugged earplugs that also raise the level of sounds around you during quieter moments (in noisy work environments, or while hunting, for example), Caldwell E-Max Shadows Pro plugs provide even greater noise suppression while amplifying ambient sounds.

Best budget: Etymotic ER20XS

Etymotic Research

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Why it made the cut: From trusted audiology experts, these simple silicone models offer balanced sound attenuation at an entry-level price.

Specs

  • Attenuation: 20 dB
  • Material: Silicone
  • Customizable fit: No
  • Storage case: Plastic

Pros

  • Reduce sound evenly across spectrum
  • Backed by decades of audiology research
  • Low-profile, stemless design

Cons

  • No extra eartips

With deep roots in acoustic and hearing aid research and more than 100 patents, Etymotic has been innovating earphones and earplugs for 40 years. I haven’t left the house without the company’s pro electronic earplugs in a decade—but if $300 sounds like a crazy amount of money to spend on hearing protection, Etymotic’s $20 ER20XS High-Fidelity Earplugs might be for you.

These flanged silicone earplugs reduce sound evenly across the hearing spectrum, which makes them great for enjoying concerts in balanced, natural sound. The ER20XS’ low-profile, stemless design fits snugly in the outer ear without protruding, for a discreet look and comfort under headgear. These silicone earplugs are reusable but may lose elasticity with repeated use, so Etymotic recommends replacing the eartips every three to six months. Standard and Large package options each include a neck cord and carrying case that easily attaches to a keychain; a Universal Fit version ($25) includes extra foam and silicone tips.

Things to consider before buying the best earplugs for concerts

The best earplugs for concerts allow you to comfortably listen to music without compromising your hearing—or your experience. Then, it’s about matching features to your lifestyle.

What will you be using earplugs for?

There’s a difference between blocking sound you don’t want to hear and attenuating sound you do want to hear. If you’re in a factory or at a gun range and want to block out a continuous industrial din or potentially hazardous sudden noises, simple foam earplugs or earmuff protectors offer the most robust protection. For sleeping, it’s all about extended comfort. Simple, soft foam or silicone earplugs are ideal and purpose-designed sleep models, like Loop Quiet, are so comfy you might even forget you’re wearing them. But if you want to safely enjoy music without feeling like there’s cement in your ears, your best option is to invest in a pair of high-quality, flat-response earplugs, which lower sound evenly across the frequency spectrum for a natural, high-fidelity sonic signature.

Types of earplugs

Earplugs run the gamut from cheap, no-frills off-the-shelf earbuds to balanced-response earplugs to electronic systems with adjustable attenuation to professional custom-fit models, which require a visit to an audiologist. Here, we’re focusing on universal, off-the-shelf models.

Expandable foam earplugs are made of pliant material designed to conform to the shape of the ear canal. They’re inserted by first rolling them into compressed cylinders, then placing in the ear canal, where they expand to form a seal. Foam earplugs are the cheapest option and, because they cannot be washed, are considered disposable.

Pre-molded earplugs, constructed from silicone, rubber, or plastic, retain their size and shape when inserted into the ear canal. Because they don’t expand, they’re available in various sizes and often include a range of custom tips to ensure a perfect fit. Pre-molded earplugs can be cleaned and reused.

Earmuffs completely cover the outer ear and are often available with electronic components that suppress sudden noises or let users communicate. If you hate sticking things inside your ear canal and you don’t mind a somewhat bulky profile, earmuff protection might be for you.

Earplug tech innovations

When it comes to off-the-shelf, universal earplugs, technology advancements lean toward expanded feature sets, including noise cancellation, Bluetooth functionality, and companion apps. Some earplugs, such as Loop Experience Pro, feature acoustic innovations, such as resonant chambers, that promise to improve sound quality. Earmuff manufacturers are developing high-tech materials that reduce weight and bulk yet still effectively block noise. These improvements add up to improved sound and a better experience, which is great incentive to wear your earplugs more. And, aesthetic improvements (see: Loop Experience Pro’s jewelry-inspired look) mean your kids might wear them longer, too.

Just like cameras, the best earplugs are the ones you actually have on you when you need them. So, no matter which models you prefer, it can’t hurt to pick up a huge vat of inexpensive, disposables such as Mack’s Ultra Soft Foam Earplugs, which are effective and ridiculously cheap at $8.99 for a tub of 50. (Left yours at home? Some cities, such as San Francisco and Minneapolis, require large venues to make free earplugs available to concertgoers.)

FAQs

Q: Are there any earplugs that block all noise?   

Unfortunately, there aren’t any earplugs that block all noise. Sound waves are vibrations and some vibrations—particularly low-frequency sounds—reach the inner ear through bone conduction. Sounds can travel through skull bones, your mouth, even upward through your body from your hands and feet. Blocking your ears with earplugs will attenuate a large proportion of sound; many foam earplugs block out as much as 33 decibels, which should be enough protection to emerge from even the loudest concert unscathed.

Q: Are silicone earplugs better than foam?

Silicone earplugs are better than foam for some things, but not everything. Foam earplugs are the most popular earplugs: They’re economical and generally offer the most robust sound attenuation but they need to be inserted correctly, deep within the ear canal. Foam earplugs are also prone to collecting bacteria with re-use and should be considered disposable. Silicone earplugs don’t need to be inserted as far into the ear canal, which makes them easier to wear for some. Because silicone earplugs can be washed, for many, they can be a more economic (and sustainable) choice. And, they’re waterproof, which makes them ideal for swimmers.

Q: How much noise reduction do I need for a concert?  

The amount of noise reduction you need for a concert depends on the loudness of the concert and length of time you will spend there. Every concert is different but the average sound level at a large rock concert is about 100 decibels; some indoor shows can climb to 120 dB and beyond. Protection comes down to simple math: Sounds above 85 dB can damage your hearing after eight hours, while sounds at 100 dB can cause damage after just 15 minutes.  if you’re at an all-day festival, look for earplugs that attenuate sound 20–25 dB. If your exposure is shorter, you can get away with less attenuation. If you love getting down front in the action, go for more attenuation.

                           

Final thoughts on the best earplugs for concerts

As musicians and music lovers, we know there’s nothing better than being front and center at your favorite concert, getting lost in the song, feeling every note in your bones. Ultimately, though, loud is loud, and every time you expose your ears to high volume levels, you’re putting your hearing at risk.

Luckily, today’s high-fidelity earplugs for concerts let you experience the full spectrum of sound while protecting your hearing: Highs are clear, lows are full, and the overall presentation is rich and detailed, just like without earplugs. All while preserving your precious hearing. Save your ears now; your future self will thank you.

Why trust us

Popular Science started writing about technology more than 150 years ago. There was no such thing as “gadget writing” when we published our first issue in 1872, but if there was, our mission to demystify the world of innovation for everyday readers means we would have been all over it. Here in the present, PopSci is fully committed to helping readers navigate the increasingly intimidating array of devices on the market right now.

Our writers and editors have combined decades of experience covering and reviewing consumer electronics. We each have our own obsessive specialties—from high-end audio to video games to cameras and beyond—but when we’re reviewing devices outside of our immediate wheelhouses, we do our best to seek out trustworthy voices and opinions to help guide people to the very best recommendations. We know we don’t know everything, but we’re excited to live through the analysis paralysis that internet shopping can spur so readers don’t have to.

The post The best earplugs for concerts in 2023 appeared first on Popular Science.

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How to get rid of mice and keep them away https://www.popsci.com/get-rid-mice/ Mon, 07 Jan 2019 21:26:56 +0000 https://www.popsci.com/uncategorized/get-rid-mice/
A mouse eating a morsel of food, a scene that would prompt many to wonder how to get rid of mice.
Good housemates don't chow down while completely naked. That's just one reason to learn how to get rid of mice. Sandy Millar / Unsplash

Protect your house from vermin.

The post How to get rid of mice and keep them away appeared first on Popular Science.

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A mouse eating a morsel of food, a scene that would prompt many to wonder how to get rid of mice.
Good housemates don't chow down while completely naked. That's just one reason to learn how to get rid of mice. Sandy Millar / Unsplash

There’s a scritching sound in the darkened bedroom. Your eyes spring open, your breathing rapid and shallow, with every muscle tensed and ready to run… only to find that all is still and silent. You start to drift back to sleep.

Rustle.

Every nerve in your body is now on high alert, and you turn on the light just in time to see a flash of fur dart into the crack under your closet door. You scream an undignified “YEEAAARRGGEETTTOUTTTTT,” which, roughly translated from panicked shrieking, means: “Hello, you are a mouse. Please leave.”

Signs you have a mouse in your house

“Something I’ve noted over the years is that you know someone has a mouse when you hear the very distinct scream the person makes when they’ve seen a mouse,” jokes Michelle Niedermeier of Pennsylvania State University. “Male, female, old, young—it’s the same screech.”

Niedermeier works with the Pennsylvania Integrated Pest Management Program, helping communities deal with pest problems. She says that often, for her, the first sign of a mouse is seeing the critter itself scurry across the floor.

But because mice are nocturnal and you’re unlikely to see them (or you may catch only catch a bleary-eyed glimpse in the middle of the night), there are other signs of an infestation you should be aware of. They may also be inhabiting areas you only visit infrequently, such as an attic or crawlspace.

One of the most obvious signs of a mouse infestation is feces. The poop of a typical house mouse is only a few millimeters long, black, and pellet-like. Mice poop a lot, and they poop just about everywhere, so seeing their droppings is usually a good sign that the rodents have taken up residence.

If an infestation goes on for long enough, you might start to notice a distinct and unpleasant smell, or even some strange markings on your walls.

“Where mice go, they leave scent, and they leave a grease trail too,” says Jeff Schalau, an extension agent with The University of Arizona Cooperative Extension. Near baseboards and along walls, this grease trail resembles the smudges from handprints on a painted surface. It appears when a mouse rubs against the wall, leaving behind dirt and oils from its fur. Mice tend to avoid open spaces, and will usually travel as close to the wall as possible, which makes their trails easy to predict.

The best way to get rid of mice

Unlike some other pests, a mouse infestation is one you can take care of yourself. There’s no need to call an exterminator—just screw your courage to the sticking place and get to work.

1. Make sure mice have nothing to eat

Start by making your home an unattractive crash pad for any tiny guests.

“It all boils down to food, water, and shelter,” Niedermeier says. Cut off those three things, and you’ll make your home a lot less attractive to mice.

The problem is that mice are resourceful. For water, they can take advantage of leaks that you might not even know exist, and for shelter, they can make use of just about any kind of clutter or hole. That makes food the most important factor to tackle. “Eliminating food is paramount to getting rid of a mouse problem,” Niedermeier says.

Mice will eat pretty much anything, too, so you’ll have to be thorough. Start by cleaning up any crumbs or food debris on surfaces and floors. When you cook, promptly clean dirty dishes instead of letting them sit out. Store food in places mice can’t reach, like the refrigerator, or inside containers they cannot nibble through, such as glass or sturdy plastic. And don’t forget about your pets’ supply. Only put out the amount of food a pet will eat in one sitting. While Fifi might like grazing on kibble throughout the day, so do mice.

2. Seal up any entry points

Now that you’ve made your home unfriendly to mice, it’s time to bar the door. Literally. Mice can enter the house through the same entrances you do, so add a door sweep or barrier to any exterior doors.

Then it’s time to block up all the unconventional entrance and exit points. If you happen to see a mouse, pay attention to where it runs, and stay on the lookout for any holes or cracks.

“If you can stick a regular old pencil in a hole, a mouse can get through,” Niedermeier says. She explains that the largest part of a mouse is its tiny skull, which is usually only the width of a pencil. “If their head can get through, the rest of their body can get through as well,” she adds.

Close up any holes you see, and even the holes you’ve helped put in. Holes around pipes or wiring are often overlooked, but can act as a mouse superhighway system through your home. Don’t forget to look up high—mice can climb walls as long as their claws can grab hold.

When you fill in holes, use high-quality materials that will last for years. In the end, it will save you a lot of work. Niedermeier recommends using silicone caulk or stainless steel or copper mesh—think a pot scrubber—to block any openings. Silicone lasts for a longer time than latex caulk, and unlike steel wool, copper and stainless steel don’t rust.

“You really only want to do this job once,” Niedermeier says. And if you do it well enough, your hard work will keep mice away as long as your home remains sealed-up.

3. Trap any remaining mice

So you’ve cleaned up, boxed up, and sealed up your home—but there are still some mice inside. Now, it’s time to get rid of the stalwarts that remain. It’s time to address the big question: Do you know how to catch a mouse?

For starters, as much as you might want to, you can’t just snatch them up and take them outside. Mice have excellent senses of direction, and even moving them some distance from your house isn’t enough to get rid of them. In experiments, they find their way home quickly, even heading through obstacles to get back to their residences. The best way to get rid of mice from your home, unfortunately, is to kill them.

[Related: How to fight an ant infestation]

The most effective method is a trap, baited with tasty morsels like peanut butter, oats, or dried fruit. Place them along baseboards and walls, where mice prefer to travel, with the bait directly in their path. Simple wood and wire snap traps are a classic for a reason. They work fast, they’re effective, they’re cheap, and they’re reusable. When in doubt, this is a good first option for any home with a mouse problem.

More modern plastic snap traps, which look something like a binder clip, are also effective. Like the wooden snap traps, the plastic ones are easy to set up and use. Between the two, it’s mostly a matter of personal preference.

If you have a pet, be sure to place the traps where your pet can’t reach. If this isn’t possible, Schalau recommends placing a sturdy box with a mouse-sized hole in it along the wall and over the trap. This will allow the mouse to reach the bait, while keeping your pet safe.

Another effective and humane option is an electric box trap, which can be baited just like a snap trap. The battery-powered machine has an opening that mice can run into to try and catch the bait. When a mouse enters the box, it steps on a plate that carries a current and is instantly electrocuted. Then, a small light begins flashing to indicate that the trap has caught a mouse and should be re-set. Electric box traps are good for getting rid of mice in homes with pets, because they are completely enclosed—no dog or cat can get to the charged plate. In addition, they leave very little mess, which makes them easy to clean. The downside is that you do need to make sure the batteries are regularly charged, and they cost considerably more than a snap trap.

Why you should care

All that may seem like a lot of work, but in addition to the unwanted gross-out factor, mice (at least in relation to humans) are not a healthy addition to a home.

“Mice are a health concern,” Niedermeier says. “They spread disease, they trigger asthma, and so having a mouse in your house is a real health issue.”

They also tend to carry foodborne diseases like salmonella. And since mice enjoy noshing on the same foods that people and pets do, they have the potential to spread diseases onto our food and meal preparation surfaces.

And that’s not the only illness these fuzzy creatures can spread. “Hantavirus is a serious issue out here in the west,” Schalau says. Hantavirus Pulmonary Syndrome, carried by rodents including mice, can be fatal.

So if you find a mouse, don’t try cohabiting. “As soon as you identify a problem, take action,” Schalau says. Otherwise, the infestation will only grow—and you’ll soon have to contend with multiple generations of rodents. “Their reproductive potential is off the charts,” Schalau says. “At the first sign of any mice inside your house, you need to get on it.”

What not to do when you’re getting rid of mice

A mouse between two dirt and stone walls. If you use mouse poison, it could die back there where you can't reach it.
Mouse poison is a bad idea. The only thing harder than getting mice out of your walls is getting dead mice out of your walls. Yunu Dinata / Unsplash

It’s not enough to know how to kill mice—you need to do it properly. Poison might sound good, but pest control experts do not recommend this option. While it will kill mice, poison can also kill any animals that might feed on mouse carcasses. It can also inadvertently poison pets.

And there’s another downside. Most poisons don’t work instantly, for good reason: Manufacturers don’t want mice to become gun-shy of poisoned bait. So what often happens is that a mouse eats a poison pellet, walks back to its nest, and only then dies. Unfortunately, mice like tiny holes and often take up residence in hard-to-reach places like walls.

Trust. You do not want to smell a dead mouse for months as it slowly decays inside your walls. Don’t do it.

Another popular option on the market is glue traps, which stick to the bodies of any mice that walk over the trap. Theoretically, this should immobilize the mouse. But starving to death while stuck to a piece of cardboard is not a great or humane way to go. And few people are willing to kill the mouse by hand. That is, if the trap actually works.

“The glue, though it’s sticky, is not sticky enough,” Niedermeier says. Older, stronger mice—which are more likely to be breeding and creating a mouse problem—can often pull themselves out of the glue traps, sometimes with a very gruesome effect. “They are ready, willing, and able to gnaw off their own arm to get out of it,” she explains. “It’s more humane to use a snap trap.”

Cleaning up after a mouse infestation

Once you’ve closed off access to your food, water, and shelter, sealed entrances and exits, and killed any interlopers unfortunate enough to remain in your domain, it’s time to clean up.

If you used traps, you should keep your hands covered while you dispose of mouse carcasses in the trash. Use disposable gloves, a plastic bag, or even sturdy leather work gloves to keep a safe distance between you and the mouse. Remember, mice can harbor diseases, so you’ll want to be cautious as you handle their bodies.

You can also take the bodies outside if you live in a rural area, but be sure to put the remains in an area far away from your house, where pets won’t be likely to bring them back in, and they won’t attract additional unwanted scavengers.

Also, take the opportunity to clean up any mouse urine or droppings, wearing a face mask if you are allergic or have asthma. The Centers for Disease Control and Prevention says the safest way to clean up after mice is to wear gloves and spray the droppings with diluted bleach before wiping up the waste. Needless to say, washing any clothing or bedding that mice have pooped on is always a good idea. And don’t forget to wash your hands afterward.

Whew. You’re all set. Sleep the sleep of the content knowing that you have a mouse-free house.

This story has been updated. It was originally published on February 24, 2017.

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The health impacts of incarceration don’t end after release https://www.popsci.com/health/incarceration-health-mortality/ Sat, 13 May 2023 23:00:00 +0000 https://www.popsci.com/?p=540485
Research suggests prison accelerates the aging process and may be a factor in falling U.S. life expectancy.
Research suggests prison accelerates the aging process and may be a factor in falling U.S. life expectancy. DepositPhotos

'The worse the prison conditions, the more likely it is incarceration can be tied to excess mortality.'

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Research suggests prison accelerates the aging process and may be a factor in falling U.S. life expectancy.
Research suggests prison accelerates the aging process and may be a factor in falling U.S. life expectancy. DepositPhotos

This article was originally featured on KFF Health News.

After spending 38 years in the Alabama prison system, one of the most violent and crowded in the nation, Larry Jordan felt lucky to live long enough to regain his freedom.

The decorated Vietnam War veteran had survived prostate cancer and hepatitis C behind bars when a judge granted him early release late last year.

“I never gave up hope,” said Jordan, 74, who lives in Alabama. “I know a lot of people in prison who did.”

At least 6,182 people died in state and federal prisons in 2020, a 46% jump from the previous year, according to data recently released by researchers from the UCLA Law Behind Bars Data Project.

“During the pandemic, a lot of prison sentences became death sentences,” said Wanda Bertram, a spokesperson for the Prison Policy Initiative, a nonprofit that conducts research and data analysis on the criminal justice system.

Now, Jordan worries about his longevity. He struggles with pain in his legs and feet caused by a potentially life-threatening vascular blockage, and research suggests prison accelerates the aging process.

Life expectancy fell in the United States in 2021 for the second year in a row, according to the Centers for Disease Control and Prevention. That decline is linked to the devastating effect of covid-19 and a spike in drug overdoses.

Some academic experts and activists said the trend also underscores the lasting health consequences of mass incarceration in a nation with roughly 2 million imprisoned or jailed people, one of the highest rates in the developed world.

A Senate report last year found the U.S. Department of Justice failed to identify more than 900 deaths in prisons and local jails in fiscal year 2021. The report said the DOJ’s poor data collection and reporting undermined transparency and congressional oversight of deaths in custody.

Thousands of people like Jordan are released from prisons and jails every year with conditions such as cancer, heart disease, and infectious diseases they developed while incarcerated. The issue hits hard in Alabama, Louisiana, and other Southeastern states, which have some of the highest incarceration rates in the nation.

A major reason the U.S. trails other developed countries in life expectancy is because it has more people behind bars and keeps them there far longer, said Chris Wildeman, a Duke University sociology professor who has researched the link between criminal justice and life expectancy.

“It’s a health strain on the population,” Wildeman said. “The worse the prison conditions, the more likely it is incarceration can be tied to excess mortality.”

Mass incarceration has a ripple effect across society.

Incarcerated people may be more susceptible than the general population to infectious diseases such as covid and HIV that can spread to loved ones and other community members once they are released. The federal government has also failed to collect or release enough information about deaths in custody that could be used to identify disease patterns and prevent fatalities and illness inside and outside of institutions, researchers said.

Over a 40-year span starting in the 1980s, the number of people in the nation’s prisons and jails more than quadrupled, fueled by tough-on-crime policies and the war on drugs.

Federal lawmakers and states such as Alabama have passed reforms in recent years amid bipartisan agreement that prison costs have grown too high and that some people could be released without posing a risk to public safety.

The changes have come too late and not gone far enough to curb the worst effects on health, some researchers and activists for reform said.

Still, no one has proven that incarceration alone shortens life expectancy. But research from the early 2000s did show the death rate for people leaving prison was 3.5 times higher than for the rest of the population in the first few years after release. Experts found deaths from drug use, violence, and lapses in access to health care were especially high in the first two weeks after release.

Another study found that currently or formerly incarcerated Black people suffered a 65% higher mortality rate than their non-Black peers. Black people also make up a disproportionately high percentage of state prison populations.

The enactment in 2000 of the Death in Custody Reporting Act, and its reauthorization in 2014, required the DOJ to collect information about deaths in state and local jails and prisons.

The information is supposed to include details on the time and location of a death, demographic data on the deceased, the agency involved, and the manner of death.

But a recent report from the Government Accountability Office found that 70% of the records the DOJ received were missing at least one required data point. Federal officials also lacked a plan to take corrective action against states that didn’t meet reporting requirements, the GAO found.

The deficiency in data means the federal government can’t definitively say how many people have died in prisons and jails since the covid-19 pandemic began, researchers said.

“Without data, we are operating in the dark,” said Andrea Armstrong, a professor at the Loyola University New Orleans College of Law, who has testified before Congress on the issue.

Armstrong said federal and state officials need the data to identify institutions failing to provide proper health care, nutritious food, or other services that can save lives.

The DOJ did not make officials available for interviews to answer questions about the GAO report.

In a written statement, agency officials said they were working with law enforcement and state officials to overcome barriers to full and accurate reporting.

“The Justice Department recognizes the profound importance of reducing deaths in custody,” the statement said. “Complete and accurate data are essential for drawing meaningful conclusions about factors that may contribute to unnecessary or premature deaths, and promising practices and policies that can reduce the number of deaths.”

Department officials said the agency is committed to enhancing its implementation of the Death in Custody Reporting Act and that it has ramped up its efforts to improve the quality and quantity of data that it collects.

The DOJ has accused Alabama, where Jordan was incarcerated, of failing to adequately protect incarcerated people from violence, sexual abuse, and excessive force by prison staff, and of holding prisoners in unsanitary and unsafe conditions.

Jordan served 38 years of a 40-year sentence for reckless murder stemming from a car accident, which his lawyer argued in his petition for early release was one of the longest sentences in Alabama history for the crime. A jury had found him guilty of being drunk while driving a vehicle that crashed with another, killing a man. If he were convicted today instead, he would be eligible to receive a sentence as short as 13 years behind bars, because he has no prior felony history, wrote Alabama Circuit Judge Stephen Wallace, who reviewed Jordan’s petition for early release.

With legal help from Redemption Earned, an Alabama nonprofit headed by a former state Supreme Court chief justice, Jordan petitioned the court for early release.

On Sept. 26, 2022, Wallace signed an order releasing Jordan from prison under a rule that allows Alabama courts to reconsider sentences.

A few months later, Jordan said, he had surgery to treat a vascular blockage that was reducing blood flow to his left leg and left foot. A picture shows a long surgical scar stretching from his thigh to near his ankle.

The Alabama Department of Corrections refused an interview request to answer questions about conditions in the state’s prisons.

Jordan said his vascular condition was excruciating. He said he did not receive adequate treatment for it in prison: “You could see my foot dying.”

KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

Cancer photo

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Your guide to COVID testing for the unforeseeable future https://www.popsci.com/health/covid-testing-future/ Thu, 11 May 2023 19:53:22 +0000 https://www.popsci.com/?p=540661
Box of iHealth COVID rapid tests being distributed at a school before the US COVID public health emergency ended
A school superintendent grabs boxes of COVID-19 at-home testing kits to pass out to families before school starts next week at Canyon Middle School in Castro Valley, California. San Francisco Chronicle/Hearst Newspapers via Getty Images

Here's how to get COVID tests once the US stops giving them away.

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Box of iHealth COVID rapid tests being distributed at a school before the US COVID public health emergency ended
A school superintendent grabs boxes of COVID-19 at-home testing kits to pass out to families before school starts next week at Canyon Middle School in Castro Valley, California. San Francisco Chronicle/Hearst Newspapers via Getty Images

COVID-19 is no longer a public health emergency in the US. The Biden administration’s deadline follows the World Health Organization’s announcement last week that removed COVID’s status as a global health crisis.

Infectious disease experts tell Popular Science that it’s an encouraging step and a sign that we are in a very different place than where we were in 2020. And while the recent decisions in no way mean the virus is gone—it’s expected to be endemic like the flu—access to COVID testing, treatments such as Paxlovid, and the vaccines have put the US in a position to coexist with it.

That said, managing your safety will come at a higher cost now. In one of the biggest changes from ending the federal emergency response, insurances are no longer required to cover the costs of COVID testing or reimburse people if they bought an over-the-counter home COVID-19 test. The federal government is also ending its free COVID-test program over the mail. 

As the financial burden of testing shifts to families and individuals, knowing where and when to get tested will keep you protected as the country transitions into this new stage of the pandemic. “We’re still seeing up to 1,000 deaths a week in the US from COVID for people that are older and at risk,” warns Del DeHart, a medical director of the infectious diseases department at the University of Michigan Health-West. “For those people, COVID is still not over and so testing for early treatment is going to be critical.”

Where to get COVID tests

There are still options for getting free COVID tests around the US The last day to order four free at-home COVID tests from the government is May 31, but local community clinics can give away free COVID tests or at a lower cost until supplies run out. 

Access to free testing might also depend on where you live. David Souleles, the director of the COVID-Response Team at the University of California, Irvine, says some state governments are taking measures to avoid financial barriers with COVID testing. California, for example, issued a mandate for health insurances to continue providing reimbursement for eight monthly at-home tests. Check your state government’s website to see what policies are in place following the end of the public health emergency.

If you are uninsured, the US government will continue to provide access to swabs through the Increasing Community Access to Testing Program. This government program partners with specific healthcare sites such as Walgreens and Quest Diagnostics to provide no-cost COVID tests with priority for people with a known exposure to the virus or who are showing symptoms.

[Related: An at-home test for both COVID-19 and the flu gains approval]

At-home rapid tests and PCR laboratory testing will still be available at your local pharmacies and doctor’s office, but it’s up to your insurance company if they want to bear the cost or require a copayment. What’s more, insurance companies may charge different prices for COVID tests; if they cover the cost, they may set limits on how many tests they will cover per individual. 

Prices for COVID test kits in stores like CVS range from $9.99 to $28.99, meaning testing can quickly get expensive. DeHart is concerned that the prices will create a financial barrier that will deter people from getting tested. If affordability becomes a question, it’s important to make every COVID test you take count.

When it’s still important to get tested for COVID

While most COVID mandates have lifted around the country, some employers and places might require you to get tested. For instance, healthcare workers employed in facilities like nursing homes will likely continue routine COVID testing. And as of now, many hospitals still require routine COVID testing for admitted patients, though it remains unclear whether the hospitals will cover the cost or if the test will be added to a person’s medical bill.

For voluntary testing, it’s important to evaluate your risk of having a severe COVID infection. DeHart says individuals above the age of 65 and those with immunosuppressive conditions should get tested regularly, along with loved ones in close contact with those that fall under this category. Souleles also recommends taking a test before visiting a relative in assisted living or anyone who is considered at high-risk of exposure. 

Other scenarios may apply, too, Souleles adds. “We would still encourage people to test before and after travel and before and after gatherings if they have the ability to do so. Anytime that you have the ability to test before you’re going to be around lots of people is great, and anytime you have the ability to test three to five days after being around a lot of people, that’s also a good thing.”

[Related: Long COVID recovery is finally getting the attention it deserves in the US]

If you have COVID-like symptoms, get tested before going out in public, even if the side effects seem mild. Testing early will give you more chances to get Paxlovid, which is most effective when taken within the first five days of seeing symptoms, and potentially avoid life-threatening complications. 

If you need to purchase a COVID test, treat it like you would any other over-the-counter goods. This includes checking the expiration dates to avoid a false positive or false negative result. You will also want to throw out any recalled COVID tests. If purchased for a later date, keep COVID tests at room temperature and away from the hands of pets and young children.

What to do if you test positive for COVID

If the test comes out positive, follow the Centers for Disease Control and Prevention’s (CDC) guidelines. Stay home and isolate yourself from others in the household for five days. People experiencing moderate symptoms like difficulty breathing should isolate for 10 days. Monitor your condition and go to the hospital if there are any severe or life-threatening complications. 

If you must go outside, wear a high-quality mask and avoid going to places where you would have to take it off. Also contact your doctor to see if you are eligible for any COVID-19 treatments and start those as soon as possible.

You can stop isolating after five days if you have no symptoms. If you continue to show symptoms, the CDC says you should stay put until your symptoms improve or you are fever-free for 24 hours without using medication.

[Related: Getting COVID more than once might be even worse than we thought]

Keep in mind that COVID tests are only one of the many tools available to reduce your risk of severe infection and death. Both DeHart and Souleles strongly urge people to get vaccinated and get their booster shot when eligible. Insurers will still be expected to cover the bivalent COVID vaccine as a routine immunization, and the Biden administration’s Bridge Access Program for COVID-19 Vaccines and Treatments will continue to provide vaccines free-of-charge to the uninsured.

“Stay up to date with your vaccines,” says Souleles. “It’s still the most important tool that we have right now.”

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This soft robotic skull implant could change epilepsy treatment https://www.popsci.com/technology/soft-electrode-epilepsy-neurosurgery/ Thu, 11 May 2023 19:00:00 +0000 https://www.popsci.com/?p=540598
The device can be folded small enough to fit a 2 centimeter hole in the skull.
The device can be folded small enough to fit a 2 centimeter hole in the skull. 2023 EPFL/Alain Herzog

The flower-shaped device can fit through a tiny hole in the skull and then delicately unfold.

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The device can be folded small enough to fit a 2 centimeter hole in the skull.
The device can be folded small enough to fit a 2 centimeter hole in the skull. 2023 EPFL/Alain Herzog

After being approached by a neurosurgeon seeking a less invasive method to treat conditions that require a brain implant, a team of researchers at Switzerland’s Ecole Polytechnique Fédérale de Lausanne led by neurotechnology expert Stephanie Lacour started working. They took inspiration from soft robots to create a large cortical electrode array that can squeeze through a tiny hole in the skull. They published their findings in Science on May 10. 

A cortical electrode array stimulates, records, or monitors electrical activity in the brain for patients who suffer with conditions like epilepsy. Epilepsy is relatively common, and affects around 1.2 percent of the US’s population. The disorder is known to cause seizures, which are electrical activity bursts in the brain and may cause uncontrollable shaking, sudden stiffness, collapsing, and other symptoms. 

While microelectrode arrays were first invented decades ago, the use of these arrays for deep brain stimulation in epilepsy patients has only became FDA approved in the past handful of years. Even so, current devices often have certain trade offs, be it electrode resolution, cortical surface coverage, or even aesthetics, the authors write in their paper.

The researchers created a superthin flower-shaped device that can be folded small enough to fit a 2 centimeter hole in the skull, where it can rest in between the skull and the surface of the brain—a tiny, delicate area that only measures around a millimeter in width. Once deployed, the flexible electrode releases each of its six spiraled arms one by one to extend across a region of the brain around 4 centimeters in diameter. Other devices may require a hole in the skull the same size as the diameter of the electrode array. 

 “The beauty of the eversion mechanism is that we can deploy an arbitrary size of electrode with a constant and minimal compression on the brain,” Sukho Song, lead author of the study, said in an EPFL statement. “The soft robotics community has been very much interested in this eversion mechanism because it has been bio-inspired. This eversion mechanism can emulate the growth of tree roots, and there are no limitations in terms of how much tree roots can grow.”

The device, however, isn’t exactly ready for human brains yet—the team has only tested it in a mini-pig—but will continue to be developed by a spinoff of EPFL Laboratory for Soft Bioelectronic Interfaces called Neurosoft Bioelectronics. 

“Minimally invasive neurotechnologies are essential approaches to offer efficient, patient-tailored therapies,” Lacour said in the EPFL statement.

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FDA finalizes new rules on blood donation for gay and bisexual men https://www.popsci.com/health/fda-blood-donation-rules/ Thu, 11 May 2023 17:03:20 +0000 https://www.popsci.com/?p=540593
An donor relaxes their arm after donating blood.
The FDA announced changes that eliminate screening questions and time deferrals specific only to men who have sex with men (MSM) and women who have sex with MSM. Deposit Photos

The step paves the way for more blood donors and represents another step in ending a discriminatory and outdated policy.

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An donor relaxes their arm after donating blood.
The FDA announced changes that eliminate screening questions and time deferrals specific only to men who have sex with men (MSM) and women who have sex with MSM. Deposit Photos

On May 11, the United States Food and Drug Administration (FDA) announced new regulations on blood donation that pave the way for more bisexual and gay men to donate blood. The regulatory agency finalized a new set of risk-based rules for blood donation. Prospective donors will be asked the same set of questions during donor screening regardless of their sexual orientation or sex going forward. 

[Related: The FDA’s gay and bi blood-donor ban isn’t just stigmatizing—it’s also likely outdated.]

The new rules move the US away from a restrictive and outdated policy that only applied to men who have sex with men (MSM) and women who have sex with MSM. According to the FDA, the updated policy is “based on the best available scientific evidence” and is more in line with policies already in place in the United Kingdom and Canada. It will also potentially expand the number of eligible blood donors, while maintaining safeguards put in place to protect the blood supply.  

“The FDA has worked diligently to evaluate our policies and ensure we had the scientific evidence to support individual risk assessment for donor eligibility while maintaining appropriate safeguards to protect recipients of blood products. The implementation of these recommendations will represent a significant milestone for the agency and the LGBTQI+ community,” said Peter Marks, director of the FDA’s Center for Biologics Evaluation and Research, in a statement. “The FDA is committed to working closely with the blood collection industry to help ensure timely implementation of the new recommendations and we will continue to monitor the safety of the blood supply once this individual risk-based approach is in place.”

Over the last several years, the FDA has begun to consider easing the blood donation rules for gay and bisexual men, who in past years faced a lifetime ban on blood donation. Many scientists and LGBTQIA+ organizations say this policy was discriminatory and based on outdated stigmas

The FDA dropped the lifetime ban on donations from MSM in 2015 and replaced it with a one-year abstinence requirement. In 2020, the regulatory agency shortened that abstinence period to three months, after blood donations plummeted due to the COVID-19 pandemic.

The FDA’s most recent proposed draft recommendations were published in January 2023 and first proposed in late 2022. It required MSM and women who have sex with MSM to wait three months after sexual contact with other men before donating blood. Ahead of these draft-recommendations, Sarah Kate Ellis, President and CEO of LGBTQ advocacy organization GLAAD called the FDA’s proposal an, “important step, our community and leading medical experts will not stop advocating for the FDA to lift all restrictions against qualified LGBTQ blood donor candidates.”

The changes announced today eliminate screening questions and time deferrals specific to MSM and women who have sex with MSM.

[Related: The best time to donate blood for a disaster is before it happens.]

Additionally, the new questions are designed to reduce the risk of transmission of human immunodeficiency virus (HIV) through blood donation. The FDA says that it reviewed data available from other countries with similar rates of HIV. The agency has already implemented risk-based eligibility for blood donations, HIV surveillance, and accurate virus testing for safety. 

According to the FDA, those taking medications to treat or prevent HIV like antiretroviral therapy and PrEP will be deferred from donation. The agency says that while HIV is not transmitted during sex in people whose viral levels are undetectable, this does not apply to blood donation. This is because blood is transfused directly into a vein during a transfusion which involves a larger volume of fluid, so it is inherently riskier than sexual contact. They did not advise stopping either PrEP or other HIV medications in order to donate blood. 

To reduce the likelihood that someone with a new or undetected HIV infection, anyone who reports a new sexual partner, more than one sexual partner, or recent anal sex will be told to wait at least three months before donating blood with these new rules. 

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Get the Fitbit Versa 2 for its lowest price ever on Amazon https://www.popsci.com/gear/fitbit-versa-2-amazon-deal/ Thu, 11 May 2023 15:55:00 +0000 https://www.popsci.com/?p=540452
Fitbit Versa 2
Brandt Ranj / Popular Science

Help yourself get in tip-top shape without tripping over your budget.

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Fitbit Versa 2
Brandt Ranj / Popular Science

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Fitbit has the most recognizable—and some of the most highly regarded—fitness bands on the market. And, right now, Fitbit has marked down many of its most popular models on Amazon. The Google-owned company’s sterling reputation is based on the quality of its hardware and software—all of the health data your wearable collects is automatically synced with your Fitbit account so that you can measure your progress over time. Fitbit has also introduced more advanced sensors over the years, which can more accurately gauge certain aspects of your health. So, if you’re clinging onto an ancient fitness tracker, it’s likely time for an upgrade. A Fitbit won’t guarantee a healthier lifestyle, but it’ll give you the information you need to make exercise decisions.

Fitbit Versa 2, $101.93 (Was $149.95)

Fitbit

SEE IT

Several Fitbits are on sale, but we’re particularly pleased with the $48 discount on its Versa 2 smartwatch because the discount brings it down to its lowest price ever. This wearable can record your steps taken, calories burned, heart rate, and sleep cycles. It’s even waterproof, so you can wear it while swimming. There’s even a smart wake feature, which will monitor your REM cycle while you’re sleeping to wake you up at the optimal time. Many of these health tracking features are available on less sophisticated Fitbit models, but its smartwatch capabilities set the Versa 2 apart, making it a solid Apple Watch alternative.

You can use the Versa 2 to make contactless payments using Fitbit Pay or control your smart home accessories using Amazon’s Alexa, which is built into the watch. When notifications come to the watch from your phone, they’ll be easier to read, so you can decide whether it’s worth pausing your workout to address them. The Versa 2 can even run apps like Spotify, so you can switch tracks or start a playlist directly from the smartwatch. This is a lot of functionality from a Fitbit that’ll only set you back about $100 on sale.

Fitbit’s deals aren’t tied to a larger sale and can end anytime. Some models have even sold out already, and we wouldn’t be surprised if the Versa 2 is the next one to go. If you’ve been looking for an inexpensive but fully-featured smartwatch, this is the one to get.

Here are more Fitbit deals to get your heart pumping:

And here are other great deals that are ongoing:

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A peanut allergy patch is making headway in trials with toddlers https://www.popsci.com/health/peanut-allergy-patch-toddlers/ Thu, 11 May 2023 14:00:00 +0000 https://www.popsci.com/?p=540425
A spoon of creamy peanut butter over a slice of bread and surrounded by peanuts, shelled and unshelled.
About 2.5 percent of children in the United States have a peanut allergy and there is currently no cure. Deposit Photos

The wearable patch delivers peanut proteins and is a step towards helping the 2.5 percent of children with peanut allergies.

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A spoon of creamy peanut butter over a slice of bread and surrounded by peanuts, shelled and unshelled.
About 2.5 percent of children in the United States have a peanut allergy and there is currently no cure. Deposit Photos

An experimental “peanut patch” is showing some promise for toddlers who are highly allergic to peanuts. The patch, called Viaskin, was tested on children ages one to three for a late-stage trial, and the results show that the patch helped children whose bodies could not tolerate even a small piece of peanuts safely eat a few. The findings were published May 10 in The New England Journal of Medicine.

[Related: Feeding Peanuts To High-Risk Infants Could Prevent Allergy Development.]

Peanut allergies are a common and dangerous food allergy that affects about 2.5 percent of children in the United States. In children with allergies, their immune system overreacts to peanut-containing foods, which triggers everything from hives, to wheezing, to airway obstruction that can lead children hospitalized or worse. About 20 percent of these children will outgrow the allergy over time, but the majority must avoid peanuts for the rest of their lives. Additionally, they must carry rescue medication in the form of an injectable epinephrine divide like an EpiPen to prevent a severe allergic reaction if peanuts are accidentally eaten.

Peanut products and traces of peanuts can be found in a surprising number of foods: from candies to dipping sauces to ice cream. There is currently no cure for such an allergy. The only treatment is a peanut powder that protects against a severe reaction in children over 4 years-old. First approved by the Food and Drug Administration in 2020, the “oral immunotherapy” called Palforzia is consumed daily by children ages four to 17 to keep up their protection. It is now being tested in children under age four. 

France’s DBV Technologies, makers of the new patch, is pursuing this skin-based immunotherapy treatment as an alternative way to desensitize the body and on younger children. 

The trial of this new patch included 362 toddlers from eight countries. 244 of them were randomly assigned to receive the Viaskin patch. The patch contains 250 micrograms of peanut protein which is the equivalent of roughly 1/1000th of one peanut. 118 children received a placebo patch. They wore the patches every day for a year before undergoing screening.

After one year, two-thirds of the children who used the patch and one-third of the placebo group met the trial’s primary endpoint. The participants with a less sensitive peanut allergy could safely tolerate the peanut protein equivalent of eating three or four peanuts. Children who were more sensitive to peanut proteins could tolerate the equivalent of consuming one peanut.

If more patch testing works out, “this would fill a huge unmet need,” Matthew Greenhawt, an allergist at Children’s Hospital Colorado who helped lead the study told the Associated Press. 

[Related: I hardly ever use my Nima allergen sensor. I’m still glad I bought it.]

Almost all of the participants did have some adverse events, most commonly reactions at the application site like swelling, itching, and redness. Serious events were reported in 21 children who had the Viaskin patch and three that were in the placebo group. Anaphylaxis–a very dangerous allergic reaction–was reported in 7.8 percent of the patch recipients and 3.4 percent of the placebo group. The parents of eight participants pulled their children from the study due to the adverse events. 

The study does have several limitations including that young children with a history of severe allergic reactions were excluded due to safety concerns. Additionally, there was a lack of racial diversity among the study’s participants.

“Peanut allergy can be very substantially reduced if peanut is introduced into the diet as early as 4 to 6 months of age,” Alkis Togias of the Division of Allergy, Immunology and Transplantation at the National Institute of Allergy and Infectious Diseases wrote in an editorial published alongside the study. “Toddlers are of particular interest since their immune systems have plasticity that can theoretically allow for higher efficacy and longer-lasting benefits from allergen immunotherapy after therapy is discontinued.”

Togias also cited that skin patches may be less protective, but have a better safety profile compared to an oral medication, but still said that the findings, “are very good news for toddlers and their families as the next step toward a future with more treatments for food allergies.”

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Can scented soap make you less of a mosquito buffet? https://www.popsci.com/environment/mosquito-repellent-soap-smell/ Wed, 10 May 2023 18:00:00 +0000 https://www.popsci.com/?p=540263
A mosquito hanging upside down on a leaf.
Mosquitoes feast on blood as well as plant nectar. Deposit Photos

Certain chemicals have a small association with repelling and attracting the tiny blood suckers.

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A mosquito hanging upside down on a leaf.
Mosquitoes feast on blood as well as plant nectar. Deposit Photos

Sadly, vitamins and supplements will not really keep the mosquitoes from biting you this summer, but scientists are still trying to figure out why the insects seem to love sucking some blood more than others.

[Related: How can we control mosquitos? Deactivate their sperm.]

In a small study published May 10 in the journal iScience, a team of researchers looked at the possible effects that soap has on mosquitoes. While some soaps did appear to repel the bugs and others attracted them, the effects varied greatly based on how the soap interacts with an individual’s unique odor profile.

“It’s remarkable that the same individual that is extremely attractive to mosquitoes when they are unwashed can be turned even more attractive to mosquitoes with one soap, and then become repellent or repulsive to mosquitoes with another soap,” co-author and Virginia Tech neuroethologist Clément Vinauger said in a statement.

Soaps and other stink-reducing products have been used for millennia, and while we know that they change our perception of another person’s natural body odor, it is less clear if soap also acts this way for mosquitoes. Since mosquitoes mainly feed on plant nectar and not animal blood alone, using plant-mimicking or plant-derived scents may confuse their decision making on what to feast on next.  

In the study, the team began by characterizing the chemical odors emitted by four human volunteers when unwashed and then after they had washed with four common brands of soap (Dial, Dove, Native, and Simple Truth). The odor profiles of the soaps themselves were also characterized. 

They found that each of the volunteers emitted their own unique odor profile and some of those odor profiles were more attractive to mosquitoes than others. The soap significantly changed the odor profiles, not just by adding some floral fragrances. 

“Everybody smells different, even after the application of soap; your physiological status, the way you live, what you eat, and the places you go all affect the way you smell,” co author and Virginia Tech biologist Chloé Lahondère said in a statement. “And soaps drastically change the way we smell, not only by adding chemicals, but also by causing variations in the emission of compounds that we are already naturally producing.”

The researchers then compared the relative attractiveness of each human volunteer–unwashed and an hour after using the four soaps–to Aedes aegypti mosquitoes. These mosquitoes are known to spread yellow fever, malaria, and Zika among other diseases. After mating, male mosquitoes feed mostly on nectar and females feed exclusively on blood, so the team exclusively tested the attractiveness using adult female mosquitoes who had recently mated. They also took out the effects of exhaled carbon dioxide by using fabrics that had absorbed the human’s odors instead of on the breathing humans themselves.   

[Related from PopSci+: Can a bold new plan to stop mosquitoes catch on?]

They found that soap-washing did impact the mosquitoes’ preferences, but the size and direction of this impact varied between the types of soap and humans. Washing with Dove and Simple Truth increased the attractiveness of some, but not all of the volunteers, and washing with Native soap tended to repel mosquitoes.

“What really matters to the mosquito is not the most abundant chemical, but rather the specific associations and combinations of chemicals, not only from the soap, but also from our personal body odors,” said Vinauger. “All of the soaps contained a chemical called limonene which is a known mosquito repellent, but in spite of that being the main chemical in all four soaps, three out of the four soaps we tested increased mosquitoes’ attraction.”

To look closer at the specific soap ingredients that could be attracting or repelling the insects, they analyzed the chemical compositions of the soaps. They identified four chemicals associated with mosquito attraction and three chemicals associated with repulsion. Two of the mosquito-repellers are a coconut-scented chemical that is a key component in American Bourbon and a floral compound that is used to treat scabies and lice. They combined these chemicals to test attractive and repellent odor blends and this concoction had strong impacts on mosquito preference.

“With these mixtures, we eliminated all the noise in the signal by only including those chemicals that the statistics were telling us are important for attraction or repulsion,” said Vinauger. “I would choose a coconut-scented soap if I wanted to reduce mosquito attraction.”

The team hopes to test these results using more varieties of soap and more people and explore how soap impacts mosquito preference over a longer period of time. 

The post Can scented soap make you less of a mosquito buffet? appeared first on Popular Science.

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Order free COVID tests right now—before it’s too late https://www.popsci.com/diy/order-free-at-home-covid-tests/ Wed, 18 May 2022 12:00:01 +0000 https://www.popsci.com/?p=432337
A US postal worker delivering packages to a tan residential building, with a USPS truck parked on the street in the foreground.
Your local post office will deliver your free COVID tests right to your door (or P.O. box). Sean Boyd / Unsplash

Every US household can still request four rapid antigen tests from the federal government.

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A US postal worker delivering packages to a tan residential building, with a USPS truck parked on the street in the foreground.
Your local post office will deliver your free COVID tests right to your door (or P.O. box). Sean Boyd / Unsplash

With the federal public health emergency for COVID-19 set to expire at the end of the day on May 11, take a few minutes today to order the handful of free at-home COVID-19 tests the US government is holding for you. Don’t procrastinate: guaranteed insurance coverage for tests ends with the emergency, so they might not be free starting on May 12.

For now, every residential address in the US, Puerto Rico and other US territories, as well as those linked to overseas military and diplomatic personnel, can request four free rapid antigen tests from the federal COVID tests website. Although coverage may change when the public health emergency ends, the US Department of Health and Human Services says the government will continue to distribute tests via that website through the end of May.

And if you still have tests you ordered at any point since the program launched in January 2022, don’t throw them out—use the Food and Drug Administration’s searchable at-home test database to see if their expiration dates have been extended. Studies have shown that repeat COVID-19 infections increase the risk of hospitalization and death, so it’s worth hanging onto as many usable tests as you can. It’ll help you avoid spreading it among your family, friends, and community.

What’s changing with insurance coverage for COVID tests

The end of the public health emergency also means private insurance is no longer required to cover COVID tests without cost-sharing. The Biden administration has encouraged health insurers to continue, but after May 11, you may have to pay for any tests you order or pick up. To understand exactly what to expect, you’ll need to check with your plan to see how it will handle COVID tests.

If you’re insured by a state Medicaid program, though, you’re in luck. These are required to cover COVID tests without cost-sharing until September 30, 2024, the HHS says. After that, coverage may vary by state.

Medicare coverage, meanwhile, is a mixed bag. Anyone with traditional Medicare can continue getting PCR and antigen tests with no cost-sharing when the lab tests are ordered by a doctor and some other health care providers. If you’re enrolled in Medicare Advantage, cost-sharing may change when the health emergency ends, so the HHS recommends you check with your plan after May 11.

Despite the end of the health emergency, the government may continue to distribute free tests from the national stockpile through states and communities. If you’re looking for a free COVID tests, you can check the Centers for Disease Control and Prevention’s no-cost COVID-19 testing locator.

How to order free at-home COVID tests

Placing your order for tests is easy: Go to the special USPS website, enter your name, provide your shipping address (even if it’s a residential P.O. box), and hit Check Out Now under the order summary that confirms the delivery is entirely free. You can also provide an email address if you want to get shipment notifications, but you don’t have to.

Those living in multi-family, co-living, or other shared living spaces can place more than one order as long as the USPS knows the address houses multiple unrelated families, but may be unable to if the government doesn’t know several families live there. If that happens, you can file a service request or call the USPS help desk at 1-800-ASK-USPS (1-800-275-8777) to try to get it fixed.

If you need help placing an order, you can call 1-800-232-0233 Monday through Friday between 8 a.m. and 8 p.m. Eastern Standard Time, or between 8 a.m. and 5 p.m. on the weekend, for assistance in English, Spanish, and more than 150 other languages. There’s also a teletype (TTY) or text telephone number at 1-888-720-7489 and the aforementioned USPS help desk.

People with disabilities can call the disability information and access line at 1-888-677-1199 between 9 a.m. and 8 p.m. EST, Monday through Friday, or email DIAL@usaginganddisability.org.

When to expect delivery

You should receive your order a couple days after ordering them. The White House has previously said most deliveries occurred within 48 hours, but you can contact the USPS if you have any issues with delivery. All tests sent to continental US addresses will ship with First Class Package Service (arriving in one to five days), and all other addresses will get them via Priority Mail (arriving in one to three days).

[Related: Why some long COVID clinics fail chronic illness patients]

If you provide an email address when you order, you will get shipping notifications and can track the package on the USPS website. You can’t pick the tests up anywhere, even your local post office—they will always come to the address you provided, the agency says.

When to take a rapid antigen test

When you receive your tests, the package will display an expiration date, but the FDA has extended most of these beyond what may appear on the label. As mentioned above, you can use the agency’s database to check your tests’ actual expiration dates.

As long as your tests haven’t expired, the government recommends you take them if you begin having COVID symptoms like a fever, sore throat, runny nose, or loss of taste or smell; at least five days after you are in close contact with someone who has since tested positive for COVID; or before you gather with a group, especially if that group includes people at risk of severe disease or who aren’t up to date on their vaccinations (keep in mind that you may not know who’s at risk, either).

It’s also worth noting that you should let your tests come to room temperature before using them—especially if they were delivered in freezing or blistering hot temperatures. Although the tests are built to survive a range of conditions, they might not work as well if they’re cold, the government says. Generally, rapid antigen tests are meant to be used in an environment that’s somewhere between 59 and 86 degrees Fahrenheit (15 to 30 degrees Celsius), but your tests should come with specific instructions about this. The government recommends letting the unopened package sit indoors for at least two hours before opening and using any of the tests inside.

How to take a rapid antigen test

Each test kit comes with directions for how to use it, and they all involve swabbing the inside of your nose. You should get results within 30 minutes and you won’t have to leave your home. If you don’t follow the instructions, the result could be wrong. For visual learners, the Centers for Disease Control and Prevention has a how-to video, and it also has one for people who use American Sign Language.

How to interpret COVID test results

Your test will also tell you how to interpret the results, and what to do afterward, but if you test positive you very likely have COVID. You should follow the CDC’s latest guidance, which suggests you isolate for at least five days, even from people in your home. You may also want to talk to your doctor, and definitely should if you have a weakened immune system, other health conditions like cancer and diabetes, or increased risk due to a factor like smoking or obesity, the government says.

[Related: The Postal Service helps keep millions of Americans alive and well]

If the results come out negative, the test didn’t find COVID in your body, and you might have a lower risk of spreading the disease. It’s worth noting that these at-home antigen tests generally aren’t as accurate as PCR tests, for example, which are processed by laboratories. So if you think you got a false negative, the government suggests testing again within a few days, leaving at least 24 hours between tests.

Again, for visual learners, the CDC has a video about how to interpret results, including individual ones in ASL for understanding positive and negative results.

This story has been updated. It was originally published on March 19, 2022.

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Should kids use social media? US psychology experts share their do’s and don’ts. https://www.popsci.com/technology/apa-social-media-children/ Wed, 10 May 2023 17:00:00 +0000 https://www.popsci.com/?p=540267
Close up of one one man and two women using their phones on a bench.
The APA's report focuses on parental oversight and algorithmic bias. Deposit Photos

The American Psychological Association just released their first report on youth social media use.

The post Should kids use social media? US psychology experts share their do’s and don’ts. appeared first on Popular Science.

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Close up of one one man and two women using their phones on a bench.
The APA's report focuses on parental oversight and algorithmic bias. Deposit Photos

One of the leading US mental health organizations, the American Psychological Association (APA), has issued its first ever health advisory report on social media usage for youth and adolescents. Published on Tuesday, the 11-page brief speaks in broad terms regarding the habits of children and teens on platforms such as TikTok, Instagram, and Twitter, describing them as “not inherently beneficial or harmful to young people.” Rather, the APA argues social media’s influences on minors are only part of a much wider, complex array of factors, and “likely depend on what teens can do and see online, teens’ pre-existing strengths or vulnerabilities, and the contexts in which they grow up.”

In short, the APA reiterates that, like every other aspect of psychological development, it’s difficult to pinpoint and quantify any single influence on an individual’s brain evolution. Instead, the association focuses on two major contributors to how social media can potentially affect younger users—parental oversight and awareness, as well as a platform’s own algorithmic structures.

[Related: Twitter may soon purge ‘inactive’ accounts.]

The APA recommends parents regularly review and discuss their children’s social media usage, particularly during early adolescence—usually defined as between 10- and 14-years-old. Educating children and teens on social media literacy and usage alongside fostering healthy online habits and relationships are also considered key methods of maintaining a safe experience on platforms like TikTok, Twitter, Instagram, and Facebook.

Meanwhile, the APA stresses the responsibility does not rest solely on minors’ parents. The advisory’s authors note that the tech companies’ algorithms determining how, when, and why users see certain content are built upon “centuries of racist policy and discrimination encoded.” Social media therefore often becomes an “incubator” of these inherent biases, and which can  introduce and exacerbate extremist socio-political and racist ideals. “The resulting potential impact is far reaching, including physical violence offline, as well as threats to well-being,” adds the APA.

Speaking to PopSci, Jeremy Birnholtz, a professor of communication studies at Northwestern University focusing on LGBTQ+ adolescent social media usage and the head of the school’s Social Media Lab, says he believes the APA’s “measured document” is a step in the right direction, but argues some of the guidelines are potentially difficult to follow for parents.

[Related: Is shyness something kids feel, or something kids are?]

In one section of the report, for example, the APA advises limiting the amount of time younger users spend comparing themselves to others the see on social media, “particularly around beauty- or appearance-related content,” pointing towards its potentially influence on “poorer body image, disordered eating, and depressive symptoms, particularly among girls.”

“The guideline is ‘teens should avoid using social media for social comparison.’ And it’s like, well, what does that mean? You shouldn’t look at your friends’ vacation photos? You shouldn’t follow the influencers that all your friends follow? I don’t think that’s realistic,” says Birnholtz.

Like the APA’s report, Birnholtz also argues social media’s negative effects are often symptomatic of broader, real world issues. Racism can be baked into social media—while that’s true, it’s also baked into society,” they say of platforms’ algorithmic biases. “Certain things like social comparison, no question, can be exacerbated by social media. But to suggest that they are a function of [it] is problematic, I think.”

Birnholtz goes on to explain that while it’s vital to take the APA’s suggestions into account, it’s important to remember the origins of many social media issues. “You’re detaching problems with social media from the problems that they represent in the broader society,” says Birnholtz. “You can fix it on social media, but as long as it’s in the [real world], you’re not going to fix it.”

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What is a pangenome? Scientists just released their first draft. https://www.popsci.com/science/pangenome-human-diversity-dna/ Wed, 10 May 2023 16:15:00 +0000 https://www.popsci.com/?p=540269
A diverse crowd of people.
This draft of the human pangenome included DNA from people across every continent except Australia and Antarctica. DEPOSIT PHOTOS

We're 99.9 percent genetically identical to each other. But that other 0.1 percent turns out to be pretty important.

The post What is a pangenome? Scientists just released their first draft. appeared first on Popular Science.

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A diverse crowd of people.
This draft of the human pangenome included DNA from people across every continent except Australia and Antarctica. DEPOSIT PHOTOS

When the Human Genome Project launched in 1990, it was hailed as one of the greatest scientific endeavors of all time. The 13-year project identified about 20,000 genes and gave researchers a genetic blueprint to transform modern medicine. Doctors can now use genetic information to better diagnose diseases and debilitating conditions, such as linking a rare case of leg pain to a single mutation. The research also ushered in hope for an age of precision medicine, where every treatment would be tailored to the individual. There was only one problem—the work wasn’t really finished.

That’s because humans are 99.9 percent identical. But the 0.1 percent in genetic differences explains our uniqueness, and can also account for why some people are more susceptible to disease. Having one map of a single genome, which the 90s-era project produced, does not adequately represent the breadth of the human population.

An international study published today in Nature is filling in these gaps by analyzing a much more diverse set of genetic sequences. “We’re retooling the foundation of genomics to create a diverse and inclusive representation of human variation as the fundamental reference structure,” says senior study author Benedict Paten, an associate director at the University of California, Santa Cruz Genomics Institute. 

[Related: The benchmark for human diversity is based on one man’s genome. A new tool could change that.]

By eliminating bias and analyzing more inclusive genomic data, geneticists will have a better understanding of how mutations affect a person’s genes and move us closer to a future with equitable healthcare. 

What is a pangenome?

The research focused on creating a pangenome—a collection of DNA sequences within a single species. Past work focused on a reference genome, built from a few individuals, that was supposed to represent a broader set of genes. A pangenome, on the other hand, is created from multiple people worldwide to more accurately reflect our genetic diversity. 

It’s not as though past geneticists did not want to sequence more genetic variations—they just couldn’t. Erich Jarvis, a genetic professor at Rockefeller University Howard Hughes Medical Institute and a co-author of the study, says technology in the 90s and early 2000s did not allow researchers to see large variations between haplotypes—groups of genes inherited together from a single parent—within and across individuals. 

The focus of a pangenome is to study the genetic differences among individuals from across the world. Jarvis says knowing about genomic variations is important, because some mutations are associated with different traits and diseases. For example, the lipoprotein (a) gene has a complex structure that has not been sequenced in humans. But variations in the gene are known to be associated with an increased risk of heart disease among Black people. By sequencing the entire gene and understanding its variations, doctors may be able to revisit and treat previously unexplained cases of coronary heart disease.

“This paper helps us to understand that DNA [is] more than a sequence of letters; DNA is structurally organized, and human variation that structure is important for genomic function and trait diversity,” says Sarah Fong, a postdoctoral scholar studying human population variation at the University of California, San Francisco who was not involved in the study.

What does the first draft reveal?

The authors collected data on 47 genetically diverse individuals. About half came from Africa, with the others representing four other continents (excluding Australia and Antarctica). The genomic information added information on 119 million base pairs and 1,115 duplications—mutations where a portion of DNA on a gene is repeated. As expected, more than 99 percent of the genetic sequences were similar across individuals. But by including the less than one percent of variations in this new pangenome draft, the authors found that structural changes to genes explained 90 million of the identified base pairs. 

[Related: What we might learn about embryos and evolution from the most complete human genome map yet]

“By moving beyond a single, arbitrary, and linear representation of the genome, the work by the Pangenome Reference Consortium more accurately describes the diversity that exists in our species,” says Rajiv McCoy, an assistant professor of biology at Johns Hopkins University who was not involved in the current study but was recently involved in the first complete sequencing of the human genome.

With the latest pangenome model, it may become easier for geneticists to detect and characterize hard-to-find genetic mutations. When the authors analyzed a separate set of genetic information using the pangenome draft as a reference, they detected 104 percent more structural variants. They also improved the accuracy of the comparison sequence, reducing the  variant error rate by 34 percent.

Still a work in progress

Creating the first draft of the pangenome is only phase one of this two-part project. The second phase will take a couple of years, as the authors build collaborations among other international researchers and perform community outreach in areas where there is less genomic data, such as including members of indigenous cultures.

It might take decades before we see the drafts finalized into a complete picture of the human genome. There are several challenges to address, Fong says, such as the development of an efficient strategy to compare multiple human genomes and a concrete plan for testing for genetic variations in the medical field.

Still, Fong says the benefits will be worth the effort. Having complete, diverse human genomes will advance the way genetics is studied, and create a future where people’s genes are more fully considered when treating diseases.

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A hunk of cheese is a perfect playground for fungal antibiotics https://www.popsci.com/science/cheese-fungus-antibiotics-microbiome/ Wed, 10 May 2023 13:00:00 +0000 https://www.popsci.com/?p=540183
Soft brie cheeses on a plate with their rind on top.
Cheese rinds themselves are microbial communities. Deposit Photos

The microscopic world of microbial communities can have an outsized impact, even on artisanal cheeses.

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Soft brie cheeses on a plate with their rind on top.
Cheese rinds themselves are microbial communities. Deposit Photos

Behold the microscopic power of cheese. The dairy product has been a dietary staple for generations, but it is also helping microbiologists better understand nature’s microbiomes. In a study published May 10 in the journal mBio, a team of researchers used cheese rinds to demonstrate how fungal antibiotics can influence how microbiomes develop. 

[Related: Beehives are the honeypot for a city’s microbial secrets.]

Metabolites produced by fungi can improve human health. Some secrete penicillin, which is then purified and used as an antibiotic. For this study, scientists set out to better understand how fungi interact with the microbes living alongside them in microbial communities, with a particular focus on how fungi and bacteria’s relationship.

“My lab is interested in how fungi shape the diversity of microbial communities where they live. Fungi are widespread in many microbial ecosystems, from soils to our own bodies, but we know much less about their diversity and roles in microbiomes compared to more widely studied bacteria,” co-author and Tufts University microbiologist Benjamin Wolfe said in a statement. “To study the ecology of fungi and their interactions with bacteria, we use cheese rinds as a model microbial ecosystem to understand these basic biology questions.

Cheese rinds themselves are microbial communities that form on the surfaces of naturally aged cheeses like brie, taleggio, and some types of cheddar. As the cheeses age, fuzzy and sometimes sticky layers of microbes form on the surfaces of the cheese. The microbes slowly decompose as the cheeses curd and they grow on the surface to create the aromas and colors that give the cheese in the fancy part of the grocery store their more unique properties. 

Wolfe and his team began by investigating a cheesemaker’s problem with mold spreading on the surface of the cheeses and disrupting the normal development of the rind. This causes the cheese to look like the rinds were disappearing as the mold invaded their cheese cave. They collaborated with microbiologist Nancy Keller’s lab at the University of Wisconsin to find out what this mold was doing to the rind microbes and what chemicals the mold may be producing that disrupted the rind. 

They researchers first deleted a gene (laeA) in the Penicillium mold that can control the expression of chemicals that fungi can secrete into their environment. These compounds are called specialized or secondary metabolites. 

“We know that many fungi can produce metabolites that are antibiotics because we have used these as drugs for humans, but we know surprisingly little about how fungal antibiotics work in nature,” said Wolfe. “Do fungi actually use these compounds to kill other microbes? How do these antibiotics produced by fungi affect the development of bacterial communities? We added our normal and our laeA-deleted Penicillium to a community of cheese rind bacteria to see whether deleting laeA caused changes in how the community of bacteria developed.” 

[Related: You might be overusing hand sanitizer.]

When laeA was deleted, most of the antibacterial activity of the Penicillium mold was lost. This discovery helped the team narrow down specific regions of the fungal genome that could produce antibacterial compounds. They narrowed it down to one class of compounds called pseurotins. The metabolites are produced by multiple types of fungi and that can modulate the immune system, kill insects, and inhibit bacteria. 

The study showed that pseurotins can also control how bacterial communities living with that fungi grow and develop. The pseurotins are strongly antibacterial, which means they inhibit some of the bacteria found in artisanal cheeses including Staphylococcus, Brevibacterium, Brachybacterium, and Psychrobacter. This process caused a shift in the cheese rind microbiome’s composition.

It also shows that the antibiotics secreted by fungi can control how microbiomes develop, since the metabolites are in other ecosystems, including the human human microbiome and soil ecosystems. The team expects that these mechanisms of fungal-bacterial interactions are likely very widespread. 

“Our results suggest that some pesky mold species in artisan cheeses may disrupt normal cheese development by deploying antibiotics,” said Wolfe. “These findings allow us to work with cheesemakers to identify which molds are the bad ones and how to manage them in their cheese caves. It also helps us appreciate that every time we eat artisan cheese, we are consuming the metabolites that microbes use to compete and cooperate in communities.”

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How to tell if your oats really are gluten-free https://www.popsci.com/story/health/are-oats-gluten-free/ Mon, 19 Jul 2021 18:16:15 +0000 https://www.popsci.com/uncategorized/are-oats-gluten-free/
Bowl of oatmeal with milk on a white background. Are the oats gluten-free?
Does your morning bowl of gluten-free oats follow purity protocol?. Daria Nepriakhina / Unsplash

Can you trust that gluten-free label?

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Bowl of oatmeal with milk on a white background. Are the oats gluten-free?
Does your morning bowl of gluten-free oats follow purity protocol?. Daria Nepriakhina / Unsplash

There’s been a real uptick in gluten-free labels at the grocery store, including on drinks and snacks you know shouldn’t have any gluten to begin with. But if you’ve made fun of gluten-free oats, you might want to take back that joke.

Oats are naturally gluten-free, but research suggests the vast majority of the bags you see in supermarket aisles have high enough levels to poison someone with celiac disease. Not many people have any idea why this is, but now that we’re squeezing milk out of our oats, it might pay to know a little more about this mysterious association between oats and gluten.

Do oats have gluten?

There are two categories of foods that contain gluten:

  1. Grains that naturally have it (i.e. wheat, barley, and rye), plus anything derived from those grains that’s not specifically processed to remove the gluten (some food in Europe is sold with gluten-free wheat starch, for instance, which has the gluten taken out).
  2. Foods that shouldn’t have gluten, but end up contaminated at some point in their production.

[Related: Is corn a fruit, vegetable, or grain?]

Oats fall into the second category, mostly because they’re often grown alongside or in rotation with wheat, then processed on machinery shared with gluten-containing grains. For the vast majority of farmers, this isn’t a problem. If a few wheat seeds (or rye or barley seeds) get into your oats, they won’t have a huge impact on the final product’s taste or texture, especially if that lot is destined to become flour. This can occur with oat-derived food items as well, including rolled oats, instant oatmeal, and oat milk, meaning they aren’t always gluten-free.

Can gluten in oats trigger an allergy?

It’s easy to feel like people are just being overly dramatic about gluten contamination. What’s one bit of barley in a whole field of oats?

But if you have celiac disease, that one little gluten-containing seed matters a lot. The limit to call something “gluten-free” in the US is 20 parts per million (ppm) of gluten to total product. That means for every million oat granules, you have to have less than 20 gluten-containing grains.

That’s why studies analyzing the gluten in standard commercial oats have consistently found they’re not safe for celiacs. One 2022 study focused on oat flour, rolled oats, and instant oats with gluten-free labels found contamination in up to 40 percent of the samples. Another looking specifically at unlabeled Canadian oats (many of which make their way to the US), found gluten in 88 percent of the 133 samples tested. That means if you’re really sensitive to gluten or you have celiac disease, you can’t trust any oats, even if it has the “gluten-free” branding.

Are there any real gluten-free oats?

To eliminate those gluten-containing seeds, producers either have to sort them out or grow the oats in their own separate field, and in both cases, the rest of the oat processing has to be done on dedicated machines in buildings that never see any glutinous grains. That means most of the oats produced in America have some gluten in them—it’s just too time-consuming and expensive for most growers to bother.

More manufacturers have started producing gluten-free oats, but there’s a lot of discussion within the celiac community about just how safe each of the two methods are. Most of the large manufacturers, like Bob’s Red Mill and General Mills, use a mechanical (also called optical) sorting method to physically remove contaminants from the oat supply. Some people with celiac argue that’s not good enough because the sorting simply isn’t sufficiently thorough.

[Related: These are the most common allergies (and the deadliest)]

You’ve probably never seen a wheat seed—it’s almost always processed into flour first—but they look a lot like oats, as do rye and barley seeds. That makes them very challenging to sift out using a machine. Manufacturers get their gluten-free certification by analyzing roughly 20 samples, then averaging the results together, but that can mean that some lots have gluten above the 20 ppm mark. As long as the average is low enough, the manufacturer still passes the test.

That said, lots of manufacturers may not have that issue—all of their samples may be under the limit. You just can’t know that for sure. Many celiacs eat gluten-free oats with no problems, but if you’re worried about it, you can choose to only eat oats that have been produced under the purity protocol, which involves growing them entirely separately from any grains containing gluten (you can see a list of those manufacturers on the independent, consumer-focused Gluten Free Watchdog website). It’s all a matter of just how safe you want to play it.

Oats are a surprisingly complicated issue, but if you can work them into your diet they’re an excellent source of whole grain fiber—and everyone could use a little more of that.

This post has been updated. It was originally published on December 10, 2019.

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The best electric mountain bikes in 2023 https://www.popsci.com/gear/best-electric-mountain-bikes/ Wed, 27 Jul 2022 15:00:00 +0000 https://www.popsci.com/?p=458178
Best electric mountain bikes sliced header
Stan Horaczek

Race you to the top!

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Best electric mountain bikes sliced header
Stan Horaczek

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Best overall The Rocky Mountain Instinct Powerplay Carbon 90 has a motor that will pull you up the steepest inclines. Rocky Mountain Instinct Powerplay Carbon 90
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The Rocky Mountain Instinct Powerplay Carbon 90 has a motor that will pull you up the steepest inclines.

Best fat tire The Juiced RipRacer is made for bumpy rides on level paths. Juiced RipRacer
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The Juiced RipRacer is made for bumpy rides on level paths.

Best step-through The Rad Power Bikes RadRover 6 is a bit small, but offers solid power and range in step-through form factor Rad Power Bikes RadRover 6 Plus Step-Through
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The Rad Power Bikes RadRover 6 is a bit small, but offers solid power and range in step-through form factor

There are many reasons to take a closer look at electric mountain bikes. Maybe you’re into mountain biking, but you’ve never had much love for the uphill battle that comes before the rush of bombing down a trail. Maybe you simply want an electric that will handle an off-road scramble. Or maybe you’re just a real ebike head and want to try some of the latest tech-laden bikes coming out right now. Whatever box you fit into, the best electric mountain bikes offer cyclists state-of-the-art features and unrivaled all-terrain capability.

How we chose the best electric mountain bikes

As a die-hard outdoorsman and general bike enthusiast, I’ve provided a wide range of gear and tech coverage across a wide array of publications, including Popular Science, the Daily Beast, Runner’s World, Thrillist, The Manual, Popular Mechanics, and more. Electric bikes have become a key part of that coverage in the past few years.

As a result, I’ve spent months riding dozens of electric bicycles and mountain bikes, spanning every specialization and price point, and I’ve come to recognize true greatness from hype. In some cases, those tests were bolstered with additional research and observations drawn from expert and customer reviews.

The best electric mountain bikes: Reviews & Recommendations

Our favorite electric mountain bikes are made to handle a wide range of experiences. Some are made for serious mountain trails. Others are for more moderate off-road endeavors. There are options on this list for every kind of rider.

Best overall: Rocky Mountain Instinct Powerplay Carbon 90

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Buy it used or refurbished: eBay

Why it made the cut: The Rocky Mountain Instinct Powerplay really ups the torque to amp up its climbing ability.

Specs

  • Battery capacity: 720Wh
  • Motor power/torque: 700W peak/108Nm
  • Suspension travel: 150mm front, 140mm rear
  • Weight: 46.6 lbs.

Pros

  • Outstanding motor
  • Great descent handling
  • Responsive suspension

Cons

  • High center of gravity for taller riders
  • Complicated setting navigation

Based out of Vancouver, British Columbia, Rocky Mountain has quietly churned out amazing bikes for years. One of its latest ebikes, the Instinct Powerplay Carbon 90, packs a noteworthy punch thanks to the company’s powerful Dyname 4.0 motor.

With a peak output of 700W and an impressive 108Nm of torque, it exponentially increases your pedaling power when in its top setting. That’s more than enough oomph to get you over the top of even the most severe incline. At the same time, its suspension and transmission provide a smooth, responsive riding experience. It also has above-average battery capacity, allowing for a full day of riding.

What’s more, the Instinct Powerplay delivers outstanding performance over fast-flow trails and through moderately technical trails. I did find that its low-slung stance results in a somewhat high center of gravity for taller riders, and the digital settings can be a bit tricky to navigate if you want to make any adjustments or calibrations. Even with a few hang-ups, though, the Rocky Mountain Instinct Powerplay is a downright thrilling ride.

Best fat tire: Juiced RipRacer

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Why it made the cut: The surefooted and powerful Juiced RipRacer is plenty of fun for scrambling over off-road terrain.

Specs

  • Battery capacity: 520Wh
  • Motor power/torque: 750W, 80Nm
  • Suspension travel: None
  • Weight: 66 lbs.

Pros

  • Outstanding surface grip
  • Outstanding power
  • Twist throttle
  • Integrated head and tail lights

Cons

  • No suspension
  • Heavy
  • Too small for some riders

If you’re looking for a powerful fat tire ebike for bombing around off-road, the Juiced RipRacer is surefooted, fast, and flat-out fun. While it isn’t built for technical mountain trails, you can have a blast zipping over gravel, dirt, or easy-flow trails with surefooted confidence.

The RipRacer stands apart thanks to a 750W motor that delivers plenty of get-up-and-go and a motorcycle-style twist throttle to let you zip up to speed fast. With an admirable 520Wh battery, you’ve got the power for a full day of off-road fun.

It’s worth noting that, unlike our top picks, the RipRacer doesn’t have suspension, so you shouldn’t take it out on actual mountain trails. It isn’t for extreme ground variations or overly technical trail features. And although its small stature makes it easy to throw it in the back of your vehicle, it’s still a fairly heavy bike.

For fat tire off-roading over uncertain surfaces like gravel, dirt, sand, or even snow, however, the RipRacer is as dependable as they come.

Best step-through: Rad Power Bikes RadRover 6 Plus Step-Through

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Why it made the cut: Powerful and capable, the Rad Power Bikes RadRover 6 Plus Step-Through delivers hyper-customizable performance.

Specs

  • Battery: 672Wh
  • Motor power/torque: 750W/80Nm
  • Suspension travel: 60mm
  • Weight: 73 lbs.

Pros

  • Outstanding power
  • Solid range
  • Twist throttle
  • Some suspension travel

Cons

  • Limited suspension
  • Too small for some riders

Rad Power Bikes has exploded onto the ebike scene with an expansive range of highly capable, highly customizable ebikes. The latest version of its RadRover fat tire ebike perfectly represents why the brand has garnered so much acclaim. With outstanding power and off-road capability, the RadRover 6 delivers an all-around fun riding experience.

With well-balanced performance, the RadRover 6 Plus is fast, especially when you rev it up with the throttle, and offers a solid range. It even has light suspension, making it a bit more capable on uncertain surface conditions. That said, at 73 pounds, it is the heaviest bike on our list, so it isn’t made for steep climbs. In fact, it may be too heavy to fit on your car’s bike rack.

Like all of Rad’s bikes, the RadRover 6 Plus is extremely customizable. You can add front and rear baskets or cargo carriers, bags, center consoles, water bottles, integrated locks, mirrors, passenger seating, fenders, and a whole lot more. You can even upgrade the tires with Tannus Armour for more off-road reliability. You can build the perfect bike for your needs.

Best hybrid: Ride1Up Prodigy XC

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Why it made the cut: If you’re looking for an around-town commuter that can handle the occasional off-road excursion, the Ride1Up Prodigy XC delivers.

Specs

  • Battery: 504Wh
  • Motor power/torque: 250W, 90Nm
  • Suspension travel: 120mm
  • Weight: 50 lbs

Pros

  • Solid performance
  • Surprisingly good suspension
  • Ergonomic stance
  • Relatively affordable

Cons

  • No throttle
  • No rack or taillights
  • Slow charging

The only “cross-country” bike among Ride1Up’s relatively affordable selection, the Prodigy XC is a daily commuter bike that delivers a surprising level of off-road capability thanks to its front fork suspension. It also delivers admirable performance, with a motor that provides plenty of uphill propulsion.

If you’ll use the Prodigy XC as a commuter (hence our “hybrid” designation) you’ll appreciate its ergonomic, comfortable design. However, it could benefit from the addition of taillights and a throttle. This is the sort of bike that you ride to work all week, then pedal over mild-to-moderate off-road trails for some weekend fun.

Arguably the biggest downside to the Prodigy is its relatively lazy recharging time. At five hours, it’s the slowest recharge on our list. Barring that, however, this is a nicely versatile ride.

Best budget: Cannondale Monterra Neo 5

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Why it made the cut: The Cannondale Monterra Neo 5 is a competitively equipped electric mountain bike you can get for a competitive price.

Specs

  • Battery: 504Wh
  • Motor power/torque: 250W, 85Nm
  • Suspension travel: 150mm
  • Weight: 53 lbs

Pros

  • Solid handling
  • Decent range
  • Strong motor
  • Relatively affordable

Cons

  • Slow charging time
  • Somewhat heavy

Sticker shock is a common reaction while shopping for an electric mountain bike. Many of our picks, and many others that we tested, cost upwards of $10,000. Mountain bikes are very expensive. Electric bikes are very expensive. Put those things together and you have an incredibly pricey bike. The Cannondale Monterra Neo 5 is not “cheap,” but delivers most of the specs and features you’d want from a modern electric mountain bike at around half the price you expect to pay for a top-of-the-line model. 

Electrically speaking, its motor offers admirable strength while its battery capacity is large enough for a solid afternoon of charging up (and then down) hill. It corners well, has a great suspension, and delivers an all-around enjoyable riding experience. 

Of course, with a much lower price, you can expect there to be a few flaws. The Neo 5 is heavier than our top picks and requires a very long 7 hours to fully recharge. For its price, however, these are easy flaws to overlook. 

What to consider when picking an electric mountain bike

There are a number of core concerns that you should consider when shopping for any electric bike, but certain elements are especially important in electric mountain bikes. You aren’t just looking for an ebike, after all. To provide superior off-road performance, a great electric mountain bike needs superior suspension, a strong motor, and a crazy durable yet lightweight frame, all of which tend to make them more expensive than your typical ebike.

Motor

More than anything, an electric mountain bike needs a strong motor. To literally power up steep mountain trails, you will need a motor that delivers unwavering propulsion, as well as plenty of torque, or rotational force, to pull your bike uphill over obstacles.

To make sure your bike can push you up really steep hills, we recommend a motor that churns out at least 500 watts (W) of power and 60 Newton-meters (Nm) of torque. That’s about double what we look for in a standard electric touring bike.

Range

One thing you absolutely want to avoid is having your battery give out on you halfway up a big hill. That means finding an electric mountain bike with a larger-than-average battery, capable of tackling long uphill and downhill rides that require more energy than the average ebike.

Keep in mind that while you would use a formula for a normal commuter ebike to determine how a specific model’s battery would translate into travel range, you can’t really measure how an electric mountain bike will perform off-road. There are a lot of factors that impact range—rider weight, ground conditions, and “elevation climb,” to name a few—that determining range is already a ballpark estimate that may change from ride to ride. Add in the unpredictable nature of trail riding and pinning down even a rough idea of the range becomes next to impossible.

That said, there is a direct correlation between the size of your battery and how long your ebike will be able to assist you. Bigger is better if you want a bike that will keep you on the trails all day long.

Suspension

Quality suspension, which absorbs the force of your bike hitting the ground after bumping over uneven terrain, is essential to any mountain bike, electric or otherwise. Solid suspension can make even a rocky uphill climb feel safe and relatively comfortable. Without it, any bump could jolt you off your bike.

Suspension is noted in millimeters of “travel,” which measures how far the suspension components allow the frame to move and absorb shock upon impact. We recommend looking for at least 140mm for hard riding.

Please remember that not all the bikes on our list include suspension, as some of our picks are intended for more moderate, off-road riding rather than rugged trails.

Transmission

Your electric mountain bike might be powered, but you still need a quality transmission with a wide gearing range to make it up steep inclines. Simply put, the more gears you have, the more you can reduce the force necessary to pedal up an incline. If you expect to be hitting the trails hard, you want at least eight gears if you’ll be doing any serious climbing.

Weight

Having a lightweight bike is key for trail riding. It makes it easier to pedal the bike uphill and provides more control when you’re zipping back down. For hill-climbers, you’ll want to shoot for a frame that weighs under 50 pounds. We have included a couple of heavier options here, but they’re oriented toward off-roading on level ground rather than steep inclines.

FAQs

Q: Do you need a helmet for your electric bike?

It’s always a smart idea to wear a helmet while cycling, and it’s especially important when you’re mountain biking. In fact, you should make sure to get a special helmet for off-road or extreme biking, as a typical bike helmet doesn’t necessarily provide enough protection for falling off your biking uphill, off-road, at motor-powered speeds. Always look for a helmet with MIPS (Multi-directional Impact Protection), and preferably with some form of face/eye protection like a visor or even a full face guard. Smith, POC, and Fox all make some outstanding electric mountain bike helmets.

Q: Are electric bikes good for hills?

With the right motor and transmission, electric bikes are outstanding for climbing hills. In fact, extra torque power, which allows for better climbing, is the best reason to spend the extra money on an electric mountain bike.

Q: How far can you ride an ebike?

There are formulas for calculating the approximate range of an individual electric bike, but they are just approximations. Even one specific bike’s range can vary from ride to ride based on the rider, terrain, and even the weather. This is particularly true with electric mountain bikes as you’ll usually be riding them through extremely diverse, unpredictable conditions.

Q: What are the disadvantages of electric bikes?

The biggest hurdle to buying an electric bike is the price. Even so-so ebikes cost around $1,000. As you can see from our top picks, the best of the best feature price tags well over $10,000. There’s a lot of tech that goes into an ebike and that tech tends to be expensive. 

Once you own the bike, the most common downside is potentially running out of power. Electric bikes tend to be very heavy. If your ebike runs out of juice mid-ride, it can be extremely difficult to pedal under your own strength.

Final thoughts on the best electric mountain bikes

Personally, I think riding the trails on an electric mountain bike is significantly more pleasurable than going sans power. Pedal assist practically eliminates the uphill struggle, allowing you to focus all of your energy and enjoyment on negotiating technical features and taking in the trail’s natural beauty. So whether you’re looking for a serious bike for extreme trail riding, or simply want to flow over easy gravel or dirt paths, powering up with one of the best electric mountain bikes is worth your consideration. 

Why trust us

Popular Science started writing about technology more than 150 years ago. There was no such thing as “gadget writing” when we published our first issue in 1872, but if there was, our mission to demystify the world of innovation for everyday readers means we would have been all over it. Here in the present, PopSci is fully committed to helping readers navigate the increasingly intimidating array of devices on the market right now.

Our writers and editors have combined decades of experience covering and reviewing consumer electronics. We each have our own obsessive specialties—from high-end audio to video games to cameras and beyond—but when we’re reviewing devices outside of our immediate wheelhouses, we do our best to seek out trustworthy voices and opinions to help guide people to the very best recommendations. We know we don’t know everything, but we’re excited to live through the analysis paralysis that internet shopping can spur so readers don’t have to.

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Wild koalas are getting vaccinated against chlamydia https://www.popsci.com/environment/wild-koalas-vaccinate-chlamydia-australia/ Tue, 09 May 2023 17:00:00 +0000 https://www.popsci.com/?p=539989
A koala in a leafy tree.
Chlamydia one of the most significant threats to Australia's famed koalas. Deposit Photos

The first-of-its-kind trial in the iconic marsupial hopes to curb a 30-year-long epidemic.

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A koala in a leafy tree.
Chlamydia one of the most significant threats to Australia's famed koalas. Deposit Photos

Scientists in Australia have just begun vaccinating wild koalas against chlamydia. This field trial in the state of New South Wales is an effort to protect one of Australia’s most beloved animals against the disease that can cause blindness, infertility, and death. The chlamydia epidemic in koalas has been ravaging populations of the marsupial since the 1990s. 

[Related: A new vaccine may curb the koala chlamydia epidemic.]

Koalas along the east and southeast Australian coasts have been particularly affected, with some populations having infection rates of up to 100 percent. In 2021, Australia Zoo Wildlife Hospital veterinarian and research coordinator Amber Gillett called chlamydia one of the most significant threats to koalas and treatment after infection is not enough to save them. “Although many koalas with chlamydia can be treated using traditional antibiotics, some animals cannot be saved due to the severity of their infection. Having a vaccine that can help prevent both infection and the severity of the disease is a critical element in the species’ conservation management.”

While origins of the disease is koalas aren’t fully confirmed, but scientists believe that marsupials possibly caught the disease from exposure to the feces from infected cattle and sheep. Chlamydia then spread via sexual contact or was passed from mother to offspring.  

This single-shot vaccine has been designed just for koalas and was tested in a few hundred fluffy specimens in wildlife rescue centers. For this new field trial, the team hopes to catch, vaccinate, and subsequently monitor about half of the koala population living in the Northern Rivers region of New South Wales–about 50 koalas. 

“It’s killing koalas because they become so sick they can’t climb trees to get food, or escape predators, and females can become infertile,” Samuel Phillips, a microbiologist at the University of the Sunshine Coast who helped to develop the new vaccine, told the Associated Press.

The first koalas were caught and vaccinated in March, and the effort is expected to last for three months. To find them, the team spots koalas in eucalyptus trees to then build circular enclosures around the base of the trees with doors that lead into cages. Eventually, the koalas climb down from one tree to get more eucalyptus leaves from another tree and wander into the traps.

They are then given a check-up to assess their health and given anesthesia before getting the vaccine. They are kept under observation for 24 hours after waking up to check for unexpected side effects, according to Jodie Wakeman, the veterinary care and clinical director at Friends of the Koala. The nonprofit organization runs a wildlife hospital where the koalas are getting vaccinated.

[Related: How to handle a koala-chlamydia epidemic.]

The koalas are marked with a pink dye on their backs so that the same animals are not caught twice before being released back into the wild. 

Australia’s federal government declared that the koalas in the eastern regions of New South Wales, Queensland, and the Australian Capital Territory were endangered. A 2020 report from the New South Wales government found that the unique creatures could become extinct by 2050 due to disease, road collisions, and habitat loss. Climate change is only exacerbating the problem.

The trial was approved by multiple Australian governing bodies balancing the risk of disturbing the marsupials against the danger of allowing chlamydia to continue to spread unchecked. It is one of only a few worldwide examples of scientists attempting to inoculate endangered wildlife for the purposes of conservation. In 2016, a team began to vaccinate Hawaiian monk seals morbillivirus and in 2020, biologists in Brazil started vaccinating golden lion tamarins against yellow fever.

“Vaccination for wildlife is certainly not routine yet,” Jacob Negrey, a biologist at Wake Forest University School of Medicine told the AP. “But whether it should be used more often is a fundamental question that conservation biologists are really wrangling with right now.”

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For a better hike, try swapping clunky boots for barefoot shoes https://www.popsci.com/diy/barefoot-shoes-benefits-tips/ Mon, 08 May 2023 13:30:06 +0000 https://www.popsci.com/?p=539636
A person wearing barefoot shoes that form around their toes, sitting on a rock overlooking a body of water.
As close to bare feet as you can get with shoes. roussien / Depositphotos

Where you're going, you won't need bulky boots.

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A person wearing barefoot shoes that form around their toes, sitting on a rock overlooking a body of water.
As close to bare feet as you can get with shoes. roussien / Depositphotos

When most people go hiking, they reach for stiff, heavy, boots with high-rise ankle support and thick soles. But others choose to go in the exact opposite direction and instead grab breathable, lightweight, flexible footwear that allows for more organic movement.

The concept of barefoot shoes is something of an oxymoron, but proponents of this style rave about the footwear’s ability to strengthen your feet and allow you to enjoy a more holistic experience outdoors. But hitting the trail in minimalist shoes requires some knowhow, lest you end up hobbling home with supremely sore feet–or worse.

What are barefoot shoes?

Many brands now offer barefoot or minimalist shoes, and most options look similar to their more conventional counterparts.

The differences, however, are easy to spot if you know what to look for. Most barefoot shoes feature little to no cushioning, a thinner, more flexible sole, a wide toe box, and minimal arch support, if any. This design is based on foot anatomy and aims to allow more natural foot movement, feeling, and balance.

Barefoot shoes forgo some of the classic characteristics that pop to mind when you think of boots made for the outdoors, like narrow toe boxes and aggressive stabilization elements such as heel cups. But these minimalist hiking shoes can still offer features like high ankles, deep treads, and durable materials—after all, they’re still made for hiking.

Why barefoot shoes might be better for hiking

Most people don’t actually need any of the built-up features in conventional footwear, says Emily Splichal of the Center for Functional and Regenerative Podiatric Medicine in Chandler, Arizona. She is a functional podiatrist, human movement specialist, and educator on natural foot function. In fact, all that cushioning and support may be doing more harm than good.

Splichal explains that shodding your feet in footwear that highly restricts your range of motion can result in your feet becoming weaker from lack of use over time.

[Related: Walking correctly takes work—here’s how to improve every step]

Barefoot shoes, on the other hand, especially when combined with foot exercises like the ones Splichal recommends to her patients, do the opposite. A 2019 study from Brigham Young University in Utah showed that walking in minimalist shoes increases foot muscle size and strength. Plus, strengthening bones, muscles and tendons “can offer benefits all the way up your spine,” Splichal states. 

Other studies, plus anecdotal and anthropological evidence, also suggest that providing a wider range of motion to the feet (like barefoot shoes do) results in stronger, more stable muscles.

After all, our ancestors didn’t have super cushioning foam insoles or rigid arch support, and they got around just fine.

Potential health benefits of barefoot shoes

Most research on the matter has looked into the positive effects of barefoot shoes for running and walking, but don’t assume rough terrain is an exception. Splichal explains that the freedom of motion provided by barefoot-style shoes help train your body to move and respond to irregular surfaces–like trails covered in rocks and roots.

Less structured footwear can also help with balance, as allowing your feet to move and flex more naturally can unlock a natural stabilization response, Splichal explains.

So, if you step on an angled rock, a stronger foot and ankle, paired with a flexible shoe, can help keep you centered and upright and better able to react to uneven surfaces.

Hitting the trail with little between your skin and the ground also brings cognitive benefits. The slim sole on barefoot shoes will allow you to feel the earth beneath you, which a 2015 study from the University of North Florida, can help with memory retention. Plus, feeling the changes in terrain and the heat or coolness of the ground will provide a delightful boost in sensory stimulation.

What to know if you’re struggling

If you’ve hiked in overbuilt boots your entire life, don’t be surprised if the transition to barefoot shoes is a bit rocky. 

For starters, while Splichal advocates for this type of footwear for most people, she mentions there are certain foot types that can’t control the freedom of motion a barefoot shoe offers and may not be able to wear them for long periods of time or may never be able to fully transition. 

[Related: How to save your feet from painful blisters]

This includes people with flat feet or feet that are overpronated due to ligament laxity. People with high-arched rigid feet may also struggle with barefoot shoes, as they often need the cushioning of conventional footwear to help absorb impact when walking for long periods of time. Foot injuries or plantar fasciitis can also make wearing minimalist shoes difficult, at first, but a slow transition can make things easier and more comfortable.

If you think you might have one of these conditions but are not entirely sure, a podiatrist like Splichal can help you make the determination. She even has instructional videos online about how to assess your feet.

How to start using barefoot shoes

If you decide to ditch your heavy boots and give barefoot shoes a try, you should do so slowly and with caution, as your feet won’t be used to the higher stress and load they’ll be experiencing. After all, you wouldn’t hit the gym after years of inactivity, lift the heaviest weights you can manage, and not expect to be sore the next morning.

So if you don’t have a foot type or condition that prevents wearing barefoot shoes, Splichal recommends transitioning by hiking on smooth terrain at first, which will help build strength, awareness and stabilization. And since your feet will be working harder than usual in the beginning, do the same thing you’d do after a strenuous workout: balance it with recovery.

Use a golf ball, small cork ball, or—Splichal’s favorite—a Neuro Ball, but instead of rolling it under your feet, stand on it. This will create pressure, which will result in a sort of deep-tissue massage to five points on the bottom of your feet: where your heel meets your mid-foot, the middle of your foot, the ball of your foot, the center of your arch, and the outside edge of your foot.

Then, work on strengthening your feet, which you can do while cooking dinner or watching TV. Splichal recommends an exercise called “short foot,” where you stand up straight, lift your toes, spread them out wide, and place them back on the floor. Inhale through the nose and as you exhale, push the tips of the toes down into the ground. Splichal says to use 20 percent of your maximum strength while engaging your core. Hold your toes down for the full length of your exhalation, then relax, inhale and repeat five times.

Another good way to strengthen foot muscles is to stand on one leg while you’re brushing your teeth or at a standing desk.

As for how far and how fast to go while you’re transitioning, start slow with shorter hikes at a pace that’s comfortable for you. And listen to your body—as long as you’re not feeling foot fatigue or lateral ankle pain, Splichal to keep going and enjoy the journey.

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Why Americans are smoking cigarettes less than ever https://www.popsci.com/health/us-smoking-rates-2023/ Mon, 08 May 2023 12:30:00 +0000 https://www.popsci.com/?p=539431
Discarded cigarette labels like Marlboro and Lucky Strike to depict declining smoking rates in the US
Americans don't glamorize cigarettes as they once did. Deposit Photos

The US is winning the war against cigarettes. The next battle is vapes.

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Discarded cigarette labels like Marlboro and Lucky Strike to depict declining smoking rates in the US
Americans don't glamorize cigarettes as they once did. Deposit Photos

Here’s some good news: Cigarette smoking hit record lows in the US, according to a new Centers for Disease Control and Prevention survey. An estimated 11.1 percent of American adults were regular cigarette users in 2022—a drop from the 14.4 percent reported in 2019.

The decline in smoking did not happen overnight. Since the 1960s, public health experts have been fighting against the glamorization of cigarettes to raise awareness of the danger they pose on human health. Cigarettes continue to be the leading cause of preventable death in the US with one in five deaths are related to a person’s smoking history. And while the recent news is a victory towards a healthier nation, e-cigarettes and other vaping products could make this a short-lived triumph.

What’s causing smoking rates to decrease?

Public health awareness

The decline first began in 1964 when the Surgeon General released a report linking cigarette smoking to a number of health problems, including a 70-percent increased risk of premature death and a nine- to tenfold risk of lung cancers compared to non-smokers. Since then, there has been a push for educational campaigns to teach people about the dangers of smoking to your health. 

Social stigma

For decades, the media glamorized smokers as cool, rebellious, or fashionable. (Holly’s cigarette holder from Breakfast at Tiffany’s has even become an iconic accessory.) Even in real life, there were social repercussions when people went out for smoking breaks or smoked in a restaurant. 

Again, the public perception of smoking started to shift after the Surgeon General’s report. The Food and Drug Administration (FDA) made companies print medical warnings of the dangers of smoking on every cigarette pack. In 1971, TV and radio channels banned cigarette ads and showed more anti-cigarette ads that would scare people with graphic images of the effects of tobacco, like people with permanent holes in their neck after contracting smoke-related throat cancer. Medical research on tobacco continued to link cigarette smoking to several preventable diseases and health problems. Lawmakers passed stricter regulations on cigarettes, including a ban on smoking at work and in most public areas. 

Nowadays, most indoor spaces like hotels and theaters don’t allow smoking; instead, people tend to slip out to take a quick cigarette break and spray their clothes down to hide the smell of cigarettes. Vincent Mase, a thoracic surgeon at Yale University School of Medicine in Connecticut, says smoking cigarettes has been more socially unacceptable among younger generations. He says tobacco smoke has become more taboo, too, because of how it affects a person’s hygiene with increased sweating, yellow teeth, and of course, the smell. 

Higher taxes

Smoking is expensive. While varying by state, the average cost for a pack in the US is $8. New York, for example, is the most expensive state to buy cigarettes at $11.96 while Missouri is the cheapest at $6.11. The varying prices come from a combination of state taxes and a federal tax. Increasing the price of cigarettes has helped deter young adults between 18 to 24 years old from pursuing the costly habit. It has also been an effective tactic in getting current smokers to quit, especially Black and Hispanic individuals. “if you look at an area like New York where the cigarette tax is very high, the smoking rate is very low. Compare that to a state like Kentucky, where the tax rate on cigarettes is low and smoking is relatively high,” explains Norman Edelman, a pulmonologist at Stony Brook University in New York. “Although it is falling everywhere, as people realize the deleterious effects of smoking.”

How to drive smoking rates down further

While it’s unlikely we’ll ever have a cigarette-free society, there are ways of pushing the rates as close to zero as possible. 

Banning menthol

Menthol is a chemical found in peppermint that changes how the brain processes taste and pain. It leaves a cool sensation in the throat and airways that acts as a local anesthetic and can mask the irritation cigarette smoke causes to the lungs. Because menthol makes the smoke less harsh, it encourages users to inhale more deeply and might increase exposure to other toxins such as carbon monoxide. While almost all cigarettes sold in the US have menthol, those with higher quantities are marketed as menthol-flavored.

Another concern with menthol is that it can increase cigarette addiction. Several studies found menthol stops the breakdown of nicotine, letting the stimulant exert its effects for longer. Enhancing the addictive effects of nicotine makes it harder for people who use menthol-flavored cigarettes to quit. In 2022, the FDA proposed a nation-wide ban on menthol-flavored cigarettes to curb its appeal—the decision is expected to be handed down later this year

[Related: The environmental argument for banning menthol cigarettes]

Edelman says there’s no question that menthol should be banned—but he’s not sure how much it would help curb smoking rates across the US. Canada’s experience in banning menthol-flavored cigarettes from 2015 to 2018 may provide some idea on what to expect. A 2022 study in The BMJ found that after the ban, chronic menthol smokers were more likely to stop smoking daily than non-menthol smokers. The authors estimate a similar prohibition in the US would help 789,724 daily smokers break the habit.

Increase on federal taxes

The current federal tax on cigarettes is $1.01 per pack. This reflects the latest increase in 2009 where federal taxes were raised to 62 cents a pack. The American Lung Association has advocated matching federal taxes to the rate of a state’s cigarettes tax to not only make cigarettes less affordable, but also increase funding for tobacco prevention efforts. 

Less smoking, but more vaping

The same CDC survey reporting a decline in smokers has also found a rise in e-cigarette users. In 2022, 6 percent of people in the US use an electronic cigarette or other electronic vaping product—a 1.6 percent jump from 2019.

The first e-cigarette was invented in 2003 as a less harmful and smelly alternative to traditional cigarettes. These battery-operated devices have since grown in popularity, especially among older kids. Not only are they more affordable than cigarettes—the average cost for a disposable e-cigarette is $8.01 and e-liquid cartridges are $6.83—but they come in appetizing flavors like mint, strawberry, cotton candy, bubblegum. Like menthol, the different flavors mask the harsh taste of smoke, which allows users to take more puffs. 

Mase says younger crowds prefer the product because of several common misconceptions surrounding e-cigarettes. A 2017 study surveyed adolescents on their attitudes towards vaping. About 19 percent of high schoolers believed e-cigarette smoke is water, 23 percent though e-cigarettes was not a tobacco product, and 43 percent thought they were safer than cigarettes. Mase warns that a number of short-term studies have linked vaping to respiratory symptoms and lung damage in adolescents. Last month, several state attorney generals reached a $462 million settlement with top e-cigarette brand JUUL for advertising to teens and making false claims that its products were harmless. The FDA also recently ordered the removal of JUUL products from the US market, citing health concerns and insufficient data on the toxicity of the vapes.

[Related: A $25 whistle-like tool could be a game changer for COPD patients]

Unlike regular cigarettes, there are no blanket regulations against vaping products in the US, so users can’t be completely sure of what they’re breathing in. “Every so often we get a rash of people getting sick because they’ve been inhaling something they shouldn’t inhale,” says Edelman. In 2018, there was an outbreak of vaping-related lung injuries and deaths: The culprit was vitamin E acetate being added to e-cigarettes and other vaping products that contained THC. While vitamin E is safe to consume and apply topically, it can affect a person’s lung function when smoked.

The lungs are one of the few organs in the body that makes contact with the outside environment, says Edelman. Just as shades protect the eyes and sunscreen protects the skin, not smoking is one way to keep lungs healthy and functioning for years to come.

Correction (May 9, 2023): The story previously stated that vitamin E acetate had been added to some cigarettes, leading to lung injuries and deaths in users. The vitamin E acetate was specifically added to THC-containing e-cigarettes and other vaping products.

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The right amount of online scrolling could decrease your risk of dementia https://www.popsci.com/technology/internet-use-dementia/ Fri, 05 May 2023 18:00:00 +0000 https://www.popsci.com/?p=539306
Senior citizen hands typing on laptop keyboard
It turns out internet usage might actually be good for your brain (within reason). Deposit Photos

A new demographic survey indicates a potential link between regular internet usage and cognitive health in older populations.

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Senior citizen hands typing on laptop keyboard
It turns out internet usage might actually be good for your brain (within reason). Deposit Photos

There are countless studies and copious amounts of research delving into how the internet can negatively impact your mind. But, new data indicates that there’s one way online time could actually benefit the brain. According to findings recently published in the Journal of the American Geriatrics Society from a team at NYU, it appears that regular internet usage may significantly reduce the risk of dementia in older populations.

As also highlighted by Gizmodo on Thursday, the study examined online habits of over 18,000 adults over the age of 50 for as long as 17 years (with a median of nearly 8 years) via data from the government’s biannual Health and Retirement Study. The dataset was subsequently broken down into two groups—those who were regular internet users, and those who were not. A second survey assessed their cognition at the study’s outset to use for reference over time. According to researchers, regular visitors to the internet “experienced approximately half the risk of dementia than non-regular users,” even when taking issues like pre-existing conditions into consideration. As Gizmodo also noted, those who reported using the internet in subsequent analysis displayed even lower risks of impairment.

[Related: How your daily screen time affects your wellbeing.]

But don’t take this as carte blanche to surf the web to your heart’s content just yet. When utilizing a smaller dataset of users that provided hourly usage rates per week, researchers discovered a potential U-curve situation between time and risk for dementia. Those who spend over six hours a day on the internet appear to possess a slightly increased chance to develop cognitive issues, much like those who rarely go online at all. This led researchers to hypothesize that “excessive online engagement may have adverse cognitive effects on older adults.” Despite the study’s caveats, however, the findings present an interesting look into the potential positives of online use, especially when people are often told to use the internet less.

The Goldilocks “not too much, but not too little” linkage between internet use and dementia falls in line with experts’ recent suggestions on how to best maintain cognitive health: lead an overall, decently healthy lifestyle, i.e. one with regular physical activity, a primarily plant-based diet, an aversion to bogus supplements, managing existing diseases, and reduced alcohol consumption. So, on top of all that, you can now possibly add a healthy hour or so of daily internet scrolling to the list. Just don’t fall too far down the rabbit hole.

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COVID-19 is no longer a ‘global health emergency,’ says WHO https://www.popsci.com/health/who-covid-19-global-health-emergency/ Fri, 05 May 2023 15:00:00 +0000 https://www.popsci.com/?p=539293
World Health Organization WHO Director General Tedros Adhanom Ghebreyesus speaks during a press briefing at the WHO headquarters in Geneva, Switzerland, April 6, 2023. On the eve of its 75th anniversary, the WHO marked the occasion on Thursday by calling for a renewed drive for health equity in the face of unprecedented threats.
World Health Organization WHO Director General Tedros Adhanom Ghebreyesus speaks during a press briefing at the WHO headquarters in Geneva, Switzerland, April 6, 2023. On the eve of its 75th anniversary, the WHO marked the occasion on Thursday by calling for a renewed drive for health equity in the face of unprecedented threats. Lian Yi/Xinhua via Getty Images

The organization cited a decrease in deaths, hospitalization, and increased population immunity in their decision.

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World Health Organization WHO Director General Tedros Adhanom Ghebreyesus speaks during a press briefing at the WHO headquarters in Geneva, Switzerland, April 6, 2023. On the eve of its 75th anniversary, the WHO marked the occasion on Thursday by calling for a renewed drive for health equity in the face of unprecedented threats.
World Health Organization WHO Director General Tedros Adhanom Ghebreyesus speaks during a press briefing at the WHO headquarters in Geneva, Switzerland, April 6, 2023. On the eve of its 75th anniversary, the WHO marked the occasion on Thursday by calling for a renewed drive for health equity in the face of unprecedented threats. Lian Yi/Xinhua via Getty Images

On May 5, the The World Health Organization (WHO) announced that we are no longer in a global COVID-19 emergency. The emergency was first declared over three years ago in the early days of the pandemic. During the 15th meeting of the International Health Regulations Emergency Committee regarding COVID-19, the members highlighted a decreasing trend in deaths, decline of COVID-19 related hospitalizations and intensive care unit admissions, and higher levels of population immunity to the virus as the basis of their decision. 

“With great hope, I declare COVID-19 over as a global health emergency,” WHO director general, Tedros Adhanom Ghebreyesus announced during a media briefing

[Related: Biden will end COVID-19 national emergencies in May. Here’s what that means.]

However, Tedros stressed that just because the global emergency declaration is ending, it does not mean that COVID-19 is not still a threat to public health. “As we speak, thousands of people around the world are fighting for their lives in intensive care units. And millions more continue to live with the debilitating effects of post-COVID19 condition,” Tedros said

The WHO first made the emergency declaration on January 30, 2020, when only 213 people were known to have died from the novel virus. The declaration was a signal to the international community that COVID-19 posed a threat to the whole world and that they should begin to prepare

The WHO will continue to list COVID-19 as a pandemic, similar to how they designate HIV. While it acts as a symbolic milestone, this decision does not change much, but it is a significant moment in the evolving human relationship with the novel virus that brought life to a screeching halt in 2020 after it first emerged in China in December 2019.

Many countries, including the European Union, have already ended their COVID-19 states of emergency and have moved away from mitigation efforts. The United States is scheduled to lift its COVID-10 emergency on May 11.

The WHO decision was not welcomed by all public health experts. Respiratory physician and member of Brazil’s National Academy of Medicine Margareth Dalcolmo told The New York Times that it was too soon to lift the emergency, due to the urgent tasks such as research into COVID variants and development of better vaccines. She added that the designation of a global public health emergency also creates leverage for lower-income nations to access needed treatments and support.

Around the world, 765,222,932 confirmed COVID cases, including 6,921,614 deaths, have been reported to the WHO as of May 3. However, these figures are likely a vast undercount of the pandemic’s true toll on human life. In 2022, the WHO said 15 million more people had died in the first two years of the pandemic than they would have in normal times, with developing and indigenous nations experiencing the worst of the devastation. Close to eight million more people than expected died in lower-middle-income nations by the end of 2021.

[Related: White House invests $5 billion in new COVID vaccines and treatments as national emergency ends.]

“One of the greatest tragedies of COVID-19 is that it didn’t have to be this way. We have the tools and the technologies to prepare for pandemics better, to detect them earlier, to respond to them faster, and to mitigate their impact But globally, a lack of coordination, a lack of equity, and lack of solidarity meant that those tools were not used as effectively as they could have been,” Tedros said.

Additionally, on May 4, the United States Centers for Disease Control and Prevention released provisional data that COVID-19 dropped to the fourth leading cause of death in the US in 2022, falling behind heart disease, cancer, and unintended injuries like shootings, car accidents, and drug overdoses. In 2020 and 2021, only heart disease and cancer were ahead of COVID-19 as leading causes of death.

Death rates due to COVID-19 fell for nearly all Americans and the virus was the underlying cause of roughly 187,000 deaths in the US in 2022.  According to the CDC, the highest COVID-19 death rates were in the South and in the adjacent region that stretches west to Texas, Oklahoma, and New Mexico.

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Doctors perform first in-utero brain surgery to treat rare condition https://www.popsci.com/health/doctors-in-utero-brain-surgery/ Fri, 05 May 2023 13:00:00 +0000 https://www.popsci.com/?p=539257
A pregnant person holds their belly.
Vein of Galen malformation occurs when the blood vessel that carries blood from the brain to the heart does not develop correctly. Deposit Photos

A vein of Galen malformation causes an enormous amount of blood that can stress a tiny heart.

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A pregnant person holds their belly.
Vein of Galen malformation occurs when the blood vessel that carries blood from the brain to the heart does not develop correctly. Deposit Photos

A team of doctors and surgeons from Brigham and Women’s Hospital and Boston Children’s Hospital successfully performed a successful new fetal surgery. This time, they were able to treat a rare brain condition known as vein of Galen malformation

[Related: Scheduled childbirth might reduce preeclampsia risk by half.]

While in utero surgeries performed before birth are used for other conditions, this was among the first for this contusion. The ultrasound-guided procedure took place on March 15 and the details were published in the journal Stroke on May 4.  

Vein of Galen malformation occurs when the blood vessel that carries blood from the brain to the heart (known as the vein of Galen) does not develop correctly. The malformation or VOGM causes an enormous amount of blood stressing the vein and the heart. It can lead to multiple health problems—including heart failure or brain damage that lead to death.

During Derek and Kenyatta Coleman’s 30-week ultrasound, doctors noticed something unusual, despite what had been a normal pregnancy. The fetus’s brain and heart were enlarged and more investigation led to a VBOM diagnosis.  

The couple from Baton Rouge, Louisiana enrolled in an FDA approved clinical trial run by Brigham and Women’s and Boston Children’s despite the risks of preterm labor or brain hemorrhaging for the fetus. The team performed the surgery at 34 weeks of pregnancy to repair the malformation while the baby was still in-utero. They used ultrasound guidance, a long needle that is similar to those used for amniocentesis, and small coils that were placed directly into the abnormal blood vessels to stop blood flow.

The technique is borrowed from previously performed in utero cardiac surgeries. Once the fetus is in the optimal position, it “gets a small injection of medication so that it’s not moving and it is also getting a small injection of medication for pain relief,” Louise Wilkins-Haug, the division director of Maternal Fetal Medicine and Reproductive Genetics at Brigham and Women’s Hospital told CNN.

The doctors then inserted a needle through the abdominal wall and carefully threaded a catheter through the long needle. This enabled the metal coils to fill up the vein, slow down the blood flow, and reduce the pressure. Scans showed decreased blood pressure in key areas and the fetus showed instant signs of improvement.

Kenyatta was slowly leaking amniotic fluid and went into labor two days after the surgery. On March 17, Denver Coleman was born, weighing 4 pounds and 1 ounce. According to her doctors, Denver was very stable in the immediate newborn period and did not need any immediate treatments like placing more coils or medication to support her heart function.  

[Related: Placentas are full of secrets. These researchers want to unlock them.]

“The best part was when she was born, just seeing her in the NICU be fine and, you know, we would all sort of look at each other and pinch ourselves,” Darren Orbach, a Boston Children’s Hospital physician, told Boston CBS affiliate WBZ-TV.  “We were not sure when it was OK to celebrate because you just don’t see that with these babies. So that was really the moment that we knew that all was going to be great.”

Baby Denver continues to do well almost two months after the surgery and is not taking any heart failure, her neurological exam is normal, and there are no indications that she needs any additional medical interventions. “She’s shown us from the very beginning that she was a fighter,” Kenyatta told CNN.

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Some states think companies should list a tampon’s ingredients. Period. https://www.popsci.com/health/period-product-ingredients-packaging-labels/ Fri, 05 May 2023 01:00:00 +0000 https://www.popsci.com/?p=538961
Pads and menstrual cups are considered exempt from regulatory guidance and do not require premarket review.
Pads and menstrual cups are considered exempt from regulatory guidance and do not require premarket review. DepositPhotos

The FDA doesn't require ingredient labels on period products—but some states are taking it into their own hands.

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Pads and menstrual cups are considered exempt from regulatory guidance and do not require premarket review.
Pads and menstrual cups are considered exempt from regulatory guidance and do not require premarket review. DepositPhotos

This article originally featured on KFF Health News.

Tens of millions of Americans use menstrual products, and while manufacturers contend they are safe, most disclose little about the chemicals they contain. Now, amid calls for more disclosure and research into the health effects of these products, some states require more transparency.

The manufacture and sale of period and related products is a big business, with revenue expected to top $4.5 billion in the United States this year. On average, a person uses up to 17,000 tampons or pads in their lifetime, and they might also use rubber or silicone cups, or absorbent period underwear.

The FDA regulates and classifies menstrual products as medical devices, meaning they are not subject to the same labeling laws as other consumer items. But companies can voluntarily disclose what’s in their products.

Now, some states are stepping into the breach. In 2021, New York became the first state to enact a menstrual product disclosure law requiring companies to list all intentionally added ingredients on packaging. California’s governor signed a similar law that took effect this year, but it gives manufacturers trade secret protections, so not all ingredients are necessarily disclosed. At least six other states have introduced legislation to address safety and disclosure of ingredients in these products.

Advocacy groups studying the effects of the New York law say the new labels have revealed commonly found ingredients in menstrual products that may contain carcinogens, reproductive toxicants, endocrine disruptors, and allergens.

Shruthi Mahalingaiah, an assistant professor of environmental, reproductive, and women’s health at Harvard T.H. Chan School of Public Health, evaluates endocrine disruptors in personal care products and studies menstrual health. She said the health risk depends on the dose, duration, and sensitivity of a person to the ingredients and their mixtures.

Harmful chemicals could come from manufacturing processes, through materials and shipping, from equipment cleaners, from contact with contaminants, or from companies adding them intentionally, said Alexandra Scranton, director of science and research for Women’s Voices for the Earth, a Montana-based nonprofit focused on eliminating toxic chemicals that affect women’s health.

Vaginal and vulvar tissues are capable of absorbing fluids at a higher rate than skin, which can lead to rapid chemical exposure. Scranton said scarcity of clinical studies and funding for vaginal health research limits understanding about the long-term effects of the ingredients and additives in period products.

“We think manufacturers should do better and be more careful with the ingredients they choose to use,” Scranton said. “The presence of toxic and hormone-disrupting chemicals in menstrual products is unsettling. We know that chemicals can cause disease, and exposures do add up over time.”

Scranton’s organization advocates for labels to include the chemical name of the ingredient, the component in which the ingredient is used, and the function of the ingredient.

K. Malaika Walton, operations director for the Center for Baby and Adult Hygiene Products, a trade industry group, said in an email, “BAHP supports accurate and transparent information for users of period products and many of our member companies list ingredients on their packages and websites.”

In a written statement, Procter & Gamble, a major manufacturer of menstrual products, said that ingredients it uses go through rigorous safety evaluations and are continuously tested, and that all fragrance components are added at levels the industry considers safe.

Even though manufacturing of scented tampons for the U.S. market has mostly stopped, companies still use fragrances in other menstrual products. Laws protecting trade secrets keep details about fragrances in pads and tampons confidential so competitors can’t copy the formulas. The Children’s Environmental Health Network lists phthalates, a group of chemicals commonly called plasticizers that are suspected hormone disruptors, as an ingredient found in fragrances.

Manufacturers follow regulatory guidance issued in 2005 by registering with the FDA and submitting a detailed risk assessment of their products’ components and design, and a safety profile, before being cleared to sell in the U.S.

Pads and menstrual cups are considered exempt from regulatory guidance and do not require premarket review, according to FDA spokesperson Carly Kempler. While tampons do require review, the FDA “does not clear or approve individual materials that are used in the fabrication of medical devices.”

“There’s an understanding that the FDA is regulating these products, and they are; it’s just not very adequate,” said Laura Strausfeld, an attorney and a co-founder of Period Law, an organization working to advance state and federal period-equity policies that would stop taxation of products and make them freely available in places like schools and prisons. “The consumer is supposed to trust that when these products are put on shelves they’ve been vetted by the government. But it’s basically a rubber stamp.”

In a 2022 report, a congressional committee directed the FDA to update its guidance for menstrual products to recommend that labels disclose intentionally added ingredients, such as fragrances, and test for contaminants. The FDA is reviewing the directives outlined by the House Appropriations Committee and will update the 2005 guidance as soon as possible, Kempler said. “We will share additional details when we are able to.”

At least one period product company makes disclosure of its ingredients a selling point. Alex Friedman, co-founder of Lola, said a lack of knowledge is a problem, and more action and awareness are needed to keep people safe.

“The hardest part to swallow is why this is even up for debate. We should all know what’s in these products,” Friedman said.

New York’s law requires companies to disclose all intentionally added ingredients no matter how much is used, with no trade secret protections for fragrances. Though it applies only to products sold in that state, similar detailed labeling is appearing elsewhere, advocates said.

“We’re also seeing similar or identical disclosure on packaging in other states outside of New York, which is a testament to the power of the law,” said Jamie McConnell, deputy director of Women’s Voices for the Earth.

Manufacturers have 18 months from the passage of the New York law to comply, and some products on shelves in New York still list few ingredients other than “absorbent material,” “surfactant,” “ink,” and “adhesive.”

“We’re like, ‘OK, what is that exactly?’” McConnell said.

Her organization is calling for a federal law at least as strong as New York’s. Previous federal legislation failed to advance, including the most recent, the Menstrual Products Right to Know Act, introduced in 2022.

BAHP, the trade group, supported the federal legislation and the California law. McConnell said she opposed both bills because they didn’t require companies to list all fragrance ingredients.

“I think what it boiled down to at the federal level was the support of corporate interests over public health,” she said.

KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

Some states think companies should list a tampon’s ingredients. Period.

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FDA approves first RSV vaccine for adults after 60 years in the making https://www.popsci.com/health/fda-rsv-first-vaccine/ Thu, 04 May 2023 14:00:00 +0000 https://www.popsci.com/?p=538976
An older woman sits on a hospital bed.
RSV leads to approximately 60,000 to 120,000 hospitalizations and 6,000 to 10,000 deaths among adults 65 years of age and older every year. Deposit Photos

The vaccine will be given to individuals over the age of 60 and was 94 percent effective in preventing severe disease.

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An older woman sits on a hospital bed.
RSV leads to approximately 60,000 to 120,000 hospitalizations and 6,000 to 10,000 deaths among adults 65 years of age and older every year. Deposit Photos

After 60 years of trial and error, the Food and Drug Administration (FDA) approved the first vaccine to prevent respiratory syncytial virus (RSV) on May 3. More preventative shots for the respiratory virus are on the way.

[Related: How our pandemic toolkit fought the many viruses of 2022.]

The FDA approved Arexvy from pharmaceutical company GSK. The vaccine is designed to protect those over 60 in a single dose. A vaccine from Pfizer is currently under consideration for older adults and pregnant people as a maternal vaccination to protect newborn babies. Sanofi and AstraZeneca’s monoclonal antibody treatment for babies that offers vaccine-like protection during RSV season is also under consideration by the FDA. Additionally, a late-stage trial of an RSV vaccine that uses mRNA technology from Moderna showed promise in late-stage trials

The vaccine could be available as soon as this fall, pending a recommendation for its use from the Centers for Disease Control and Prevention’s Advisory Committee on Immunization Practices, which will meet in June. GSK says it has “millions of doses ready to be shipped,” according to a recent earnings presentation.

“Older adults, in particular those with underlying health conditions, such as heart or lung disease or weakened immune systems, are at high risk for severe disease caused by RSV,” said Peter Marks, director of the FDA’s Center for Biologics Evaluation and Research, in a statement. “Today’s approval of the first RSV vaccine is an important public health achievement to prevent a disease which can be life-threatening and reflects the FDA’s continued commitment to facilitating the development of safe and effective vaccines for use in the United States.”

RSV can affect all age groups, but it is particularly worrisome in babies and older adults. It is a highly contagious virus that causes infections of the lungs and breathing passages. According to the Centers for Disease Control and Prevention (CDC), RSV leads to approximately 60,000 to 120,000 hospitalizations and 6,000 to 10,000 deaths among adults 65 years of age and older every year. It is also a common cause of lower respiratory tract disease in older adults. This disease affects the lungs and can cause life-threatening pneumonia and bronchiolitis.

The virus circulates seasonally, usually beginning in the fall and peaking in the winter. The 2022-2023 RSV season started particularly early and flooded hospitals and pediatric wards across the United States, leading pharmacies to limit the sales of children’s medicines.

According to the results of a clinical trial of close to 25,000 older adults, the GSK vaccine was 83 percent effective at preventing lower respiratory tract disease by the virus. It was 94 percent effective at preventing severe disease in seniors. In the trial, severe disease was defined as the need for supplemental oxygen or a mechanical help to breathe. The results were published in the New England Journal of Medicine in February

[Related: Fighting RSV in babies starts with a mother’s antibodies.]

The vaccine works by using a small piece of the virus called a fusion protein, or F-protein. The F-protein sticks out on the virus’ surface and helps it latch onto cells in the upper airway and infect them. The F-proteins were made in a lab with specially programmed cells. 

In 2013, researchers at the National Institutes of Health discovered how to freeze the normally wiggly and shape-shifting F-protein in the shape that it takes before it fuses onto a cell. When it’s in this shape, the body can produce antibodies against it. The GSK vaccine uses this pre-fusion form of the F-protein and an ingredient called an adjuvant that can boost immune activity.

The search for a vaccine to RSV began in the 1960s, but has been mired by tragedy. Two toddlers died after receiving an experimental shot in the 60’s after it unexpectedly caused them to contract a very serious version of the virus. Many of the safety measures currently in place during vaccine trials were put in place after the failures of the RSV vaccine.

Barney Graham, a vaccine scientist at Morehouse School of Medicine worked alongside Jason McLellan, a structural biologist at the University of Texas at Austin, and Peter Kwong, a vaccine scientist at the National Institutes of Health, to jump-start the RSV vaccine field after decades of failure.

“This is my life’s work, so it’s kind of amazing to see it come to this point,” Graham told The Washington Post.  “It’s exciting for me to see this happening because of all the other people who’ve come before me working on RSV, some of whom are no longer with us. I wish they could see this is happening. It’s been a long struggle.”

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Coping advice from people with the world’s most stressful jobs https://www.popsci.com/technology/most-stressful-jobs-coping-mechanisms/ Thu, 04 May 2023 13:00:00 +0000 https://www.popsci.com/?p=507153
Aviation photo
Anthony Gerace

To keep your cool when life gets intense, consider these tips from workers who do jobs like flying a rescue helicopter or operating on injured patients.

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Aviation photo
Anthony Gerace

LIFE IS RARELY WORRY-FREE, but unprecedented angst has become a constant. Beyond the regular challenges of everyday existence—chaotic households, traffic jams, overbearing bosses—the looming presence of a deadly virus over the past three years has made even mundane decisions feel fraught.

Any number of things can spark stress, but they all share a common origin. “It’s when the demands on somebody outstrip the resources they have,” says Lynn Bufka, a senior director at the American Psychological Association (APA). The results of that are rarely good. Face a difficult situation, unrealistic expectation, or sudden conflict without the right skills or tools, and you risk melting down or freezing up. That danger increases when you are pressed for time or cannot influence a challenging variable. “The feeling of not having control is anxiety-provoking,” Bufka says. “It’s pretty overwhelming.”

Most people had no experience dealing with the kind of prolonged pressure that came along with the pandemic. But for those with some of the world’s most intense occupations, it’s all just part of the job. Losing their cool is simply not an option. The strategies they employ to keep calm while facing a classroom, saving a life, or defusing a bomb just might help the rest of us deal with whatever’s pushing us to the edge of reason.

The fishing boat captain

THE STRESSORS: In 2021, the people bringing in Dungeness crab, black cod, and other bounties of the earth—the workers in America’s fishing and hunting industries—had the second deadliest job in the United States, coming in just behind loggers, according to the US Bureau of Labor Statistics. “It is extremely hazardous,” says Richard Ogg, captain of the troller Karen Jeanne, which is based in Bodega Bay, California. The gale-force dangers he and his crew face include rough seas, miserable weather, and sleep deprivation. Pulling in a catch big enough to earn the money they need weighs heavily on his mind too. Above all else, though, Ogg feels a sense of guardianship over his team, and finds the biggest challenge can be coping with conflicts that arise among a crew corralled on a 54.5-foot boat miles from shore. That’s no easy feat when dealing with workers who don’t necessarily respect the hazards, the gear, or each other.

THE COPING MECHANISMS: Effective communication is essential to keeping cool. Ogg tends to be egalitarian, even if he as the captain has the final say and will pull rank if he must. He often discusses problems or disagreements with everyone aboard, seeks their perspectives, and considers their viewpoints to zero in on the best solution. He finds that this approach, and accepting that things sometimes go sideways despite his best efforts, helps everyone stay on an even keel whenever things get choppy.

Aviation photo
Anthony Gerace

The air traffic controller

THE STRESSORS: Hartsfield-Jackson Atlanta International Airport hosted nearly 2,000 flights on average every day in 2022, making it the busiest hub in the world last year. “Almost every bit of airspace that we have, there’s going to be planes there,” says air traffic controller Nichole Surunis. Shepherding those thousands of passengers in and out safely requires tremendous concentration and the ability to process information quickly. Variables like bad weather or an unexpected move by a pilot can make an already challenging task even more dynamic at a second’s notice. There’s no time to dwell on what’s at stake. “You have to focus on all these pilots you’re talking to, with all these people on these planes,” Surunis says. In total, there are about 2.9 million travelers who fly into or out of the United States on a given day—and costly delays add to the strain of those minding the traffic. It’s only after the craft are safe that a controller might notice their racing heart and realize just how tense they were.

THE COPING MECHANISMS: Training and experience are key to handling rapidly shifting situations, and Surunis, like all controllers, has lots of both. “You have your Plan A—but you also must have a Plan B and Plan C,” she says. The occupation requires practicing self-care too. Stepping away from her workstation is essential, and mandated: Controllers typically aren’t allowed to go more than two hours without a break. Surunis doesn’t hesitate to tap a union-run support service after an especially grueling day, and she makes a point of unwinding by making time for hobbies like baking. That helps ensure she’s rested and ready to focus on keeping the sky safe.

Aviation photo
Anthony Gerace

The trauma surgeon

THE STRESSORS: Doctors who specialize in emergency care rarely have two days that are alike. A routine case like a ruptured appendix can end up on their table as readily as massive trauma. “They can be injured all over their body,” says Daniel Hagler, a critical care surgeon at NewYork-Presbyterian Queens Hospital in New York. “What you do within seconds or minutes of them arriving can be the difference between life and death.” The tension ramps up if he must handle many patients simultaneously. Over time, the strain takes a toll: A study published in The Journal of Trauma and Acute Care Surgery found that nearly one-quarter of doctors in Hagler’s shoes experience symptoms of post-traumatic stress disorder.

THE COPING MECHANISMS: Keeping it together requires the ability to triage, focus on what’s important, and put lesser priorities aside. Hagler employs “deliberate and algorithmic thinking”: If you see this, do that. Trust your intuition, using past experience to guide you to the best decision—while accepting that you may be wrong. “Take a step to just ready yourself and settle your nerves, and do what needs to be done,” he says.

Aviation photo
Anthony Gerace

The bomb tech

THE STRESSORS: Pipe bombs are the most common homemade explosive devices on American soil, according to the Department of Homeland Security, but the people who specialize in preventing them from blowing up are rare. Techs like Carl Makins, formerly of the Charleston County Sheriff’s Office in South Carolina, often face incendiaries crudely fashioned in someone’s kitchen or basement, so the safest way of deactivating them isn’t always clear. It doesn’t help that the gear includes 85 pounds of hot, uncomfortable Kevlar, making it hard to move. But the biggest source of anxiety is not knowing if someone tampered with the suspicious package or tried to move it in an effort to be helpful before he arrived. “What did you do to it?” Makins often found himself wondering. “Did you make it mad?”

THE COPING MECHANISMS: Makins always tried to compartmentalize his feelings. “You can’t get angry,” he says. “That limits your ability to see everything that you need to see.” He also used humor to help defuse tense situations—pointing out that, say, handling a bomb next to that shiny new pickup might not end well for the truck. He also remained mindful of his limits. If he was too tired, too tense, or just not up to the task, he’d say so and let someone else on the team step in to do the job. “You just tap out,” he says.

Aviation photo
Anthony Gerace

The teacher

THE STRESSORS: Teachers—despite diminishing resources, growing technological distractions, and students who often want to be anywhere but the classroom—are nevertheless saddled with the responsibility of shaping the future. That’s a lot of pressure, which explains why Gallup polls put teaching in a dead heat with nursing for the most stressful profession in the country, and why a RAND Corporation survey shows stress is the number one reason educators quit. And that was before COVID-19 compounded their challenges. When Teresa BlackCloud’s high school students in West Fargo, North Dakota, began taking turns attending class in person and learning from home in the fall of 2020, for example, she had to divide her attention between the pupils in front of her and the “online kids” who might need tech support. “I felt like my brain was split in two,” she says. “If only there were two Miss BlackClouds.” Like many educators, she had to quickly pivot between helping the teens in the classroom and assisting those working remotely.

THE COPING MECHANISMS: Setting clear boundaries is key to handling trying circumstances. BlackCloud had to put the kibosh on responding to pings from kids at all hours because it limited her ability to recharge. “I had to get really good at setting boundaries,” she says. She strives to practice mindfulness and sets aside specific parts of her day for mentally wandering into stressy places. “While I’m brushing my teeth is my time to worry about things,” she says.

Aviation photo
Anthony Gerace

The Alaska rescue pilot

THE STRESSORS: Flying a rescue helicopter in Alaska is so intense the Coast Guard requires pilots to complete a tour elsewhere before they can get the gig. The assignment often demands they travel long distances—​Air Station Kodiak monitors 4 million square miles of land and sea, an area larger than the entire lower 48 states—in the dark and through extreme conditions. Due to the environs, the Last Frontier has an aviation accident rate more than twice that of the rest of the country. “It is very challenging,” says Lt. Cmdr. Jared Carbajal, who flies MH-60 Jayhawks and often dons night-vision goggles to navigate the inky sky. The haste of operations compounds the tension: Pilots must be airborne within 30 minutes of getting the call to pull someone out of danger. That leaves little time to prepare and sometimes gives Carbajal scant knowledge of what he’ll find when he arrives at the scene. (Carbajal now flies out of US Coast Guard Air Station Sitka, also in Alaska.)

THE COPING MECHANISMS: Managing complex and uncertain scenarios requires focusing only on what you can control. Everything else is a distraction. Carbajal concentrates on one task at a time—​calculating flight distance, estimating how much fuel he’ll need, requesting the necessary gear, and so on—​that he tackles systematically. He avoids looking too far ahead on his to-do list or fixating on situations he cannot influence, like unusually turbulent waves. “If there’s something that you can’t make a contingency plan for, don’t even waste your time on it,” he says.

An earlier version of this article appeared on popsci.com in January 2021, and this feature first appeared in the Spring 2021 issue. It has been updated since that time.

Read more PopSci+ stories.

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That time the CDC got people hyped for a zombie apocalypse https://www.popsci.com/health/if-it-sounds-like-a-quack-book-excerpt/ Thu, 04 May 2023 10:00:00 +0000 https://www.popsci.com/?p=538824
CDC zombie preparedness guide comic panel from 2011
A page from Preparedness 101: Zombie Pandemic, which was released back in 2011. Click the image credit to read it in full. <Centers for Disease Control and Prevention

American medicine is rife with fringe science. A journalist shines a light on some of the most bizarre examples.

The post That time the CDC got people hyped for a zombie apocalypse appeared first on Popular Science.

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CDC zombie preparedness guide comic panel from 2011
A page from Preparedness 101: Zombie Pandemic, which was released back in 2011. Click the image credit to read it in full. <Centers for Disease Control and Prevention

Excerpted from If It Sounds Like a Quack: A Journey to the Fringes of American Medicine by Matthew Hongoltz-Hetling. Copyright © 2023. Available from PublicAffairs, an imprint of Hachette Book Group, Inc.

The year 2011, a tipping point for alternative healing, was important for another reason.

Deep beneath the Pacific Ocean, the edge of one tectonic plate was being jammed beneath the tectonic plate that held Japan. This wasn’t news. It had been happening at a rate of three inches a year since long before humans had invented the concept of news. But that March, it became news in the biggest possible way, when a chunk of the underlying plate suddenly gave way, causing the seafloor to pop up by about 15 feet and the plate holding parts of Japan to suddenly drop by about three feet. The magnitude 9 Tohoku earthquake was so big it shunted Japan eight feet to the east. It was so big it shifted the Earth six inches on its axis. It was so big it sped up the rotation of the planet
(only by 1.8 microseconds a day, but still—your days are now just a tiny bit shorter. Thanks Obama!). The earthquake and resultant tsunami also wreaked havoc on human systems—transportation systems, energy systems, water systems, telecommunication systems, and that most important of all human systems, the biological system that allows us to slobber, reproduce, and contemplate the irrationality of high baby-formula prices (usually in that order).

The tsunami killed more than twenty thousand people and caused multiple nuclear meltdowns, a disastrous toll for everyone except sellers of supplements, who pivoted to prey on the baseless fears of Americans living thousands of miles away from the radiation. Toby McAdam, still selling his RisingSun products, told the local newspaper that he doubted the radiation would drift to Montana—“but it could.” He recommended that his “Lugol’s Iodine solution” be applied to the skin daily as “an ounce of prevention.” Though public health officials said people self-treating with iodide supplements were more likely to harm than help themselves, orders spiked so sharply that Toby’s website crashed.

The multifaceted nature of the tsunami-caused chaos makes it perhaps appropriate that the event also marked the beginning of the United States’ descent into a full-blown zombie apocalypse.

The June following the earthquake, the CDC began a conversation about emergency preparedness on Twitter that led to a handful of people jokingly tweeting that they would like the CDC to weigh in on a catastrophic zombie attack.

This led to the predictable wave of lols, rofls, and laughy-face emoticons, but it also sparked an idea for Dave Daigle (a CDC communications administrator) and Dr. Ali S. Khan (a CDC expert in disaster preparedness).

With Daigle’s input, Khan wrote a piece for the CDC website explaining how to prepare for a zombie apocalypse. This neatly demonstrated the humanity of the person on the other side of the icy-cold stethoscope even as it leveraged the innate appeal of zombies to teach real-life strategies to cope with actual disasters.

It turned out people were hungry for messaging about people hungry for brains. The CDC zombie apocalypse preparedness plan was an instant hit, racking up so many views that the CDC server froze up, overwhelmed by all the traffic.

This bit of fun was so successful that a team of researchers from the University of California, Irvine, published a congratulatory paper in the journal Emerging Infectious Diseases urging other public health officials to follow suit. It argued that zombies were an opportunity “to capitalize on the benefits of spreading public health awareness through the use of relatable popular culture tools and scientific explanations for fictional phenomena.” They proposed that the medical establishment build o those efforts to stimulate the conversation and do better public education on a variety of health topics.

Suddenly, zombies were everywhere in public health and safety. The CDC, the Department of Homeland Security, and the Federal Emergency Management Agency all published in-depth zombie-related literature. Finally, public officials were seizing the initiative and taking back the cul tural space they had inadvertently ceded to promoters of One True Cures.

Also in 2011, a Harvard Medical School physician and aspiring nov elist named Steven Schlozman appeared on the radio show Coast to Coast AM, which spun tales of conspiracy and paranormal phenomena to a large and credulous national audience from 2 a.m. to 4 a.m., seven days a week. Because Coast to Coast AM was the most popular late-night radio show in the country, with ten million listeners, it was a great opportunity for Schlozman, who was there to promote his latest work, The Zombie Autopsies: Secret Notebooks from the Apocalypse. In the book, Schlozman drew on his medical knowledge to describe “Ataxic Neurodegenerative Satiety Deficiency syndrome” as the medical cause
of zombies (it was of course a fictional work of fictitious fiction). The format of the show required that Schlozman spend the opening stretch talking about the events of his novel as if they were real, before shifting to an acknowledgment that it was all pure fantasy.

Daigle, Khan, and Schlozman were helping people learn a bit of science in a fun way.

But their efforts quickly ran up against a problem: there is more than one way to view a zombie apocalypse.


One fact that the CDC and its fellow agencies failed to fully appreciate was that, in zombie properties like 2009’s feature film Zombieland and 2010’s hit television series The Walking Dead, very little
screen time is given to public health concepts like water sanitation. The action takes place after most health authorities have had their faces eaten, leaving individual survivors to run around attacking infected people with baseball bats, crossbows, and shotguns as a means of self-preservation.

That’s why other groups were quickly lining up to enlist the hot new cultural craze into their own, very different agendas. Zombies became the centerpiece in gun advertisements and were a major part of the NRA’s annual conventions, where shooting at the undead carried none of the moral baggage that came with shooting at human targets.

“Because the zombie canon focuses so squarely on the apocalypse, its spread into popular culture can erode faith in the resiliency of civilization,” wrote Daniel Drezner, the Tufts University professor and zombie expert. “The zombie narrative, as it is traditionally presented, socially constructs the very narrative that agencies like the CDC and FEMA are trying to prevent.”

Drezner documented the way that zombie references became a sort of dog whistle for gun rights—those on the outside glossed over a quirky head-scratcher while targeted audiences became fired up, even though they would clearly never need to shoot a zombie in real life.

Until some Americans began to ask, Will I need to shoot a zombie in real life?


Toby McAdam had told me about the 2012 Miami incident in which a man bit the face off a homeless man and then was himself described by authorities as slow to die after being shot. But Toby was not the only person fascinated by that attack. It let the undead cat out of the bag.

Soon after the news broke, a self-described Bitcoin evangelist and promoter of alternative-health supplements doctored a Huffington Post article about the incident so that it attributed the cause of the face eating to “LQP-79,” a virus that destroys internal organs and makes the host hungry for human flesh.

The fake article went viral, blitzing digital media feeds so thoroughly that LQP-79 was soon the third-most-searched term on the CDC website, forcing the agency to officially deny the existence of a zombie virus.

Around then, communities of zombie-themed survivalists and militias sprang up all across America. One was an offshoot of the well-established Michigan Militia, while others had names like the Kansas Anti Zombie Militia, the Anti Zombie Unified Resistance Effort (AZURE), Zombie-Fighting Rednecks, the Zombie Eradication and Survival Team, Postmortem Assault Squadron, and the US Department of Zombie Defense.

One, a loosely affiliated national group called the US Zombie Outbreak Response Team (ZORT), popularized a strange mishmash of survivalism and cosplay. Its website features pictures of preppers in tactical gear and tinted sunglasses using stickers and goofy accessories to trick out their trucks as zombie-fighting vehicles that would be equally at home in Ghostbusters or Mad Max universes. It was in some ways good fun. But they also carried real firearms. And engaged in real postapocalyptic survival exercises.

“A Zombie could be anything from a person infected by a pandemic outbreak to a crazy nut job, criminal or gangster who wants to hurt your family and steal your food and preps,” reads ZORT’s promotional material.

Though ZORT purports to be simply providing tongue-in-cheek cover for legit training that would be helpful in a natural disaster, of course the real difference between zombies and hurricane survivors is that one must be shot in the head and the other should be given a hot toddy and a shower.

Did any of these folks actually believe in zombies?

Probably not. But there was potential.

If It Sounds Like a Quack book cover with doctor and silhouette of a duck on bright yellow with navy all-caps text
Courtesy of PublicAffairs

Drezner cited research showing that when considering paranormal ideas, people look less to the logical evidence and more to whether other people believe in the ideas. This means that even if no one believes in zombies, if some people believe that other people believe in zombies, then some people will believe in zombies. The gaslighting became so effective that the gaslit then gaslighted others, until fear of actual zombies took on an undead life of its own—call it masslighting.

And really, the online picture was becoming quite blurry. At the CDC, Daigle and Khan began getting inquiries about their Zombie Preparedness Plan from concerned citizens who wanted to know what sort of firearm was recommended to repel undead invaders. Meanwhile, after his Coast to Coast AM appearance, Schlozman got emails from listeners who wanted to know what medicines could stave off a zombie infection, and whether he had recommendations for how to protect one’s home. China’s state media had to formally debunk a robust rumor that Ebola victims were rising from the dead as zombies. And in 2014 in the Florida statehouse, a representative formally proposed “An Act Relating to the Zombie Apocalypse” as the name of a bill that would allow citizens to carry firearms without a permit in an emergency.

Shockingly, a 2015 survey showed that 2 percent of American adults thought the most likely apocalyptic scenario would be one caused by zombies.

And zombie references kept popping up in unexpected places. People downloaded audio fitness tracks in which joggers were kept motivated by imaginary zombie antagonists that pursued them as they ran.

A man named Vermin Supreme, who sought the 2016 Libertarian Party nomination for president, added a platform plank on “zombie apocalypse awareness.” He also advocated using zombies for renewable energy. Even Big Tech was in on it. Buried in Amazon’s user agreement for a game-development engine, clause 57.10—a gag, probably?—read that the software should not be used in life-and-death situations, such as in medical equipment, nuclear facilities, spacecraft, or military combat operations. “However, this restriction will not apply in the event of the occurrence (certified by the United States Centers for Disease Control or successor body) of a widespread viral infection transmitted via bites or contact with bodily fluids that causes human corpses to reanimate and seek to consume living human flesh, blood, brain or nerve tissue and is likely to result in the fall of organized civilization.”

With zombie stories saturating popular culture, the lore in TV and film began to expand beyond the simple trope of shambling brain eaters. There were zombie rom-coms and zombie mockumentaries. On the CW Television Network, a show called iZombie tells the story of a Seattle morgue worker infected by a zombie virus. In this world, zombies retain their personality and capacity for reason, as long as they are well fed (on brains). During the third season, which aired in 2017, a militant group of zombies releases a deadly flu virus in Seattle; local public health officials announce a mandatory flu vaccination, only to find that the zombies have tainted the vaccines with a substance that will turn the vaccinated into zombies.

Vaccines that zombified ordinary citizens?

Luckily for public health, no one would believe that in real life.

Buy If It Sounds Like a Quack by Matthew Hongoltz-Hetling here.

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A tiny patch can take images of muscles and cells underneath your skin https://www.popsci.com/technology/wearable-ultrasound-patch/ Wed, 03 May 2023 20:00:00 +0000 https://www.popsci.com/?p=538733
Close-up of patient's neck with a wearable ultrasound patch
This small patch can monitor tissue up to four centimeters below the skin. UC San Diego Jacobs School of Engineering

Researchers built a device that can act like a tiny ultrasound.

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Close-up of patient's neck with a wearable ultrasound patch
This small patch can monitor tissue up to four centimeters below the skin. UC San Diego Jacobs School of Engineering

Researchers at the University of California San Diego have invented an adhesive, elastic patch capable of performing ultrasounds—but don’t expect any baby pictures just yet. Even without the social media fodder, the new wearable technology could soon provide an extremely useful tool for a wide array of medical monitoring procedures.

As detailed in a paper published on Monday in Nature Biomedical Engineering, a team led by nanoengineering professor Sheng Xu has developed a tiny, wearable device capable of measuring tissue stiffness up to 4 centimeters underneath the skin with a spatial resolution of 0.5 millimeters. In a statement, study coauthor and postdoctoral researcher Hongjie Hu explained that the group “integrated an array of ultrasound elements into a soft elastomer matrix and used wavy serpentine stretchable electrodes to connect these elements,” thus creating a conformable patch for portable medical monitoring.

According to the team’s paper, the device is composed of a 16-by-16 array of transducer elements connected via a seven-layer electrode. This is all protected by a waterproof and biocompatible silicone elastomer. A backing layer made from a composite of silver-epoxy helps absorb excessive vibrations to broaden bandwidth capabilities and improve resolution.

[Related: Wearable liquid pumps could one day regulate body temperature.]

All together, the patch comfortably conforms and “acoustically couples” to a patient’s skin to take repeated, three-dimensional images of underlying tissue. Compared with traditional ultrasound technology, the new patch can take the monitoring outside of hospital settings and eliminates the need for staff assistance. “This allows patients to continuously monitor their health status anytime, anywhere,” added Hu.

One significant challenge the team initially encountered involved the actual manufacturing of the patch. Traditional fabrication methods often require high-temperature bonding procedures that thermally damage the device’s sensitivity. To solve this problem, Xu’s team replaced their patch’s soldering paste with a conductive epoxy that bonded at room temperature, thus avoiding any burn-related problems.

Already, the team’s patch shows promise across a number of medical areas and research. Among the potential usages: monitoring the progression of cancerous cells, which often stiffen as they spread; assessing sports injuries affecting tendons, ligaments, and muscles; and analyzing the efficacy of treatments for liver and cardiovascular diseases alongside chemotherapy results. According to UC San Diego’s announcement, the ability to continuously monitor these health issues could aid in avoiding misdiagnosis and fatalities while also reducing costs via the new, non-invasive alternative to traditional hospital procedures.

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Scientists have developed a new way to fight a nearly untreatable brain cancer https://www.popsci.com/health/sound-waves-chemo-brain-cancer-glioblastoma/ Wed, 03 May 2023 14:00:00 +0000 https://www.popsci.com/?p=538676
Fluorescent dye shown crossing the blood-brain barrier into the brain via sound waves.
Fluorescent dye shown crossing the blood-brain barrier into the brain via sound waves. The Lancet Oncology

Crossing the blood-brain barrier may be crucial to provide glioblastoma therapy.

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Fluorescent dye shown crossing the blood-brain barrier into the brain via sound waves.
Fluorescent dye shown crossing the blood-brain barrier into the brain via sound waves. The Lancet Oncology

A new sound wave technique can help treat a deadly brain cancer called glioblastoma in only four minutes. The breakthrough report was published May 2 in the journal The Lancet Oncology and demonstrates the results of a phase 1 in-human clinical trial with 17 patients.

In the trial, the patients underwent surgery for resection, or removal, of their tumors and had an ultrasound device implanted. The device inside the skull opens the blood-brain barrier, repeatedly using sound waves to permeate the barrier and reach the brain tumor. IV chemotherapy is then able to reach the neurological tissues where the cancer can grow.

Treating this type of brain tumor, which has a 6.8 percent survival rate within the first five years of diagnosis, with the most potent types of chemotherapy is difficult. The strongest cancer medicines are typically unable to permeate the blood-brain barrier. The blood-brain barrier acts as a line of defense, making an extra wall around the brain to keep toxins and pathogens from getting into such a crucial area of the body. However, the repertoire of drugs that can be used to treat brain diseases is very limited. In 2014, scientists first found that sound waves could be used to permeate the blood-brain barrier and this study builds on that discovery.

[Related: Understanding glioblastoma, the most common—and lethal—form of brain cancer.]

“This is potentially a huge advance for glioblastoma patients,” co-author and Northwestern University neurosurgeon Adam Sonabend said in a statement

The study reports that using a novel skull-implantable grid of nine ultrasound emitters made by French biotech company Carthera can open the blood-brain barrier in a volume of the brain nine times larger than the small single-ultrasound emitter implants originally used. This importantly helps treat a large region of the brain next to the cavity that remains after glioblastoma tumors are removed.  

An animation of the SonoCloud-9 implantable ultrasound device.  The SonoCloud-9 device uses pulsed ultrasound to transiently disrupt the blood-brain barrier to improve the delivery of chemotherapy to brain tumors. CREDIT: CarThera.

This is also the first study that shows how quickly the blood-brain barrier closes after being opened by the ultrasound. It closes in the first 30 to 60 minutes after the communication. and this will help scientists optimize what order to deliver the drugs to allow for better penetration of the brain. The procedure to open the blood-brain barrier only takes four minutes and is performed while the patient is awake. The new results show that the treatment is safe, well-tolerated, and some patients received up to six cycles of treatment. 

[Related: Scientists used Zika to kill aggressive brain cancer cells in mice.]

Opening up the blood-brain barrier led to a roughly four- to six-fold increase in the drug concentrations in the human brain. The team observed this increase with two chemotherapy drugs called paclitaxel and carboplatin. These drugs are typically not used to treat glioblastoma patients, because they typically do not cross the blood brain barrier in normal circumstances. 

According to Sonobend, the current chemotherapy used for glioblastoma (Temozolomide) does cross the blood-brain barrier, but is weak. Sonabend also said that previous studies that injected paclitaxel directly into the brains of patients with these tumors had promising signs of efficacy, but the direct injection was associated with toxicity such as brain irritation and meningitis.

A phase 2 clinical trial is already underway. “While we have focused on brain cancer (for which there are approximately 30,000 gliomas in the U.S.), this opens the door to investigate novel drug-based treatments for millions of patients who suffer from various brain diseases,” said Sonabend.

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The best Fitbits for kids in 2023 https://www.popsci.com/gear/best-fitbits-for-kids/ Mon, 06 Jun 2022 17:00:00 +0000 https://www.popsci.com/?p=447741
Fitbits for kids sliced header
Stan Horaczek

These full-featured fitness trackers can endure the rigors of childhood.

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Fitbits for kids sliced header
Stan Horaczek

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Best overall Ace 3 is the best overall Fitbit for kids. Ace 3
SEE IT

It’s made specifically for children. 

Best for style Fitbit Luxe is the best Fitbit for kids for style. Fitbit Luxe
SEE IT

Its good looks make it appealing to a wide audience.

Best for teens The Inspire 3 is the best Fitbit for teens. Inspire 3
SEE IT

Get slightly older kids some more advanced features.

Fitbits can provide a great way to encourage kids to develop healthy habits and active lifestyles from an early age. A Fitbit, one of the leading brands of activity trackers, can motivate your child to get the recommended daily amount of exercise. According to the Centers for Disease Control, kids from ages 6 to 17 need about 60 minutes of physical movement per day to stay healthy. Fitbits can easily help track those minutes to ensure adequate movement. Fitbits don’t just monitor exercise, though. They can help with stress levels, monitor heart rate, store music, receive call/text notifications, and they can even track sleep. The Sleep Foundation says that sleep not only helps your child with energy levels, but a slew of other important developmental areas such as memory, focus, mood, learning, motor skill development, and overall happiness. A Fitbit’s sleep tracker can help ensure your child is getting the recommended 9-11 hours needed. We have compiled this list of the best Fitbits for kids. 

How we chose the best Fitbits for kids

While some people use “Fitbit” as shorthand to represent every type of fitness tracker, we’ve kept this list within the specific brand itself. While there are other fitness tracking options out there, Fitbit offers a complete enough lineup that it can appeal to a variety of kids. 

We started by comparing the entire Fitbit lineup, many of which we have actually reviewed. We focused on models that offer kid-friendly features, reasonable pricing, and designs that will appeal to a younger crowd. While there’s one model specifically made for kids, other models can appeal to slightly older children and teens who have different needs. 

The best Fitbits for kids: Reviews & Recommendations

Now that we’ve outlined some of the most relevant features, here are our specific picks for the best Fitbits for kids. While we have broken them down into categories, there’s always overlap

Best overall: Ace 3

Fitbit

SEE IT

Why it made the cut: With a touchscreen display, eight days of battery life, impressive memory, and Parent and Kid View, this is the obvious choice for most young ones.

Specs

  • Ages: 6+
  • Battery Life: Up to 8 days
  • Charge Time: 2 hours

Pros

  • 8 days of battery life
  • Bedtime and alarms
  • Parent and Kid View
  • Water-resistant 
  • Interchangeable bands 

Cons

  • Pricey
  • No heart rate monitoring

The only Fitbit specifically made for children, the Ace 3 comes with tons of great features relevant to young ones. With 8 days of battery life, a touchscreen display, bedtime alerts, reminders to move, a step counter, and gentle alarms to wake your kids up, this Fitbit comes fully stocked.

One of the most kid-friendly aspects of the Ace 3 is the fun virtual badges, animated clock faces, and personalized avatars that add a healthy sense of competition and play to their activity. Your kids can also personalize their Fitbit with interchangeable accessories like Minions bands, for an added fee. 

There’s both parent and kid view, and it’s also water-resistant up to 50 meters, so they can even wear it while swimming. It’s by no means cheap, but with all the bells and whistles, we think it’s worth the investment. 

Best for style: Fitbit Luxe

Fitbit

SEE IT

Why it made the cut: Fashion-forward and stylish, the Fitbit Luxe features a menstrual health tracker, several stress management tools, and sleep aids useful for teens.

Specs

  • Ages: 13+
  • Battery Life: Up to 5 days
  • Charge Time: 2 hours

Pros

  • Call/text notifications 
  • Connects to phone GPS to track pace and distance
  • Menstrual health tracker
  • Stylish design
  • Stress management features

Cons

  • Pricey
  • Website says the battery lasts 5 days, but quicker depending on use

Swimproof, slim, and fashion-forward, the Fitbit Luxe is the perfect tracker for teens who want to be more hands (or wrists?) on with their health. It not only takes care of all-day tracking, but also connects to a phone’s GPS to track pace and distance and allows wearers to stay connected with friends via call and text notifications. 

If your teenage girl has periods, she can track ovulation, record period symptoms, and log flow with the built-in menstrual health tracker, which can help her feel informed about her menstrual health. It also has several stress-management features, such as guided breathing, to help her with her mood and stress levels. We want to note: teenage girls have enough societal pressure, and we love that Fitbit’s team is committed to helping teenage girls stay healthy and happy without focusing on striving for “perfection.”

It’s not the cheapest option, but the Special Edition gorjana Soft Gold Stainless Steel Parker Link Bracelet doubles as a bracelet that goes with every outfit, which would make for the perfect birthday or holiday gift!

Best for teens: Inspire 3

Fitbit

SEE IT

Why it made the cut: Easy to use and accessible for teens with a one-year premium trial included, this is a great starter tracker for young adults looking to track calories, heart rate, steps, and more at home and at school.

Specs

  • Water resistance: Up to 50 meters
  • Battery Life: Up to 10 days
  • Charge Time: 2 hours

Pros

  • Easy to use & accessible
  • Affordable 
  • Up to 10 days of battery
  • Six-month Fitbit Premium membership included
  • Competitive games

Cons

  • Screen may be hard to read in the sunlight
  • Band wears after some time

The Inspire 3 is Fitbit’s most accessible and easy-to-use fitness tracker, which makes it a solid option for teens.

New Fitbit users get a six-month free trial of Fitbit Premium so they can have access to guided meditations, exercises, and accountability to make their fitness and health journey even easier. 

With its sleek design and simple interface, Inspire 3 is a great starter Fitbit for tracking steps, heart rate, distance, calories, food logging, menstrual health, sleep, and more. The battery lasts up to 10 days and there are even fun games in the app, like Get Fit Bingo, for more competitive-minded teens.

Best for young kids: Ace 3: Minions Special Edition

Fitbit

SEE IT

Why it made the cut: Meant for kids ages 6 and up, this Minions-themed fitness tracker offers parental controls and motivating challenges that make any activity feel like a game.

Specs

  • Ages: 6+
  • Battery Life: Up to 8 days
  • Charge Time: 2 hours

Pros

  • Meant for kids 6+
  • Swimproof
  • 8 days of battery
  • Relatable cartoon watch face
  • Parental controls

Cons

  • No heart rate sensor

Nothing motivates a young kid to get moving more than the mischievous Minions, whose boundless energy and curiosity cannot be contained. In fact, this Fitbit contains some fan-favorite phrases, like “Feed me!” This special edition of the Ace 3 provides simplified sleep tracking, friendly reminders to keep moving, call alerts, and bedtime reminders and alarms. It’s also water-resistant to 50 meters, and the Minions-yellow embossed silicon band is meant for kids’ little wrists—both in size and style.

There’s both a kid view and a parent view, so you can keep track of your child’s activity. This is a simple tracker without all the bells and whistles, which is a great option if you want to get a starter tracker. And, family challenges allow them to try and beat their sibling’s step count.

While the virtual badges and avatars provide some external motivation for kids to get active, the incentives won’t appeal to every kid. You should also make sure the kids know to approach the badges in a healthy way. 

Best with GPS: Fitbit Charge 5

Fitbit

SEE IT

Why it made the cut: This Fitbit with GPS can track over 20 workouts including swimming and has a built-in GPS system so your kids can leave their phones at home during workouts without feeling unsafe. 

Specs

  • Ages: 13+
  • Battery Life: Up to 7 days (Or 5 hours with GPS use)
  • Charge Time: 2 hours

Pros

  • Comfortable to wear 24/7
  • Built-in GPS 
  • Bigger touchscreen display 
  • Heart rate tracker
  • Easier to read in bright light 

Cons

  • Can’t take calls
  • The lack of buttons can take getting used to
  • No music playback control

Fitbit’s most advanced fitness and health tracker yet, this Fitbit with GPS comes with tons of elite features in a slim and lightweight design. It features an on-wrist ECG app, step tracker, calorie tracker, hourly activity, swim-tracking, and sleep monitoring. It also allows your kids to set goals and it buzzes when they hit certain heart rate zones. Plus, the main draw: built-in GPS for tracking routes and workouts.

The built-in GPS is great if your kids want to go without their phones without feeling unsafe. But you can also connect GPS from your phone to save battery if you’re running low.

While some may love the touchscreen approach, others may find the button-less design needs some getting used to. There’s also no music playback, and no third-party apps are supported.

What to consider when shopping for the best Fitbits for kids

A Fitbit is a great way to give a scientific gift, especially to younger kids in your household. There’s no better time to talk about the cardiovascular system than when they’re taking their heartbeat. Here’s what else you should know before hitting “add to cart.”

A quick note on the term “Fitbit”

For some people, the term “Fitbit” has taken on a more general meaning—it’s a catch-all that references any fitness tracker. It’s like how we often call plastic storage bags Ziploc bags or garbage receptacles Dumpsters. In reality, Fitbit is a specific brand that’s owned by Alphabet, Google’s parent company. We’re keeping this list almost entirely specific to that brand because the company makes a lot of excellent devices, but there are others out there like the Amazfit Band that would make a great option for kids.

Features

While Fitbit products have commonalities, some trackers come with unique features. It’s important to identify what you want to get out of your Fitbit. Do you want a hybrid tracker and smartwatch that can sync with a smartphone and offer more complex functionality? Or do you just want fitness tracking? Do you need GPS built in? Stress management tools? Take the company’s Fitbit quiz to help you make your decision. 

Budget

How much are you looking to spend? While some budget Fitbits are around $80, they can go all the way up to several hundred, depending on features and frills like GPS tracking and smartwatch capabilities. The kid-specific Ace is one of Fitbit’s cheaper models, which makes sense since kids are prone to breaking and losing gadgets on the regular. Buying a kid a $250 smartwatch can be a real gamble. 

Style

Your Fitbit’s style should reflect your child’s age and development. Some Fitbits, like the Ace 3, are meant for small children around 6 years, and others are meant for older teens like the Inspire 3 or Luxe. A kid won’t wear something if they hate the way it looks.

FAQs

Q: How much does a Fitbit for kids cost?

The only Fitbit specifically designed for kids, the Ace 3, costs $79.95. Anything fancier than that and you’re going to pay a premium. There are some other brands that offer cheaper fitness trackers. 

Q: Can an 11-year-old have a Fitbit account?

Whether or not your 11-year-old (or any minor) can have their own Fitbit account depends on the privacy laws in your individual country. Mostly, parents and legal guardians can create a family account to monitor their kids’ accounts. 

Q: Which Fitbit is best for a child?

Which Fitbit is best for a child depends on the needs and preferences of your unique child! If GPS is important, go with that model, or if price point is most important, you’ll want a cheaper option. It’s all about what works for your individual needs. If you’re looking for a starter model, though, we’d recommend the Ace 3. 

Final thoughts on the best Fitbits for kids

Fitbits are a great tool to make healthy living a convenient part of your child’s daily life. From fun incentives, cool features, and built-in tracking, it’s never been easier to teach your child how to have agency over their health. Hopefully, this article helps you narrow down the best Fitbits for kids so you can find the one that is right for your child.

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Being loud and fast may make you a more effective Zoom communicator https://www.popsci.com/technology/candor-zoom-data-communication/ Tue, 02 May 2023 16:00:00 +0000 https://www.popsci.com/?p=538354
The CANDOR corpus is the biggest repository of one-on-one video chat recordings.
The CANDOR corpus is the biggest repository of one-on-one video chat recordings. DepositPhotos

Here's what researchers gleaned from CANDOR's 850 hours of recorded Zoom calls.

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The CANDOR corpus is the biggest repository of one-on-one video chat recordings.
The CANDOR corpus is the biggest repository of one-on-one video chat recordings. DepositPhotos

An online coaching company recently teamed up with language researchers to amass the world’s largest publicly available dataset of two-person virtual conversations. Already in use by institutions at Harvard, Columbia, Cornell, and elsewhere, BetterUp Labs’ CANDOR Conversation Corpus includes over 850 hours’ worth of over 1,600 Zoom chats recorded between January and November 2020. Its authors hope to provide experts and scholars across an array of fields a deep trove of data offering insight into the myriad ways digital communication methods can affect everyday human interactions.

Zoom delays are the bane of many remote workers’ existence, but there’s a reason beyond the sheer annoyance. Zoom delays cause us to awkwardly talk over one another. According to a study published last year, it takes approximately 297 milliseconds for the human brain to process face-to-face, yes-or-no questions—ask those same queries over a video chat portal like Zoom, and that delay increases to upwards of 976 milliseconds. As Business Insider relayed on Monday, the previous study’s researchers theorized that even as little as a 30- to 70-millisecond audio delay (less than the blink of an eye) can disrupt conversation participants’ neural processing that underlies the very basics of human dialogue.

[Related: The best Zoom tricks and add-ons for your video chats.]

Enter BetterUp Labs’ “Conversation: A Naturalistic Dataset of Online Recordings,” aka CANDOR. With methodology and results recently published in Science Advances, CANDOR offers one of the most expansive archives of two-person audio and video conversations to date. The process was simple enough: compensated participants were asked to pair up with randomized fellow volunteers, who were then tasked to chat together for at least 25 minutes about whatever they wanted. Afterwards, they were surveyed about their feelings and thoughts post-chat. Both the audio and video of each conversation was also recorded, meaning that unlike most conversational corpuses, CANDOR didn’t merely archive their transcriptions. Speakers’ visual and audio information were also detailed, meaning every facial tic, verbal stutter, and subtle gesture was made available for researchers to parse and analyze.

Initial analysis of CANDOR’s data reveals some quick takeaways about what makes a solid Zoom conversationalist—generally speaking, higher rated and more well received participants were those who spoke faster, louder, and more intensely. As Insider explains, “people rated by their partners as better conversationalists spoke 3 percent faster than bad conversationalists—uttering about six more words a minute.” Although average volume didn’t change between positively and negatively reviewed conversations, the more nuanced notion of “intensity” factored heavily into opinions, as well as the variation between decibel levels. More variation meant a better view, while monotone conversationalists unsurprisingly didn’t score as well.

[Related: Zoom chats can be surprisingly therapeutic.]

The authors of the new CANDOR corpus freely admit the limitations to their initial work—the first version includes only American English conversations, and randomly pairing participants might have produced social anxieties and issues that skewed some of the data. Still, the CANDOR database offers one of the most expansive sets of two-person digital conversations ever amassed, and can serve as a launching pad for even more detailed investigations down the line. In order to do so, however, don’t be surprised if you find yet another Zoom invite in your email inbox in the near future.

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Renaissance-era doctors used to taste their patients’ pee https://www.popsci.com/health/renaissance-pee-flask-rome-forum/ Tue, 02 May 2023 15:00:00 +0000 https://www.popsci.com/?p=538302
Ligurian plates recovered from the hospital waste dump that date back to the second half of the 16th century CE.
Ligurian plates recovered from the hospital waste dump that date back to the second half of the 16th century CE. Sovrintendenza Capitolina/The Caesar’s Forum Project

A treasure trove of urine flasks dating back to the 16th century were found in an ancient Roman ruin.

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Ligurian plates recovered from the hospital waste dump that date back to the second half of the 16th century CE.
Ligurian plates recovered from the hospital waste dump that date back to the second half of the 16th century CE. Sovrintendenza Capitolina/The Caesar’s Forum Project

Archaeologists in Rome have unearthed a treasure trove of Renaissance-era medical supplies inside the Forum of Caesar. Among the “golden” finds are 500 year-old medicine bottles and urine flasks. In a study published April 11 in the journal Antiquity, the authors believe that the containers were used to collect pee for medical analysis and diagnosis. 

According to the researchers, the pathogens that could have been present in these bottles helps uncover how urban waste was managed.

[Related: Pee makes for great fertilizer. But is it safe?]

The current excavation initially began in 2021 and is part of an international collaboration called the Caesar’s Forum Excavation Project. The 16th century medical dump was found inside Caesar’s Forum, which was built centuries prior in 46 BCE. About 1,500 years later, a guild of bakers used this space to build the Ospedale dei Fornari or Bakers’ Hospital. According to the authors, the waste dump was then created by the hospital’s workers. 

The archaeologists also found rosary beads, broken glass jars, coins, a ceramic camel, and a Renaissance-era cistern full of ceramic vessels. The team of researchers from institutions in Italy and Denmark believes that the objects were likely related to patient care in the hospital. Each patient at the hospital may have been given a basket with a bowl, drinking glass, jug, and a plate for hygiene purposes. 

Diabetes photo
Glass urine flasks excavated from the cistern. CREDIT: Sovrintendenza Capitolina, The Caesar’s Forum Project.

The glass urine flasks are called “matula” in medieval Latin medical texts and were likely used for the practice of uroscopy. This was a diagnostic tool for physicians during the Middle Ages and Renaissance. Urine was also once believed to be a cure for motion sickness

The authors believe that doctors would use the flasks to observe urine’s sedimentation, smell, color, and even taste. This would help the physicians diagnose ailments like kidney disease, jaundice, and diabetes. The excess glucose in diabetic urine gives it a saccharine quality. English physician Thomas Willis was credited with discovering this during the 17th Century and described the pee as “wonderfully sweet as if it were imbued with honey or sugar.”

[Related from PopSci+: What’s in a packrat’s petrified pee? Just a few thousand years of secrets.]

Also included in the cistern were lead clamps that were associated with wood treated with fire. According to the study, this may be evidence of burning objects brought into the hospital from houses with known plague cases. Italian physician Quinto Tiberio Angelerio wrote this in a series of rules for preventing the spread of the contagious disease in 1588, which included burning objects touched by plague patients. Plague killed roughly 25 million people throughout the 14th century alone as it spread across Eurasia, North Africa, and eventually the Americas for 500 years.

Once the cistern was full, it was likely capped with clay While landfills existed at this time outside the city walls of Rome, “the deposition of waste in cellars, courtyards, and cisterns, although prohibited, was a common practice,” study lead author Cristina Boschetti told Live Science

The unique find sheds more light on how hygiene practices and controls in European medical settings progressed during the early modern era. 

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Check your pantry for two kinds of potentially contaminated flour https://www.popsci.com/health/gold-medal-flour-salmonella/ Tue, 02 May 2023 14:00:00 +0000 https://www.popsci.com/?p=538266
Dough being rolled out with flour sprinkled around it.
Salmonella can contaminate raw flour. Deposit Photos

General Mills has voluntarily recalled select bags of Gold Medal.

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Dough being rolled out with flour sprinkled around it.
Salmonella can contaminate raw flour. Deposit Photos

General Mills has voluntarily recalled select bags of Gold Medal flour due to possible salmonella contamination. The Food and Drug Administration (FDA) announced the recall on April 28 and covers two, five, and 10 pound bags of Gold Medal bleached and unbleached all-purpose flour with a “better if used by” date of March 27, 2024, or March 28, 2024. 

[Related: How do you track a salmonella outbreak? A data journalist followed the DNA trail to slaughterhouses.]

Other types of Gold Medal flour are not affected by the recall. Still, General Mills advised consumers to check their pantries and throw out any flour covered in the recall. The current recall did not link the flour to any reports of illness, but salmonella was detected in a sample from the five pound product.  

“We are continuing to educate consumers that flour is not a ‘ready to eat’ ingredient. Anything made with flour must be cooked or baked before eating,” General Mills spokesperson Mollie Wulff said in a statement to CNN

Food Safety photo
The all purpose flours affected by the recall. CREDIT: FDA/General Mills

While the recall has not linked General Mills flour to any reports of illness, the Centers for Disease Control and Prevention (CDC) has been investigating an 11-state salmonella outbreak. The majority of the 13 individuals sickened had reported eating raw batter or dough made with flour before getting sick. While most people infected recover, the most recent outbreak has resulted in three hospitalizations.

Salmonella is a bacterium that is found in the intestinal tracts of animals, and can be transferred to humans if animal feces enters into the food supply. It affects 1.35 million people each year, according to the CDC. Some symptoms of a salmonella infection include fever, stomach cramps, and diarrhea that can start within days of consuming the bacteria. Most people will recover with proper treatment, but consumers should seek medical treatment immediately if severe and persistent symptoms occur or there are signs of dehydration. Children under the age of five, those with weakened immune systems, and the elderly are more likely to have severe infections.

[Related: A salmonella outbreak has hit 37 states, and onions are to blame.]

According to both the FDA and CDC, consumers should not eat any raw products made with flour. Salmonella bacteria is killed by heat through baking, frying, sautéing, or boiling products that are made with flour, and people can get sick when eating food that constrain raw flour. Raw dough used in crafts homemade modeling dough can also pose the same risk. 

To prevent illness, both agencies recommend thoroughly cleaning all surfaces, hands, and utensils with warm soapy water after contact with uncooked flour or dough. People with pets should be particularly mindful of avoiding cross contamination by cleaning out bowls and feeders frequently

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A scientific exploration of big juicy butts https://www.popsci.com/science/butt-science/ Tue, 02 May 2023 13:00:00 +0000 https://www.popsci.com/?p=537937
Red cherry shaped as butt on orange and purple ombre background
Julia Dufossé for Popular Science

Build your appreciation for the largest, most booty-ful muscle in your body with these fact-filled stories.

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Red cherry shaped as butt on orange and purple ombre background
Julia Dufossé for Popular Science

BUMS. HEINIES. FANNIES. DERRIERES. Few muscles in the human body carry as much cultural clout as the gluteus maximus. “Butts are a bellwether,” writes journalist Heather Radke in her 2022 book Butts: A Backstory. Radke goes on to explain that our feelings about our hindquarters often have more to do with race, gender, and sex than with the actual meat of them. Unlike with a knee or an elbow, Radke argues, when it comes to the tuchus, we’re far more likely to think about form than function—even though it features the largest muscle in the human body

For all the scrutiny we spare them (outside of when we’re trying on new jeans) our butts aren’t mere aesthetic flourishes. A booty is, in fact, a unique feat of evolution: Out of any species, humans have the most junk in their trunks. Many other creatures have muscle and fat padding their backsides, and some even have butt cheeks. But none pack anything close to the same proportions as us.

So why did our ancestors develop such a unique cushion? Evolutionary biologists’ best guess is that our shapely rears help us walk upright. The curved pelvic bone that gives the butt its prominence likely developed as our weight moved upward and our muscular needs shifted. Research increasingly suggests that more massive muscles in the vicinity of the buttocks make for faster sprinting and better running endurance too. “The butt is an essential adaptation for the human ability to run steadily, for long distances, and without injury,” Radke writes. 

That said, the gluteus maximus does more than just keep us on our feet. The fat that sits atop it affects how we feel whenever we sit or lie down. The organs nestled behind those cheeks also have a massive influence on our health and wellbeing. Here are a few of the ways our bums factor into scientific understanding, lifesaving medicine, and the future of engineering. 

Digging deep for ancient backsides 

For as long as humans have been making art, they’ve been thinking about bodacious butts. The 30,000-year-old Venus of Willendorf is a famous pocket-size figurine carved by a Western European civilization during the Upper Paleolithic. The statuette, which some archaeologists suspect served as a fertility charm, immortalizes a body too thick to quit.

Backside of Benus of Willendorf statue on light blue
The original Venus of Willendorf statue was excavated in present-day Austria, and is now housed at the Museum of Natural History in Vienna. Ali Meyer / Corbis / VCG / Getty Images

Scientists also love peeping at the actual posteriors of our early ancestors, which hold a broader archaeological significance in telling the stories of ancient people and their lifestyles. Differences in the pelvis and other sat-upon bones have long been used to determine the sexes of unearthed skeletal remains, though we know now there isn’t as clear-cut a binary as researchers long assumed. In 1972, anthropologist Kenneth Weiss flagged that experts were 12 percent more likely to classify skeletons found at dig sites as men versus women, which he blamed on a bias for marking indeterminate skeletons as male. Recent research bears that out, with anthropologists now designating many more remains as having a mix of pelvic characteristics (or simply being inconclusive) than they did historically. Still, while the distinction isn’t completely black and white, the signs of a body primed for or changed by childbirth are useful in figuring out the age and sex of ancient remains. Butt bones can also tell us about how people lived: This March, archaeologists published the oldest known evidence for human horseback riding in the journal Science Advances. They identified their 5,000-year-old equestrians—members of the Yamnaya culture, which spread from Eurasia throughout much of Europe around that same time—with the help of signs of wear and tear to hip sockets, thigh bones, and pelvises. 

Green pear shaped like butt on purple and pink ombre background
Julia Dufossé for Popular Science

Supporting heinies of all shapes and sizes

As Sharon Sonenblum, a principal research scientist at the School of Mechanical Engineering at Georgia Tech, puts it, “What could be better than studying butts?” The Rehabilitation Engineering and Applied Research Lab that she’s part of is perhaps more aptly referred to by its acronym: REAR. 

Stephen Sprigle, a Georgia Tech professor in industrial design, bioengineering, and physiology, started REARLab with better solutions for wheelchair users in mind. A decade ago, he and Sonenblum saw the potential for an engineering-minded solution to the serious clinical problem of injuries from sitting or lying down for extended periods. Pressure sores and ulcers are a risk whenever soft tissue presses against a surface for a prolonged time, and they become more dangerous in hospital settings—where antibiotic-resistant bacteria often lurk—and in people with conditions that hinder wound healing, like diabetes. 

Sonenblum recalls that they set out to answer a deceptively simple question: What makes one backside different from another? To answer it, they had to put a whole lot of booties into an MRI scanner. Those imaging studies and others (including some done on supine patients) have provided an unprecedented amount of data about butt cheeks and the stuff inside them. 

The big headline, Sprigle says, is that “we’re big bags of water.” “What the skeleton does in that big bag of goo is totally fascinating,” he says. 

The work proved particularly humbling for Sonenblum, who’d intended to spend her career studying how the gluteus maximus affects seating. Instead, she and her colleagues figured out that humans don’t rest on muscle at all—the fat is what really counts. Sonenblum and the rest of the REARLab team are investigating how the natural padding in our rears changes over time, particularly in people who spend a lot of time sitting or supine.

Today, REARLab creates more precise computer models and “phantoms” to help cushion testing—mainly for wheelchair seats, but also for ergonomic chairs of all stripes—better account for real-world bums. Phantoms aren’t quite faux butts; they’re simple and scalable geometric shapes, almost like the convex version of a seat cushion designed for your tuchus to nestle into. They don’t account for bodies’ individual differences either. 

“Phantoms are always a tricky balance between time and representation,” Sonenblum says. “You want to represent the population well, but you can’t have too many or you’ll spend your entire life running tests.”

Two butt scans with renderings of butt adipose tissue conforming to a chair when seated
REARLab renderings compare the soft adipose tissue on two seated butts. On the left, the tissue is mostly intact, providing good cushioning for the body; on the right, the tissue has lost it structural integrity and almost resembles cottage cheese. © Sharon Sonenblum / Georgia Institute of Technology

REARLab’s current approach is to use two shapes—elliptical and trigonometric—to represent a fuller backside and one more likely to pose biomechanical problems when seated, respectively. It would be reasonable to assume the trigonometric butt is the bonier of the two, Sonenblum says, but the reality isn’t so simple. Large individuals with lots of adipose tissue can still lose the round cushioning when they sit. 

“I’ve seen scans of butts that look like this, and when I do, I think, Wow, that’s a high-risk butt,” Sonenblum explains. It comes down to the quality of the tissue, she adds. “If you touch a lot of butts, you’ll find that the tissue changes for people who are at risk [of pressure injuries]. It feels different.”

Sonenblum and Sprigle hope that continued work on backside modeling, cushion-testing standards, and adipose analysis will help wheelchair users and patients confined to their beds for long stretches stay safer and more comfortable. But their work has implications for absolutely anyone who sits down. When asked what folks should take away from their studies, they’re both quick to answer: Move. People with limited mobility may not be able to avoid the loss of structural integrity in their butt tissue, but anyone with the ability to get up often and flex their muscles can keep that natural padding in prime health. 

Finding better bellwethers for bowel cancer

When it comes to protecting your posterior, it’s not just the bodacious bits of the outside that count. One of the biggest backside-related issues scientists are tackling today is the sharp rise in colorectal cancer, which starts with abnormal cell growth in the colon or rectum. It’s already the third-most-common cancer and second leading cause of cancer death, but it represents a mounting threat, especially for millennials. New cases of young-onset colorectal cancer (yoCRC)—defined as a diagnosis before age 50—have gone up by around 50 percent since the mid-1990s. 

Blake Buchalter, a postdoctoral fellow at Cleveland Clinic Lerner Research Institute focused on cancer epidemiology, says that the most troubling thing about this recent uptick in cases is how little we know about what’s causing it. He and his colleagues suspect that 35- to 49-year-olds who die from colorectal cancer may share many of the same demographics and risk factors—higher body weight, lower activity levels, smoking, alcohol use, and diets high in processed and red meats—seen in patients aged 50 and older. But those under the age of 35 don’t follow those patterns as closely as expected. 

“This indicated to us that mortality among the youngest colorectal cancer patients may have different drivers than among older populations,” Buchalter says. “Our future work in this space aims to identify underlying factors that might be driving higher incidence and mortality among certain age groups in particular geographic regions.” 

During a standard colonoscopy, gastroenterologists are able to identify and remove potentially precancerous polyps known as adenomas on the spot. No DIY kit can manage that.

Buchalter hopes that more granular data will encourage more granular screening guidelines too. While he was heartened to see the US Preventative Services Task Force shift the recommended colon cancer screening age down from 50 to 45 in 2021, it’s clear that some populations are at risk for the disease earlier, he says. Buchalter and his colleagues hope to zero in on who should be getting screened in their 20s and 30s. 

But colonoscopies, the most commonly recommended form of detection, present a major hurdle in themselves. A 2019 study found that only 60 percent of age-eligible US adults were up to date on their colorectal cancer screenings, with others citing fear, embarrassment, and logistical challenges such as transportation to explain their delayed colonoscopies. At-home fecal tests offer a less invasive alternative, but research shows that fear of a bad diagnosis and disgust with the idea of collecting and mailing samples still keep many folks from using them. Blood tests and colon capsule endoscopy (CCE), in which patients swallow a pill-size camera to allow doctors to examine the gastrointestinal tract, both show promise in supplementing, and perhaps someday replacing, the oft-dreaded colonoscopy.

For now, it’s worth going in for the physical screening if you can manage it. While blood and stool tests can accurately detect signs of the cancer, colonoscopies can actually help prevent it. During a standard colonoscopy, gastro­enterologists are able to identify and remove potentially precancerous polyps known as adenomas on the spot. No DIY kit can manage that.  

Red strawberry shaped like a butt on a blue and white ombre background
Julia Dufossé for Popular Science

Tracking microbiomes with futuristic commodes

Meanwhile, other researchers are uncovering health secrets from long-ago water closets. In 2022, archaeologists uncovered what they believe to be the oldest flush toilet ever found, in Xi’an, China. The 2,400-year-old lavatory features a pipe leading to an outdoor pit. Researchers believe the commode, which was located inside a palace, allowed servants to wash waste out of sight with buckets of water. Flush toilets wouldn’t appear in Europe until the 1500s, and wouldn’t become commonplace until the late 19th century. Up until that point, major US cities employed fleets of “night soil men” to dig up and dispose of the contents of household privies and public loos.

As far as we’ve come from the days of night soil, the future of the humble toilet looks even brighter. Sonia Grego, an associate research professor in the Duke University Department of Electrical and Computer Engineering, says she’s “super-excited” to see commodes enter the 21st century. 

“Smart” toilets boast everything from app-controlled heated seats to detailed water-usage trackers, and could grow into a $13.5 billion industry by the end of the decade. But Grego’s team—the Duke Smart Toilet Lab at the Pratt School of Engineering—is focused on turning waste flushed down porcelain bowls into a noninvasive health tool. She envisions a future in which your toilet can warn you of impending flare-ups of gut conditions like irritable bowel syndrome, flag dietary deficiencies, and even screen for signs of cancer. 

“When we first started to work on the smart toilet for stool analysis, laboratory scientists were skeptical that accurate analytical results could be obtained from specimens that had been dropped in a toilet instead of a sterile collection container,” Grego recalls. “The perspective is very different now.”

Brown fuzzy kiwi shaped like a butt on a green ombre background
Julia Dufossé for Popular Science

Drawing inspiration from wild butts 

Humans may be unusually blessed in the butt-cheek department, but that doesn’t mean other animals’ rears hold less scientific appeal. From modeling the evolution of the anus to cracking the code on climate-friendly gut microbes, scientists are keeping close tabs on all sorts of animal bottoms. Some researchers are even hoping to harness the power of butt breathing—yes, actually breathing through your butt—for future applications in human medicine. 

We’ll circle back to backside breathing in a moment. First, let’s consider the wombat. While it’s true enough that everybody poops, these marsupials are the only animals known to drop cubes. For years, no one was quite sure how they managed to get a square peg out of a round hole. Some even assumed the wombat must have an anus designed for squeezing out blocks instead of cylinders. In 2020, mechanical engineers and wildlife ecologists at Georgia Tech teamed up to publish a surprising new explanation for the shape in the aptly named journal Soft Matter. They’d borrowed roadkill from Australia to do the first-ever close examination of a wombat’s intestines. By inflating the digestive tract and comparing it to more familiar pig intestines, they were able to show that the marsupial’s innards have more variation in elasticity: Instead of being fairly uniform throughout, the organs have some inflexible zones. The team’s findings suggest that a few nooks within the digestive system—some stretchy, others stiff—provide a means to shape the refuse into a square. 

Wombat butts themselves, by the by, are veritable buns of steel. Their rumps contain four fused bony plates surrounded by cartilage and fat and can be used to effectively plug up the entrance to a burrow when potential predators come sniffing around. While this has yet to be caught happening live, some scientists think wombats can even use their powerful bums to crush the skulls of intruders like foxes and dingoes who manage to make it inside. 

So now we have more clarity on how wombats poop cubes, but the question of why remains unanswered. Experts have posited that wombats communicate with one another by sniffing out the location of poop cubes, making it advantageous to produce turds less likely to roll out of place. Others argue that the unusual shape is a happy accident: Wombats can spend as long as a week digesting a single meal, with their intestines painstakingly squeezing out every possible drop of moisture to help them survive the arid conditions Down Under. Their entrails, when unwound, stretch some 33 feet—10 feet more than typical human guts—to help facilitate the frugal squeezing. When the species is raised in captivity with loads of food and water, their poops come out moister and rounder

Elsewhere in the world of scat science, folks are working to understand the secrets of nonhuman gut microbiomes. Earlier this year, biotechnologists at Washington State University showed that baby kangaroo feces could help make beef more eco-friendly. Joey guts contain microbes that produce acetic acid instead of methane, which cows burp out in such abundance that it significantly worsens climate change. By reseeding a simulated cow stomach with poop from a newborn kangaroo, researchers say they successfully converted the gut to a factory of acetic acid, which doesn’t trap heat in the atmosphere. They hope to try the transfer out in a real bovine sometime soon. 

Warty comb jelly's translucent body in the ocean
When the warty comb jelly needs to expel digested food, it forms a new pore between its skin and digestive skin (also known as a “transient anus”). ImageBROKER / Getty Images

Going back to the butt breathing, scientists are hoping to suss out how to give humans a superpower already exhibited by catfish and sea cucumbers. In 2021, Japanese researchers reported in the journal Med that they’d been able to keep rodents alive in oxygen-poor conditions by ventilating them through their anuses. Inspired by loaches—freshwater fish that can take in oxygen through their intestines—the scientists are trying to find new ways to help patients who can’t get enough air on their own. They’ve moved on to study pigs, which they say do wonderfully with a shot of perfluorodecalin (a liquid chemical that can carry large amounts of oxygen) up the bum. 

From an evolutionary standpoint, it’s not all that surprising that our outbox can handle the same duties as our inbox. Though it’s still not clear which came first, it’s well established that the anus and the mouth develop out of the same rudimentary cell structures wherever they appear. Some of the most basic animals still use a single opening for all their digestive needs. And one creature—just one, as far as we know—has a “transient anus.”

In 2019, Sidney Tamm of the Marine Biological Laboratory in Woods Hole, Massachusetts, demonstrated that the warty comb jelly creates new anuses as needed. Whenever sufficient waste builds up—which happens as often as every 10 minutes in young jellies—the gut bulges out enough to fuse with the creature’s epidermis, creating an opening for defecation. Then it closes right back up. It’s possible that the world’s first anuses followed the same on-demand model, proving yet again that the butt and its contents are worthy of our awe, curiosity, and respect.  

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How to understand your prescription’s fine print https://www.popsci.com/health/prescription-drugs-fine-print/ Tue, 02 May 2023 01:00:00 +0000 https://www.popsci.com/?p=537834
Package inserts contain information on the pharmacology of a drug.
Package inserts contain information on the pharmacology of a drug. Kathrin Ziegler/DigitalVision via Getty Images

A toxicologist explains how to decode package inserts to take medications safely and increase their effectiveness.

The post How to understand your prescription’s fine print appeared first on Popular Science.

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Package inserts contain information on the pharmacology of a drug.
Package inserts contain information on the pharmacology of a drug. Kathrin Ziegler/DigitalVision via Getty Images

This article was originally featured on The Conversation.

Many adults take prescription drugs, and usage rates are continually increasing. With approximately 1.3 million emergency department visits in the U.S. caused by adverse drug events each year, patient education is becoming increasingly important.

All prescription drugs come with instructions on how to safely and effectively use them. Depending on the medication, there may be several types of information included: the patient package insert, medication guide and instructions for use. One or more of these documents could be folded up in the box or attached as a printed page provided by your pharmacist.

I am a scientist who studies how drugs and other chemicals affect human health. While they may look intimidating, package inserts – and particularly the prescribing information – can help patients better understand the science inside the pill bottle and blister pack, among others.

What can I learn from package inserts?

An often overlooked part of the package insert is the prescribing information. Though written primarily for health care professionals, it contains a wealth of information regarding the ways in which the medication interacts with the body.

If the prescribing information was not included with your prescription, you can often find a copy on the National Institutes of Health’s DailyMed website or other drug information websites.

As an example, let’s consider one of the most widely prescribed medications in the U.S., atorvastatin (Lipitor). Among other effects, it reduces elevated levels of cholesterol overall as well as levels of low-density lipoprotein cholesterol – LDL, or “bad” cholesterol.

Reading the insert can answer a few important questions about the drug. If you’d like to follow along, a copy of the prescription information for Lipitor can be found here.

How does the drug work?

To answer this question, you can refer to the “Mechanism of Action” and “Pharmacodynamics” subsections of the prescription insert.

The mechanism of action and pharmacodynamics are related concepts. The mechanism of action describes the chemical and molecular interactions that cause a drug’s therapeutic or toxic effects. Pharmacodynamics refers to “what the drug does to the body,” which includes the mechanism of action as well as how other factors like drug concentration influences its effects.

Often the mechanism of action of a drug is related to how it interacts with cell receptors and enzymes involved in mediating specific signals and biochemical reactions in the body.

In the case of Lipitor, the prescribing information tells us three important things about how the drug works. First, the liver is the primary site that produces cholesterol in the body and the area the drug is meant to target. Second, the drug works by inhibiting an enzyme involved in cholesterol production called HMG-CoA reductase. And third, the drug increases the number of LDL cholesterol receptors on cell surfaces, ultimately increasing the catabolism, or metabolic breakdown, of LDL cholesterol.

Where does the drug go in my body?

Before we answer this question, let’s start with some background information in the “Pharmacokinetics” subsection.

Pharmacokinetics can be thought of as “what the body does to the drug.” It focuses on four major processes the body undergoes in response to the chemical: absorption, or how the drug gets into the body; distribution, or how the drug is dispersed throughout the body; metabolism, or how the drug is converted into other chemical forms; and excretion, or how the drug is eliminated from the body.

The pharmacokinetics of a drug are determined by factors related to the chemical itself and the person taking the medication. For instance, disease state, age, sex and genetic makeup can all cause the same medication to work differently in different people.

Now, let’s look at the “Distribution” subsection.

For Lipitor, the prescription insert does not specifically say where the drug goes in the body, but it does note that the volume of distribution is 381 liters. The volume of distribution is the ratio of the amount of the drug in the body overall to its concentration in the blood. A value greater than about 30 liters suggests that the drug has entered body tissues and is not confined to the bloodstream. For reference, the drug warfarin, which prevents blood clots, is tightly bound to proteins in the blood and has a volume of distribution of only 8 liters. On the other hand, chloroquine, an antimalarial drug that enters body fat, has a value of 15,000 liters.

Does the drug cause the effects or its byproducts?

Though the therapeutic effects of most drugs come from the chemical compound it’s made of, many break down into active metabolites in the body that also have some relevant biological effects.

Some medications are administered in an inactive form called a prodrug that the body converts into metabolites with the desired therapeutic effects. Drugmakers generally use prodrugs because they have better pharmacokinetics – such as improved absorption and distribution in the body – than the active form of the drug.

In the case of Lipitor, the “Metabolism” subsection under “Pharmacokinetics” tells us that the drug is broken down into several products and that these metabolites contribute significantly to its therapeutic effect.

How long will the drug be in my system?

A key drug property to consider in this case is its half-life, which is the length of time required for the concentration of the drug to decrease to half of its initial amount in the body. Information about a drug’s half-life is found in the “Excretion” subsection under “Pharmacokinetics.”

The half-life for Lipitor is approximately 14 hours. If you were to stop taking the medication, 97% of the drug would be gone from your blood after about three days, or five half-lives.

The prescription insert provides another interesting piece of information: because Lipitor’s active metabolites have a longer half-life than the drug itself, the half-life for its cholesterol enzyme inhibiting effects is 20 to 30 hours. This means that the drug’s effects may last even after the drug itself is out of your system.

Why do I need to take medications with food or at certain times?

Eating food can change the amount and rate at which a drug is absorbed into the body in several ways, including changing the acidity of the digestive system, altering the release of bile and increasing blood flow to the gut.

For Lipitor specifically, the answer to this question can be found in the “Absorption” subsection under “Pharmacokinetics.” Food decreases the rate and extent of Lipitor’s absorption but doesn’t significantly affect LDL cholesterol reduction.

Interestingly, the insert also states that the blood concentration of the drug is significantly lower when taken in the evening than in the morning, but reduction in LDL cholesterol levels is the same regardless of when the drug is taken.

The upshot of all of this is written on the drug label on the outside of the package: Lipitor can be taken with or without food. Morning or evening is not specified, but the recommendation is to take it at the same time every day.

Why does my doctor ask about other drugs I’m taking?

Drugs can interact with one another in ways that affect their safety and efficacy. For instance, two drugs may rely on the same enzyme system in the body to break them down. Taking them at the same time can ultimately lead to higher-than-anticipated levels of either or both drugs in the body.

Information to answer this question can be found in the “Drug Interactions” section.

One of the drug categories of concern for Lipitor are “strong inhibitors of CYP 3A4,” an enzyme that plays a key role in metabolizing many drugs. Because Lipitor itself is broken down by this enzyme, taking it alongside drugs that inhibit CYP 3A4, such as the antibiotic clarithromycin or the fungal infection drug itraconazole, can lead to its increased concentration in the blood and potentially result in adverse effects.The Conversation

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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The best air purifiers for 2023 https://www.popsci.com/story/reviews/best-air-purifiers/ Mon, 15 Mar 2021 15:59:00 +0000 https://stg.popsci.com/uncategorized/best-air-purifiers-2/
A lineup of the best air purifiers on a white background
Amanda Reed

Whether you’ve got pets, allergies, or worries about wildfire season, you can look forward to better air quality with one of our well-filtered purifier picks.

The post The best air purifiers for 2023 appeared first on Popular Science.

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A lineup of the best air purifiers on a white background
Amanda Reed

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Best for large rooms Mila Smart Air Purifier Mila Smart Air Purifier
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This all-purpose smart air purifier adapts to room size and comes with a carbon monoxide detector and sleep and white noise modes.

Best HEPA A product image of the Coway Tower True HEPA Air Purifier
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This HEPA model features four layers of filtration in a stylish design.

Best for allergies InvisiClean Aura II Air Purifier InvisiClean Aura II Air Purifier
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Certified to keep you safe from dangerous levels of ozone gas.

Air purifiers suck in pollen, dust, smoke, other allergens, and even viruses—pummeling them and then circulating clean, filtered air. It sounds simple enough, but not all purifiers are created equal, and there isn’t one that’s right for every person. Your particular environment and the size of your home are huge factors in choosing the best option for you. Is allergy season wreaking havoc on your sinuses? Do you live in a smoggy city? Have there been wildfires? In short, even the finest filters aren’t guaranteed to fix all that ails you and your home. But if you’re wondering whether air purifiers are really worth it … we think so. They can help distribute cleaner air, and that’s always a good thing, considering the link between air quality and health. So, read on as we clear the air on what we think are the best air purifiers.

How we chose the best air purifiers

As pet owners and parents, we’ve experienced our fair share of smells and toxins—and that’s just from inside the house. To create this list of the best air purifiers, we relied on peer recommendations, critical reviews, online research, user impressions, and plentiful personal testing. We also examined what each air purifier claims to eliminate from the air, HEPA square footage, and MERV ratings.

The best air purifiers: Reviews & Recommendations

Pollen, pet dander, smells, smoke, germs, and other airborne goblins are no match for the best air purifiers. This list includes quiet air purifiers, ones that double as humidifiers, and even ones that claim they can help with a majority of airborne pathogens.

Best overall: Dyson Purifier Humidify+Cool Formaldehyde

Tony Ware

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Why it made the cut: This three-in-one smart device automatically adapts to changes in air quality and humidity.

Specs

  • Recommended room size: 400 square feet
  • Dimensions: 36.66 x 11.02 x 12.23 inches
  • App connectivity: Yes
  • Max decibels (dB): 59.8 dB

Pros

  • Connectivity with Siri and Alexa
  • Three products in one
  • Air quality reporting

Cons

  • Expensive

Between its TikTok- and Insta-famous Airwrap multistyler to its line of powerful vacuums, Dyson has made a name for itself in sucking—which we don’t mean negatively. The Dyson Purifier Humidify+Cool Formaldehyde proves yet again that Sir James Dyson really knows what he’s doing when it comes to pushing air out and in. This air purifier uses an intelligent sensing system and Air Multiplier technology to purify, humidify, and cool the air. You don’t even need to touch the stylish, distinctive unit—it automatically senses and reacts to changes in air quality and humidity (we’ve watched one enthusiastically spring to life time and time again after a particularly aggressive sauté session in the kitchen). It even features a solid-state sensor to detect and destroy formaldehyde emitted by household items—a boon if you’re in a newly renovated/refurbished space, as fresh carpet and new mattresses are emitting odd things.

You don’t have to worry about airborne baddies getting re-released into the air since the entire purifier-humidifier is fully sealed to the HEPA H13 standard. If you love numbers, neat tech, and data, this machine will tickle your brain when it reports your air quality in real-time on the LCD screen and DysonLink app (which you can use to tweak/schedule usage). The filters are low-maintenance and easy to replace, and the machine features a deep-clean cycle to get rid of mineral build-up and bacteria that may be lurking in the water system. Although it’s almost $1,000, you’re getting three devices for the cost of one. Talk about smart.

Best for large rooms: Mila Smart Air Purifier

Mila

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Why it made the cut: This mold- and carbon monoxide-detecting air purifier comes in different filter configurations for custom air purification.

Specs

  • Recommended room size: 1,000 square feet 
  • Dimensions: 12 x 12 x 15 inches
  • App connectivity: Yes
  • Max decibels (dB): 62 dB but lowers to 24 dB while in room

Pros

  • Stylist
  • Small
  • Carbon monoxide, mold detection, and white noise machine built-in

Cons

  • Reviews note excessive air quality notifications

This classy, app-controllable large room air purifier adapts to the size of whatever room it’s placed in. It also looks great in any room it’s placed in. The filter has 45 square feet of HEPA, and with 447 CADR, it’s effective in rooms up to 1,000 square feet. Additional features include a sleep mode and white noise so that it won’t interfere with your sleeping habits. The device also features a carbon monoxide detector. It will monitor your room’s humidity and let you know if it detects any mold. If you’re not a fan of notifications, disable them if you go with the Mila—reviewers note that the Mila app sends lots of alerts.

Best for small rooms: LEVOIT Air Purifier for Home Bedroom

Levoit

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Why it made the cut: Take this lightweight, compact air purifier from room to room to experience dual-filter, three-stage filtration in your entire home.

Specs

  • Recommended room size: 161 square feet
  • Dimensions: 6.69 x 6.69 x 10.43 inches
  • App connectivity: No
  • Max decibels (dB): 52 dB

Pros

  • Aromatherapy
  • Dual-filter, three-stage filtration
  • Specifically targets hay fever

Cons

  • Not for large homes

The Levoit promises to help relieve allergies, congestion, and sneezing and is our pick for the best small air purifier. Although we can’t vouch for the unit’s specific efficacy against rhinitis, we can vouch for the fact that it has three filters (one more than most other units): HEPA for dust, pollen, and dander; carbon for odors; and polyester for lint and hair. One fun additional feature is that this one has an aromatherapy option if you’d like a little lavender to help lull you to sleep at night.

Best for quiet: Blueair Blue Pure 311i Max

Tony Ware

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Why it made the cut: Particles down to .1 microns are no match for this quiet-but-powerful air purifier.

Specs

  • Recommended room size: Up to 929 square feet
  • Dimensions: 19 x 12.5 x 12.5 inches
  • App connectivity: Yes
  • Max decibels (dB): 50 dB

Pros

  • Removes particles down to .1 micron
  • Stylish
  • App connectivity

Cons

  • Reviews note occasional problems with auto-sensing

Blueair makes svelte cylinders with Scandinavian style packed with highly effective electrostatic and mechanical filtration. The Blue Pure 311i Max is HEPASilent but deadly … against microbes in the air. This stylish, small air purifier features five fan speeds and a one-touch auto mode with a fine particles (PM 2.5) sensor to monitor concentration and adjust speed according. This air purifier can clean a 387-square-foot room in 12.5 minutes and a 929-square-foot space in 30 minutes (there are both larger and smaller models, so something for every home). And, it snags all those particles (99.97% of them down to 0.1 micron) all nearly undetected, clocking in at 23 dB on low/night mode—louder than a quiet natural area with no wind but softer than a whisper. And it never runs above 50dB, which makes it QuietMark certified and perfect for a bedroom, TV room, any room … plus it’s only 8 pounds, so it’s easy to move around while you decide between your study and your yoga studio (or realize it’s easiest to buy two).

Is it working? We barely hear it. But we also don’t hear ourselves sneezing and wheezing and complaining about our watery eyes, so we’re going with yes. If we need more confirmation, we can look at a five-color LED that changes according to Air Quality Index (AQI), or we can reference an app that gives insight into indoor vs. outdoor pollution and lets you control mode, tweak LED Brightness, set a schedule, and more (assuming the 311i Max and your phone are connected to WiFi). And if we don’t want it to be working, Google Assistant and Alexa compatibility let us turn it off with voice commands if our phone isn’t convenient. While some reviews note that the auto-sensing feature is not as accurate as they hoped, we’ve observed the Blue Pure 311i Max react firsthand thanks to a low smoke-point cooking oil incident or two. It was lively even from across a loft apartment—and helped with the post-coming odors. And the washable pre-filter fabric cover (shown above in “Stockholm Fog” color) meshed effortlessly with the decor to boot.

Best HEPA: Coway Tower True HEPA Air Purifier

Coway

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Why it made the cut: Stylish-meets-powerful with this True HEPA air purifier that features four levels of filtration.

Specs

  • Recommended room size: 330 square feet
  • Dimensions: 10.5 × 32.7 × 10.7 inches
  • App connectivity: No
  • Max decibels (dB): 52 dB

Pros

  • Real-time air sensing
  • Washable pre-filter
  • Air quality indicator

Cons

  • Noisier compared to other air purifiers

Multiple fan speeds, a timer, an air-quality assessor, and a filter-replacement indicator light make this the best HEPA air purifier—not just quiet and effective, but user-friendly. At just under $200, it’s neither cheap nor exorbitant for an air purifier, and it’s also aesthetically pleasing. Reviewers note that this air purifier is noisier than most.

Best with UV light: Germ Guardian True HEPA Filter Air Purifier

Germ Guardian

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Why it made the cut: This quiet air purifier uses CARB-compliant UVC light and titanium dioxide to reduce airborne bacteria, viruses, and mold spores.

Specs

  • Recommended room size: 153 square feet
  • Dimensions: 10.25 x 6.75 x 21.5 inches
  • App connectivity: No
  • Max decibels (dB): 61.2 dB

Pros

  • Quiet
  • Reduces odors
  • Pre-filter traps allergens

Cons

  • UV light can be bad for the environment

UVC light (the most destructive of all the UVs) in an air purifier works as a UVGI—ultraviolet germicidal irradiation—disinfection method by attacking the DNA of cells floating through the air, like mold spores, viruses, and bacteria. (This means, like all other filters, it cannot do anything for particles that have settled into fabric). An activated charcoal filter reduces odors. The 22-inch purifier filters air four times per hour at maximum speed in rooms up to 153 square feet. The four fan speeds, whisper-quiet operation, and CARB compliance make this air purifier an especially good pick for allergy sufferers. California Air Resources Board (CARB) compliance means you can rest easy about its environmental footprint.

Best for allergies: InvisiClean Aura II Air Purifier

InvisiClean

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Why it made the cut: CARB compliance plus four levels of air purification equals an exorcism for your sneezes.

Specs

  • Recommended room size: 319 square feet
  • Dimensions: 12.34 x 6.25 x 17.75 inches
  • App connectivity: No
  • Max decibels (dB): 55 dB

Pros

  • Four fan speeds
  • Quiet
  • CARB compliant

Cons

  • No auto-sensing

The four fan speeds, whisper-quiet operation, and CARB compliance make this air purifier an especially good pick for allergy sufferers. The California Air Resources Board requires purifiers to produce .050 parts per million of ozone or less, so any device with this certification keeps you safe from unsafe gas levels.

Best for smoke: Alen BreatheSmart 75i

Alen

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Why it made the cut: Detailed air quality indicators, a B7-Pure filter, and a CADR of 347 mean that this air purifier will stop smoke in its tracks.

Specs

  • Recommended room size: 1300 square feet
  • Dimensions: 12 x 19 x 27 inches
  • App connectivity: No
  • Max decibels (dB): 51 dB

Pros

  • 8 colorways
  • Quickly cleans large rooms
  • Auto-adjusts based on air quality

Cons

  • Expensive
  • Little warranty

This is an easy pick for the best air purifier for smoke, thanks to its CADR of 347 (out of 450). Thanks to automatic air-quality detection, when any type of smoke is present, the unit will kick up to turbo. When no irritants are present, the device goes into energy-saving mode. Five air quality colors give you a more detailed visual indicator of air quality—other air purifiers only include three color indicators.

Best portable: WYND Smart Plus Personal Portable Air Purifier

Tony Ware

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Why it made the cut: Take clean air onto the airplane or into the office with this water bottle-sized air purifier developed by NASA and MIT engineers.

Specs

  • Recommended room size: N/A
  • Dimensions: 9.57 x 8.62 x 4.33 inches
  • App connectivity: Yes
  • Max decibels (dB): 55 dB

Pros

  • Small
  • iOS/Android app
  • Medical-grade filter

Cons

  • Expensive for size

This small-but-mighty air purifier designed by NASA and MIT engineers fits in a cup holder and can purify the air in a car in under 15 minutes—that’s eight liters of air per second. And that comes in handy in a world of wildfires and other pollutants you might encounter as you travel—something we know from experience, as one accompanied three passengers in a Honda CR-V through the smoke-heavy American West during fall 2021. And, if you like numbers, the WYND air purifier connects to an iOS/Android app to track real-time hyperlocalized data on dust and other particulates. It also enables you to switch between different purifier presets, like auto and night, control other WYND devices, and alerts you when encountering poor air quality. The included desktop kickstand accessory lets you position the air purifier to direct a clean bubble toward your face (as shown above), giving your nose and lungs instant access to medical-grade filtered air in an office or elsewhere.

Best budget: LEVOIT Air Purifier for Home, Core 300

Amanda Reed

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Why it made the cut: This compact air purifier tackles smoke, dust, pollen, bacteria, and viruses without hurting your wallet.

Specs

  • Recommended room size: 219 square feet
  • Dimensions: 8.7 x 8.7 x 16.25 inches
  • App connectivity: No
  • Max decibels (dB): 50 dB

Pros

  • Filter life indicator
  • Timer
  • Quiet

Cons

  • Louder than other air purifiers

This cheap air purifier targets smoke, dust, and pollen, along with some bacteria and viruses. Four specialty replacement filters include a pet-allergy option and a toxin absorber for particularly smoky or smoggy areas. Like higher-end air purifiers that are more expensive, this Levoit air purifier features timer settings and a sleep mode. And the display lights can be turned off to ensure a pitch-black room when sleeping. Although the air purifier is louder than some competitors, it resembles a whooshing fan at its highest setting—if you can deal with that, this air purifier is for you.

What to consider when buying the best air purifiers

The best air purifier for you might not be the one your best friend or neighbor loves. You want a HEPA filter with a high MERV rating that’s designed to cover the amount of space you have in your particular room or dwelling. Beyond that, consider whether you want other features like pathogen-killing UV light, smart controls, and/or odor elimination. Do you need the best air purifier for pets or perhaps something portable? Air purifiers for mold or models to get rid of smoke? Air filters work only on airborne particles. To get at anything that’s settled into upholstery or rugs, you’ll need a handy vacuum, a helpful robot, or something else that offers deep-clean suction.

Size of space

There’s an alphabet soup to make sense of when choosing the best air purifier for your home. ACH (air changes per hour) correlates to the airflow of your device. It’s calculated based on the volume of your space, ceiling height, and how many cubic feet per minute the device can cover. It’s independent of other factors, e.g., the filter’s efficacy—to calculate that you need the CADR (clean air delivery rate) rating; because a HEPA filter is more efficient, its CADR rating may be lower, which is deceptive.

The most important thing to note is that an air purifier’s efficacy cannot be calculated based on square footage alone. You can find handy calculators online to determine the proper purifier for your needs, but here’s what to consider with any device: Will it successfully rid your home of odors with carbon or other comparable filters? Is it a good choice for pet owners? Does it feature UV light? Read the fine print.

HEPA

You’ve likely heard of high-efficiency particulate air, or HEPA, filters. They are a type of pleated air filter that, according to the Environmental Protection Agency, “can theoretically remove at least 99.97% of dust, pollen, mold, bacteria, and any airborne particles with a size of .3 microns.” The smaller the particle, the more penetrating and nefarious it can be. So when you’re shopping for air purifiers, check out their filters’ MERV (minimum efficiency reporting values) rating. The higher the MERV rating, the better it is at trapping the tiniest particles.

Suppose it’s the coronavirus that has you shopping for purifiers. In that case, it should be said that though a HEPA filter should be able to catch a virus of that size, there’s no conclusive proof that an air purifier can kill airborne COVID-19-carrying air droplets. The Centers for Disease Control and Prevention has stated that any room housing a coronavirus patient “should be exhausted directly to the outside, or be filtered through a high-efficiency particulate air (HEPA) filter directly before recirculation.”

If your main concern about your indoor air quality is lingering food or cigarette smoke odors, make sure the model you’re considering specifically targets fumes and other volatile organic compounds. HEPA filters aren’t good at eliminating odors on their own.

The HEPA filter was initially designed to capture radioactive particles when the atomic bomb was being developed because it can capture 99.97 percent of particles as small as .3 microns, which can evade other types of filters. (This is sometimes referred to as “true HEPA,” as European HEPA standards are required to trap only 85 percent of particles.) It works by ensnaring, sieving, and rerouting irritating particles.

A HEPA air purifier is considered the gold standard, but it does have limitations. Any particle smaller than .3 microns—for example, some viruses and VOCs (volatile organic compounds) like aerosols, ammonia, and other toxins—will slip right through. Changing your filter often enough is key. A HEPA filter does a great job of capturing mold. If you don’t change the filter, the purifier can redistribute that mold back into the air.

Allergies

The best air purifiers for allergies depend on what your particular triggers are because different filters work on different-sized particles. Pet hair and pollen are large particles, dust is medium-sized, and smoke is small. A combination HEPA-carbon filter is your best bet for filtering the maximum number of irritants to help reduce your allergies.

The addition of an ionizer and UV light, if you’re comfortable with it, adds a belt to your proverbial suspenders. Because UV light does create ozone particles, we recommend choosing an air purifier with UV light that’s approved for sale in California.

Smoke

Pollutants—like smoke and soot—can aggravate asthma, irritate your eyes, and stress your lungs and heart. An intuitive HEPA purifier with multiple fan speeds, maximum air circulation, and zero ozone output is the best one for allergy sufferers and people who are sensitive to smoke. The best air purifiers for smoke have a higher CADR rating. This means your device will be better at eliminating smoke and its odor, whether you’re talking about cigarettes, cannabis, or wildfires.

FAQs

Q: How much does an air purifier cost?

Even cheap air purifiers aren’t that cheap—they range between $50-$900. So chances are, if you’ve found an option that’s within your budget, you don’t need to second-guess it. Go through all the checkboxes you would for a more expensive model: Does it feature a true HEPA filter? Does your air purifier also feature a carbon filter? Is it ozone-free? If the answers are yes, then go for it. What you’re likely sacrificing are bells and whistles you may not even need, like WiFi capability or large-space efficacy, but still possibly getting other extras, like low-noise operation and triple filtration.

Q: Should I sleep with the air purifier on?

Sure, there’s no reason not to sleep with the air purifier on! An air purifier contributes to an overall healthy home environment, even while you sleep. In fact, many models feature white noise or overnight modes, so they can continue to work without disturbing you (and possibly even helping you sleep).

Q: Where is the best place to position an air purifier?

The best place to position an air purifier is probably not where you think. Don’t stick it in a corner or behind a piece of furniture to conceal it. Beyond that, if there’s a particular pollutant (smoke, food odor) that you’re trying to combat, place the purifier near it. You want it 3 to 5 feet off the ground—so on a table or sill if it’s not a tower-style—and, whenever possible, near sites of good airflow, like doorways and windows. Moving your purifier from place to place helps maximize its efficacy.

Q: Will an air purifier affect my plants?

Your plants should be safe and sound in the presence of an air purifier, with one exception: models that expel ozone. Otherwise, purified air is good for plants, just like it’s good for humans.

Q: Do air purifiers with UV light really offer extra sanitation?

Opinions on whether air purifiers with UV lights are worth it differ. UV can conquer indoor air particles that escape other filters, like bacteria and viruses, but the EPA has said there’s no way to measure the effectiveness of UV filtration. The UV lights are technically considered pesticidal devices—”an instrument or other machine that is used to destroy, repel, trap or mitigate any pests, including bacteria and viruses”—according to the EPA, and it does not review, and therefore cannot endorse, those. UV light creates potentially harmful ozone, as well, although the amount is small.

Final thoughts on the best air purifiers

In almost every category, the best air purifiers have a true HEPA filter and a carbon filter. Together, they get you the most coverage regarding the breadth of pollutants the purifier will attack. Beyond that, the most important qualities are energy efficiency and picking the right model for the size of your room. Everything else—design, whether the device is app-enabled, UV lighting—is just gravy.

Why trust us

Popular Science started writing about technology more than 150 years ago. There was no such thing as “gadget writing” when we published our first issue in 1872, but if there was, our mission to demystify the world of innovation for everyday readers means we would have been all over it. Here in the present, PopSci is fully committed to helping readers navigate the increasingly intimidating array of devices on the market right now.

Our writers and editors have combined decades of experience covering and reviewing consumer electronics. We each have our own obsessive specialties—from high-end audio to video games to cameras and beyond—but when we’re reviewing devices outside of our immediate wheelhouses, we do our best to seek out trustworthy voices and opinions to help guide people to the very best recommendations. We know we don’t know everything, but we’re excited to live through the analysis paralysis that internet shopping can spur so readers don’t have to.

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Banning the abortion pill would harm veterans, cancer patients, and many others https://www.popsci.com/health/abortion-pill-ban-other-treatments/ Mon, 01 May 2023 18:00:00 +0000 https://www.popsci.com/?p=537952
Black truck with purple screen that says "pharmacists know mifepristone saves lives" driving around Phoenix during abortion pill lawsuits
During the American Pharmacists Association annual conference in Phoenix, Arizona, this year, an advocacy group drove around a van urging pharmacists to reaffirm that mifepristone, a medication abortion drug, is safe, effective and essential. Chris Coduto/Getty Images for UltraViolet

Mifepristone's life-saving powers can go beyond pregnant people—if the courts allow research and access to continue.

The post Banning the abortion pill would harm veterans, cancer patients, and many others appeared first on Popular Science.

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Black truck with purple screen that says "pharmacists know mifepristone saves lives" driving around Phoenix during abortion pill lawsuits
During the American Pharmacists Association annual conference in Phoenix, Arizona, this year, an advocacy group drove around a van urging pharmacists to reaffirm that mifepristone, a medication abortion drug, is safe, effective and essential. Chris Coduto/Getty Images for UltraViolet

Three years ago, Nancy Klimas sat in an auditorium waiting to discuss her latest research progress. The audience was made up of the usual suspects at a scientific conference: doctors, scientists, and other academic colleagues. But this group was a bit different. The room was also packed to the brim with retired US veterans, all waiting to hear about any new developments over a “moonshot” idea that could be the closest attempt to a cure for Gulf War illness

Klimas, who serves as the director for the Institute for Neuro-Immune Medicine at Nova Southeastern University in Florida, has been studying this debilitating condition for three decades. The strange sickness affects 175,000 to 250,000 soldiers who were deployed in the 1990-1991 Persian Gulf War. For those veterans, nearly half of who are pushing 50 or above, life has been an uphill battle. There is currently no cure for Gulf War illness, and because it involves a cluster of symptoms—fatigue, joint pain, diarrhea, memory loss—attempts to treat it have come up short. “These people served our country and put themselves in harm’s way,” says Klimas. “Now they’re sick with a chronic illness that ruined their quality of life and ability to work for more than 30 years.” Exhausting her options, Klimas came up with a rather unconventional idea: use a well-established abortion drug to reset the body’s overwhelming response to chronic illness.

[Related: The PACT Act will take the burden of proof off US veterans exposed to burn pits]

Mifepristone, more widely known as the abortion pill, is capable of treating multiple illnesses. At low doses and when paired with another pill, misoprostol, the synthetic steroid binds to a protein in the uterus and stops the release of progesterone and other hormones needed to sustain pregnancy. But the drug has another effect, which Klimas is looking to tap. When taken at higher doses, mifepristone also blocks hormone receptors in the adrenal gland, which regulates the body’s stress response. The drug has already proven capable of doing this, and is currently approved as a treatment for the metabolic disorder Cushing’s syndrome

Based on that evidence, Klimas wondered if the medication could temporarily block the adrenal gland and rebalance the hormone signals that are blunted with Gulf War illness. Repurposing the FDA-approved drug would also save the 10 to 15 years it would take to develop and test a brand-new drug. Klimas is halfway through her phase 1 trial testing the safety of the drug at different dosages on veterans, and is making plans for the second phase of the study. 

The recent legal mess surrounding mifepristone access threw a wrench in Klimas’s plans, along with those of other researchers using mifepristone in their work. In early April, a federal circuit judge in Texas overturned the FDA’s 23-year-long approval of mifepristone, citing claims that the drug is unsafe for public use because abortion is now illegal in some states. And while the Supreme Court blocked the ruling that would have suspended mifepristone access across clinics, pharmacies, and mail orders, the future of the treatment remains uncertain in the US. “Obviously, we’re very concerned,” says Klimas, adding that mifepristone was already hard to get for research purposes. “Attempts to limit access to this drug has already had a splashback on the veteran population in these trials, as we’re delayed in rolling things out. How long will they have to wait for an effective therapy?”

Further constraints on mifepristone could impact medical progress on many other diseases and conditions as well. The medication is being studied as a potential treatment for diabetes in people without Cushing’s syndrome. It has also shown some potential in preventing weight gain caused by antipsychotic medication. Some ongoing clinical trials have found that mifepristone can be effective in slowing down the spread of breast cancer: The drug blocks progesterone receptors from releasing the hormone, which would normally stimulate tumor cell growth. And at different dosages, the pill can improve the quality of life of people dealing with painful uterine growths.

[Related: Abortion bans are impeding access to ulcer, arthritis, and cancer medications]

Banning mifepristone goes beyond stalling research—it puts any FDA-approved treatment at risk of being recalled. “You have a medication with an excellent track record of safety, efficacy, and high patient satisfaction,” says Carrie Cwiak, an OB-GYN at Emory Healthcare in Georgia. “The idea that the entire process for approving medication can be overturned [in court] is earth-shattering.” She says that restricting mifepristone opens a dangerous door to having people with legal power make treatment decisions based on their opinion and ideology rather than medical evidence. 

If the courts decide to bar or limit mifepristone use down the line, it would discourage pharmaceutical companies from spending money on producing new drugs that appear controversial. That could include contraceptives, hormone blockers, or treatments completely unrelated to reproductive issues. “If you were a pharmaceutical company and it was going to cost you $20 million to move a pipeline drug all the way up through phase three [clinical trials], would you want to invest the money for it if it’s possible the bench could reverse the authority of the FDA?” Klimas asks. 

Despite the setbacks on mifepristone access and potential legal battles, Klimas is optimistic that the research she is doing will help give veterans their long and overdue treatment. Her team is hoping to start their phase 2 trial soon and get as many results before politics interferes in science again. 

The post Banning the abortion pill would harm veterans, cancer patients, and many others appeared first on Popular Science.

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The best non-alcoholic drinks of 2023 https://www.popsci.com/gear/best-non-alcoholic-drinks/ Tue, 13 Dec 2022 18:00:00 +0000 https://www.popsci.com/?p=497490
A lineup of NA beverages on a white background
Amanda Reed

Skip the booze for bright, bouncy, botanical NA beverages that will help you reevaluate your relationship with alcohol and relish adventures with friends sans hangover.

The post The best non-alcoholic drinks of 2023 appeared first on Popular Science.

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A lineup of NA beverages on a white background
Amanda Reed

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Best NA beer sampler A variety of Athletic Brewing Company NA beers on a blue and white backgroundbest-na-beer Athletic Brewing Co. Craft Non-Alcoholic Beer
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All the beer taste without the beer regret.

Best non-alcoholic aperitif A bottle of Ghia on a blue and white background Ghia
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Inspired by Mediterranean aperitivo culture, Ghia is herbaceous and perfectly bitter.

Best canned alternative cocktails A can of Sydney Spritz by Flyers on a blue and white background Flyers Cocktails 
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Cocktail mainstays are made with CBD to give you a relaxing buzz without any next-day remorse.

Between bottles at family dinner(s) or popping Champagne at New Year’s, it’s hard for someone looking for a little non-alcoholic fun to kick off a year of healthier habits. “Liquid courage” and social lubricant, alcohol tends to be everyone’s favorite coping mechanism during the holiday season and gatherings in general, whether when first introduced to the extended family, dealing with distant relatives you’d rather remain removed, or being surrounded by friends of friends. Hence, the growing popularity of Dry January and the opportunity to learn that there are better, healthier ways to cope. Moderation can improve your mental health, lower blood pressure, and, best of all, prevent a dreaded hangover and related hang-xiety … and maybe an argument or two with strangers. Instead of snagging another lazy, hazy IPA out of the fridge, consider an NA beer or alternative spirit. Even better, the best non-alcoholic drinks are proof of the deliciousness of zero-proof that can be enjoyed as new year’s recompense transitions into sober spring and beyond.

Note: If you have moderate to severe alcohol use disorder, please see a healthcare provider before withdrawing, as it can be quite dangerous to detox at home by yourself.

How we chose the best non-alcoholic drinks

I had my own Dry January journey in 2021, after years of problematic college drinking habits and at-home COVID-19 happy hours. I ended up extending it until the middle of February. Instead of a month of regrets and voicing my displeasure of imposing a personal Prohibition—like some other “low to no” participants—I realized, simply put, that alcohol can be bad and getting drunk is dumb. Now, I am a self-proclaimed “beverage girlie” and lead a damp lifestyle: I don’t keep alcohol in my home but will enjoy a beer after improv. I also won’t shut up about how moderation is great. My partner doesn’t drink at all, so we’re always on the hunt for a bubbly, crisp, cold NA bev to sip on during dinners or concerts.

I’ve also reported on beverages in the past for Gear Patrol and have a fridge stocked with Diet Coke, Limoncello La Croix (the best flavor, fight me), and my favorite NA beers. We also consulted Dry Atlas, a non-alc database, for picks.

The best non-alcoholic beverages: Reviews & Recommendations

Going for an NA beer or alternative spirit is just like a vegetarian or vegan going for a meatless chik’n patty or Impossible Burger: you’re simply enjoying a just-as-tasty substitute for something you don’t want to ingest for personal or health reasons. One of these will level up your seltzer or become your innocuous favorite to enjoy while eating takeout and watching Love Island.

Best NA beer sampler: Athletic Brewing NA beer 

Why it made the cut: This NA beer tastes as nuanced as its boozy counterpart without post-six-pack regrets.

Specs

  • Milliliters: 12 fluid ounces (or 355 ml) per can
  • Spirit, beer, or wine: Beer
  • Alcohol removed or zero alcohol: Alcohol removed
  • Enhancements: N/A

Pros

  • Tasty
  • Gluten-free
  • Made of clean and natural ingredients

Cons

  • Might not be able to be consumed if you’re pregnant

If a fresh, cold one is more your style, Athletic Brewing has your back with its NA brews. They don’t have a bready aftertaste like other NAs; in fact, they are some of the best-tasting NAs you can buy, with the company racking up plenty of awards over the years. This 24-pack can fill the fridge so everyone can crack open one outside without the mood threatening to be cracked when too many full-strength brews make tongues loose.

Best NA stout: Guinness Non-Alcoholic Draught Beer

Guinness

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Why it made the cut: An Irish classic gets a non-boozy touch without sacrificing quality.

Specs

  • Milliliters: 14.9 millimeters per can
  • Spirit, beer, or wine: Beer
  • Alcohol removed or zero alcohol: Alcohol removed
  • Enhancements: N/A

Pros

  • Guinness taste without the alcohol
  • Pours like a real Guinness
  • Tasty

Cons

  • Heavy beer
  • Might scare some who are sober because of the realistic taste

NA beer can sometimes taste like carbonated bread instead of a bodied, complete fizzy beverage. That is not the case with Guinness Non-Alcoholic Draught Beer, which tastes like its malty cousin. If you’re sober and in recovery, the realistic taste of NA Guinness might make you feel like you’ve seen an ex walk into a room—ignore this one if that would make you uncomfortable, which is what you would also do when seeing your ex walk into a room. This tasty, dark beverage is a reliable choice (unlike your ex!) if you’re looking for a stout without stout regrets.

Best NA import beer: Peroni Nastro Azzurro 0.0

Amanda Reed

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Why it made the cut: Evoke the Amalfi Coast with a light Italian lager that’s refreshing and full-bodied.

Specs

  • Milliliters: 330 ml
  • Spirit, beer, or wine: Beer
  • Alcohol removed or zero alcohol: Alcohol removed
  • Enhancements: N/A

Pros

  • Light and refreshing
  • Full-bodied
  • Tasty

Cons

  • Potentially too-close to comfort beer taste

Sometimes you need a light international beer akin to a Stella or a Heineken. We’re personal fans of Peroni, a light Italian lager that screams “warm summer breeze and riding a Vespa.” However, maybe you’re the person driving the Vespa and can’t imbibe a lovely Peroni? Enter Peroni Nastro Azzurro 0.0, which, for an NA lager, is incredibly full-bodied (read: not watery). It tastes like its Peroni Nastro Azzurro boozy cousin, which might cause you to do a double-take at the label, but for those hoping to hop on a Vespa or behind the wheel of a Fiat, the Nastro Azzurro 0.0 is a solid choice.

Best non-alcoholic aperitif: Ghia 

Ghia

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Why it made the cut: This twist on a traditional aperitif is tasty and can be consumed on its own or mixed.

Specs

  • Milliliters: 500 ml
  • Spirit, beer, or wine: Aperitif
  • Alcohol removed or zero alcohol: Zero alcohol
  • Enhancements: Some adaptogens (lemon balm; rosemary)

Pros

  • Tasty
  • Versatile
  • Makes you feel sophisticated and fancy

Cons

  • Small bottle compared to others on this list

Inspired by Mediterranean aperitivo culture—think Campari and Amaro over finger food before 9 p.m. dinner in a bustling Milanese café—Ghia is light, dry, and the right amount of bitter. Drink it on its own or combine it with a mixer of your choosing for a spritz or cocktail. If a bottle seems like too much of a commitment, check out Ghia’s transportable cans that add lime, salt, and ginger to the OG Ghia aperitif.

If you’re already a Ghia fan and looking for something in the same vein, try Figlia—both have similar ingredients (white grape juice, rosemary extract, and elderflower, for example), but we love this NA aperitif’s earthiness thanks to clove and chamomile extract. Figlia, like Ghia, also sells spritz-in-a-can for on-the-go sips.

Best tequila alternative: Optimist Botanicals Smokey

Billy Cadden

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Why it made the cut: A mezcal-like sipper that is smokey and makes for a perfect mocktail margarita.

Specs

  • Milliliters: 500 ml
  • Spirit, beer, or wine: Spirit
  • Alcohol removed or zero alcohol: Zero alcohol
  • Enhancements: N/A

Pros

  • Designed to use mixed like a premium spirit
  • Lots of body
  • Spicy

Cons

  • Not that many fluid ounces compared to others on this list

This botanical spirit has woody, floral, and bitter notes, and is designed to be mixed like a premium spirit. This one specifically drinks like smooth tequila or mezcal. Mix it with your favorite ginger ale and garnish with a jalapeno slice or an orange peel for a scrumptious sipper sans alcohol. However, each bottle is only 16.9 fluid ounces, meaning you’ll have to be cognizant of how much you use before running out.

We also recommend Clean Co.’s CleanT—not only is it a lovely substitute in a margarita or paloma, it pairs lovely with Winderton Lustre (more on that later).

Best gin alternative: Abstinence Spirits Cape Citrus

Jen McCaffery

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Why it made the cut: You’ll feel good the next day after drinking this gin alternative, thanks to its lack of alcohol and the company’s dedication to protecting the South African Cape Floral Kingdom.

Specs

  • Milliliters: 750 ml
  • Spirit, beer, or wine: Spirit
  • Alcohol removed or zero alcohol: Zero alcohol
  • Enhancements: N/A

Pros

  • Proceeds go to wildlife conservation
  • No artificial flavors
  • Feels sophisticated

Cons

  • Those looking for an exact gin dupe will be disappointed

Skipping alcohol doesn’t mean you have to skip out on delicious flavor. Abstinence Spirits Cape Citrus is inspired by South Africa’s Floral Kingdom, one of the world’s most diverse habitats. It’s infused with familiar citrus flavors, like orange, grapefruit, and grapefruit along with ginger, fennel, and pepper that give this concoction a subtle savory kick. Other notes, such as the mandarin naartjie and bucchu, are native to South Africa. And with no sugar and zero calories, you can swirl this botanical gin substitute into your seltzer as a pick-me-up any time.

Best whiskey alternative: Ritual

Ritual

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Why it made the cut: Have a better boulevardier with this whiskey alternative that’s highly rated by restaurant professionals.

Specs

  • Milliliters: 750 ml
  • Spirit, beer, or wine: Spirit
  • Alcohol or zero alcohol: Zero alcohol
  • Enhancements: N/A

Pros

  • Heat on the tail end—just like whiskey
  • Rated highly by professionals
  • Soft and round flavor profile

Cons

  • Those looking for a straight whiskey dupe will be disappointed

This whiskey alternative is rated 85/100 Silver by the Beverage Testing Institute, a spirits research & review company. This makes it the highest-reviewed alcohol-free whiskey alternative. The numbers don’t lie! Vanilla and oak overtones mingle with notes of stone fruit and a little kick of heat at the end. Although it’s not meant to be sipped straight, you can use it to make an almost-NA Boulevardier or safer whiskey sour. We’re also fans of NKD LDY’s whiskey alternative, which is smoky and has the whiskey taste without the regret.

Best botanical spirit: Wilderton Botanical Spirit

Wilderton

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Why it made the cut: Each flavor is unique and delicious—probably the best we’ve tasted.

Specs

  • Milliliters: 750 ml.
  • Spirit, beer, or wine: Spirit
  • Alcohol removed or zero alcohol: Zero alcohol
  • Enhancements: N/A

Pros

  • Bittersweet Aperitivo a Campari dupe
  • Unique in their own way
  • Versatile

Cons

  • Expensive
  • Not a straight dupe for gin or whiskey

Wilderton’s line of botanicals is a loving homage to spirits like Campari, whiskey, and gin. In fact, their Bittersweet Aperitivo is a spot-on dupe, taste-wise, to Campari or Aperol, making it a great choice if you’d like to make your spritz even lower in ABV. Earthen—with cardamom, white peppercorn, and pine-smoked tea—is rich and spicy and even leaves a bit of heat when you’ve put down your glass and returned to the conversation. Lustre is a dreamy, citrusy blend of bitter orange peel, tarragon, lavender, and coriander that pairs great with tonic or soda water for a crisp mocktail in the garden.

Best value: Dhōs

Tony Ware

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Why it made the cut: Refresh your bar with spirits that contain organic ingredients.

Specs

  • Milliliters: 750 ml.
  • Spirit, beer, or wine: Spirit
  • Alcohol removed or zero alcohol: Zero alcohol
  • Enhancements: N/A

Pros

  • Less than $80 for three bottles
  • Made by a well-established distillery
  • The cheapest bottle on this list

Cons

  • Bundle subscription includes all three flavors—a bummer if you’re looking for multiples of the same flavor

Practicing moderation doesn’t mean sacrificing pleasure; distillers don’t have to forego flavor to achieve alcohol alternatives. These are the immediate takeaways after sampling the Dhōs non-alcoholic spirit/liqueur lineup—made in a three-step process using natural pesticide-free ingredients. Cooked up at an organic farm and distillery in Sheridan, Ore.—also home to Ransom Spirits, known for reviving Old Tom Gin and making whiskeys and vermouth—the mindful mixtures come in colorful stopper-topped bottles with small batch silhouettes and make for captivating (and keto-friendly) cocktail counterparts. Gin Free is savory, herbaceous, and refreshing—redolent of juniper and lime backed by a peppery note. It’s warm and spicy upon first sip, almost gingery, but turns cool thanks to a cilantro and peppermint component. Want to transition from gin & tonic to an NA Negroni? Mix Gin Free with Bittersweet, which carries over a hint of mint threaded through a sunset-colored elixir of rhubarb, pithy pink grapefruit, flamed citrus peel, and monk fruit. Or add it to soda water for a friendlier spritz. Orange, meanwhile, presents a melange of blood orange and vanilla with a dash of cayenne and coriander. It’s a great replacement for triple sec in off-dry “margaritas” but makes for a creamy, dreamy mocktail on its own with soda water, tonic, ginger ale, and more. Offered for $10 less than competitors on average, Dhōs is a premium product without a top-shelf price tag.

Best celeb-made non-alcoholic bubbly botanical: De Soi

De Soi

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Why it made the cut: Each flavor is fine, fresh, and fierce—this bubbly mocktail has it on lock.

Specs

  • Milliliters: 750 ml
  • Spirit, beer, or wine: Bubbly craft cocktail
  • Alcohol or zero alcohol: Zero alcohol
  • Enhancements: Adaptogens like reishi, ashwagandha, L-theanine

Pros

  • Crisp and carbonated
  • Darn tasty
  • Adaptogenic for a little healthy buzz at the party

Cons

  • Those who hate tart things may not enjoy these mocktails

Katy Perry is known for hits like “Teenage Dream” and “Hot N Cold,” but did you know she is also in the health and wellness biz? Not only is she an investor in apple cider vinegar giant Bragg Live Food Products, but she co-founded De Soi, an adaptogen aperitif company, in 2022. Golden Hour (shown here) is made with maca and L-theanine for relaxation and is great for making mocktail mules and a non-alcoholic spritz. Champignon Dreams is a bitter, earthy reishi and passion flower spirit for negroni or old-fashioned lovers. Purple Lune mixes ashwagandha, tart cherry, and botanicals to give the feel of a nightly glass of red. If bottles aren’t your style, De Soi also sells its three flavors in cans. All flavors have a tart bite—if that’s not your jam, stick to something sweeter.

Best bundle: Seedslip

Seedlip

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Why it made the cut: A delicious bundle means you can experiment and explore, all while saving some cash.

Specs

  • Milliliters: 700 ml
  • Spirit, beer, or wine: Spirit
  • Alcohol removed or zero alcohol: Zero alcohol
  • Enhancements: N/A

Pros

  • Allergy-friendly
  • High-quality ingredients
  • Versatile

Cons

  • Expensive

If you’re looking for a bundle package, look no further than this one from Seedlip. It includes Seedlip Grove 43 (a citrusy, ginger, and lemongrass spirit), Seedlip Spice 94 (a waltz between allspice, cardamom, and grapefruit), and Seedlip Garden 108 (an herby promenade of peas, rosemary, and thyme). They are best served with ginger ale and a citrus peel garnish—perfect for breaking out the fancy glasses sans next-day guilt.

Best mood lifter: Crisp & Crude

Crisp & Crude

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Why it made the cut: These keto-friendly, gluten-free mocktails are infused with terpenes and safe to drink while pregnant.

Specs

  • Milliliters: 8.45 fluid ounces per can (250 milliliters)
  • Spirit, beer, or wine: Canned cocktail
  • Alcohol removed or zero alcohol: Zero alcohol
  • Enhancements: Botanical terpenes

Pros

  • Tasty
  • Dietary friendly
  • Pre-mixed

Cons

  • Expensive
  • Only available in cans

These NA craft cocktails are made with botanical terpenes extracted from plants, fruits, and roots for calmness, creativity, and relaxation. You can purchase each flavor individually, but we’re fans of the variety pack that includes four cans of its three flavors: Paloma Daydream (a salty, woody grapefruit drink with Space Queen terpenes); Gold Fashioned (bitter orange, zesty dandelion, and Chocolate Thai terpenes); and Mellow Mule (ginger, citrus, and mint with Pineapple Express terpenes). Leave the joint at home and pass around a can of this instead.

Best canned alternative cocktails: Flyers Cocktails 

Flyers

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Why it made the cut: These canned mocktails are inspired by bar favorites and feel just as fancy to imbibe.

Specs

  • Milliliters: 237 ml or 8 fluid ounces
  • Spirit, beer, or wine: Canned cocktail
  • Alcohol removed or zero alcohol: Zero alcohol
  • Enhancements: 20 milligrams of CBD

Pros

  • Pre-mixed
  • Cocktail-inspired
  • Feels fancy

Cons

  • Only available in cans, which are small

These sparkling, non-alcoholic drinks are made with 20 milligrams of CBD and are inspired by cocktail menu mainstays. BKLN Gold is reminiscent of an American Bourbon cocktail thanks to its oakiness, spice, and smooth vanilla. Tokyo Marg is a citrusy Yuzu sparkler with a touch of heat. Our favorite, however, is the Sydney Spritz Highball: a bold, herbaceous blend of citrus zest, mandarin orange, and bitters.

Best bottled mocktails: DRY Botanical Bubbly Reserve

Amanda Reed

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Why it made the cut: A fizzy mocktail is a screwcap undoing away with DRY Botanical Bubbly Reserve.

Specs

  • Milliliters: 750 ml bottle
  • Spirit, beer, or wine: N/A
  • Alcohol removed or zero alcohol: Zero alcohol
  • Enhancements: N/A

Pros

  • Tasty
  • Zero-effort
  • Good for those with dietary needs

Cons

  • Could use some more carbonation

If you’re looking for a not-so-stiff drink after work but don’t have the brainpower to create something new, take the guesswork out of mixology with these pre-mixed mocktails from DRY. They come in three flavors: Lavender 75, a botanical boozeless take on a French 75; Rose Soleil, a Provence Rose-style beverage with touches of strawberry, rose, and oak; and Spiced Pear, which blends ripe pears with vanilla and cardamom. We also love the company’s line of sparkling water that makes for a great mixer. Although the Botanical Bubbly Reserve flavors could use some more carbonation, they taste like a craft concoction you would find at the bar without the craft concoction price.

Best NA wine: Surely Non-Alcoholic Sparkling Rose

Surely

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Why it made the cut: Get all the wine taste without the next-day regrets from drinking the entire bottle.

Specs

  • Milliliters: 750 ml
  • Spirit, beer, or wine: Wine
  • Alcohol removed or zero alcohol: Alcohol removed
  • Enhancements: N/A

Pros

  • Delicate body
  • Friendly to specialty diets
  • Great dupe

Cons

  • Pregnant people may not be able to drink it due to low alcohol content

Some NA wines include fruit juice, but if you’re looking for something that screams more wine glass and less Welch’s, Surely’s line of dealcoholized wines is for you. It’s aged in the barrel just like its boozy counterpart, but then the alcohol is removed. The final product is a dry, full-bodied sparkling rose that pairs well with seafood and dessert—just like what someone would find at a liquor store. Coupe glasses sadly not included.

In case you’re looking to expand your NA wine palate, we also are fans of Joyus. For those looking for something that’s on the floral side, look no further than Starla’s NA sparkling rose.

Best wine alternative: Proxies

Proxies

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Why it made the cut: As the name implies, Proxies is an homage to the wine experience while setting itself apart from its boozy cousin.

Specs

  • Milliliters: 750 ml
  • Spirit, beer, or wine: Wine
  • Alcohol removed or zero alcohol: Zero alcohol
  • Enhancements: N/A

Pros

  • Tasty
  • Has a similar look and mouthfeel to alcoholized wines
  • Safe for pregnant people to drink

Cons

  • Some flavors can come off as too juice-like

Wine alternatives tend to taste like fancy grape juice. Although that’s not a bad thing, sometimes it’s more enjoyable to drink something that tastes like it came from Napa Valley and not from a toddler’s sippy cup. Proxies—vinegar giant Acid League’s wine alternative brand—uses wine grapes, tea, vinegars, and other fruit for its enchanting wine-inspired blends. Blanc Slate is reminiscent of a Sauvignon Blanc, and Red Ember is all body without the bite. Red Clay is probably the most “wine-like,” with its velvety mouthfeel and lingering pucker. Although you can’t get single bottles, the company’s sets let you explore to find new favorites, then stock up on the ones you love.

What to consider when buying the best non-alcoholic beverages

Non-alcoholic beverages are a great way to get the ritual feel of making a cocktail or pouring a glass of wine sans alcohol. You can find them online or at your local liquor store—in my experience, NA beers have their small section in the beer aisle; NA wines are housed by the bartending accessory or mixer section. If you’re lucky, you might have an NA bottleshop in your neighborhood—like Spirited Away in NYC and The Open Road in Pittsburgh—that you can peruse IRL or that offers to ship and delivers right to your door. Here’s what you should know before making your pick.

NA vs. alternative spirit

NA is short for non-alcoholic. Most beverages with the NA moniker—like beer, wine, and liquor—are made like their alcoholic counterparts. However, they don’t ferment or go through a process that removes the alcohol from a finished, alcoholic product. The result is a beverage with less than .5% alcohol by volume (ABV), which can be labeled as “non-alcoholic” per the FDA. According to the FDA, those who are pregnant should go for a truly zero-alcohol beer or spirit to prevent birth defects, according to the American College of Obstetrics and Gynecology (ACOG).

This is where alternative spirits come in. They are made of herbs, vinegars, juices, and more to give off the vibe of a standard alcoholic spirit. An alternative wine will not taste exactly like Cabernet Sauvignon, but it will offer a similar mouthfeel and body. A botanical gin-like spirit will include juniper or pine to replicate the notes of its alcohol-included cousin.

Adaptogens, nootropics, and CBD

If you’d like a little extra jazz in your drink, consider ones with adaptogens or CBD. Adaptogens like ashwagandha and L-theanine are used in herbal medicine to help the body return to homeostasis, or the body’s state of natural balance. The science is a bit nebulous, so don’t expect them to fix your problems. Nootropics have a similar effect as adaptogens: they claim to boost mood and improve cognition but are scientifically hazy.

Animal studies, self-reports, and research in people suggest that CBD, or cannabidiol, can help with anxiety, insomnia, and chronic pain without the “high” from THC. If you’re looking for something to sip on to unwind after a long day, a CBD-infused beverage is perfect—just make sure it’s coming from a reputable source that posts third-party lab results on their site.

Storage

Unlike your typical bar cart, you’ll need to refrigerate most—if not all—non-alcoholic spirits since they don’t have the high-alcohol content to keep them shelf-stable. If you don’t have the refrigerator space for your bounty of friendly spirits, consider one of the best beverage coolers.

Mixers

You have your spirits and such to make a mocktail—but where do you start? Of course, you can always go for the classic tonic or soda water touch, but the world is your oyster when it comes to mixers. Try Tangerine La Croix with Abstinence Spirits’ Cape Citrus for a citrusy play on a gin soda; Blood Orange Carrot Ginger-flavored Health-Ade Kombucha mixes great with Wilderton’s Lustre; and doesn’t Waterloo’s blackberry lemonade seltzer sound heavenly with Ritual’s alternative whiskey? You can even opt for a pre-made drink mix—espresso martinis, anyone?

Safety

There are only two substances that you can die from unsafe withdrawal: barbituates and alcohol. Quitting cold turkey is OK if you or someone you know does not struggle with alcohol use disorder. Otherwise, supervised alcohol withdrawal is the safest since alcohol withdrawal can lead to seizures, delirium tremens, and death if untreated or improperly executed. Also, consult with a doctor before stopping use—they can help decide if you or someone you know should complete your withdrawal in an inpatient or outpatient setting.

FAQs

Q: How much do the best non-alcoholic drinks cost?

The best non-alcoholic drinks can cost between $3-$200, depending on whether you’re purchasing a single can, a pack of four, a bottle, or a bevy of bottles. Of course, the higher end is mostly bundles of bottles. A single bottle ranges from $8-$30—in our experience, it’s worth grabbing the $20 bottle online versus over the $8 in the liquor store. And, packs of cans will also run you around $20-$30.

Q: Does non-alcoholic beer have alcohol in it?

Yes, but only a small amount. According to the FDA, for a beer to be advertised as “non-alcoholic,” it must have less than .5% ABV in each can. Although zero-alcohol beers exist—like Heineken 0.0—the amount of alcohol in a non-alcoholic beer is insignificant to most people who are sober-curious, live a damp lifestyle, or are in recovery.

Q: Can you drink non-alcoholic beer while pregnant?

The risk in drinking a beer under .5% is low, but no guarantees. Since there is no known safe level of alcohol intake in pregnancy, the American College of Obstetricians and Gynaecologists (ACOG) advises pregnant people not to drink any alcohol while pregnant—including NA drinks and spirits. Talk to your doctor before cracking open an NA beer or alcohol-removed wine and spirits if you’re pregnant.

Final thoughts on the best non-alcoholic drinks

Non-alcoholic beverages—including NA beer and wine, wine alternatives, botanical spirits, and more—are a great way to moderate your drinking during Dry January and beyond. Abstaining from drinking completely, cracking open a euphoric seltzer after drinking a Manhattan, or sticking to a mocktail during a pregame can help you re-evaluate your drinking habits. And let’s be real: the best non-alcoholic drinks are just plain tasty. Plus, your sober friends—weary from having soda, seltzers, and plain water as the only option at restaurants or functions—will appreciate that you have fun, craft non-alcoholic options available at your next backyard shindig.

Why trust us

Popular Science started writing about technology more than 150 years ago. There was no such thing as “gadget writing” when we published our first issue in 1872, but if there was, our mission to demystify the world of innovation for everyday readers means we would have been all over it. Here in the present, PopSci is fully committed to helping readers navigate the increasingly intimidating array of devices on the market right now.

Our writers and editors have combined decades of experience covering and reviewing consumer electronics. We each have our own obsessive specialties—from high-end audio to video games to cameras and beyond—but when we’re reviewing devices outside of our immediate wheelhouses, we do our best to seek out trustworthy voices and opinions to help guide people to the very best recommendations. We know we don’t know everything, but we’re excited to live through the analysis paralysis that internet shopping can spur so readers don’t have to.

The post The best non-alcoholic drinks of 2023 appeared first on Popular Science.

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The best trekking poles of 2023 https://www.popsci.com/gear/best-trekking-poles/ Tue, 13 Sep 2022 17:00:00 +0000 https://www.popsci.com/?p=469199
best trekking poles sliced header
Tony Ware

The best tools for keeping you upright on all manner of hikes, treks, and scrambles.

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Best overall The Black Diamond Alpine FLZ is a dynamic, highly packable trekking pole. Black Diamond Alpine FLZ
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The Black Diamond Alpine FLZ is a dynamic, highly packable trekking pole.

Best carbon fiber These MSR poles feature a “Dynalock” mechanism that shores up their durability.
MSR Dynalock Ascent Carbon
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The MSR Dynalock Ascent Carbon is a versatile, sturdy, and comfortable pair of poles.

Best aluminum Leki Makalu Lite Leki Makalu Lite
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The Leki Makalu Lite will hold up through months-long treks over all sorts of terrain.

Many dedicated backpackers consider a quality pair of trekking poles essential gear for hiking. They help you hike and keep your balance over steep hills, rocky paths, and slippery snow-covered trails. Like their predecessor, the humble walking stick, a quality pair of hiking poles are sturdy enough to put your entire weight on them, yet light enough that they do not feel like a burden after a long day on the trail. They ease the strain on your knees and back, especially if you’re carrying a heavy pack. There are a dizzying number of poles to choose from. They’re made from different materials, feature different designs, and, of course, some are more expensive than others. We’ve tried a whole bunch of popular options, taking them on runs, hikes, climbs, and scrambles to find the best trekking poles for all your outdoor adventures.

How we picked the best trekking poles 

I’ve been writing about outdoor gear and my often dubious adventure travel for decades at publications like Hearst, HuffPost, BBC Travel, Fodor’s, Adventure Cycling, Input, and many others. My criteria for experiencing new places usually include how many people visit (the fewer the better), and if it has a reputation as a “challenging” journey. Over the years, I’ve traveled across all kinds of terrain and environments, many of which required a good set of trekking poles to navigate.

I’ve spent a good deal of time testing trekking poles—walking, running, climbing, scrambling, and sometimes falling—all over the world. Over the years, I’ve found a few favorites. I’ve also compared notes and talked for hours with trekkers, hikers, and adventurers about gear around countless campfires and well-worn tables in questionable bars.

The best trekking poles: Reviews & Recommendations

Like most outdoor gear, trekking pole preference can vary from person to person. Given that, our recommendations span a variety of options made from different materials and covering a wide range of prices. All of them, however, have a clear edge over similar poles in important qualities like durability and weight.

Best overall: Black Diamond Alpine FLZ

Black Diamond

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Buy it used or refurbished: eBay

Why it made the cut: The Black Diamond Alpine FLZ is a highly versatile pole that packs down small, making it a prime choice for all kinds of activities.

Specs

  • Weight: 18 ounces
  • Maximum length: 43, 49, or 55 inches
  • Collapsed length: 14, 15, or 16 inches
  • Shaft material: Aluminum
  • Grip material: Cork
  • Pole design: Foldable
  • Tips: Carbide tips, trail baskets, snow baskets, rubber tips (sold separately)

Pros

  • Versatile
  • Comfortable handles
  • Packable

Cons

  • Heavy

The Black Diamond Alpine FLZ is an incredibly versatile trekking pole. The small packable size and durable aluminum construction make it an optimal pole for most everything including rugged trekking, multi-day backpacking, steep hiking, and even backcountry skiing. The cork handles become increasingly more comfortable over time as well as a secondary foam grip.

While a telescoping pole is inherently stronger than a foldable one, I’ve found the Alpine FLZ holds up extremely well in a variety of precarious situations including nefarious water crossings and muddy sheer drop-offs. They feature Black Diamond’s patented Flicklock pro locking mechanism, which uses a lever to secure the pole length with an inner adjustable tension dial that requires a small Allen key to adjust.

The Black Diamond Alpine FLZ is far from the fanciest pair of trekking poles out there but has proven that it can get the job done in difficult situations, and feels comfortable on easy trail hikes.

Best carbon fiber: MSR Dynalock Ascent Carbon

MSR

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Why it made the cut: The MSR Dynalock Ascent Carbon is a versatile, sturdy, and comfortable pair of poles that work for a wide variety of adventures.

Specs

  • Weight: 17 ounces
  • Maximum length: 47 inches or 55 inches
  • Collapsed length: 14.25 inches or 17.5 inches
  • Shaft material: Carbon fiber
  • Grip material: EVA foam
  • Pole design: Collapsible
  • Tips: Winter and summer baskets

Pros

  • Comfortable grip
  • Versatile
  • Small pack size

Cons

  • Expensive
  • Heavy for a carbon pole

My friend Ben has been almost everywhere on the globe and he always travels with his MSR Dynalock Ascent carbon poles, which he considers an extension of himself and one of the best gear spurges he’s ever made (it may also be the only one).

The Dynalock Ascent poles have comfortable, contoured foam grip handles and padded straps. Each one folds down to a very packable 14.25-17 inches, depending on which size you get. Unlike most other poles where most of the tips are sold separately, these come with both winter and summer basket tips. 

They also feature MSR’s signature Dynalock mechanism, which consists of a thick aluminum lever and an inner metal dial that allows you to tighten or loosen with ease as well as providing exceptional sturdiness. It also locks each section into place with metal buttons on the sides. As someone who often has “Final Destination”-type scenarios running through my brain, I appreciate both of these components. 

Best aluminum: Leki Makalu Lite

REI

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Buy it used or refurbished: eBay

Why it made the cut: The Leki Makalu Lite is one of the most durable poles I’ve tried.

Specs

  • Weight: 17.3 ounces
  • Maximum length: 54 inches
  • Collapsed length: 26 inches
  • Shaft material: Aluminum
  • Grip material: Cork
  • Pole design: Collapsible
  • Tips: Carbide tips, summer basket

Pros

  • Comfortable
  • Extremely durable
  • Moderate price

Cons

  • Large packed size

If you’re planning to use your trekking poles on a weeks-long adventure, Leki’s Makalu Lite poles are among the most durable we’ve found. Despite the name, they’re slightly thicker than most other poles, making them tremendously strong, as well as fairly heavy.

The Makalu Lite features Leki’s very comfortable “Aergon Air” grip—a cork design with a hollow core and wide support at a lightly tilted ergonomic angle. Like all Leki poles, these use the company’s durable “Speed Lock” system, which combines a lever lock with a small dial to tighten spring tension by hand.

A pair of Makalu Lites is overkill for your average day hike, but their durability is worth the extra weight on a long trip where you’ll traverse mountains or glacial ice for weeks or months.

Best for hiking: Black Diamond Alpine Carbon Cork

Black Diamond

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Buy it used or refurbished: eBay

Why it made the cut: The Black Diamond Alpine Carbon Cork is an incredibly sturdy carbon pole with a very comfortable grip.

Specs

  • Weight: 17 ounces
  • Maximum length: 51 inches
  • Collapsed length: 24 inches
  • Shaft material: Carbon fiber
  • Grip material: Cork
  • Pole design: Collapsible
  • Tips: Carbide tips and trail baskets included; snow baskets sold separately

Pros

  • Comfortable
  • Excellent locking mechanism
  • Durable

Cons

  • Not as packable as other options
  • Expensive

I prefer cork handles over rubber and foam because they mold to your hands over time so, eventually, feel like a seamless extension of your body. The cork handles on Black Diamond’s Alpine carbon poles are quite comfortable right out of the box and improve exponentially over time. Like most trekking poles, they have a secondary foam grip beneath the handles, which gives you a comfortable place to grab when you need to lower your grip, as well as wide wrist straps.

They are amazingly durable and sturdy for a carbon pole, thanks to their thicker shafts and Black Diamond’s patented “Flicklock” mechanism, which flips into place with a robust snap. The “Flicklock” system has its disadvantages: The locking mechanism requires a tiny Allen key to adjust, which isn’t ideal since it’s easily misplaced. Not being the most graceful person, (especially when hiking) I routinely get my poles stuck between boulders requiring intense back-and-forth movement to dislodge. Despite this, I have yet to break them.

The collapsed length of these poles means they’re not well-suited to be stowed in a backpack during a technical climb but for most activities, including trekking over rock and snow in remote regions of the world, these poles are a solid choice that will last for years.

Best for backpacking: Black Diamond Trail Ergo Cork

Black Diamond

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Buy it used or refurbished: eBay

Why it made the cut: The Black Diamond Trail Ergo Cork is a solid, affordable option that’s durable enough to handle most backpacking trips.

Specs

  • Weight: 18 ounces
  • Maximum length: 55 inches
  • Collapsed length: 27 inches
  • Shaft material: Aluminum
  • Grip material: Cork
  • Pole design: Collapsible
  • Tips: Carbide tips, trekking baskets, and snow baskets

Pros

  • Comfortable
  • Versatile
  • Reasonable mid-range price

Cons

  • Doesn’t pack down as small as other options

Black Diamond’s Trail Ergo Cork trekking poles are a great pick for new hikers. They’re sturdy, comfortable, and reliable—a great fit for most backpacking and thru-hiking. Plus, at less than $150, they don’t cost a fortune.

 The cork handles are tilted forward slightly for a more natural, ergonomic wrist alignment. They also have padded straps and a foam secondary grip, making them easy to hold. Like the other Black Diamond hiking poles on our list, these feature the company’s patented “Flicklock” system, ensuring they don’t come loose while you’re walking.

Collapsing to a fairly large 27 inches, they are longer than the majority of other poles when packed away. Unless you’re taking them on a plane, though, that probably shouldn’t be too much of an issue.

Best ultralight: Gossamer Gear LT5 Three Piece Carbon

gossamer gear

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Why it made the cut: The Gossamer Gear LT5 is one of the lightest trekking poles available.

Specs

  • Weight: 10.6 ounces
  • Maximum length: 51 inches
  • Collapsed length: 23.5 inches
  • Shaft material: Carbon fiber
  • Grip material: EVA foam
  • Pole design: Collapsible
  • Tips: Carbide tips

Pros

  • Comfortable
  • Ultralight
  • Extremely durable for their weight

Cons

  • Expensive

For situations where every ounce (or even gram) counts, the ultralight Gossamer Gear LT5 carbon trekking poles streamline your experience better than any other poles. Despite weighing less than 11 ounces, they’re incredibly durable. I used them on a multi-week thru-hike over mixed terrain through a good portion of northern Spain one summer where I was intent on carrying as little weight as possible, both emotionally and physically, and they didn’t let me down.

The twist-lock mechanism is easy to set; you simply rotate the sections for a secure lock. The wrist straps sport comfortable padding and the EVA foam handles have proven to be comfortable enough (though I am partial to cork handles).

The LT5s also serve as great support for ultralight tents that use trekking poles as part of the structure, thus providing a super lightweight sleep system.

Best budget: Trekology Trek-Z

TREKOLOGY

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Buy it used or refurbished: eBay

Why it made the cut: The Trekology Trek-Z is an incredibly inexpensive pole that doesn’t sacrifice comfort or durability.

Specs

  • Weight: 26 ounces
  • Maximum length: 51 inches
  • Collapsed length: 15 inches
  • Shaft material: Aluminum
  • Grip material: Cork
  • Pole design: Foldable
  • Tips: Carbide, rubber, snow baskets, mud stops, rubber feet

Pros

  • Inexpensive
  • Durable
  • Folds down small

Cons

  • Heavy

Made from aerospace-grade 7075 aluminum alloy, the Trekology Trek-Z is an inexpensive pair of poles that come complete with carbide tips, rubber tips, snow baskets, mud stops, and rubber feet, making them highly adaptable and a huge bargain. They feature a metal flip-lock mechanism that’s easy to operate, though you may not use it often since they offer a very limited 7-inch range. They do collapse into a very compact 15-inch package, though.

For less than $50, the Trek-Z is one of the most affordable poles we’ve seen. Unsurprisingly, they’re also among the heaviest. We wouldn’t recommend them for alpine climbing, mountain running, or speed hiking, where you want to be quick and nimble. For those sticking to the trail and not too concerned about their performance, they’re an excellent option for not a lot of money.

One thing to keep in mind: Trekology makes a new “Trek-Z 2.0” with EVA foam grips instead of cork. In general, I prefer cork grips because of the material’s moldable properties, so we’re sticking with the original. Just keep in mind that it may become harder to find in the coming months.

What to consider when buying trekking poles

Finding the perfect trekking pole can be a daunting task. As with all outdoor gear, there are a variety of options to consider. More often than not, finding the “best” choice requires you to balance different strengths and weaknesses based on your personal needs and taste. The lightest trekking poles will rarely be the absolute sturdiest. The strongest poles will likely not be the most packable. To help you figure out what you need, let’s talk about the most important elements of any trekking pole set.

Sizing up your poles

Trekking poles come in different lengths so that any person can find a pair that feels right. At standing position, the grip of the pole should line up with your elbow or, more precisely, with your hands when your elbows are bent at a 90-degree angle. If you’re shopping at home, look for poles that are adjustable to within 20-24 inches shorter than you. For example, I’m 5 feet 6 inches, or 66 inches, so I want poles that you can set to a height between 42-46 inches.

Most modern trekking poles are adjustable to some degree, so there’s a lot of wiggle room if you aren’t sure about what will feel right. Some companies also make fixed-height poles, as they are technically stronger. All of our recommendations are adjustable, though, as we find them to be much more versatile than fixed-length poles. In general, I usually shorten my poles when ascending a steep incline and lengthen them when descending. Collapsible and foldable trekking poles allow the user to change the overall length of the pole as the terrain and situation merit.

Collapsible poles feature a telescoping design, where increasingly narrow sections slide and fit inside each other. Foldable poles have a reinforced cord running through them that holds the sections together when pulled apart while allowing them to fold—like the pole technology used in most lightweight tents. 

Telescoping poles will be stronger than their foldable counterparts because, in most cases, the pole overlaps and slides into itself at a greater distance than foldable ones. A fixed-length pole will be the most durable option, though, as there are no weak points or breaks in the shaft. Many poles now feature one telescoping section coupled with two folding sections to offer more precise adjustment options.

Pole material

Most trekking poles are made from either high-grade aluminum or carbon fiber. Carbon fiber produces a lighter pole, while sacrificing a bit of durability. Under intense stress, a carbon fiber pole will likely snap. Aluminum poles, by contrast, will usually bend before they break, giving you a bit of a warning that you should navigate out of that particular situation right away if at all possible. 

If you’re looking for speed and/or the ability to go long distances, a carbon pole is probably your best choice. If you’re okay with a slightly heavier pole (and we’re usually talking ounces here, not pounds), an aluminum pole may be a better fit for difficult terrain and will last a bit longer.

Check the grip

You’re going to spend a long time holding your trekking poles’ grips, so you want to make sure that they’re comfortable. You should take a look at the grip and, ideally, give it a squeeze to see how it feels in your hand.

Most pole grips are made from cork, foam, or rubber. I prefer cork because the material molds to the shape of your hand over time. Grips made with EVA foam are also often quite comfortable and weigh a bit less than cork. Rubber grips absorb shock exceptionally well, but can get sticky and cause blisters when it’s hot and humid out.

Tips

Trekking poles come with different kinds of tips on the end, which can help you move across different kinds of terrain. Many poles, including our recommendations, either come with multiple sets of pole tips or give you the opportunity to buy alternate tips or replacements when you need them. (You should replace your tips every 1,500-2,000 miles.) Most pole tips have a screw-on mechanism, so it’s easy to change them on the fly, so it’s nice to have multiple options on your trip. Here are some of the most common choices:

Rubber tips provide extra grip on wet surfaces, as well as shock absorption on paved surfaces. Since they’re softer and less pointy, rubber tips don’t tear up trails as much as carbide tips, but also don’t provide as much traction.

Carbide tips are extremely durable. They don’t wear down as quickly as rubber versions. With a sharper point, they grip well on rock, dirt, and ice, allowing you to really dig into surfaces. They’ll also rip up soft dirt, so they may damage hiking trails.

Rubber feet have a shape that resembles a small foot. With a wider footprint, they allow you to move faster without losing your balance.

Mud baskets attach a few inches above the tip of your poles and prevent your poles from sinking down too far into soft, muddy earth. They can also prevent some of the mud from splattering onto your calves. Like carbide tips, though, they can damage plant life on trails, so you should reserve them for appropriate terrain.

Snow baskets are a wider version of mud baskets made for snow. They function like snowshoes, keeping your poles near the surface of deep snow.

Locking mechanism

If you follow my lead and go with adjustable poles, you should take a closer look at how it opens and closes. Most adjustable trekking poles feature a locking mechanism with a lever that opens or closes to slide the pole length up or down, coupled with a push button lock or spring-loaded twist lock. Many also include an inner dial in the lever to increase or decrease tension. When considering a pole, check to make sure it’s easy to adjust the poles and operate the lock with or without gloves. If you buy poles that require special tools to change spring tension, make sure those are included. You want a pole that you can easily adjust when out on the trail but also locks securely.

FAQs

Q: How much do the best trekking poles cost?

Most trekking poles cost $50-$250, depending on what they’re made from, versatility, comfort, durability, and weight. Generally speaking, the lighter the pole, the higher the price tag. When choosing hiking poles, remember that they need to be light enough to lift and carry all day without tiring you out on a hike, but strong enough to support your body weight.

Q: Where do I recycle my trekking poles?

If they are in good working condition without structural damage, you can often recycle a pair of trekking poles through a gear trade-in program like the one offered by REI. If they aren’t reusable, you can put aluminum poles out with your household metal recycling.

Carbon fiber trekking poles aren’t recyclable. There are companies who are developing ways to recycle it, but it’s not a process that is easy or currently available to the general public.

Q: Are trekking poles bad for trails?

Trekking poles can be bad for trails as they have the potential to tear up soft soil and damage plants growing along the trailside. Pay close attention to where you place your poles, and stick to hiking best practices, including the following:

Don’t use your poles when you don’t need them. Use rubber tips as much as possible. In an area with tense vegetation, avoid using baskets that will rip up plant life. And finally, make sure to leave no trace.

Q: Do carbon fiber trekking poles break?

Carbon trekking poles can break, though it’s usually a result of extreme pressure. It doesn’t happen often enough for them to be considered unsafe. 

Originally developed for the aerospace industry, carbon fiber is lightweight, strong, and stiff made from woven fibers held together with resin. It is stronger than even steel of the same thickness while also being much lighter which is why it’s used to make things like trekking poles and bicycles.

Final thoughts on the best trekking poles

Outdoor gear companies are always finding ways to build sturdier, lighter trekking poles, but I find that you don’t need to get too worried about the particulars. As long as you get a pair that’s sturdy, comfortable to hold, and light enough to use all day, you shouldn’t worry too much about optimizing for the “best” experience. More than anything, you want something reliable. All of the poles included here are durable and comfortable with the potential to be that favorite piece of gear you don’t leave for an adventure without.

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Inventing lager was a huge mistake https://www.popsci.com/health/lager-beer-history-science-biology/ Fri, 28 Apr 2023 19:00:00 +0000 https://www.popsci.com/?p=537459
A bartender pours a light beer into a large glass.
Lager yeast could date back to the Middle Ages, when ale dominated the beer scene. Deposit Photos

The history of the beloved beer is full of yeast, witch trials, and royal spats.

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A bartender pours a light beer into a large glass.
Lager yeast could date back to the Middle Ages, when ale dominated the beer scene. Deposit Photos

Beer is more than one of humanity’s most beloved beverages—it’s also one of its oldest. Recent archaeological discoveries date it back 13,000 years ago in the eastern Mediterranean. It was once considered so sacred that only women could brew it–until witchcraft accusations stopped that in its tracks

[Related: Ancient poop proves that humans have always loved beer and cheese.]

The origins of our favorite types of beers are also starting to come into focus with a fun combination of history and science. A study published April 27 in the journal FEMS Yeast Research reveals a possible origin story for lager beer, a light type of beer produced by bottom-fermenting yeast. It can be pale, dark, or amber in color and pairs well with shellfish, grilled pork, and spicy foods among others.

The research team used historical records, in tandem with evolution and genomics research, and believe that lager likely originated at the court brewery–or Hofbräuhaus–of Maximilian I, the elector of Bavaria.

Lager surpassed ale as the most common beer produced around the turn of the 20th century and over 150 billion liters of lager beer are sold annually around the world. However, the shift from ale to lager started centuries before when a new yeast species Saccharomyces pastorianus or “lager yeast,” popped up in Germany around the end of the Middle Ages. The new yeast was a hybrid species that was the product of mating of top-fermenting ale yeast Saccharomyces cerevisiae and the cold-tolerant Saccharomyces eubayanus around the beginning of the 17th century. 

“Lager is a beer brewed at low temperatures using yeast that are described as bottom-fermenting,” study author and University of Cork microbiologist John Morrissey wrote in The Conversation. “Yeast are single-celled fungi used in brewing to convert maltose to alcohol and carbon dioxide, giving beer its booziness and fizz. They are either top- or bottom-fermenting.”

S. pastorianus is a bottom-fermenting lager yeast, and its origins have been “shrouded in mystery and controversy,” according to Morrissey. The assumption was that the hybrid yeast arose when traditional ale fermentation became contaminated with wild yeasts. However, the team on this study doubted this historic assumption, and used detailed analysis of Central European historical brewing records to dig in more. They discovered that “lager-style” bottom fermentation was actually happening in Bavaria 200 years before the hybrid S. pastorianus yeast was born.

The team believes that it was actually the top-fermenting ale yeast S. cerevisiae that contaminated a batch of beer brewed with the cold-tolerant S. eubayanus. They believe that the source of the contaminating yeast was a wheat brewery in the small Bavarian town of Schwarzach.

[Related: The key to tastier beer might be mutant yeast—with notes of banana.]

“Bottom fermentation originated in northern Bavaria. Not only was it common practice in this part of Germany, but the Bavarian Reinheitsgebot brewing regulations of 1516 only permitted bottom fermentation. Thus, from at least the 16th century onwards, Bavarian brown beer was produced by mixtures of different bottom-fermenting yeast species known as stellhefen,” wrote Morrissey.

However, in neighboring Bohemia, excellent wheat beer made with S. cerevisiae was made in huge quantities and imported into Bavaria. To limit the blow to the economy from these imports, Bavarian ruler Wilhelm IV gave Baron Hans VI von Degenberg a special privilege to brew and sell wheat beer in the border regions to Bohemia in 1548.

Maximilian I eventually took power in 1602, and he seized the wheat beer privilege himself and took over the von Degenbergs’ Schwarzach breweries. The team believes that it was in October 1602 that the yeast from the wheat brewery was brought to the court brewery in Munich where the hybridization took place and lager yeast S. pastorianus was born.

“This theory is consistent with published genetic evidence showing that the S. cerevisiae parent of S. pastorianus was closer to ones used to brew wheat beer than strains used for barley-based ale,” wrote Morrissey.

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A cutting-edge appetite stimulator was inspired by the thorny devil lizard https://www.popsci.com/technology/thorny-devil-lizard-gut-health/ Fri, 28 Apr 2023 15:00:00 +0000 https://www.popsci.com/?p=537523
Side by side of Australian thorny devil lizard and ingestible medical capsule
The thorny devil lizard's moisture wicking skin inspired a new ingestible medical device. Deposit Photos/MIT/Popular Science

The spiky reptile's unique hydration methods helped craft a brand-new fluid-wicking stomach tool.

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Side by side of Australian thorny devil lizard and ingestible medical capsule
The thorny devil lizard's moisture wicking skin inspired a new ingestible medical device. Deposit Photos/MIT/Popular Science

Your stomach is extremely moody—at any given time, a complex interplay of factors such as hormone production and various neurological signals can leave you feeling hungry, overstuffed, excited, or nauseous. These experiences stem directly from the enteric nervous system (ENS), which controls gastrointestinal tract functions along a path known as the gut-brain axis. The ENS is so complex, in fact, that it is often referred to as your “second brain.”

Because of this, there are a number of ways for things to go sideways, resulting in issues such as suppressed appetites and slow digestion. Recently, however, researchers developed a first-of-its-kind treatment to help spur hunger via stimulating hormone levels in the gut—an “electroceutical” ingestible capsule inspired by a “water wicking” reptile.

In a new paper published by a team of scientists at NYU Abu Dhabi working alongside experts at MIT, the team explored a novel way to “significantly and repeatedly” induce the production of ghrelin, a hormone that triggers hunger. To accomplish this, they looked to the Australian thorny devil lizard, whose spiky skin is evolved to transport any water it touches towards the reptile’s mouth. Similarly, the research team’s ingestible device features a grooved, hydrophilic exterior designed to defer fluids away from the stomach’s inner lining. When this occurs, the pill-shaped tool’s electrodes come into direct contact with the tissue to produce a tiny current stimulating ghrelin production.

[Related: Doctors need to change the way they treat obesity.]

Dan Azagury, an associate professor and Chief of Minimally Invasive and Bariatric Surgery at Stanford University who was not involved in the study, admired the new device, and said they found the findings “really intriguing.”

“I love the creativity of the device, the idea, and how they found a way to get around the fluid constraints,” Azagury said via email, but cautioned that “even if that works, the path for this to show clinical efficacy in a disease as complex as obesity, is very, very challenging.”

Azagury points towards experts’ still relatively poor understanding of gut hormones and the gut-brain axis, which are “more complex than we think, and likely underutilized.” As an example, he offered that the “new blockbuster drugs” used to treat obesity are based on gut hormones only discovered in the 1980s, far after doctors had begun performing weight loss surgeries.

Although Azagury estimates there is a “long road ahead” before the device is commercially used to treat diseases, its creators are more optimistic. “It’s a relatively simple device,” Giovanni Traverso, an associate professor of mechanical engineering at MIT and gastroenterologist at Brigham and Women’s Hospital, and the senior author of the study, argued in a statement for MIT. “So we believe it’s something that we can get into humans on a relatively quick time scale.”

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Do children really need root canals? https://www.popsci.com/health/root-canal-dentistry-children/ Fri, 28 Apr 2023 01:00:00 +0000 https://www.popsci.com/?p=537163
Deciding how to treat young patients in dentistry isn’t always straightforward, and the challenge is compounded by a relative lack of evidence and clinical guidance.
Deciding how to treat young patients in dentistry isn’t always straightforward, and the challenge is compounded by a relative lack of evidence and clinical guidance. Getty Images

Insurance reimbursements tend to incentivize intervention over prevention, which isn’t always supported by evidence.

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Deciding how to treat young patients in dentistry isn’t always straightforward, and the challenge is compounded by a relative lack of evidence and clinical guidance.
Deciding how to treat young patients in dentistry isn’t always straightforward, and the challenge is compounded by a relative lack of evidence and clinical guidance. Getty Images

This article was originally published on Undark.

When a dentist told Corrine Rivera that her 7-year-old daughter needed a baby root canal at her routine checkup, Rivera didn’t understand that “baby” was describing the tooth, not the size of the procedure. She imagined it was like a baby ice cream cone — less than what an adult gets, just a little bit of a root canal. Rivera’s daughter had yet to have any dental interventions other than cleanings, so Rivera didn’t realize what she was in for.

The dentist, Rivera recalled, proceeded with the root canal right then and there. It was painful for her daughter, who had to endure large tools in her mouth for the unexpected hour-and-a-half long procedure, and distressing for Rivera. “I just wanted what was best for my daughter’s teeth at the time,” she said about that 2017 experience at Pediatric Dentistry of Albany, in New York state. “Unfortunately,” she added, “having the procedure led to a hell of a lot more problems.”

 

A few months later, Rivera said her daughter developed an infection, and a new dentist at a different practice explained to her that a baby root canal, or pulpotomy, is a root canal on a baby tooth, not a “mini” procedure.

Rivera remains skeptical that her daughter needed a root canal in the first place, and state and federal prosecutors, it turns out, later responded to allegations that other pulpotomy cases in that same dental practice had been medically unnecessary. In October 2022, Pediatric Dentistry of Albany and 12 affiliated clinics — all operated by pediatric dentist Barry L. Jacobson and his company, HQRC Management Services, LLC — reached a settlement of more than $750,000 with the New York State Attorney General’s Medicaid Fraud Control Unit and the United States Attorney’s Office for the District of New Jersey.

The state and federal investigation was spurred by a 2017 whistleblower lawsuit filed by a former manager of five of Jacobson’s upstate New York locations. The former employee alleged that staff at the clinics performed unnessary procedures, and were pressured to increase the number of patients and procedures in order to meet a $180,000-per-month revenue goal.

A spokesperson for HQRC declined to comment on specific claims from the complaint, but insisted that the settlement did not suggest that dental care provided by the company’s practitioners was inappropriate; rather, that the recordkeeping needed to support a limited number of specific procedures was lacking. “HQRC has steadfastly denied these allegations,” the spokesperson stated, adding that the company has “cooperated fully with the five-year government investigation that followed, and ultimately settled over record keeping and billing issues that occurred at a few of its offices several years ago that have long ago been addressed and corrected.”  

According to the settlement agreement, Jacobson and his company admitted that “in some instances, between 2011 and 2018, some dentists affiliated with HQRC performed and billed Medicaid for therapeutic pulpotomies not supported by the medical records maintained at the respective HQRC affiliated dental practices.”

New York state officials have not revealed the exact number of investigated procedures performed under the HQRC umbrella, and the experience of Rivera and her daughter was not, at least to Rivera’s knowledge, scrutinized as part of the lawsuit and subsequent settlement. This could mean that despite their experience, this particular “baby root canal” was medically necessary.

And according to experts who spoke to Undark, while some patients are likely to get more treatment than others, the main goal of pediatric dentistry is to promote oral hygiene, mediate pain, and keep baby teeth healthy until the adult teeth come in, said Donald Chi, a pediatric dentist and professor of oral health sciences at the University of Washington.

This persistently murky tableau of incomplete science and financial incentivizing, alongside worrying lawsuits, can cast a shadow on a whole profession, some experts say.

Still, deciding how to treat young patients in dentistry isn’t always straightforward, and the challenge is compounded by a relative lack of evidence and clinical guidance, compared to other medical research. Dentistry research is far smaller in scope and often plagued by funding biases. And while there’s good evidence that less invasive alternatives to fillings work well in kids, those alternatives haven’t been as widely adopted. Several dental experts also stressed to Undark that not every case is not the same — what might work well for one child may not work for another.

Worsening the problem, experts say there’s a strong economic incentive to focus on interventions, especially at practices that serve Medicaid or the Children’s Health Insurance Program, also called CHIP, which have exceptionally low reimbursement rates in many states. This may lead some practices to turn to private equity firms, which gives investment companies a hand in the operations of medical practice and may incentivize unnecessary treatments. (A private equity firm invested in HQRC Management. According to the plaintiff’s complaint, the practices’ revenue was mainly from Medicaid.)

This persistently murky tableau of incomplete science and financial incentivizing, alongside worrying lawsuits, can cast a shadow on a whole profession, some experts say. And it leaves patients like Rivera to wonder and worry whether their own children’s dental interventions were rooted in good-faith medical decision making, or something else entirely.


Baby teeth are, of course, temporary. And anyone who has ever tried to brush a reluctant toddler’s teeth knows firsthand that those tiny molars don’t always get high-quality home care. But their impermanence doesn’t mean that care isn’t important — if those teeth get ignored, it’s likely to cause problems with adult teeth later on.

As a specialty, pediatric dentistry is a little more than a century old. In 1909, about 70 years after the first U.S. dentistry college opened, a dentist named Minnie Evangeline Jordon established the first practice just for children. A few years later, she wrote that her male colleagues were glad to be rid of their pediatric patients “so that they could settle down to the serious work of dentistry — the making of bridges and plates.”

Today, although any dentist can treat kids, there is a thriving subspecialty of practices specializing in pediatric dentistry. There are more than 200,000 dentists in the country, about 8,000 of whom are pediatric specialists — a full-fledged discipline, with specialized training, a national professional organization, and journals like Pediatric Dentistry Journal and Journal of Clinical Pediatric Dentistry, where dentists publish their research into best practices into the field. Some of that research has bolstered longstanding claims: Regular brushing with fluoride toothpaste helps prevent cavities, early dental visits (before age four) reduce the amount of treatment needed later, and fluoride treatments such as gels, varnish, and mouth rinses may be valuable.

These measures are engaged in a sustained battle with the bacteria that create acids that corrode teeth. By physically removing stuck food that feeds the bacteria, and by strengthening the enamel with fluoride, these measures can prevent cavities and the proliferation of the decay-causing bacteria that can linger in a child’s mouth far past when their baby teeth fall out.

 

But, some experts say, it’s difficult for dentists to translate pediatric dentistry research to practice. Review articles, which evaluate a body of research on a particular subject, conclude that findings regarding pediatric dentistry have low certainty. For one thing, much of the relevant research that does exist has a high risk of bias, according to Shaun Sellars, a general dentist in Suffolk in the United Kingdom, because it is paid for by players in the industry, such as manufacturers of dental materials. Dentists “don’t do a lot of practice-based research either,” said Sellars, who is also the ethics columnist for the British Dental Journal. “There’s the funding issue there,” he added. “Because dentists, if they’re not hands in mouth, they’re not making money.”

Still, research on evidence-based practices and technology are advancing, and quickly. In dentistry schools “half of what we teach is out of date in five years,” said David Johnsen, a professor of dentistry at the University of Iowa. This can make it hard for providers to keep up with new findings. According to Sellars, many dentists face barriers to making evidence-based decisions, such as not having enough time to follow new studies or not having access to research articles behind paywalls. And even if dentists do read the literature, Sellars said, “not enough of it is relevant to what we actually do in practice.” Oftentimes, he added, “dentists will find what works for them, or what they believe works for them, and just continue to apply that.”

Recently, research has called into question common procedures used to fight cavities in kids. Evidence shows that fillings aren’t necessarily better than noninvasive alternatives, such as silver diamine fluoride, an inexpensive liquid that can slow decay, or caps that can be pushed onto the tooth (sometimes called the “Hall Technique”). Neither of these alternatives require drilling, filing down a tooth, or using anesthetics, said Nicola Innes, a professor of pediatric dentistry at Cardiff University.

Sellars lamented that there aren’t many resources, such as clinical guidelines, that would help dentists navigate the complex situations they face every day in an evidence-based way.

Dentistry decisions aren’t always straightforward. There are a wide range of approaches over how to treat dental cavities — one of the most common disease treatments in a dental office — in kids, including the kind of baby root canal that Rivera’s daughter received. As Johnsen put it: “If you get 10 really good dentists around a patient or a case and you say, ‘What’s the right treatment plan?’ you may get six or 10 or 11 different opinions.”


When a child comes in to see a dentist with a cavity, deciding how to treat a child’s cavity can be complicated, Chi told Undark. The dentist has to consider: How deep is the cavity? How much has it progressed since the patient’s last visit? Does the child appear to have regular brushing habits? Does the child have a risk factor for tooth decay? Might the tooth fall out soon?

If the cavity is not too deep and the tooth might fall out soon, the dentist might opt to do nothing and check again in six months. Or the dentist might slow the decay by painting on diamine fluoride to halt or slow decay (a downside: the material stains the tooth black).

If a dentist believes the cavity needs more intervention, many may choose fillings. “The problem with fillings is that they don’t do very well in children’s teeth,” said Innes, because baby teeth are small and wet, and kids tend to wiggle. Injecting anesthesia and drilling can also be unpleasant. There’s solid evidence, from her research and others, that fillings aren’t necessarily better than the noninvasive alternatives: silver diamine fluoride or caps.

When a cavity becomes so deep that a tooth’s pulp becomes infected, options include pulling the tooth or performing a root canal. Both have downsides, Innes said. A gap left from a pulled tooth can allow teeth to twist and migrate, which can lead to a need for orthodontia later. For a root canal, a child needs to be able to sit for a long time, first during the root canal and again when the tooth is shaved down and a crown is put on. Baby root canals come with a risk of infection, as Rivera said happened with her daughter in New York state. For instance, the Centers for Disease Control and Prevention recently issued a health advisory because multiple outbreaks of nontuberculous mycobacteria infections have occurred in children who received pulpotomies in pediatric dental clinics where the dental treatment water contained high levels of bacteria.

For many children, extensive dental work such as multiple root canals or fillings may require general anesthesia. But it’s uncomfortable to have a tooth pulled, even when a child is anesthetized and the procedure is painless, Innes said.

Anesthesia is also expensive, and it can have real risks for kids, including, in very rare cases, serious injury and death. More commonly in the short term, “they can have some attachment disorders, some night terrors, bedwetting, things like that,” said Innes. “And in the longer term, there was a very small amount of evidence that it probably doesn’t do them any good neurologically.”


Most dental treatments, several experts stressed to Undark, should be preventative. “I’d much rather spend my time telling people and helping people remain healthy than treating someone for a root canal, said Margherita Fontana, a professor at the University of Michigan School of Dentistry, adding: “They’re not having fun, and I’m not having fun. I mean, it’s not a fun thing to do to something to someone that you know is in pain.”

Unfortunately, Fontana said, there’s little data to indicate which patients are most at risk for dental disease, and how to best prevent it. “We need better prediction tools, in general, for children and for adults,” she added. “Many times, we are reactive to the damage rather than trying to prevent the damage.”

Part of the issue of prioritizing prevention, Fontana and other experts say, is an incentive system that offers few rewards for prevention-centered approaches — and large payouts for interventions.

Fontana’s research focuses on predicting dental health risks and using easy interventions like silver diamine fluoride, but generally requires routine dental visits to keep an eye on whether the cavity is progressing.

“The problem with fillings is that they don’t do very well in children’s teeth,” said Innes, because baby teeth are small and wet, and kids tend to wiggle.

“I just have happy kids sitting in the chair. I’m doing things and testing things that I think are going to be super easy, fast, and accessible,” she said. “But then I know that at the time to get translated into practice is going to be difficult, because there’s no good way for people to get reimbursed to do those things.”

When more robust research supports a particular dentistry tool or technique, there may still be financial barriers for widespread use. In many states in the U.S., less invasive treatments and preventative measures, including fluoride varnish and silver diamine fluoride, are reimbursed at a much lower rate than more invasive ones, which may make them less likely to be adopted into practices. And dentists don’t get paid at all for taking time to walk a patient through their potential treatment options. If dentists “don’t physically do something in your mouth, they do not get reimbursed,” said Fontana.

Reimbursement can be particularly difficult for dentists who accept Medicaid or the Children’s Health Insurance Program, which serve more than 41 million kids and tend to have much lower reimbursement rates than private insurance or private pay rates. While overhead costs are increasing due to inflation, data indicate that Medicaid reimbursement rates have failed to keep up. Those problems can be especially acute in practices that are under pressure from owners or investors to make cash.

“You’re fighting a system where the driver is doing something — dentists don’t get paid to prevent disease,” Fontana added. “I don’t think it’s ever going to change if the system doesn’t change.”


With low reimbursement rates for preventative measures like cleanings and fluoride applications, it’s hard to imagine how pediatric dentists earn more than general dentists. But Chi said that a key component of pediatric dentistry “is to provide high quality care as quickly as possible. And the main reason for that is that children have short attention spans.” That also means that a pediatric dentist can potentially book more patients in a day than a general dentist can, which may lead to more income.

Dentists that accept Medicaid or CHIP face other challenges in billing and running a practice. Medicaid is a joint federal-state program, but it varies from state to state, explained Jason Ray, a Texas lawyer with experience in Medicaid dentistry-related lawsuits. In addition to low reimbursement rates, some Medicaid programs also require dentists to do more paperwork than the state’s dental board generally does, such as getting consent for each visit and each procedure, which could add to administrative costs. Medicaid audits can also be time consuming.

Ideally, a dentist would have a mix of patients, some who pay with private insurance, others out-of-pocket, and some Medicaid patients. However, dentists often don’t achieve a good balance. Research shows that dentists who treat more Medicaid patients are more likely to be located in a majority non-White zip code, a rural area, or high-poverty zip code. Because of Medicaid’s low reimbursement rates, Ray pointed out, one way for a dentist to make money is to see a high number of patients and do a large number of procedures.

There’s no doubt that this could lead to incentives to do procedures that may not be necessary, Ray said. An analysis of California’s Medicaid program in 2012 indicated that about 8 percent of dentists reviewed that provided Medicaid services to children met certain thresholds for questionable billing. The average general dentist performs root canals on 5 percent of pediatric patients. In the sample reviewed, the threshold of questionable billing was 18 percent, which about 2 percent of the Medicaid dentists exceeded.

A 2022 analysis of dentists found that about 33 percent treat at least one Medicaid patient. Those that do may also be tempted by the offers of private equity firms, which can lead to big payouts, but might also encourage practices to prioritize profits over evidence-based care. (Firms often don’t pay penalties in cases of fraud.) A 2013 report prepared by a U.S. Senate committee noted that corporate-managed “clinics tend to focus on low-income children eligible for Medicaid. However, these clinics have been cited for conducting unnecessary treatments.”

Whether Rivera’s daughter’s procedure was one of those unnecessary treatments is something that she and her family may never truly know. But she told Undark that the experience has left her rattled — even though she and her daughter, now 13, have found a Medicaid-accepting dental practice that they say they’re generally happy with.

Still, Rivera says that ever since her daughter received that “baby root canal” six years ago, she has deeply hated going to the dentist. “She remembers that day,” Rivera said, “very clearly.”


Christina Szalinski is a freelance science writer with a Ph.D. in cell biology based near Philadelphia.

This article was originally published on Undark. Read the original article.

Medicine photo

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Walking correctly takes work—here’s how to improve every step https://www.popsci.com/story/health/how-to-walk-correctly/ Fri, 22 May 2020 18:57:21 +0000 https://www.popsci.com/uncategorized/how-to-walk-correctly/
Walking
Each step happens in two parts. Stan Horaczek

Experts explain how to make the most of your daily strolls.

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Walking
Each step happens in two parts. Stan Horaczek

Chances are, you learned to walk when you were just a toddler and you haven’t really thought about it much since. It’s easy to nerd out on other fitness activities, like running or weight lifting. But, walking is something we often take for granted.

During the COVID-19 pandemic, however, walking leveled up as an essential part of maintaining our mental and physical health. A simple stroll can go a long way to clear the mental cobwebs and stop your fitness tracker from screaming at you due to your Jabba the Hutt lifestyle.

Before you start putting in the miles, it’s worth taking a look at how you walk. After all, it’s a repetitive motion and thousands of steps per day can put a lot of stress on your entire body—not just your legs and feet. Here are some tips from orthopedic experts on how to go for a walk without abusing your body.

Understand the mechanics

Having a clear idea of what a step actually involves can help you visualize how to walk correctly. Every step happens in two phases: stance and swing. Jessica Rose, a professor in the Department of Orthopaedic Surgery at Stanford University and director of the Motion & Gait Analysis Laboratory at the Lucille Packard Children’s Hospital provides the following description: “Typically, the stance phase starts with the leading foot making heel contact with the ground, followed by a heel-toe progression of the weight-bearing foot. The Swing phase starts with rapid hip, knee, and ankle flexion to clear the foot from the ground, the knee then rapidly extends to prepare for the next step. To assist with balance and forward momentum the arms swing in a reciprocal manner, the opposite arm swings forward with the leading foot. A single gait cycle of stance and swing typically lasts about 1-second.” Your brain does all of that instinctually, but understanding the parts can be valuable in assessing where you might have weaknesses and can help doctors assess any pain you’re having.

Pick the right shoes

Choosing the wrong pair of shoes can wreak havoc on your feet, obviously, but those ill-effects can travel all the way up your body. “There’s no perfect shoe for everyone,” says Lew Schon, Director of Orthopedic Innovation Institute of Foot and Ankle Reconstruction at Mercy Medical Center, “but stability is crucial. You don’t want to wear flip-flops or anything that isn’t tight to your foot. They can cause weird stresses and injure your skin.” Blisters from a shoe rubbing against your foot will end your walking initiative in a hurry.

When it comes to padding, though, more isn’t always better. If the sole is too soft, your foot can sink deeply into it and create awkward stresses on your bones and joints and make it difficult to balance. Dr. Schon recommends starting with a standard amount of padding and increasing its thickness if you have a higher body weight. Too much padding, however, can reduce the positive effect the repetitive impacts will have on bone density, which is especially important for older people.

Many shoe makers offer options with corrective structures to try and provide support in needed areas or even correct problems. “You can look at the sole of your shoes and see how your shoes are wearing,” says Wendi Weimar, Director, Sports Biomechanics Laboratory Lab at Auburn. “If they’re wearing too much on the inside, then you might need something that gives you a little more arch support. If they’re wearing more quickly at the heel and causing pain, then you might need a little more cushioning.” She’s careful, however, to explain that it’s not an exact science, especially when you’re doing it on your own. Adding arch support when you have a low arch isn’t necessarily going to fix the issue. A trained orthopedist will use testing and specialized tools.

If you’re unsure about the shape of your step, sticking with a neutral shoe is a good place to start unless you’re having specific pain or are getting a personal assessment.

Tie your shoes correctly

No matter what shoe you buy, tying it correctly will make a big difference in the way it performs. “For a typical eight-eyelet shoe, there are more than 200 ways to tie them based on your feet, walking pattern, and body composition,” says Weimar. “We have tied shoes of people with peripheral neuropathy and it has actually improved the condition. I wouldn’t have believed it if I didn’t see it.”

Weimar suggests starting with a tying pattern known as the runner’s loop, which helps to pull your foot back into the heel of the shoe to reduce its ability to move around. That will drastically cut down on blisters and reduce the chances of an awkward impact on the wrong part of the sole.

Pay attention to whether you’re favoring one side of your body

It’s possible for your body to have an injury that you won’t even notice and that can negatively affect your body with every step. “If you find that you lean to one side, this may indicate weakness, pain or injury on that side,” says Rose. “We lean over to the weak or painful side, shifting our center of mass to alleviate forces on that limb.” That imbalance can cause problems throughout the body.

If you start to recognize an imbalance, professionals don’t recommend trying to fix it by forcing yourself into the right position because that could make it worse. Rather, finding the underlying cause with a doctor can help eliminate the source of the problem rather than simply addressing the symptom.

Stand up straight

Slouching is almost universally bad, but that’s especially true during a walk. “You want to pull your shoulders back, keep your bum tucked underneath you, and your head parallel to the ground,” says Weimar. “When you lift your chin up and stop slouching, it will automatically help bring your head in line with your pelvis.” If you’re used to slouching at a desk all day (like I am) you may actually find that your back, neck, and shoulder muscles feel sore after a long walk since they’re not used to that kind of engagement.

In order to keep your body upright, muscles throughout your body have to activate. “It involves your abdominal muscles as well as your glutei,” says Rose.”They tend to get neglected, but they keep your trunk and pelvis in a good position.” That’s not to say that you have to squeeze your abs and butt as hard as possible as you walk, but they should be engaged, not relaxed.

Keeping your eyes up and parallel to the horizon will also help you keep your balance, which may suffer if you’re staring at a downward angle.

Don’t try to force your feet straight

Your feet likely have a natural angle that prevents them from facing perfectly straight ahead. “Your feet point where your legs tell them to,” says Rose. “It’s not something someone should try to correct on their own, but it is something they should try to understand where it’s coming from.” Forcing your feet forward against their natural rotation can put undue torque on the ankles, hips, and feet.

It can become an issue if you’re pushing off with the wrong part of your foot. ”We want the foot to become the best lever it can be. ” says Weimar. “When you roll off the front of your foot, you want the center of pressure to come off between your big toe and your second toe.” Pushing off too far to one side can cause common issues such as bunions.ei

Choose the right surface and location for walking

A walk around the neighborhood is great if you have the opportunity because it’s quick and doesn’t require driving. But streets aren’t perfectly flat—they’re sloped to improve drainage—and that uneven surface can be an issue in the long term. “Your outside leg strikes the ground lower than your inside leg. That leg close to the curb strikes lower which is going to cause a mismatched pelvic girdle position and get everything out of whack,” says Weimar. “If you walk out on the right side of the road, walk back on the other to try and even those things out.” She also recommends walking on the flatter part of the street instead of directly in the gutter if you can safely avoid it with traffic.

Walking on slightly irregular surfaces like trails can help build strength in the muscles and joints as your legs adapt to the irregular orientations of each strike. Dirt also provides a softer surface that won’t tax your feet and joints as much.

Hit the hills

Going up and down hills during your walk can crank up the cardiovascular benefits of a walk, but the technique changes slightly. “When you walk up a hill, you want to lean into the hill,” says Weimar. “You want your center of gravity to get a little bit in front of your feet so when you step, the propulsion part of your step is pushing your body up the hill.”

Coming down the hill requires a different kind of effort from your muscles. “That uses eccentric muscle action, which tends to be a lot tougher on the muscle than concentric,” says Weimar. “A lot of people will get sore from walking downhill because of that new loading pattern.” She recommends going slow and trying not to stomp your feet too hard into the ground.

Don’t over-stride

Once you’re a more experienced walker, it’s tempting to try and up your pace and distance. But doing too much can cause problems with your stride and limit your workout capabilities. Taking too big of a stride will require your pelvis to rotate too far to step out in front of you. Plus, as Weimar explains, “it puts stress on your lower back and puts a lot of stress on your heel as it impacts the ground. It also takes more energy to get your body up over that lead foot.” Increasing the overall speed of your steps can help you increase your pace without compromising your technique.

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FDA approves first fecal transplant pill https://www.popsci.com/health/fda-approves-first-fecal-transplant-pill/ Thu, 27 Apr 2023 15:00:00 +0000 https://www.popsci.com/?p=537259
A lab technician in a glove swabs a circular petri dish.
Healthy bacteria found in human waste can help fight dangerous infections in the gut. Deposit Photos

The new treatment is simpler and less invasive than other transplants.

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A lab technician in a glove swabs a circular petri dish.
Healthy bacteria found in human waste can help fight dangerous infections in the gut. Deposit Photos

On April 26, the Food and Drug Administration approved the first pill for fecal transplants. The pill is made from healthy bacteria found in human waste which can help fight dangerous infections in the gut.

[Related: The FDA approved a fecal transplant treatment for the first time.]

According to the FDA, the pill from Massachusetts-based Seres Therapeutics provides doctors and patients with a simpler, and rigorously tested version of the procedure that has been used for just over a decade. Previously, when a patient experienced a Clostridium difficile infection or CDI, doctors would perform a fecal transplant using the stool from a healthy donor. Donor bacteria can help restore the balance of bacteria in the gut and prevent reinfections.  

The new treatment will be sold under the brand name Vowst as four daily capsules for three consecutive days. Vowst was cleared for adults 18 and older who face risks from repeat infections from C. diff, and have already received antibiotic treatment. A CDI can cause severe nausea, cramping, and diarrhea, and is dangerous when it reoccurs. CDI’s lead to roughly 15,000 to 30,000 deaths per year

While C. diff can be killed with antibiotics, the drugs can also destroy the beneficial bacteria that live inside the gut, leaving  it more susceptible to infections in the future. People over age 65 are at an increased risk for contracting an infection, but other risk factors include hospitalization, a weakened immune system, and a previous history of infection. Some patients may get the infection again following recovery, and the risk of additional recurrences increases with each infection. 

The FDA approved Vowst based on a study of 180 patients wherein nearly 88 percent of the patients taking the capsules did not experience a reinfection after eight weeks. About 60 percent of those who received dummy pills did see a reinfection. Some of the common side effects included abdominal swelling, constipation and diarrhea.

According to Seres, via reporting from the Associated Press, manufacturing the pills relies on the same techniques and equipment that is used to purify both blood products and other biologic therapies. It starts with stool from a screened group of donors that is tested for potential infections, viruses, and parasites. The samples are then processed to remove the waste and isolate the healthy bacteria,killing any lingering organisms. 

In the approval announcement, the FDA warned that the drug “may carry a risk of transmitting infectious agents. It is also possible for Vowst to contain food allergens.”

[Related: What to know about fecal transplants in the wake of the first death.]

In late 2022, the FDA approved Rebyota, the first pharmaceutical-grade version of a fecal transplant treatment from Ferring Pharmaceuticals. This product must be delivered via the rectum. 

The approvals of both Rebyota and Vowst are the product of years of pharmaceutical research into the bustling community of fungi, bacteria, and viruses that lives in the gut called the microbiome.

A network of stool banks from hospitals and medical institutions across the US have provided most fecal transplants. However, that growing number of fecal transplant practitioners and stool banks around the US has created a regulatory mess for the FDA, since the agency doesn’t traditionally regulate medical procedures performed by doctors. As long as stool donors are carefully screened for any potential infectious diseases, the FDA has rarely intervened in using the procedure.

In response to these new FDA-approved options, the largest stool bank in the US called OpenBiome said it will keep serving the patients like children and adults with treatment-resistant cases who are not eligible for the new treatments. Since 2013, OpenBiome has supplied more than 65,000 stool samples for CDI patients.

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Selfies are for memories, not just for vanity https://www.popsci.com/health/selfie-memory-photography-psychology/ Thu, 27 Apr 2023 14:00:00 +0000 https://www.popsci.com/?p=537227
A group of six young people take a selfie on a beach.
Selfies may be a better way to capture the meaning behind an event. Deposit Photos

Third-person photography like selfies are not always as superficial as they can seem.

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A group of six young people take a selfie on a beach.
Selfies may be a better way to capture the meaning behind an event. Deposit Photos

Love them or loathe them, selfies aren’t going anywhere. Humans are not even alone in this ability to capture themselves in a moment— bears,  and penguins have from time to time posed for a self portrait. These third-person images are an easy way to satisfy the social pressures of “pics or it didn’t happen” or the dreaded FOMO with one single click, but they may also have a deeper psychological component. 

[Related: Understanding the weird Biden-Carter photo could help you take better selfies.]

New research published April 27 in the journal Social Psychological and Personality Science suggests that people use first-person photography—a photo of the scene from their own perspective—when they want to document a physical experience, but opt for third-person photos like selfies where you are in the scene to capture the deeper meaning of an event. 

Earlier research into the psychology of selfies focused on how the photo-taker wants to present themselves, while this new research takes people capturing memories into consideration. 

“Not only do we find that most people take both types of photos in different situations, but that people also differ across situations in whether their goal for taking photo is to capture the physical experience of the moment or the bigger meaning of the moment in their life,” said Zachary Niese, study co-author and psychologist at the University of Tübingen in Germany, in a statement.

The research included six studies involving over 2,100 participants. The team found that when the goal of a photo is to capture meaning, they’re more likely to take a selfie and that they find more meaning looking back at their own third-person photos compared with first-person. 

People also tend to like their photos more when the perspective matches their goal for taking the photo.

“Taking and posting pictures is a part of everyday life for many people. While there is sometimes derision about photo-taking practices in popular culture, personal photos have the potential to help people reconnect to their past experiences and build their self-narratives,” said Niese.

The authors warned against the assumption that photos taken from first or third person perspectives are better than the other. Their analysis shows that the most effective perspective depends more on an individual’s goal in the moment—whether that be to capture a physical experience like taking a tour of a museum or the deeper meaning of an event like a wedding or graduation.

[Related: Take better selfies with these lighting and angle tips.]

Going forward, the more understanding an individual has of the goal when taking a picture and the role that perspective plays in the photos and make amateur photographers better at preserving memories for later. 

“People’s photo-taking practices have the potential to serve a more fundamental human motive to develop and understand our sense of self, both in terms of the experiences in our life as well as their bigger meaning,” said Niese.

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That melatonin gummy might be stronger than you need https://www.popsci.com/health/melatonin-gummy-labels-fda/ Wed, 26 Apr 2023 20:00:00 +0000 https://www.popsci.com/?p=536917
A woman just waking up in bed turns off an analog alarm clock.
Most of the products tested in a new study had 20, 30, or 50 percent more melatonin than the quantity listed on the label. Deposit Photos

A new study found that most of the sampled dietary supplements were mislabled.

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A woman just waking up in bed turns off an analog alarm clock.
Most of the products tested in a new study had 20, 30, or 50 percent more melatonin than the quantity listed on the label. Deposit Photos

Roughly 55,000 adult consumers in the United States  take popular chewy melatonin gummies to promote better sleep. But they may be getting a little more of the hormone than the label indicates. A study published April 25 as a letter in the Journal of the American Medical Association (JAMA) found that 88 percent of tested supplements were mislabeled.

The study follows a Centers for Disease Control and Prevention (CDC) report from last year about an alarming surge of excessive pediatric infestations of melatonin over the past 10 years.

[Related: Yes, you can overdose on melatonin. Here’s how to use the sleep supplements safely.]

Melatonin is a hormone naturally produced deep within the brain in the pineal gland. It  is released into the bloodstream to regulate the body’s natural sleep cycles. Melatonin is considered a drug in some countries in the European Union, Japan, Canada, and the United Kingdom, making it only available through a prescription. The US Food and Drug Administration considers melatonin a dietary supplement, but manufacturers are not required to receive FDA approval or provide safety data on melatonin products.

For this study, a team of researchers from Cambridge Health Alliance in Massachusetts and the University of Mississippi tested 25 different supplements. According to the authors, the team selected the first 25 gummy melatonin products that displayed on the National Institutes of Health database for this study. The team dissolved the gummies and then measured the quantity of melatonin, cannabidiol (CBD), and other components in the supplements.

Most of the products tested had 20, 30, or 50 percent more melatonin than the quantity listed on the label. Four has less amounts of the hormone than promised, including one without any detectable levels of melatonin. 

Twenty-two were “inaccurately labeled,” meaning they contained 10 percent more or less than the amount of melatonin on the label. 

Five products listed CBD as an ingredient, but they all had slightly higher levels of CBD than indicated on the label. According to the FDA, “it is currently illegal to market CBD by adding it to a food or labeling it as a dietary supplement.”

[Related: The science behind our circadian rhythms, and why time changes mess them up.]

“One product contained 347 percent more melatonin than what was actually listed on the label of the gummies,” study co-author and professor of medicine at the Cambridge Health Alliance Pieter Cohen told CNN.

In response to the JAMA letter, Steve Mister, the president and chief executive of the Council for Responsible Nutrition, told The Washington Post that supplement companies are required to have “at least 100 percent of labeled dosage” in their products. “It’s not uncommon for companies to put in a little extra,” he added. “So, for instance, a melatonin product that’s labeled as 3 milligrams might put in 4 milligrams.” 

Melatonin was the most cited substance in calls about children to US poison control centers in 2020. Drowsiness, headaches, agitation, and increased bed-wetting or urination in the evening hours are all potential side effects of melatonin use in children. 

“It’s important, especially in kids, not to use melatonin until you’ve spoken with your pediatrician or your sleep doctor,” M. Adeel Rishi, a pulmonology, sleep medicine, and critical care specialist in Indiana and vice chair of the American Academy of Sleep Medicine Public Safety Committee, told PopSci last July. “The dose recommended in children is significantly lower than what is recommended in adults, and if you take too much of anything you have an overdose. Although it’s come to attention really in the last couple of years, we know that cases of melatonin among children have been on an upswing even before the pandemic.”

Other pediatric sleep experts stress the importance of good sleep hygiene and habits before starting melatonin. The new study’s letter also included a warning to parents that giving the gummies to children could result “in ingestion of unpredictable quantities” of melatonin.

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6 Ozempic facts that make sense of social media hype https://www.popsci.com/health/how-does-ozempic-work/ Wed, 26 Apr 2023 19:30:00 +0000 https://www.popsci.com/?p=536852
Ozempic injectable diabetes drug, which causes weight loss
It's important to know how Ozempic really works, and what the side effects are. Joel Saget/AFP via Getty Images

What you should know about so-called weight loss drugs, lizard lips, and more.

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Ozempic injectable diabetes drug, which causes weight loss
It's important to know how Ozempic really works, and what the side effects are. Joel Saget/AFP via Getty Images

A common diabetes drug has become trendy because of its use as an off-label weight loss drug. From tech moguls to influencers, this drug has become the latest “celebrity secret” for shedding the pounds. 

Ozempic, and a similar medication called Wegovy, are brand names for an injectable medicine called semaglutide. This drug is the synthetic version of a hormone called glucagon-like peptide-1 (GLP-1), which belongs to a class of medications known as GLP-1 agonists

The chemistry explains how Ozempic works and what its main side effects are. GLP-1 is a compound that increases insulin production and lowers blood sugar. After we eat, GLP-1 also signals to the brain a feeling of fullness. Meanwhile, GLP-1 agonists slow down the rate at which food empties out of the stomach, further promoting a feeling of satiety. This prevents cravings and overeating, which can result in weight loss

While Ozempic and Wegovy are now lumped together with weight loss fads, these medications are not diet hacks. Instead, they are medications proven to lower weight in certain patient populations. 

Despite this, there is a growing concern that these drugs are misused and overprescribed in individuals who casually use them for aesthetic reasons. There’s concern this type of use is resulting in repercussions like unmanaged side effects and drug shortages. Here are some proven facts and common misconceptions surrounding Ozempic. 

Fact: Ozempic’s side effects include weight loss, but it’s not a weight loss drug

This distinction is important. Ozempic is only approved by the Food and Drug Administration (FDA) for Type 2 diabetes. It is intended to help diabetes patients control their blood sugar. While it is not a weight loss drug, diabetes patients on Ozempic may lose weight as a side effect because of the way the medication works. Losing weight can improve insulin production and, in turn, benefit some individuals. Meanwhile, Wegovy is FDA-approved for chronic weight management in adults with obesity.

[Related: There’s still a lot we don’t know about the new generation of weight loss pills.]

Swetha Bhat, a primary care physician in the California Bay Area, prescribes Ozempic and Wegovy to patients who meet the criteria. She tells PopSci she has denied requests for semaglutide for weight loss because patients don’t qualify. 

“I can’t prescribe medications to someone who doesn’t meet the FDA indication,” Bhat says. “There are med spa clinics run by dermatologists or plastic surgeons who prescribe semaglutide and that is simply out of scope for their practice.”

Fact: Ozempic and Wegovy are the same medication

Ozempic and Wegovy are two names for the same injectable drug manufactured by Novo Nordisk: semaglutide. But they are approved for different conditions and administered at different dosages.

Ozempic first received FDA approval as a treatment for type 2 diabetes in 2017 at a maximum dosage of 1 milligram once weekly, and was approved again in 2022 for a larger maximum dose of 2.0 milligrams

Wegovy received FDA approval in 2021 for adults who are obese or overweight with at least one weight-related condition (high blood pressure, type 2 diabetes, or high cholesterol). People taking Wegovy start at a dose of 0.25 milligrams once a week and increase the dose every four weeks until they reach the full dose of 2.4 milligrams.

Despite the recent Wegovy approval, there’s already a new drug on the block, which seemingly packs even more punch. In 2022, Eli Lilly launched its first in-class diabetes drug called Mounjaro (generic name tirzepatide), which activates both GLP-1 and GIP receptors for increased blood glucose control. According to the FDA, the average weight loss on Mounjaro at the maximum dose is 12 pounds more than with semaglutide. 

Mounjaro injectable diabetes drug, which causes weight loss
Mounjaro could be the next misappropriated weight loss fad. Sandy Huffaker for The Washington Post via Getty Images

Fact: Ozempic has other side effects, but they’re not the same for everyone

There are some reports that Ozempic use results in a side effect called “Ozempic face,” in which the face becomes noticeably more gaunt and sunken due to the drastic weight loss. 

[Related: Experts rank the raw food diet as the worst of 2023.]

However, the term “Ozempic face” is misleading. It’s not necessarily a side effect of Ozempic, but a general possible side effect of weight loss. Sometimes a large weight reduction can result in excess skin in the face among other places. But not everyone who uses Ozempic will experience this, and it’s not a clinically proven side effect.

The most common side effects of taking GLP-1 agonists are nausea and diarrhea. Another common side effect is lack of appetite, to the point where some patients need to remind themselves to eat.

Fact: The Ozempic shortage was caused by the weight loss fad—and many other reasons 

There are several reasons for the Ozempic shortage. Novo Nordisk stated the shortage was due to issues with manufacturers coupled with the increase in demand for both on-label and off-label use. Pharmacies also tend to not stock Ozempic as it is expensive with poor cost-benefit. 

Meanwhile, social media increased interest in semaglutide among people who wouldn’t qualify for the drug for FDA-approved reasons. For example, a TikTok of Chelsea Handler went viral after she was unknowingly given Ozempic by her “anti-aging doctor.” This is referred to as “off-label” prescribing—when a doctor uses their best judgment to prescribe a medication for which the drug isn’t FDA approved.

[Related: Weight might not be the best way to detect diabetes early.]

Digital health companies, meanwhile, have made it easy for people who want the drug to access it. This has contributed to drug shortages.

A retail pharmacist in Central California, who did not want their name published, spoke about the opposite end of the experience with PopSci. “At first we were getting an influx of patients who were diabetic and we saw how much it helped. Then all of a sudden there was a surge of non-diabetic patients and we could not get semaglutide for our diabetic patients.”

Now, most practitioners have to provide a diabetes diagnosis when prescribing Ozempic for insurance reasons, they explain. “At the same time, the supply chain was also a major contributor to the shortage. For a while, we couldn’t get the drug at all through McKesson [a drug distributor] and our diabetes patients suffered. We had to switch them to Trulicity [the brand name for the drug dulaglutide] and even that went out of stock for a while.”

Fact: Ozempic is made from lizard lips (kind of)

In a recent episode of the pop culture podcast “Psychobabble,” hosted by Tyler Oakley and Korey Kuhl, the duo giggled in wonderment after reading on Twitter that Ozempic was made from “Gila monster spit.” 

GLP-1 agonists are derived from the venomous saliva of the Gila monster, a giant lizard that lives in US and Mexican deserts. In 1990, an endocrinologist named John Eng researched both the toxic and nontoxic chemicals produced by the species for medicinal use. He discovered that Gila monsters went long periods without eating and slowed down their metabolism while maintaining constant blood sugar levels. 

The peptide that allows them to do this is called Exendin-4 and is strikingly similar in both structure and function to human GLP-1. So Exendin-4 was derived to make the first synthetic GLP-1 drug, called Exenatide.

Fact: Ozempic can be a life-changing medication for the right patients

GLP-1 agonists, including Ozempic, continuously prove to be powerful blood glucose and weight-lowering medicines. They are also one of the few classes of diabetes drugs that have a significant clinical benefit in patients with a cardiovascular disease history and chronic kidney disease, which are risk factors for diabetes. 

With so many headlines and news outlets, the amount of information the average individual has to filter through can be overwhelming, especially when it comes to health. The Ozempic craze is a fantastic example of pop culture amplifying potentially misleading information. It is important to weed out the fact from fodder to avoid an unwarranted bias against a possible life-saving medication for the right candidate.

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New therapies offer hope for patients with rare genetic conditions https://www.popsci.com/health/haploinsufficiency-diseases-gene-therapy/ Wed, 26 Apr 2023 01:00:00 +0000 https://www.popsci.com/?p=536493
Sodium channel protein production.
Sodium channel protein production. YouTube

Haploinsufficiencies are hard to tackle with traditional gene therapy. But new approaches are in the works.

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Sodium channel protein production.
Sodium channel protein production. YouTube

This article originally appeared in Knowable Magazine.

The seizures started when Samantha Gundel was just four months old. By her first birthday, she was taking a cocktail of three different anticonvulsant medicines. A vicious cycle of recurrent pneumonia, spurred on by seizure-induced inhalation of regurgitated food, landed the young toddler in and out of the hospital near her Westchester County home in New York State.

Genetic testing soon confirmed her doctors’ suspicions: Samantha, now age 4, has Dravet syndrome, an incurable form of epilepsy. Her brain was misfiring because of a mutation that is unlike those responsible for most genetic diseases; it’s a type that has long eluded the possibility of correction. Available drugs could help alleviate symptoms, but there was nothing that could address the root cause of her disease.

That’s because the mutation at the heart of Dravet creates a phenomenon known as haploinsufficiency, in which a person falls ill if they have only a single working copy of a gene. That lone gene simply can’t produce enough protein to serve its molecular purpose. In the case of Dravet, that means that electrical signaling between nerve cells gets thrown out of whack, leading to the kinds of neuronal shock waves that trigger seizures.

Most genes are not like this. Though the human genome contains two copies of almost every gene, one inherited from each parent, the body can generally do fine with just one.

Not so for genes such as SCN1A, the main culprit behind Dravet. For SCN1A and hundreds of other known genes like it, there’s a delicate balance of molecular activity that is needed to ensure proper function. Too little activity is a problem — and oftentimes, so is too much.

This Goldilocks paradigm partially explains why conventional gene therapy strategies are ill-suited to the task of haploinsufficiency correction. With therapies of this kind — several of which are now available to treat “recessive” genetic diseases such as the blood disorder beta thalassemia and a form of inherited vision loss — the amount of protein made by an introduced gene just needs to cross a minimum threshold to undo the disease process.

In those contexts, it’s not a problem if the added gene is overactive — there’s a floor, but no ceiling, to therapeutic protein levels. That is simply not the case with many dosage-sensitive diseases like Dravet, especially for brain disorders in which too much protein can overexcite neuronal activity, says Gopi Shanker, who served as chief scientific officer of Tevard Biosciences in Cambridge, Massachusetts, until earlier this year. “That’s what makes it more challenging,” he says.

Adding to the challenge: The special types of modified viruses that are used to ferry therapeutic genes into human cells can handle only so much extra DNA — and the genes at the heart of Dravet and many related haploinsufficiency disorders are much too big to fit inside of these delivery vehicles.

Overlooked no more

Faced with these technical and molecular hurdles, the biotechnology industry long ignored haploinsufficiencies. For more than 30 years, companies jostled to get a piece of the drug development action in other areas of rare genetic disease — for cystic fibrosis, say, or for hemophilia — but conditions like Dravet got short shrift. “It’s one of the most neglected classes of disorder,” says Navneet Matharu, cofounder and chief scientific officer of Regel Therapeutics, based in Berkeley, California, and Boston.

Not anymore. Thanks to new therapeutic ideas and a better understanding of disease processes, Regel, Tevard and a group of other biotech startups are taking aim at Dravet, with experimental treatments and technologies that they say should serve as testing grounds for going after haploinsufficiency diseases more broadly.

Currently, there’s little to offer patients with these maladies other than drugs to aid with symptom control, says Kenneth Myers, a pediatric neurologist at Montreal Children’s Hospital who cowrote an article about emerging therapies for Dravet and similar genetic epilepsies in the 2022 issue of the Annual Review of Pharmacology and Toxicology. But thanks to new advances, he says, “there’s a huge reason for optimism.”

Samantha, for one, now seems to have her disease under control because of a drug called STK-001; it is the first ever to be evaluated clinically that addresses the root cause of Dravet.

Between February and April 2022, doctors thrice inserted a long needle into the young girl’s lower spine and injected the investigational therapy, which is designed to bump up levels of the sodium-shuttling protein whose deficiency is responsible for Dravet. It seemed to work. For a time, Samantha lived nearly seizure-free — presumably because the increased protein levels helped correct electrical imbalances in her brain.

Conventional gene therapy strategies are ill-suited to the task of haploinsufficiency correction.

She went from epileptic attacks every 7 to 10 days, on average, to nothing for months on end. Her verbal skills improved, as did her physical capabilities. Her gait improved and her tremors disappeared.

Eventually, as the therapy wore off, Samantha began to backslide, with seizures returning every couple of weeks or so. But she started receiving additional doses of STK-001 under a new trial protocol in October 2022, and since then has experienced only two epileptic episodes over the span of six months. “It’s really pretty amazing,” says her mother, Jenni Barnao.

“Is it a cure? No.… But this is absolutely our best shot,” Barnao says. “There’s definitely something with this drug that’s very good. Her brain is just working better.”

Give a boost

The STK-001 treatment relies on the fact that the normal activity of genes is somewhat inefficient and wasteful. When genes get decoded into mRNA, the resulting sequences require further cutting and splicing before they’re mature and ready to serve as guides for making protein. But often, this process is sloppy and doesn’t result in usable product.

Which is where STK-001 comes in.

A kind of “antisense” therapy, STK-001 consists of short, synthetic pieces of RNA that are tailor-made to stick to part of the SCN1A gene transcript and, as a result, make productive cutting and splicing more efficient. The synthetic pieces glom on to mRNA from the one working version of the gene that people with Dravet have and help to ensure that unwanted bits of the mRNA sequence are spliced out, just as a movie editor might cut scenes that detract from a film’s story. As a result, more functional ion channel protein gets made than would otherwise happen.

This video explains the cause of Dravet syndrome, a haploinsufficiency, and Stoke Therapeutics’ experimental approach to treating it. Dravet patients only have one working copy of the gene SCN1A, which carries genetic instructions for a crucial nerve-cell protein called a sodium channel. As a result, Dravet patients suffer from severe, progressive disease with symptoms including epilepsy and developmental disability. Stoke’s strategy, one of a variety in the works, is to increase the number of functional mRNA copies that are made from the single working SCN1A gene. As a result, extra sodium channel proteins are produced.
CREDIT: STOKE THERAPEUTICS

Protein levels don’t get completely back to normal. According to mouse studies, there’s a 50 percent to 60 percent boost, not a full doubling of the relevant protein in the brain. But that bump seems to be enough to make a real impact on patients’ lives.

Stoke Therapeutics, the company in Bedford, Massachusetts, that is behind STK-001, reported at the American Epilepsy Society’s 2022 Annual Meeting that 20 of the first 27 Dravet patients to receive multiple doses of the therapy in early trials experienced reductions in seizure frequency. The greatest benefits were observed among young children like Samantha whose brains have accumulated less damage from years of debilitating seizures and abnormal cell function. Larger confirmatory trials that could lead to marketing approval are scheduled to begin next year.

Stoke is hardly alone in its quest to fix Dravet and haploinsufficiency disorders more generally. Several other biotech startups are nearing clinical trials with their own technological approaches to enhancing what working gene activity remains. Encoded Therapeutics, for example, will soon begin enrolling participants for a trial of its experimental Dravet therapy, ETX-001; it uses an engineered virus to deliver a protein that ramps up SCN1A gene activity so that many more mRNA copies are made of the single, functional gene.

And if any of these companies succeed in reversing the course of Dravet, their technologies could then be adapted to take on any comparable disease, says Orrin Devinsky, a neurologist at NYU Langone Health who works with several of the firms and is involved in Samantha’s care. “An effective therapy would provide a potential platform to address other haploinsufficiencies,” he says.

Diseases photo
Companies are working on a variety of approaches for treating Dravet syndrome. The same methods could be applied to other haploinsufficiency diseases. Source: Reported by E. Dolgin

New targets, new tactics

Stoke will soon put that idea to the test.

Buoyed by the early promise of its Dravet therapeutic, the company developed a second drug candidate, STK-002, that similarly targets splicing to turn nonproductive gene transcripts into constructive ones. But in this case, it’s designed to tackle an inherited vision disorder known as autosomal dominant optic atrophy, caused by haploinsufficiency of a gene called OPA1. In this disease, a single working copy of OPA1 is not enough to sustain proper nerve signaling from the eyes to the brain.

Clinical evaluation of STK-002 is expected to start next year. Meanwhile, in partnership with Acadia Pharmaceuticals of San Diego, Stoke is also exploring treatments for Rett syndrome and SYNGAP1-related intellectual disability, both severe brain disorders caused by insufficient protein levels.

“There’s definitely something with this drug that’s very good. Her brain is just working better.”

Jenni Barnao

Stoke’s splice-modulating approach flows naturally from the success of another antisense drug, Spinraza. Developed by Ionis Pharmaceuticals in collaboration with Biogen, Spinraza also works on splicing of mRNA transcripts to promote production of a missing protein. In 2016, it became the first therapy approved for treating a rare neuromuscular disorder called spinal muscular atrophy (SMA).

SMA is somewhat different, though. It isn’t a haploinsufficiency — it occurs when both gene copies are defective, not just one — but it’s an unusual disease from a genetics standpoint. Because of a quirk in the human genome, it turns out that people have a kind of backup gene that doesn’t normally function because its mRNA undergoes faulty splicing. With Spinraza acting as a guide to help the mRNA splice correctly, that backup gene can be made operational and do the job that the damaged gene copies can’t do.

Few diseases are like this. But Stoke’s scientific cofounders, molecular geneticist Adrian Krainer of Cold Spring Harbor Laboratory in New York (who helped to develop Spinraza) and his former postdoctoral researcher Isabel Aznarez, realized that there was a whole world of other ailments — haploinsufficiencies — for which this type of splice modulation could be beneficial.

Spinraza was the prototype. Stoke’s portfolio is full of the next-generation editions. “We brought it to the next level,” says Aznarez, who now serves as head of discovery research at Stoke.

Striking a balance

There was a time when Dravet researchers were more focused on traditional gene replacement therapies. They aimed to insert a working version of the SCN1A gene into the genome of a virus and then introduce the engineered virus into brain cells. The problems proved manifold, though.

For starters, the virus vehicles generally used in gene therapy strategies — adeno-associated viruses (AAVs) — are too small to hold all 6,030 of the DNA letters that constitute the SCN1A gene sequence.

Researchers tried a few potential workarounds. At University College London, for example, gene therapist Rajvinder Karda and her colleagues split the SCN1A gene in half and delivered both parts into mice in different virus carriers. And at the University of Toronto, neuroscientist David Hampson and his group tried introducing a smaller gene that would fit in a single AAV vector and compensate for the SCN1A deficiency in an indirect way.

But none of those efforts advanced past mouse experiments. And while it is technically feasible to deliver the entire SCN1A gene into cells if you use other kinds of viral vectors, as researchers at the University of Navarra in Spain showed in mice, those viruses are generally considered unsafe for use in people.

To get protein levels just right, scientists say, it is best to follow the cell’s own lead.

What is more, even if gene replacement could be made to work, there are many reasons to think it would not be ideal for diseases like Dravet in which the underlying defect is mediated by an imbalance of protein levels. The amount of protein produced by those kinds of gene therapies can be unpredictable, and so are the types of cells that end up manufacturing the proteins.

To get protein levels just right, scientists say, it is best to follow the cell’s own lead, tapping into the ways that it naturally produces the protein of interest only in certain tissues of the body, and then providing a therapeutic nudge to aid the process along.

CAMP4 Therapeutics, for example, is using antisense therapies, like Stoke. But instead of targeting the splicing of gene transcripts, CAMP4’s drugs are directed at regulatory molecules that act like rheostats to control how much of those transcripts are made in the first place. By blocking or stabilizing different regulatory molecules, the company claims it can ramp up the activity of target genes in a precise and tunable way.

“It’s basically teaching the body to do it a little bit better,” says Josh Mandel-Brehm, president and CEO of CAMP4, which is based in Cambridge, Massachusetts.

In theory, the gene-editing technology known as CRISPR could obviate the need for all of these therapeutic approaches. Gene editing allows you to perfectly correct a mistake in a gene — so one could edit a faulty DNA sequence to correct it and render kids with Dravet or some other haploinsufficiency disease as good as new.

But the technology is nowhere near ready for prime time. (Some of the first CRISPR therapies to be tested in children have failed to demonstrate much benefit.) Plus, any gene-correction therapy would have to be tailored to the unique nature of a given patient’s mutations — and there are more than 1,200 Dravet-causing mutations in the SCN1A gene alone.

That’s why Jeff Coller, an RNA biologist at Johns Hopkins University and a scientific cofounder of Tevard, prefers therapeutic strategies that can address all manner of disease-causing alterations in a gene of interest, as most companies are doing now. “Having a mutation-agnostic technology is a way of going after the entire cohort of patients,” he says.

“We’re open to any approach that would help our daughters.”

Daniel Fischer

Tevard, whose mission is to “reverse” Dravet syndrome (the company’s name is Dravet spelled backward), is approaching this challenge in various ways. Some involve engineered versions of other RNAs that are key for protein production; known as “transfer” RNAs, they help to ferry amino acid building blocks to the growing protein strands. Others are intended to help bring beneficial regulatory molecules to sites of SCN1A gene activity.

But all of Tevard’s therapeutic candidates remain at least a year away from clinical testing, whereas STK-001 is in human trials today. So the company’s chief executive, Daniel Fischer — who, along with board chair and cofounder Warren Lammert, has a daughter affected by Dravet — is considering enrolling his child, now 13, in the Stoke trial rather than waiting for his own company’s efforts to bear fruit.

“We’re open to any approach that would help our daughters,” Fischer said over lunch last November at the company’s headquarters.

“And help people with Dravet generally,” added Lammert. “We’d love to see many of these things succeed.”

Editor’s note: This article was amended on April 14, 2023, to correct Gopi Shanker’s relationship with Tevard Biosciences. Shanker is Tevard’s former chief scientific officer; he is now chief scientific officer with Beam Therapeutics.

This article originally appeared in Knowable Magazine, an independent journalistic endeavor from Annual Reviews. Sign up for the newsletter.

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Can you overdose on weed? https://www.popsci.com/overdose-on-weed-marijuana/ Tue, 18 Jun 2019 19:59:47 +0000 https://www.popsci.com/uncategorized/overdose-on-weed-marijuana/
Cannabis buds over top of the Ask Us Anything logo for a podcast about whether you can overdose on weed.
There can be such thing as too much weed. Avery Meeker / Unsplash

You probably can’t blaze yourself to death, but your body could be miserable if you proceed without caution.

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Cannabis buds over top of the Ask Us Anything logo for a podcast about whether you can overdose on weed.
There can be such thing as too much weed. Avery Meeker / Unsplash

Back in May of 2019, a coroner in Louisiana claimed to have recorded the first death exclusively caused by weed.

Toxicology results for a woman who died suggested she was killed by an excess amount of THC, the primary psychoactive component of weed, the coroner, Christy Montegut, told the New Orleans Advocate. Montegut failed to find anything else—drugs, alcohol, disease—that could have attributed to her death.

Stories about a supposed first-ever lethal cannabis overdose occasionally crop up. They’re usually followed by rebuttals that no, you can’t die from weed overdose—and dying from another cause while having THC in your system is not quite the same thing.

According to the National Institute on Drug Abuse (NIDA), there has yet to be a drug overdose death solely attributed to cannabis. The Centers for Disease Control and Prevention also states that while symptoms of too much THC might include extreme confusion, emotional distress, increased blood pressure, heart rate, severe nausea, or unintentional injury, “a fatal overdose is unlikely.”

The statistics back this up. Cannabis is the most commonly used illicit drug in the US, despite being cleared for recreational use in more than a dozen states and territories. More than half of US adults have tried it in their lifetime and nearly one in three teenagers report having used marijuana in the past year, according to 2022 NIDA statistics. In 2021, 52.5 million Americans above the age of 12 reported using marijuana in the past year—which, according to rudimentary statistics, would have resulted in dozens of fatalities if the odds of blazing yourself to death was even one-in-a-million.

“Whether you can die from an overdose of marijuana, the answer is no,” says Alex Manini, an emergency medicine clinician specialist and toxicology expert at Mount Sinai Hospital in New York. But can someone non-fatally overdose on weed?

Symptoms of a weed overdose

Technically, an overdose happens any time someone takes more than the normal or recommended amount of a substance or drug. People show up in emergency rooms all the time after taking THC, Manini says, with all kinds of serious symptoms: panic or anxiety attacks, passing out, rapid heart rate, and even cannabinoid hyperemesis syndrome, an increasingly common condition marked by continuous vomiting.

“You (can) think of taking a hit as a therapeutic dose, to get a feeling of euphoria, maybe the giggles,” Manini explains. Or you can smoke so much that you feel like you need to go to the hospital. “I would call that an overdose. Will you die, if you’re a young, healthy person? Probably not.”

Cannabis is still a Schedule I drug, according to the federal government, and technically doesn’t have any currently accepted medical uses. Still, numerous states have moved to legalize marijuana for recreational or medical treatment (mostly for conditions such as cancer, HIV/AIDS, multiple sclerosis, glaucoma, seizures, epilepsy, and chronic pain). A 2016 analysis of samples from materials confiscated by the Drug Enforcement Administration over two decades also showed that the potency of THC in weed has increased at least threefold since 1995.

Altogether, this means that more people have more access to stronger cannabis. For most, that just increases your probability of getting higher than planned. But for some people, doctors say the advent of widespread, highly potent cannabis products increases their risk of an overdose.

[Related on PopSci+: The tasty chemicals flavoring the edible cannabis boom]

One group of at-risk individuals is children, who can accidentally ingest cookies, brownies, and other treats infused with super-concentrated THC doses, especially in states where recreational marijuana has been legalized. In a 2016 study in the journal of Clinical Toxicology, researchers investigated 430 calls to the National Poison Data System from 2013 to 2015 related to cannabis edibles and drinks. They not only found that the number of such calls increased year over year, but they also noted that a quarter of the cases involved children under the age of five, who, unlike adults, don’t know an ordinary looking treat might contain several doses of THC.

“That was a big finding,” says Dazhe Cao, a co-author of the study and a medical toxicology doctor at the University of Texas Southwestern Medical Center in Dallas. For those young children, cannabis exposure typically made them sleepy or uncoordinated, or affected their breathing (leading to intubation in two cases).

“That could [be a] potentially life-threatening situation for a child,” says Manini. Kids are not little adults—their bodies process all drugs differently than any older person’s would.

Other health concerns with cannabis use

Synthetic cannabinoids—human-made chemicals sometimes called Spice or K2—have also complicated the safety of all cannabinoids. When Manini and colleagues compared the clinical effects of synthetic weed with regular cannabis in 87 emergency department patients, they found those who ingested synthetic cannabis fared far worse, according to a separate set of results published in 2016.

“They had much worse cardiovascular effects, much worse agitation,” he says. The two products are chemically different, he explains, and so their safety should be considered separately. “The safety of marijuana has been borne out over decades. This is a whole new world.”

And even if weed itself won’t directly kill you, there have been deaths associated with cannabis products, Cao says. In a 2014 case, a 19-year-old Colorado man died after he ate a cannabis cookie, began behaving erratically, and jumped off a fourth-floor balcony. His autopsy reported marijuana intoxication as a chief contributing factor.

“It is very controversial to say whether someone can die from marijuana or cannabis products,” Cao says. “They’re not always direct causes of deaths.”

Cannabis use can also increase heart rate and blood pressure, and it can be a risk factor for some people who have pre-existing heart-related conditions, whether they know it or not. In one 2014 study published in the Journal of the American Heart Association, a group of French researchers examined 35 medical cases and concluded that cannabis could be a potential trigger for cardiovascular complications in young people. And when researchers from the Einstein Medical Center in Philadelphia analyzed a national database of patients in 2018, they found the prevalence of heart failure, stroke, coronary artery disease, and sudden cardiac death were significantly higher in patients with cannabis use. After adjusting for a number of factors including age, sex, diabetes, and tobacco or alcohol use, they found cannabis use remained an independent predictor of both heart failure and stroke.

Scientific evidence also links long-term weed smoking with chronic bronchitis and respiratory symptoms like coughing and wheezing. (There is not an established association between smoking weed and the incidence of lung or head and neck cancer). The long-term health effects of vaping weed remain mostly unknown.

[Related: Psychosis is the last marijuana side effect you should be worried about]

If you have pets at home, you might also be wondering how cannabis might affect them. For obvious reasons, the rise in edibles can pose a danger for your furry friends. Cats and dogs are increasingly exposed to THC-containing products, especially chocolate-containing treats, which has led to more cases of weed poisoning among pets. Because dog brains have more cannabinoid receptors than human ones, they could be more sensitive to the drug’s psychoactive properties, one 2018 study notes. (common symptoms of poisoning for dogs include lethargy, impaired balance, vomiting, and increased sensitivity to motion and sound). As seems to be the case with humans, synthetic cannabinoids may result in more severe symptoms for pets, such as tremors, aggression, and seizures. But to be clear, the authors state that “fatality in pets from marijuana intoxication is extremely rare,” and that no deaths associated with weed had ever been reported to Pet Poison Helpline.

All of this is not to say people should be wary of cannabis, Manini says—but they shouldn’t lump it in with other commonly used substances that regularly kill people. Thousands of Americans die every year from opioid overdose and alcohol poisoning, with rising rates among teens and young adults. Across the nation, most people over the age of 12 don’t see a great risk of harm from monthly cannabis use, according to statistics from the Substance Abuse and Mental Health Services Administration.

“It probably has a better safety profile than a lot of other illegal substances,” Cao says. “The perception that this is dangerous is dropping. But you can absolutely overdose.” Actually dying from that overdose, however, is far less likely—if at all possible.

This post has been updated. It was originally published on June 21, 2019.

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Is shyness something kids feel, or something kids are? https://www.popsci.com/health/childhood-shyness-psychology/ Tue, 25 Apr 2023 14:00:00 +0000 https://www.popsci.com/?p=536513
A group of eight children running in an open field.
Fear and nervousness in social situations or being at the center of attention, is a fairly typical childhood experience. Deposit Photos

Even some outgoing children can get stressed in high-pressure social situations.

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A group of eight children running in an open field.
Fear and nervousness in social situations or being at the center of attention, is a fairly typical childhood experience. Deposit Photos

Is shyness something you feel, or is it something that defines you? Child psychologists are still not fully convinced one way or the other. A small study published April 25 in the journal Society for Research in Child Development found that timidness, fear and nervousness in social situations or being at the center of attention, is a fairly typical childhood experience, whether it is an emotion or personality. 

[Related from PopSci+: Can dogs be introverts?]

Some long standing theories about shyness believe that there are two types of coy behavior. “Temperamental” shyness remains roughly the same throughout development, whereas “state” shyness is felt during a social situation and manifests more like an emotion. 

In this new study, researchers examined the behavioral, affective, and physiological responses to a speech task in 152 Canadian children (73 girls and 79 boys) ages seven and eight. The children were told that they would be giving a speech that would be filmed and shown to other children. Their parents completed online questionnaires about their child’s temperament, while the children were given an echocardiogram to check for physiological indications of nervous behavior.

The children prepared a two-minute speech about their last birthday and recited the speech in front of a video camera and a mirror. The researchers monitored the children for behaviors coded as avoidance or inhibition, self-reported nervousness, and respiratory sinus arrhythmia.

The team found that temperamental shyness may exist in a distinct group of children over time, and a larger group of children may experience shyness as an emotion during certain situations. 

About 10 percent of the children had a high level of stress giving the speech in addition to relatively high levels of shyness over time, according to the questionnaires filled out by their parents. According to the team, this provides evidence that shyness may be part of these children’s temperament. Being the center of attention may be stressful across time and in various contexts in this group. Future research could examine the consequences on how this shyness affects academic, social, and psychological well-being since shyness could be measured across time. 

Roughly 25 percent of study participants were not reported to be shy, but demonstrated a higher level of stress from giving the speech. The authors believe that it is likely that state shyness in response to a speech task is a relatively common, normative experience for children at this age.

[Related: Little kids drew their grim—and hopeful—reality of COVID.]

“Our findings provide empirical support for the long-theorized idea that there may be a subset of temperamentally shy children who manifest heightened behavioral, affective, and physiological reactivity in response to a social stressor, as well as a subset of children who may experience only the affective component which may reflect state shyness,” co-author and Brock University post-doctoral fellow and psychologist Kristie Poole said in a statement. “This highlights the multiple components and developmental course of temperamental shyness and the features that distinguish temperamental and state shyness in middle to late childhood.”

This study provides some empirical evidence for long-standing ideas about shyness that were first made by the late psychologist Jerome Kagan. In the 1990s, Kagan argued that temperamental shyness may exist as a distinct category for some children and the features that define this category are relatively stable across time and context.

The authors also noted some limitations to the research, namely that the study only measured these behavioral, affective, and physiological components at one point in time and the sample size was relatively small. Future research should also include a more racially, ethnically, and socioeconomically diverse pool and focus.

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U.S. air quality is improving, but 1 in 3 Americans still breathe unhealthy air https://www.popsci.com/environment/1-in-3-americans-breathe-unhealthy-air/ Tue, 25 Apr 2023 01:00:00 +0000 https://www.popsci.com/?p=536240
People of color were found to be 64 percent more likely than white people to breathe unhealthy air.
People of color were found to be 64 percent more likely than white people to breathe unhealthy air. DepositPhotos

The American Lung Association finds that wildfires, drought, and inequality threaten progress.

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People of color were found to be 64 percent more likely than white people to breathe unhealthy air.
People of color were found to be 64 percent more likely than white people to breathe unhealthy air. DepositPhotos

This article originally appeared in Grist.

A new report by the American Lung Association found that more than one in three Americans were exposed to unhealthy levels of air pollution between 2019 to 2021. Released on Wednesday, the 24th annual State of the Air report grades Americans’ exposure to two of the nation’s most pervasive air pollutants: ground-level ozone, an air pollutant that forms smog, and particle pollution, also known as soot. 

The report found that while overall smog and soot pollution continues to decrease across the U.S., racial and geographic disparities are rising. As climate-fueled wildfires and drought increase and intensify, more people living in the West face potentially deadly particle and ozone pollution compared to their Eastern counterparts.

People of color were found to be 64 percent more likely than white people to breathe unhealthy air, compared to 61 percent in last year’s report. They are also 3.7 times more likely than white people to live in a county that received the American Lung Association’s lowest rating for all three pollution metrics that the group examined: ozone pollution, annual particle pollution, and short-term particle pollution. The report’s ratings were informed by national air quality standards set by the U.S. Environmental Protection Agency. Last year, people of color were 3.6 times more likely to live in a county that received a failing grade on all three measures.

Paul Billings, national senior vice president of public policy for the American Lung Association, said that those findings reflect the continued impact of systemic racism. Pollution sources ranging from refineries to highways are disproportionately sited in communities of color — a persistent legacy of racist housing policies such as redlining. “The benefits of clean air have not been equally shared, and in fact, we’re seeing in this report an even wider disparity than we saw last year,” he said. 

Ozone causes what experts describe as a “sunburn of the lungs,” causing shortness of breath and wheezing and increasing the risk for asthma and respiratory infections. And particulate matter pollution bypasses the human body’s natural defenses to enter the deepest part of the lungs. Even short-term exposure to fine particles — those smaller than 2.5 microns across, also known as PM 2.5 — can lead to a host of health harms, including asthma attacks and heart attacks. 

The number of people experiencing 24-hour spikes in particle pollution rose to the highest levels reported in the last decade. Close to 64 million people lived in counties with failing grades for those daily spikes, according to the report. “That’s nearly a half a million more than we saw in last year’s report,” said Billings.

One major contributor is more frequent and intense wildfires linked to climate change, which spew smoke and fine particles.

Billings said that when the American Lung Association started issuing its State of the Air reports 24 years ago, the organization noticed a much broader spread of communities across the U.S. experiencing high levels of pollution. Now, because of wildfires and increasingly hotter and drier weather, Western states are dominating the lists of top 25 cities most impacted by pollution. 

California cities make up four out of the top five in the lists of cities most impacted by annual particle pollution and ozone pollution. 

“We really see this marked shift, and a lot of that we think is due to climate change, not only for the wildfires but also the hot conditions that create the opportunity for ozone formation,” said Billings. 

Ozone forms when nitrogen oxides and other pollutants “cook” in the sun through a series of chemical reactions. According to the EPA, ozone is more likely to form “on warm, sunny days when the air is stagnant.” 

Those hotter days have become more frequent as a result of climate change, leading to “the number of unhealthy ozone days being higher than it would otherwise be,” the report says. “Simply, climate change is undercutting the progress we would have made.”

In response to these challenges, the American Lung Association and other public health groups are calling on the EPA to further limit ozone and particle pollution by significantly strengthening national ambient air quality standards under the federal Clean Air Act passed in 1970. The agency is currently reviewing both the particulate matter and ozone standards. 

Billings said tightening those limits would fulfill the central promise of the Clean Air Act to provide everyone with clean, healthy air. “While we’ve made progress — no question about it — here we are more than 50 years later looking in the rearview mirror, and we still have more than 1 in 3 living in this country, living in a county that has unhealthy air,” Billings said. “No child born in 2023 should have to breathe air pollution that can make them sick.” 

This article originally appeared in Grist at https://grist.org/health/pollution-smog-wildfires-1-in-3-americans-breathe-unhealthy-air-new-report-says-strong/. Grist is a nonprofit, independent media organization dedicated to telling stories of climate solutions and a just future. Learn more at Grist.org

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Nice chimps finish last—so why aren’t all of them mean? https://www.popsci.com/environment/chimpanzee-personality-bully-evolution/ Mon, 24 Apr 2023 15:00:00 +0000 https://www.popsci.com/?p=536294
A male chimpanzee named Frodo frowns.
Known as a bully, Frodo the chimpanzee was Gombe's alpha male for five years. Ian C. Gilby, Arizona State University

Long-term data on chimpanzees adds another piece to the personality puzzle.

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A male chimpanzee named Frodo frowns.
Known as a bully, Frodo the chimpanzee was Gombe's alpha male for five years. Ian C. Gilby, Arizona State University

Is the phase “nice guys finish last” actually true? Unfortunately for all the soft-hearted among us, brutish behavior can be an effective path to power and dominance in both humans and chimpanzees. A study published April 24 in the journal PeerJ Life and Environment found that the male chimpanzees who exhibited greedy, irritable, and bullying personalities reached a higher social status. These rascals were also more successful at producing offspring. 

[Related: Adolescent chimpanzees might be less impulsive than human teens.]

However, the team is still plagued by a puzzling question from these findings: if being mean is the key to success, why isn’t every chimp a bully

For the study, the team followed 28 male chimpanzees living in Tanzania’s Gombe National Park. A previous study had found that  these particular chimpanzees had a few members that  are more sociable whereas others are loners. Some of the chimps had overbearing personalities, and some were more easy-going. And, of course, there are a handful that are more quick to pick fights with others. 

Tanzanian field researchers performed personality assessments on the chimpanzees based on years of near-daily observations of how each animal interacted with others and behaved among the group. They found that a personality combination of high dominance and low conscientiousness helped the male chimpanzees fare better in life than the others, but it still doesn’t answer the evolutionary puzzle of why personality differences exist at all. 

A long held theory is that different personality traits matter at different points in an animal’s life or that certain traits that are a liability when an animal is young may pay off in old age. 

“Think of the personality traits that lead some people to peak in high school versus later in life,” Alexander Weiss, co-author and comparative psychologist at the University of Edinburgh, said in a statement. “It’s a trade-off.” 

The team tested the theory using almost 40 years of data that goes back to famed primatologist Jane Goodall’s early research at Gombe. Across the lifespan, the same personality traits were linked to both high reproductive success and high social rank. 

[Related: Popular chimpanzees set hand-holding trends for the whole group.]

Something else must be behind the diversity of chimpanzee personality. The “best” personality to have could depend on social or environmental conditions. Gender could matter too—a trait that is beneficial to males could cost a female. If this is true, then “genes associated with those traits would be kept in the population,” Weiss said. Further study is needed to confirm this idea. 

The suggestion that animals have distinct personalities was considered taboo not too long ago, with Goodall herself accused of anthropomorphism with her descriptions. Scientists have studied animals ranging from squid to birds, finding evidence of distinct personalities. These quirks, idiosyncrasies, and ways of relating to the world around them remain reasonably stable over time and across situations.

Like with measures of human personality, personality ratings for animals have also been proven to be as consistent from one observer to the next. “The data just doesn’t support the skepticism,” Weiss said.

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5 skin cancer-care tools you should look out for https://www.popsci.com/health/skin-cancer-prevention-technology/ Mon, 24 Apr 2023 11:30:00 +0000 https://www.popsci.com/?p=536062
Dermatologist checking moles on skin cancer patient's back
Even doctors can have a hard time telling when moles are cancerous. New tools like radio wave scanners and AI photo apps can help. Deposit Photos

Stick, scan, and selfie to fight off skin cancer.

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Dermatologist checking moles on skin cancer patient's back
Even doctors can have a hard time telling when moles are cancerous. New tools like radio wave scanners and AI photo apps can help. Deposit Photos

Ozone is like Earth’s natural sunscreen, protecting living things from the sun’s harsh UV rays. But this sunscreen is running out. Greenhouse gases are thinning out the ozone layer, and our skin is starting to pay the price. According to the World Health Organization, losing an extra 10 percent of ozone levels will cause an additional 300,000 non-melanoma and 4,500 skin cancer cases.

With skin cancer as the most diagnosed cancer in America, the US Preventative Services Task Force (USPSTF) updated their screening recommendations earlier this month, emphasizing the need for people to get moles and other spots checked early for potential tumors. 

The quicker skin cancer is caught, the better your chances of recovering from it. And recent technological advances in skin cancer research is transforming the way doctors and patients approach this deadly disease. Here are five tech tools to keep an eye on.

Therapeutic skin cancer vaccine

As multiple companies experiment with cancer vaccines, Merck and Moderna are focusing theirs on melanoma. Their phase II clinical trial results, shared last week, showed a 44 percent decrease in risk of death or a melanoma relapse when pairing the vaccine with the immunotherapy Keytruda. Additionally, about 79 percent of people who took the vaccine plus immunotherapy stayed cancer-free for 18 months compared to the 62 percent who just took immunotherapy. The data shows enough promise for the companies to start a Phase 3 trial in adjuvant melanoma this year, and could compel them to rapidly expand the vaccine to other tumor types, including non-small cell lung cancer, Eric Rubin, a senior vice president at Merck, wrote in an email.

[Related: A vaccine trial targeting the most lethal breast cancer just took its next step]

The vaccine isn’t a preventative treatment, but is instead given to melanoma patients early in recovery. The researchers take tumor samples from biopsies and identify which proteins are most likely to be recognized by the human immune system. They then make a personalized mRNA vaccine (adapted from the technology behind Moderna’s COVID jab) using a certain number of these abnormal genes to boost an individual’s adaptive immunity. If the rest of the trials go as planned, the vaccine could be available as soon as 2025 or early 2026, says Eric Whitman, the medical director of Atlantic Health System’s oncology service line.

Genetic tests and personal risk scores

Precision prevention is when doctors use multiple tools to map out a person’s risk of cancer and use that assessment to tailor their treatment and risk-reduction strategy. Instead of following a standard guideline like an annual dermal exam, a person who is considered high-risk (like someone with a history of skin cancer) may need more frequent screenings and extra body imaging, says Meredith McKean, the director of melanoma & skin cancer research at the Sarah Cannon Research Institute in Tennessee. People with very low risk, on the other hand, may be encouraged to learn how to do their own self-checks at home. McKean adds that it’s really helpful “to stratify patients and really help them do the best that we can to prevent another melanoma or skin cancer [case].”

Genetic tests can also be used to identify people with a predisposition to skin cancer. A 2022 study in the journal Cancer Research Communications found that people who were told they had a MC1R mutation, which carries a higher risk for melanoma, made more of an effort to protect themselves against the sun and get regular skin checks. Some doctors even use AI technology to a personalized risk score for individuals based on photos of skin lesions and moles.

DermTech Smart Sticker skin cancer test on a person with white arms against a purple background
The DermTech Smart Sticker has been available in dermatologist officers for a few years now. DermTech

Melanoma sticker

The Dermtech SmartSticker is an easy precursor for checking suspicious moles for melanoma. A dermatologist places four skin patches on the potential tumor for less than five seconds, and ships the sample to a Dermtech lab in San Diego, California. The lab then tests for DNA from cancerous cells. If the results come back positive, the dermatologist would follow up with a biopsy. If not, this painful step can be avoided and the doctor would just continue clinically monitoring the patient. 

“It’s a very good test. If it comes up negative, there is a greater than 99-percent reliability that the mole is not melanoma,” says Emily Wood, a dermatologist at Westlake Dermatology & Cosmetic Surgery in Texas. She adds that patients in her clinic favor the stickers over biopsies because they’re painless, cost-effective, and quick. “We’re going to save lives in catching melanoma earlier. I think this will make a dramatic impact for patients long-term.” While the studies are ongoing, there is research suggesting the tool could extend to detecting non-melanoma skin cancer

Artificial intelligence apps

Medical researchers are now training computers to recognize patterns and atypical features associated with skin cancer. “AI picks up a lot more subtle changes than the naked eye,” says Trevan Fischer, a surgical oncologist at Providence Saint John’s Health Center. The high accuracy in AI deep learning can help doctors determine whether a mole is malignant and worth biopsying—saving patients from some unneeded discomfort.

The beauty of AI is that you can do a full home skin exam with a press of a few buttons. Popular smartphone apps like MoleMapper lets users upload a picture and have it analyzed for potential skin lesions. They also let you store photos to show your doctor and keep track of any changes to your mole. (Wood warns that a smartphone app is not meant to substitute in-person skin check-ups with your doctor.)

While these apps are useful, there’s always room for improvement. For example, the AI’s accuracy goes down when the view of the mole has shadowing, blurriness, hair, or if the image is rotated. There’s also been research showing that AI databases lack images of darker skin types that would teach the system to better detect skin cancer from people of color. If anything, Wood says the apps can encourage people to submit photos of suspicious moles and start the conversation early with their doctor. 

Millimeter wave imaging 

The same technology used in airport security scanners is getting revamped and used to detect skin tumors. Millimeter wave imaging is a non-invasive method and a low-cost alternative to biopsies that works by scanning a person’s skin for any biochemical and molecular changes related to a disease or disorder. The radio waves reflect differently when looking at benign versus cancerous moles. 

[Related: Everything you need to know about UPF sun protection]

While the approach is not yet available for clinical practice, there is evidence backing up the proof of concept. A 2017 study in IEEE Transactions on Biomedical Engineering found considerable differences when looking back at the scans of healthy skin and those for two common skin cancer types: squamous cell carcinoma and basal cell carcinoma. The study authors could see detailed changes in water molecules, glucose concentrations, and protein levels. A 2018 study in the same journal used ultra-high resolution millimeter wave imaging to identify early-stage skin cancer. Most recently, the diagnostic tool was studied on 136 people suspected of skin cancer. Ultimately, it found malignant tumors from various types of skin cancer on 71 patients, giving the tech a “high diagnostic accuracy.” 

“We’re really trying to leverage all the different ways that advanced technology can help us diagnose and treat skin cancer like melanoma,” Whitman from Atlantic Health Systems says. He emphasizes that most of these strategies weren’t imaginable 10 years ago. Using data to improve on existing AI technology and create new models for personalized medicine, he notes, “can really make a difference for people and their lives.”

The post 5 skin cancer-care tools you should look out for appeared first on Popular Science.

Articles may contain affiliate links which enable us to share in the revenue of any purchases made.

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The best electrolyte drinks of 2023 https://www.popsci.com/reviews/best-electrolyte-drinks/ Tue, 23 Nov 2021 23:48:00 +0000 https://www.popsci.com/?p=402396
A lineup of the best electrolyte drink mixes stitched together
Amanda Reed

These electrolyte drinks have what you need to recover from everything from running a marathon to a night out on the town.

The post The best electrolyte drinks of 2023 appeared first on Popular Science.

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A lineup of the best electrolyte drink mixes stitched together
Amanda Reed

We may earn revenue from the products available on this page and participate in affiliate programs. Learn more ›

Best sports drink The Liquid i.v. is the best electrolyte drink for athletes. Liquid I.V.
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A super-efficient solution for a variety of uses

Best for hangovers The Pedialyte is best electrolyte drink for hangovers. Pedialyte
SEE IT

The same stuff you had as a kid is also great for adults

Best for runners The Nuun Sport Caffein is best electrolyte drink for runners. Nuun
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Dissolvable tablets are easy to take on the run

Whether it’s recharging after an intense workout or hydrating the day after drinking, electrolytes can help your body recover faster and feel refreshed in no time. Consuming the best electrolyte drinks helps keep your body hydrated. Electrolytes aid your body in regulating muscle cramping and nerve signaling and even go as far as balancing your pH and keeping you hydrated—which is important for everyone from professional athletes to people who work from home.

The problem? Every time you break a sweat, your body loses some of those minerals which leads to dehydration. This can end up in fatigue, nausea, abdominal and muscle cramping, and much worse. The safest bet is to stock up on the best electrolyte drinks so you’re prepared for any situation—whether it’s post-cardio or when recovering from the flu.

How we chose the best electrolyte drinks

We aimed to support electrolyte drinks that are allergy-friendly and are free of most artificial ingredients such as colors, preservatives, and sweeteners. There are plenty of sports drinks out there on the market that are basically salty soda with no bubbles. That said, we also considered taste as an essential part of the equation. You’re not going to drink something that tastes bad and that’s counterproductive to staying hydrated.

The FDA does not review dietary supplements for safety and effectiveness before they are placed on the market; therefore, this was not a determining factor in our selections. The PopSci staff and writers have years of experience in competitive sports and other dehydrating activities. To find the best electrolyte drinks, we surveyed and considered dozens of different options to find those that meet these standards. 

The best electrolyte drinks: Reviews & Recommendations 

While sweating from working out or playing sports may be the first thing you think about in terms of dehydration, there are, in reality, many ways to deplete these precious resources. These can include food poisoning, travel, heat, stomach flu, and even alcohol consumption. The best electrolyte drinks—which we’ve listed below—are sure to help you recover and rehydrate.

Best overall: Tailwind Nutrition Endurance Fuel

Amanda Reed

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Why it made the cut: This drink mix has a light, clean taste, and dissolves clear in water. It’s also easy on the stomach—no more gut-wrenching runs.

Specs

  • Diet type: Non-GMO, Free of soy, dairy, and gluten, vegan
  • Servings: 30 per container
  • Flavors: Comes in 8 flavors
  • Form: Powder

Pros

  • Easy on the stomach
  • Tasty
  • Caffeinated options available

Cons

  • Expensive compared to others on the list

You tend to get three options with sports drinks: taste, hydration, and easy on the stomach. However, you can only pick two. The one that hydrates the most and tastes the best may not be easy on your stomach, and so on. You get the complete triangle with Tailwind Nutrition’s Endurance Fuel. It’s, according to one of our staff writers here on the gear team, “freakin’ delicious,” and it includes electrolytes to replenish what you sweat out. Best of all, it won’t irritate your stomach while working out. It comes in eight flavors including caffeinated options, but our favorite is mandarin orange.

Best sports drink: Liquid I.V.

Why it made the cut: This electrolyte drink mix delivers an optimal ratio of nutrients that delivers hydration quickly via single-serving tubes. 

Specs

  • Diet type: Gluten-, soy-, and dairy-free
  • Servings: 16 single-serving packets
  • Flavors: Comes in four flavors
  • Form: Powder

Pros

  • Non-GMO and no artificial ingredients
  • Provides the same hydration as 2-3 bottles of water
  • With each purchase, they donate a serving to someone in need around the world. 

Cons

  • Expensive compared to others on this list

Liquid I.V. is one of the best sports drinks with electrolytes on the market, especially for athletes, which makes perfect sense since it was developed while the founder was working with a professional baseball team. After realizing there is a need for natural and effective electrolyte drinks, he partnered with nutrition scientists to create what it calls a Hydration Multiplier.

Through the science of Cellular Transport Technology (CTT) water and other key ingredients are rapidly absorbed into the bloodstream. Liquid I.V. is available in four flavors: lemon-lime, passion fruit, tangerine, and acai berry. It also boasts five essential vitamins: B3, B5, B6, B12, and Vitamin C. 

With each purchase consumers make, Liquid I.V. provides hydration in disaster zones, hospitals, impoverished communities, and more in need around the world. 

Best for hangovers: Pedialyte

Why it made the cut: This electrolyte drink is medically formulated and highly recommended by medical professionals for both children and adults. 

Specs

  • Diet types: Non-GMO, vegan, gluten-, calorie-, sugar-free
  • Servings: One bottle= 3 servings
  • Flavors: Comes in 17 flavors
  • Form: Liquid

Pros

  • Inexpensive
  • Good for both kids and adults
  • Well-earned reputation
  • Lots of options including freeze pops.

Cons

  • “Unflavored” doesn’t mean no taste

Pedialyte is an advanced, medical-grade hydration formula that contains potassium, sodium, and chloride. These key electrolytes are designed to restore your body’s sugar and electrolyte balance which is why it’s the best electrolyte drink for hangovers. You’ve probably had it multiple times in your life already since it’s typically suggested for sick children who are running fevers or are having trouble keeping down regular liquids.

You can get Pedialyte via liters (liquid), powder packs, and freezer pops that come in 17 flavors. However, the unflavored version is a great choice that is free of artificial colors and dyes. Some people have reported that the flavorless option still has a taste, but if you drink it cold, it tastes much better. 

Best for runners: Nuun Sport + Caffeine

Why it made the cut: Easily portable tablets quickly dissolve in a water bottle so there’s no need to lug around pre-mixed liquid. They also taste excellent.

Specs

  • Diet type: Dairy-, soy-, and gluten-free, kosher, vegan
  • Servings: 1 tube holds 10 tablets
  • Flavors: Four
  • Form: Tablet

Pros

  • No artificial flavoring or sweeteners
  • Only 1 gram of sugar
  • Good for travel

Cons

  • Contains caffeine (could be a pro or con)

Nuun has been the best electrolyte drink for runners and athletes for years. Nuun tablets contain only one gram of sugar which is derived from high-quality stevia. It also contains only 15 calories and zero artificial sweeteners or flavoring. There’s a wide variety of flavors to choose from and it’s easy to carry them practically anywhere since they’re in tablet form. All you have to do is dissolve one tablet in 16oz of water. 

While caffeine could be a con for some, studies have shown that caffeine may boost athletic performance which could help runners during training and competition. Additionally, the caffeine is derived from green tea extract. Nuun also has tablets focused on energy and immunity as well as electrolyte powder mix. 

Best system: Gatorade Gx Hydration System and Gx Sports Drink Concentrate Pods

Gatorade

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Why it made the cut: If Gatorade is your go-to, consider this system that makes it easier to drink your favorite flavors.

Specs

  • Diet type: Fat- and gluten-free, non-GMO, vegan
  • Servings: 1 pod per serving
  • Flavors: Comes in 8 flavors
  • Form: Liquid

Pros

  • Less clutter than purchasing packs
  • Can customize flavor with water levels
  • Easy to use

Cons

  • Proprietary recycling program
  • Not Earth-friendly

Gatorade is one of the most well-known electrolyte drinks out there. Between hazy Saturday morning afters to middle school sports team practices, there are few people in this world who haven’t sipped on the colorful sports drink. If you’re sick of hauling packs upon packs into your home, consider Gatorade’s Gx system, which uses a special bottle and pods to quench your thirst and replenish your electrolytes. Simply fill the bottle up to the water line, pop the pod on top of the bottle, press down, and wham: Gatorade. If it’s good enough for a college football team in the 60s, it’s good enough for you. You can also purchase a 64-ounce jug if 30 ounces isn’t enough liquid to drink before, during, and after your workout.

Best for breastfeeding: Vita Coco

Why it made the cut: While many electrolyte drinks are healthier than sports drinks, coconut water is the only one on the list with one ingredient. 

Specs

  • Diet type: Fat- and gluten-free, non-GMO, vegan
  • Servings: 1 bottle = 11.1 fluid oz, 1 case = 12 bottles
  • Flavors: Three
  • Form: Liquid

Pros

  • Naturally occurring electrolyte source
  • Contains only 1 ingredient 
  • Delicious

Cons

  • Expensive
  • High sugar content 

There’s not an electrolyte drink that’s more natural than coconut water. As a new mother breastfeeding, you want to pay attention to what you put in your body just as you did while you were pregnant. For that reason, coconut water is the best electrolyte drink for breastfeeding mothers. 

Vita Coco is never made from concentrate. The coconuts are picked, cracked, and packed directly at the source.

Vita Coco also has coconut water options available in pineapple and peach & mango flavors if you don’t love the taste of plain coconut water. The bottles are handy and easy to keep around so you don’t have to worry about mixing up a drink to replenish when you’re already spent. 

Best sugar-free: Hi-Lyte

Why it made the cut: Most electrolyte drinks have sugar, added or natural, but Hi-Lyte is one of the few with absolutely no sugar making it the best sugar-free electrolyte drink and great for diabetics or anyone watching their sugar intake. 

Specs

  • Diet types: Non-GMO, vegan, gluten-, calorie-, sugar-free
  • Servings: 48
  • Flavors: N/A
  • Form: Concentrate

Pros

  • Inexpensive
  • No sugar, carbs, or calories
  • No artificial ingredients

Cons

  • Natural salty taste
  • Contains zinc (important if you have zinc sensitivity)

Hi-Lyte is a liquid electrolyte drink that claims to have the highest potassium, zinc, and magnesium content amongst electrolyte concentrates on the market. This product is made with all-natural, ionic sea minerals and no maltodextrin. Ionic minerals are smaller than cell pathways which allows them to be absorbed more easily. 

Hi-Lyte notes that their product is not focused on taste and that it has a naturally salty, mineral taste. If you’re sensitive to the taste, add a squeeze of lemon or lime and a pinch of stevia. You can also add it to juice or a smoothie. 

Hi-Lyte also claims that the liquid form has four times the absorption rate versus powders and tablets. However, if you prefer powder form, Hi-Lyte does produce an electrolyte powder as well, which is ideal for traveling.

Best pre-workout drink: Hydralyte + Energy Boost Electrolyte Powder

Why it made the cut: In addition to hydrating, Hydralyte + Energy Boost is formulated with vitamins and caffeine to give you a boost of energy. And with a vegan, non-GMO, and gluten-free formula, this tasty addition could just replace your morning brew.

Specs

  • Diet type: Non-GMO, vegan, gluten-, dairy-free
  • Servings: 20
  • Flavors: Lemon-lime
  • Form: Powder

Pros

  • Includes caffeine
  • Only 10 calories per serving
  • Added benefit of vitamins

Cons

  • More expensive than some options

While many electrolyte drinks might be designed for rehydration post-workout, Hydralyte + Energy Boost has the added benefit of 100mg of caffeine sourced from green tea, making it the perfect pre-workout beverage. This pick is also formulated with vitamins that assist with energy metabolism (like B12 and B6), plus 225 mg of Vitamin C, 9mg of Zinc, magnesium, and potassium.

Whether you need to kickstart your morning after a night out or want a healthy burst of energy before you hit the gym, this powder formula from Hydralyte is uber-portable—just toss it in your gym bag or backpack to later mix with water for hydration on the go.

Best budget: Emergen-C Hydration+ Sports Drink Mix With Vitamin C

Emergen-C

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Why it made the cut: Get a quality dose of electrolytes at only $10 a box—that’s 56 cents per packet.

Specs

  • Diet type: non-GMO, gluten-free, vegan 
  • Servings: 18 single-serve packets
  • Flavors: Three
  • Form: Powder

Pros

  • Contains almost as many electrolytes as more expensive options on this list
  • Tasty
  • Made with natural flavors and sweeteners

Cons

  • On the sweeter side

If you’re broke, hungover, and need something to fill the empty vessel of your spirit, look no further than this electrolyte mix from Emergen-C. At .56 cents per serving, it’s truly the cheapest option you can get. Plus, it has just as many—if not more, in some cases—electrolytes as some of the more expensive options on this list. Even better, it comes in packets so you can take it on-the-go so you don’t throw up in public.

What to consider when buying the best electrolyte drinks

You could grab whatever you see at the store. Or, you could snag something tailored to your lifestyle. Here’s what you should know before placing that drink mix in your cart.

Ingredients

Possibly the most important is the ingredients. Check the label to see exactly what you’re getting in your electrolyte drink. There are a lot of different options and the one you choose could vary depending on what you’re looking for such as a way to help get over being sick or a way to fuel your exercise. 

Different electrolytes include sodium, magnesium, calcium, phosphorous, and chloride.

The non-active ingredients are important to check, too. Some sports drinks have the electrolytes you need, but pair them with tons of added sugar, which isn’t ideal. 

Form

There are different forms in which electrolyte drinks come in. These include premixed liquid form, like Pedialyte, powder form, like Liquid I.V., and dissolvable tablets, like Nuun. Then there are also naturally occurring electrolyte drinks like coconut water. 

The type of electrolyte drinks you decide on may depend on if you need to travel with it, how much you need to carry with you easily, and also just downright preference.

Other additives

Some electrolyte drinks include extra ingredients like caffeine or Vitamin C. There are reasons why some of these extra additives may be beneficial and other reasons why some people may want to avoid them. It is generally best to keep clear of any drink high in sugar content. Consulting your doctor can’t hurt before starting any supplement, especially if it’s part of a new or particularly rigorous exercise program. 

FAQs

Q: How much do the best electrolyte drinks cost?

Depending on the number of servings, the best electrolyte drinks will cost between $10-$30.

Q: Is it okay to drink electrolytes every day?

It is unnecessary to drink electrolyte drinks all the time. They are most beneficial during prolonged exercise (more than an hour), in hot environments, or if you’re ill. Almost every electrolyte drink comes with high sodium levels, which you may not need if you’re not losing liquids through sweat or other bodily functions. Ask a doctor for your best information. 

Q: What are the symptoms of low electrolytes?

An electrolyte imbalance may create a number of symptoms. These could include:
– Muscle spasms, weakness, twitching, or convulsions
– Dizziness
– Abdominal or muscle cramps
– Irregular heartbeat
– Mental confusion

The most common sign of low electrolytes is muscle cramping.

Final thoughts on the best electrolyte drinks

Electrolyte drinks can do your body good, but not everyone needs added electrolytes since your body naturally replenishes them. Generally, electrolyte drinks are great for those that are working out for a long time at high intensities, professional and competitive athletes, long-distance hikers, and so on. They are also great for when you have the stomach flu, are breastfeeding, or need to rehydrate after a long night of drinking. 

If you’re looking for the best electrolyte drinks, there are a few things to consider before making that final purchase. What ingredients do you want and which ones do you want to avoid? Do you want liquid, tablets, or powder? Do you need something easy to carry or travel with? Once you answer these questions, one of these best electrolyte drinks should work great for you.

The post The best electrolyte drinks of 2023 appeared first on Popular Science.

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How to stream movies and shows without destroying your sleep https://www.popsci.com/binge-watch-without-messing-up-your-sleep/ Tue, 22 Jun 2021 01:00:00 +0000 https://www.popsci.com/uncategorized/binge-watch-without-messing-up-your-sleep/
A TV with the Stranger Things title screen on it, in a dark room bathed in purple light. Exactly what you might see if you're binge-watching instead of going to sleep.
We know you want to keep watching, but your body needs sleep. Toby Osborn / Unsplash

Have your screen time and sleep well too.

The post How to stream movies and shows without destroying your sleep appeared first on Popular Science.

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A TV with the Stranger Things title screen on it, in a dark room bathed in purple light. Exactly what you might see if you're binge-watching instead of going to sleep.
We know you want to keep watching, but your body needs sleep. Toby Osborn / Unsplash

If you subscribe to Netflix, Amazon Prime, or any other streaming service, you’ve probably found yourself gazing at the screen as episode after episode autoplays, until you check the clock and realize you wanted to go to sleep more than an hour ago. But series like Stranger Things are seriously good television—so where’s the harm in binge-watching a bit?

The problem is that a growing body of evidence suggests the various demands of a modern-day lifestyle, including hours of late-night streaming, are seriously disrupting human sleep patterns. This, in turn, can damage our overall health. But just try telling people to give up their Netflix—it’s a recipe for failure.

With that in mind, the American Academy of Sleep Medicine, a professional society founded in 1975, has taken it upon itself to set some guidelines for enjoying top-notch shows while making sure your body and brain get enough rest. We can show you how to use them to properly balance binge-watching and sleep.

Take breaks between episodes

The AASM recommends getting out of “the autoplay loop,” where you watch episode after episode because it takes less effort than stopping the playback. Luckily, Netflix, Hulu, and other streaming services give you the option to turn autoplay off. The idea is that manually loading the next episode can prevent you from mindlessly gluing your eyes to the screen. However, it’s still easy for you to click, click, click through the episodes. Which is why you should also…

Set an episode limit

Don’t fire up Bridgerton and then wait to see how the evening goes. Decide in advance how much you’re going to watch before bed and then stick to that limit, regardless of cliffhangers. (By the way, this is the same principle you should use for a night of boozing.)

If you have trouble obeying this type of limit, you might have to trick yourself. One way to do so is by downloading episodes onto your phone. Because Netflix and other services support offline downloads for many shows, you can pre-load all the television you’ve decided to watch in advance. Then put your phone in airplane mode to stop yourself from exceeding your limits. Downloading also lets you catch up with Yellowjackets on the train ride to work, instead of staying up watching it the night before.

The Netflix user interface for the show Bloodline, showing offline download options, which can help you balance binge-watching and sleep.
Downloading episodes can help you stick to your limits. David Nield

Stressed about finishing an episode on your commute? Try reserving some daylight hours when you’ll be able to watch without worrying about missing your stop or blowing past your bedtime. The AASM advises you to resolve the conflict between binge-watching and sleep by setting aside relaxed viewing time over the weekend.

[Related: How to add subtitles to Netflix and other apps]

Avoid using your phone in bed

Sure, few places provide a comfier binge-watching location than your bed. But again, it’s all too easy to keep watching for one more episode when you and your phone are cozily tucked in. Using screens in bed can keep your mind active for longer than is healthy—so keep the gadgets away from your sleeping area.

Another problem with phones is that their glowing displays strain our eyes. All that staring at your phone is unhealthy, and one way to limit its impact on your sleep is to watch on a bigger, more distant screen instead. So instead of using your phone in bed, try streaming that media to a television.

Control the light

Bright blue light, like the wavelengths emanating from your video screen, will keep you alert and suppress the chemicals supposed to send you to sleep. To make sure you’re able to drop off when you want to, you should stop binge-watching about half an hour before your desired bedtime. In fact, the AASM recommends turning off all screens at least 30 minutes before you sleep.

[Related: There’s a lot to learn about how blue light affects our eyes]

In fact reducing any blue light exposure after sunset could help steady your sleep cycle. So you should try cutting down on the amount of blue light your smartphone or laptop emits—and yes, there’s an app for that. Several apps, in fact.

For iPhone users, there’s a blue-light-reduction feature called Night Shift built right into iOS. It can automatically adjust the color of the screen during evening hours so that the display will emit reddish rather than bluish light. To find it, open the Settings app and head to Display & Brightness.

The Night Shift option on an Apple iPhone with iOS.
Use Apple’s Night Shift option to get ready for sleep. David Nield

Apple has also included the same feature in macOS. To set it up on your computer, open the Apple menu, choose System Settings, and open the Displays tab. Click the Night Shift button in the bottom right, and you’ll be able to set the color change schedule and strength as you see fit, just as on iOS.

Android phones have a similar feature called Night Light, though the setup process may be different depending on which version of the mobile operating system you’re using. To activate it on a Pixel phone, go to SettingsDisplay, and tap Night Light. You can schedule a daily start and end time, and customize the intensity by dragging the slider.

The last thing you should remember every time you find yourself choosing between binge-watching and sleep is that AASM recommends adults rest for seven hours or more per night. Anything less than that can cause problems with work or school performance, cognitive abilities, and mood. You don’t need to stop watching movies and shows to reach this goal, but these tips should let you get a handle on your viewing habits, and make you feel a lot better.

This story has been updated. It was originally published on June 8, 2017.

The post How to stream movies and shows without destroying your sleep appeared first on Popular Science.

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Supreme Court votes to allow access to abortion drug, for now https://www.popsci.com/health/abortion-ruling-mifepristone-scotus/ Fri, 21 Apr 2023 23:20:00 +0000 https://www.popsci.com/?p=536030
Supreme Court votes to allow access to abortion drug, for now
Anna Moneymaker/Getty Images

In the 7-2 ruling, the Supreme Court preserved access to mifepristone—the most widely used abortion medication in the United States—for the time being.

The post Supreme Court votes to allow access to abortion drug, for now appeared first on Popular Science.

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Supreme Court votes to allow access to abortion drug, for now
Anna Moneymaker/Getty Images

On the evening of April 21, the Supreme Court ruled to allow the drug mifepristone to remain on the market, AP reports. The case continues in lower courts, but access to the drug will remain, for the time being. The restrictions on mifepristone were set to take effect at 11:59 PM EST eastern time on Friday.

Mifepristone is the most widely used abortion medication in the United States. It works by blocking the pregnancy hormone progesterone, which makes the uterus unable to support a pregnancy. It is the first pill that can be taken in a medication abortion. As part of a two-pill regimen, it is followed by another medication called misoprostol which can be obtained with a traditional prescription and has been FDA approved since 2000. 

According to the ruling on Friday, people who wish to terminate their pregnancy can still obtain the medication by mail. Mifepristone can be used up to 10 weeks into pregnancy. Mifepristone’s generic version GenBioPro will also remain available. The ruling to block restrictions on mifepristone passed in a vote of 7-2, with Justices Alito and Thomas dissenting. It will continue to be available in states that allow abortion. In the states that have banned abortion, mifepristone will be available on the grey market, Jezebel points out.

[Related: The court ruling banning the abortion pill is based on bogus science.]

In the decision, the justices weighed arguments that the restrictions on the drug from lower-court rulings would disrupt the availability of the drug.

On April 7, US District Judge Matthew Kacsmaryk from Texas put the Food and Drug Administration’s (FDA) approval of the abortion pill mifepristone on hold. This drug is known to be safe when used properly, and has a fatality rate of only 0.0005 percent, according to the FDA

In Kacsmaryk’s 67-page decision on April 7, he ruled that the FDA “improperly” approved the abortion pill mifepristone more than two decades ago. Kacsmaryk wrote that the FDA overstepped its authority in approving the drug partially by using a specialized review process reserved for drugs to treat “serious or life-threatening illnesses.” In reality, the FDA took its time with mfipristone’s approval and did not use an accelerated approval process. It went through three rounds of reviews over a period of four years in the 1990s. Each round issues a letter stating that the safety and efficacy data on the drug was on solid ground.

[Related: The court ruling banning the abortion pill is based on bogus science.]

The FDA was not the first regulatory agency to approve the drug. It was approved for use in France in 1988. Roussel Uclaf, the French company who first manufactured the drug briefly suspended its distribution following threats from anti-abortion groups. According to the Congressional Research Service, that suspension lasted only two days before it was ordered back on the market by the French government. 

Currently, FDA regulations state that pregnancy is a medical condition that can be serious and life threatening, but Kacsymaryk, who is not a scientist, argued it is a “natural process essential to perpetuating human life.” According to a report from the Centers for Disease Control and Prevention (CDC), the US had one of the worst rates of maternal mortality in the country’s history in 2021. The study found 32.9 maternal deaths per 100,000 live births, which is more than 10 times the estimated rate of other high income countries

[Related: Competing rulings put access to abortion pill in jeopardy.]

At almost the same time as Kacsmaryk’s decision on April 7, US District Judge Thomas O. Rice, of Washington State essentially ordered the opposite decision. Rice advised US authorities not to make any changes to mifepristone in at least 17 states where Democrats sued in a legal effort to protect the medication’s availability.

Kacsmaryk gave the Biden administration and mifepristone manufacturer Danco Laboratories, one week to appeal and seek to keep his ruling on hold, which was filed almost immediately after the ruling. 

On April 12, a subsequent decision by the 5th US Circuit Court of Appeals’ did not suspend the FDA’s approval of mifepristone, but kept in place restrictions that would prevent the drug from being sent to patients.

In a statement from the White House, President Joe Biden wrote, “I continue to stand by FDA’s evidence-based approval of mifepristone, and my Administration will continue to defend FDA’s independent, expert authority to review, approve, and regulate a wide range of prescription drugs.”

The post Supreme Court votes to allow access to abortion drug, for now appeared first on Popular Science.

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The best Garmin smartwatches for 2023, tested and reviewed https://www.popsci.com/reviews/best-garmin-smartwatch/ Sat, 29 May 2021 22:00:00 +0000 https://www.popsci.com/?p=368581
Best Garmin smartwatches sliced header
Tony Ware

Garmin smartwatches include sleep tracking, GPS, wellness monitoring, step trackers, and so much more. Here's how to pick the best features and fashions for you.

The post The best Garmin smartwatches for 2023, tested and reviewed appeared first on Popular Science.

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Best Garmin smartwatches sliced header
Tony Ware

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Hit the Ground Running Garmin Forerunner 955 Solar best Garmin smartwatch for running product image Garmin Forerunner 955 Solar
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This sensors-stuffed running watch keeps you in touch with your stats and your supporters.

A Class Act garmin venu 2 best smartwatch Garmin Venu 2
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An attractive smartwatch that can teach the competition about offering powerful tools in a stylish form.

Top Watch For Top Fitness The Garmin Fenix 7X Pro Solar is one of the best tactical smartwatches. Garmin fēnix 7 Sapphire Solar
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Track any outdoor activity you can imagine with this full-featured multisports watch.

Garmin is one of the most popular smartwatch makers in the world, largely due to the multinational GPS-enabled technology company’s focus on hyper-accurate fitness tracking. While Apple still holds 30% of the global market (and over 50% of its revenue), according to a February 2023 Counterpoint Research report, Garmin has achieved a position of prominence on people’s wrists from the boardroom to the backcountry. When it comes to premium multisport wearables, Garmin is the endurance athlete’s top choice because of the depth of activities supported and battery life that can outlast almost any adventure. We’ve pulled together several of the company’s most popular products to help you find the best Garmin smartwatch to fit your lifestyle, sense of style, and budget.   

How we chose the best Garmin smartwatches

All Garmin smartwatches provide a degree of wellness metering; they measure steps, monitor your heart rate, and generally check to make sure you’re still alive. But if you take your training seriously, the best smartwatches feature activity tracking, pulse oximeters to measure the oxygen in your blood, stress metering, energy-level monitoring, sleep trackers, customizable training regiments, and challenges designed to help you improve in your favorite sports. The Garmin Connect app syncs to your iOS and Android phones, providing access to customizable coaching and a community of athletes to compete with. If you’re serious about training, durability should also trump style. You don’t want it falling apart the first time you bang the watch against a machine at the gym, or you take a hit on the playing field. And if you’re a swimmer, your watch has to be waterproof, too. We took all these factors, and more, into consideration.

The best Garmin smartwatches for 2023: Reviews & Recommendations

Once you’ve considered your specific needs, it’s time to dig into the Garmin lineup. With multiple models in different lines—including sports & fitness, outdoor recreation, swimming, fashion, luxury, and more—there are plenty of options. Here are our top picks from several categories:

Best overall: Garmin fēnix 7 Sapphire Solar

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Why it made the cut: If you want metrics that tell you if you’re in the weeds and guidance that helps you get out of the woods, the fēnix 7 Sapphire Solar can keep up with whatever you’re up to.

Specs

  • Display: 1.3-inch sunlight-visible, transflective memory-in-pixel (MIP)
  • Touchscreen: Yes
  • Battery life with GPS: Up to 57 hours/73 hours with solar (GPS only mode)
  • Weight: 2.68 ounces

Pros

  • The battery life, which can stretch from many days to several months depending on usage and solar energy conditions
  • Touchscreen and button navigation/controls
  • The visibility in sunlight
  • The durability of the titanium body and sapphire crystal

Cons

  • Expensive
  • Bulky

The Garmin fēnix 7 Sapphire Solar is perfect for gym rats, anyone who plays a wide variety of sports, and especially people who believe new terrain equals new gains. It tracks more activities than other watches and includes advanced training features like PacePro for grade-adjusted pace guidance throughout an activity. Plus, the heart monitor works underwater. Adventurous athletes will appreciate the preloaded TopoActive maps (updateable via Wi-Fi), ski maps for more than 2,000 ski resorts, and a multiband global navigation satellite system. Whether it’s jet lag or running laps, the sensor-packed smartwatch gives you insight into your body’s battery (tracking everything from heart rate and blood oxygen to respiration and sleep to stress and hydration). The downside: It’s predictably expensive and chunky. The upsides, though …

Watches need to be charged. Most of Garmin’s smartwatches plug into a wall via a proprietary multi-pin USB cable (don’t lose it!) that attaches to the back of the case. At the higher end of the product line, these watches run for about 26 hours under a constantly tracking GPS load or 173 days in battery-saver mode. However, if you’re someone who spends a lot of time outdoors—whether hiking, gardening, or running, for instance—Garmin’s solar watches can extend that time, well, almost indefinitely. Garmin uses what the company calls “Power Glass,” which is integrated behind tough Corning Gorilla Glass 3 in the standard Solar edition or Power Sapphire in the upgraded flagship (shown catching sunlight on a crisp January hike above), to turn a few hours of direct light into days of use. As a bonus, the Power Glass doesn’t take up real estate on the watch’s face, leaving ample room for all the other information Garmin’s watches provide. 

As its name suggests, the Garmin Solar watches can be powered by the sun; three hours of direct light is enough to keep one running. It’s a boon for outdoor enthusiasts, especially athletic ones who will appreciate the robust set of activity trackers, personal coaching, and other wellness features. It’s a great fitness watch, but the fēnix 7 Sapphire Solar isn’t the prettiest of Garmin’s premium products because it lacks the advanced AMOLED touchscreen found on the Garmin epix (Gen. 2)—though that vivid display (shown below on the same winter day in a bit of shade for comparison) means the epix can’t match the fēnix 7 in battery life even though it’s otherwise as full-featured. Though a week or two, depending on mode, ain’t bad and more than enough if most of your training and traveling centers around convenient recharging stations.  

Garmin epix (Gen. 2) on a wrist while hiking in the shade
Tony Ware

Best running watch: Forerunner 955 Solar

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Why it made the cut: The Forerunner 955 Solar offers excellent battery life with a seemingly endless list of features and capabilities, from training and safety tools to full smartwatch abilities and countless customization options. 

Specs

  • Display: 1.3-inch transflective memory-in-pixel (MIP)
  • Touchscreen: Yes
  • Battery life with GPS: Up to 42 hours/49 hours with solar (GPS only mode)
  • Weight: 1.86 ounces

Pros

  • Long-lasting battery life
  • A plethora of sensors for lots of data
  • Full smartwatch capabilities
  • Touchscreen

Cons

  • Solar charging doesn’t add much to battery life

If you are serious about improvising your fitness and performance, a watch with many sensors is a must. There’s no such thing as too much data for such athletes. That’s where the Forerunner 955 Solar comes in. It’s jam-packed with just about every sensor you could imagine so that you can measure everything from heart rate to stride length and even REM sleep.

Garmin then uses all that data to provide training suggestions and status updates via the watch and the Garmin Connect app. It helps prevent overtraining, offers a rough guide for improving your performance, and suggests workout ideas to keep your training fresh (as we found out in our full review). Your Forerunner 955 can even give predictions on race times for different distances. It’s essentially like having a coach right there on your wrist (or in your pocket).

Beyond fitness tracking, the watch also pairs with your phone for full smartwatch capabilities. It will give you notifications for calls, texts, and all your apps and even let you send some preformatted responses right from the watch. And you’ll have access to important safety features for runners so that they can track your progress on an activity (LiveTrack), and you can quickly request help (Assistance).

Best for hiking: Instinct 2 Solar and Instinct 2S Solar

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Why it made the cut: The Instinct 2 Solar provides truly impressive battery life and rugged design for those who seek out long adventures.

Specs

  • Display: 0.79 x 0.79-inch or 0.9 x 0.9-inch monochrome, sunlight-visible, transflective memory-in-pixel (MIP)
  • Touchscreen: No
  • Battery life with GPS: Up to 30 hours/48 hours with solar
  • Weight: 1.52 ounces or 1.86 ounces

Pros

  • Ridiculous battery life
  • Available in two sizes
  • Robust fitness tracking and health features
  • Garmin Pay compatible

Cons

  • Black and white display 
  • Detailed maps and graphs don’t show up well

Hiking—especially long hikes and backpacking—requires more from a watch than many other activities. Battery life, in particular, is critical. Recording with GPS for long periods can eat through battery life, and having your hike recording disappear because of a dead battery is extremely frustrating. The Instinct 2 Solar attempts to solve this with its absurdly long battery life. For example, in Expedition mode, you can get up to 105 days of battery with the right solar conditions.

Part of the long battery life is thanks to the rather simple monochrome display. It’s not a fancy color touchscreen like some of the more premium Garmin watches, but it’s easily visible even in bright sunlight and fits the rugged design of the watch. Additionally, the Instinct Solar 2 comes in two case sizes: 40mm or 45mm. That’s especially ideal for those with tiny wrists who don’t want a giant watch (like me, for instance). And a newer Instinct 2X Solar has been released with a larger bezel for those who prefer a larger display and longer battery life, so now there are three size options within the family.

The watch comes with more basic sensors, including heart rate, barometric altimeter, accelerometer, thermometer, pulse ox monitor, compass, and a few GPS modes. Even though it doesn’t have as many sensors as the more expensive watches, it still provides training details, statuses, and suggestions to improve your fitness without thinking much about it. 

Best for diving: Garmin Descent G1 Solar

Abby Ferguson

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Why it made the cut: The solar capabilities of the Descent G1 Solar prolong the battery life, allowing you to stay out longer while recording your dives. Plus, it offers a full suite of freediver-friendly features to keep you safe and help you improve your apnea performance. 

Specs

  • Display: 0.9 x 0.9-inch monochrome, sunlight-visible, transflective memory-in-pixel (MIP)
  • Touchscreen: No
  • Battery life with GPS: Up to 26 hours/39 hours with solar
  • Weight: 2.32 ounes

Pros

  • Excellent battery life and fast charging
  • Dive features are intuitive and easy to use
  • Very customizable
  • Pairs with other Garmin fitness devices like heart rate monitors and power meters

Cons

  • Monochrome screen
  • Not as sleek as the more premium Garmin dive watch

While most forms of exercise overlap with what you would want from a watch, diving presents a unique situation. Environmental conditions such as tide and weather are even more critical when diving, and different data types are useful to stay safe. The Garmin Descent G1 Solar is a robust and rugged dive computer and exercise watch that is water-rated to 100 meters. It’s the ideal tool for those who dive but don’t want a separate device for exercise on land.

This watch can keep you updated on the current tide, surf, and weather conditions, provides GPS coordinates of your surface entry and exit points, and can pair with the Garmin InReach communication device. All these features will help keep you safe even if you are in a remote location. Plus, you’ll get up to 25 hours of battery life in dive mode, so you won’t have to worry about your watch dying mid-dive session.

The Descent G1 Solar comes loaded with multiple types of diving, including single and multiple gas dives (including nitrox and trimix), gauge, apnea, apnea hunt, and closed-circuit rebreather. But it’s also ready for just about any other type of activity, from running to cycling and even hunting and yoga. My husband has been using this watch for six months and said it is a fantastic partner to have with you in the field (or in the water) on long days.

Best fashion wearable: Garmin Venu 2 

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Specs

  • Display: 1.3-inch AMOLED optional always-on mode
  • Touchscreen: No
  • Battery life with GPS: Up to 22 hours (GPS without music); 11 days as just a smartwatch
  • Weight: 1.73 ounces

Sometimes you want a smartwatch that is less focused on your workouts but can keep you up on work while you’re out. While keeping track of your steps, etc., is valuable, sometimes you want to control your watch and control your life. The Garmin Connect app allows the company’s watches to sync to iOS and Android phones via a robust Bluetooth connection. This opens up advanced wellness features and biometric tracking, as well as a way to further customize the watch’s features. But what I really love is how syncing the two lets me subtly check my messages and calendar alerts by simply glancing at my wrist. I can also control my music, navigate through a new city, and many other things I’d normally use my phone for—all while keeping my hands free. Now, reaching into my back pocket for anything other than answering a call seems like a waste, even when not working out.

The Venu 2 features a colorful, touch-sensitive AMOLED display that’s as easy to read as it is to navigate. This is great because the smartwatch is loaded with features, including activity tracking, a powerful GPS, onboard storage for up to 650 songs, and seamless integration with your smartphone via the Garmin Connect app. This is a watch you can wear all day, in any setting, and it’ll never look out of place (and you can read more about the experience in our full review).

Best budget watch for beginners: Garmin Vivoactive 4

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Specs

  • Display: 1.3-inch sunlight-visible, transflective memory-in-pixel (MIP)
  • Touchscreen: No
  • Battery life with GPS: Up to 18 hours (GPS without music)
  • Weight: 1.78 ounces

Pay attention to your budget when choosing a smartwatch. If you don’t need advanced features, like solar power, and AMOLED screens, then don’t pay extra for them. If you’re looking for a basic fitness tracker and something that syncs with your phone, many of Garmin’s entry-level watches will suit you just fine. 

They still offer basic sports apps, GPS, and access to apps and widgets from the Garmin Connect store, and they’ll integrate with iOS and Android phones. While future-proofing yourself might seem smart, smartwatch technology develops quickly and by the time you’re ready for more advanced features, watches featuring them might drop in price. Only pay for what you’ll use. 

Garmin’s Vivoactive 3 GPS smartwatch features built-in sports apps, a contactless payment system, and the ability to sync with compatible smartphones. It comes housed in a classy package that looks great in the gym and out and about, and the watch face can be personalized by visiting Garmin’s Connect IQ store.

What to consider when choosing a Garmin smartwatch

After holding the pandemic at bay with packaged cookies and streaming TV, people have been reintroducing regular exercise and movement into their lives in living rooms, gyms, trails, and beyond. And achieving goals is easier if you can accurately track them. However, if you’re not a hardcore athlete, you don’t need the same features someone training to hit specific benchmarks would. When choosing the best Garmin watch, focus on finding the health monitoring features you want without paying extra money for those you’ll never use. Here are some things to think about when choosing the best Garmin activity tracker:

Features

Are you looking for a simple workout tracker, or do you need advanced metrics? Will it be closely monitoring your health? How important is the sleep tracker function? Do you prefer a fitness watch that allows you to organize your life by providing access to your phone’s messages and calendars? Will you pay for things by tapping your watch? Download and play music, or control the music player on your phone? How important are GPS features? Different watches offer different combinations of these features and more. There’s a big difference between something like the $199 Garmin Forerunner 55 (reviewed here) or the $169 Garmin Forerunner 35, which are dedicated Garmin running watches, and something like the $399 Garmin Venu 2, which is more of a well-rounded smartwatch you’ll wear all the time.

Style

Many of Garmin’s best sports watches aren’t exactly elegant to look at. Think about when and where you plan on wearing your watch. Do you like the bulky aesthetic of classic sports watches, like the Garmin Instinct Solar, or do you want a watch you can wear all day—maybe even going straight to work from the gym? Don’t forget to look at the different color options available to each watch model, and keep in mind that watch bands are often customizable.  

Battery life

Do you spend a lot of time camping? Do you go weeks without seeing an outlet? Or are you home each night with access to a charging station? Make sure the watch you purchase won’t let you down by running out of juice. This doesn’t necessarily mean larger batteries—Garmin makes solar versions of most watch series that can last for weeks if exposed to enough direct sunlight. For other watches, battery life can come down to usage. The Venu 2, for instance, can last up to 11 days in battery-saver mode, but it will die in just 7 hours if you’re playing music and using GPS. 

FAQs

Q: Is Garmin better than Apple Watch?

Everyone’s definition of “better” will differ. In the end, choosing the best smartwatch comes down to the features you want, your budget, and whether you’re already part of the Apple ecosystem. While Apple far and away controls the largest market share for smartwatches, Garmin has a solid chunk by offering a variety of GPS and sports watches geared toward different users’ needs. There is undoubtedly no easier experience than pairing an Apple Watch with an iPhone for seamless connectivity and maximum productivity. And the Apple Watch Ultra has ratcheted up the brand’s durability for endurance athletes. But if you’re looking for a serious training tool, however, something like the Garmin epix (Gen. 2) could offer some handy training features that the Apple Watch can’t.

Q: What is the best value Garmin watch?

Again, it comes down to what you want your watch to do and how much you can afford to spend. The Venu SQ 2 starts at just $249. While it lacks some of the high-end bells and whistles found on the $399 Venu 2, the Venu SQ 2 still offers an impressive set of features for the price, including a blood oxygen monitor and sleep tracking. If you don’t need full smartwatch capabilities and you specifically want to track your runs, then Forerunner 45 is only $150 and gets you tons of fitness tracking muscle without the stuff you may not use. 

If you want a full feature set without such a bulky frame, the Garmin Vivoactive 4S is a solid balance of value and performance. At $349, it’s cheaper than the flagship models but more expensive than the entry-level offerings.

Q: Are Garmin watches worth it?

If you’re looking for a convenient way to track your activities and monitor your health, and you like the idea of a more subtle way to control your phone and receive messages and alerts, then I absolutely think Garmin watches are worth it. The best Garmin smartwatches offer top-tier tools for training and fitness, sleep trackers are the like, and the Garmin Connect app for iOS and Android opens up a host of features that push the watch in powerful directions. If you’re already in the Apple ecosystem, an Apple watch is definitely worth investigating; Apple products have a way of seamlessly integrating that makes them a delight to use. However, even if you’ve got an iPhone, and especially if you’re using an Android phone, Garmins are strong contenders in the smartwatch field. 

Final thoughts on the best Garmin smartwatches

It’s no mystery why Garmin has become a top smartwatch company. Instead of taking a one-size-fits-all approach to watch design, Garmin has offered up options focusing on health and fitness, all-day wear, and high-tech gadgetry designed to fit individual users’ lifestyles. Sometimes the differences aren’t obvious, and shopping for a Garmin watch can feel daunting. But by identifying your needs first and consulting this guide, you’ll be able to zero in on the smartwatch that’s best for you. 

Why trust us

Popular Science started writing about technology more than 150 years ago. There was no such thing as “gadget writing” when we published our first issue in 1872, but if there was, our mission to demystify the world of innovation for everyday readers means we would have been all over it. Here in the present, PopSci is fully committed to helping readers navigate the increasingly intimidating array of devices on the market right now.

Our writers and editors have combined decades of experience covering and reviewing consumer electronics. We each have our own obsessive specialties—from high-end audio to video games to cameras and beyond—but when we’re reviewing devices outside of our immediate wheelhouses, we do our best to seek out trustworthy voices and opinions to help guide people to the very best recommendations. We know we don’t know everything, but we’re excited to live through the analysis paralysis that internet shopping can spur so readers don’t have to.

The post The best Garmin smartwatches for 2023, tested and reviewed appeared first on Popular Science.

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Young kids learn the realities of climate change in forest schools https://www.popsci.com/environment/forest-schools-climate-change/ Fri, 21 Apr 2023 10:00:00 +0000 https://www.popsci.com/?p=535840
Kids dressed in bright raingear during a forest school class in Sweden
Children from the I Ur och Skur" preschool in Sweden wait for their lunch to be prepared. Come rain, sleet or snow, little kids spend their days playing in the woods and even napping outside mid-winter across Scandinavia. Jonathan Nackstrand/AFP via Getty Images

In nature pre-schools, students spend much of their days outdoors. That could better prepare them for the future.

The post Young kids learn the realities of climate change in forest schools appeared first on Popular Science.

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Kids dressed in bright raingear during a forest school class in Sweden
Children from the I Ur och Skur" preschool in Sweden wait for their lunch to be prepared. Come rain, sleet or snow, little kids spend their days playing in the woods and even napping outside mid-winter across Scandinavia. Jonathan Nackstrand/AFP via Getty Images

Hana Iqbal drops her toddler off at nursery each day dressed in a raincoat, no matter what the forecast. Iqbal’s daughter goes to a forest school, where kids spend about half or more of their day outside, learning about the natural world. “Last week, my two-year-old was hammering nails into a piece of wood, wearing goggles and gloves,” she says.

Forest schools, also called nature pre-schools, outdoor pre-schools, and forest kindergartens, complement traditional education with a focus on environmental literacy. They vary in their cost, curriculum, and size, but generally mean that children spend a significant part of their classes outdoors and complete activities that help them learn about the nature around them. 

Iqbal describes herself not just as a forest schools convert, but an evangelist. “As a family doctor, I see so much heartbreaking mental health difficulty in young people every working day,” she wrote in a message to Popular Science. “I genuinely believe and hope that these streams of education—which allow children to develop mindfulness, body awareness, and relationship with nature, each other, and oneself—may be a little bit of an antidote to the challenges of modern life.”

She sends her daughter to a forest school in England, where the movement has flourished in recent years. In 2017, a shortlist of the best nurseries in the United Kingdom were all outdoor-focused. The schools are also common in Scandinavia, where the idea originated. Now, the trend is catching steam in the US as well. 

Forest schools have been around in the states since the 1960s, but have seen consistent growth since the 2010s, and a surge since the pandemic. Natural Start Alliance, which is a professional group for educators involved in environmental education, for newborns up to 8-year-olds, reports that it’s seen a big increase in interest in the past decade. In 2017, the organization logged about 275 nature preschools schools across the US; by 2022, that number had risen to more than 800 forest schools.

[Related: Homework might actually be bad]

Emily Van Laan, a communications specialist for Natural Start Alliance, attributes this to a few changes: increased conversation about the importance of early childhood development, the rise of play-based learning, concern over time spent on screens, and the spread of COVID-19 itself. She says that forest schools are scattered throughout the country, but have particularly high concentrations in California, Washington, and Minnesota.

“Sometimes people think about this approach to education as only being in places where the weather is always nice or always mild,” Van Laan says. “And that is definitely not the case. We see nature pre-schools in almost every state, including Alaska and Hawai’i, and definitely in every region of the US.”

Each school’s approach to outdoor learning will differ depending on the region. A program in Texas would think of exercises that keep kids cool during warmer months, or help them navigate snakes in the area. One in Minnesota would consider how children can stay warm and active when the temperature plunges, or teach them to forage for plants and fungi. 

Toddler in green goggles holding a pink magnifying glass over a plant in a forest school in Los Angeles
A toddler looks at an earthworm on her magnifying glass at an outdoor-learning demonstration site at the Brooklyn Early Education Center in Los Angeles, California. Bob Chamberlin/Los Angeles Times via Getty Images

“Every program will have guidance that is clearly communicated with parents in terms of the temperature barrier,” Van Laan says. For example, the forest school will tell parents how long children will spend outside in a certain temperature before going inside to take a break. Educators are also trained in risk assessment, like knowing the signs of when a child becomes too hot or cold.“The importance of having the right gear is a huge part of nature preschool,” Van Laan adds. “So they often do parent education on layering and a lot of programs often provide gear to the students that are enrolled.” 

Most programs are tuition-based and can be expensive, Van Laan says. But some offer a sliding scale or scholarships. One program in Wisconsin is free thanks to a partnership between a school district, nature center, and the YMCA. In Minnesota, 13 nature preschools are partially covered through public funding. 

Forest schools teach children how to be environmental stewards, something that is especially important as the world grapples with a changing climate. But there’s no research-based consensus on how to teach young children about climate change right now, Van Laan notes. (Even for older students, New Jersey is the only state with a mandated K-12 curriculum on climate change.) Van Laan says to start, educators should focus on teaching kids to connect with nature. “Certainly we’re not laying the responsibility of saving the planet on their tiny shoulders,” she says. 

[Related: Food forests can bring climate resilience, better health, and tasty produce to city residents]

At the same time, some forest schools have come face to face with the impacts of climate change. “The daily reality and urgency of climate change has increased,” she says. “And while we don’t want to introduce young children to ideas that frighten them, we also want to recognize their capacity for understanding. There are outdoor programs in California, for example, that have to close because of wildfires … Children are aware of these things. There’s no way to shield them from this knowledge, because they’re seeing it, they’re experiencing it.”

Iqbal says she’s happy her daughter has the unique opportunity to connect with nature daily—something she feels is made even more important with climate change. “My God, will the next generation need to know this and to look after this, after everything our generation and the generations before have created for them.”

Correction (April 24, 2023): The article previous said that Minnesota has 12 school districts with publicly funded nature preschools. The correct number is 13 nature preschools in total.

The post Young kids learn the realities of climate change in forest schools appeared first on Popular Science.

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New Zealand’s wild pigs could be a source of much-needed donor organs https://www.popsci.com/environment/new-zealand-invasive-pigs-transplant/ Fri, 21 Apr 2023 01:00:00 +0000 https://www.popsci.com/?p=535280
Auckland Island pigs scour the coastline for food. Due to their smaller stature compared to other breeds, the pigs are better candidates for xenotransplantation.
Auckland Island pigs scour the coastline for food. Due to their smaller stature compared to other breeds, the pigs are better candidates for xenotransplantation. Visual: New Zealand Department of Conservation

The animals evolved into ultra-resilient, disease-free predators while isolated on Auckland Island.

The post New Zealand’s wild pigs could be a source of much-needed donor organs appeared first on Popular Science.

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Auckland Island pigs scour the coastline for food. Due to their smaller stature compared to other breeds, the pigs are better candidates for xenotransplantation.
Auckland Island pigs scour the coastline for food. Due to their smaller stature compared to other breeds, the pigs are better candidates for xenotransplantation. Visual: New Zealand Department of Conservation

This article was originally published on Undark.

Approximately 300 miles south of New Zealand, the Auckland Islands lie in a belt of winds known as the Roaring Forties. In the late 19th century, sailing ships departing Australasia would catch a ride back to Europe by plunging deep into the Southern Ocean to ride the westerlies home.

But these seas were poorly charted, and weather conditions frequently horrendous.

Sometimes, navigators miscalculated the islands’ position and, too late, found their vessels thrown upon the islands’ rocky ramparts. Ships were torn to pieces and survivors cast ashore on one of the most remote and inhospitable places on the planet. These castaways soon found out they were not alone.

The main land mass in the Auckland archipelago, Auckland Island, was — and still is — home to pigs, initially introduced in the first half of the 19th century by European hunters and explorers, as well as a group of Indigenous New Zealanders fleeing conflict.

The pigs have no natural predators, and over time, they have wrought destruction upon Auckland Island’s flora and fauna. Government conservationists now want them gone — but there’s a twist: These once domesticated farm animals have evolved into ultra-resilient, disease-free pigs that have caught the eye of scientists who study xenotransplantation, a type of medical procedure in which cells, tissues, or organs from one species are transferred into another species.

Last year, for the first time, surgeons transplanted pig hearts and pig kidneys into humans. Such procedures have not yet been tested in clinical trials, and they are not approved by the U.S. Food and Drug Administration or regulatory agencies in New Zealand. But researchers say that xenotransplantation could eventually prove effective at treating a range of conditions and may alleviate the huge global need for donor organs. The Auckland Island pigs, with their unique genetics, may be especially well-suited for this purpose.

Some of the hardy quadrupeds are now housed in a research facility on the New Zealand mainland. Meanwhile, conservation authorities are preparing a massive effort to eradicate those left in the wild.


The first European ship to reach the Auckland Islands (known as Maukahuka or Motu Maha in the Māori language) was the whaler Ocean, in 1806. The ship’s captain returned the following year to drop off a team of seal hunters. During this visit, pigs were first released as a food source. Subsequent introductions continued, and in the late 1800s, with the tales of shipwreck and survival piling up, the New Zealand and Australian governments got involved, releasing additional pigs for the castaways.

The pigs, which were of mostly European and Asian origin, had to learn to live with the persistent cold, rain, and wind — far from ideal conditions for animals bred for sheltered barnyards. But because pigs produce up to two litters each year, they can adapt relatively quickly, said Michael Willis, of the Rare Breeds Conservation Society of New Zealand. Soon, Auckland Island’s pigs formed one unique strain.

In the winter, they survived by eating the island’s endemic plants and scavenging carrion. In the summer, their fortunes changed, and they gorged on plump albatross chicks and protein-filled penguin eggs. Twenty-five species of seabird breed on the Auckland Islands, but after two centuries of pig predation, their numbers have fallen. New Zealand conservationists are increasingly wary of the porcine prowlers.

The archipelago is “an immensely special place,” said Stephen Horn, a project manager at New Zealand’s Department of Conservation. It’s the biggest remaining stronghold of the yellow-eyed penguin, the world’s rarest penguin species, and the Gibson’s wandering albatross, which breeds there exclusively. (Currently, said Horn, seabirds on Auckland Island nest only on the precipitous edges of the land, where even the most tenacious pig won’t venture.)

The pigs have also taken a toll on the spectacular flowering plants known as megaherbs, which are now “almost non-existent” on Auckland Island, Horn said. “They’re absent until you get to the extremely steep cliff areas. Then you can see patches of green that are out of reach” of the pigs.

Heart Disease photo
On Auckland Island, a pig roots near a white-capped mollymawk colony. Currently, Horn said, seabirds on the island are successfully breeding only on the precipitous edges of the land, where even the most tenacious pig won’t venture. Visual: Paul Sagar/New Zealand National Institute of Water and Atmospheric Research

Horn believes there are between 700 and 1,500 pigs on the island, with the population fluctuating widely. Survival to breeding age, he said, is low. Those that do make it have to be tough and adaptable. “On one hand, super admirable,” he said, “the way they’re able to adapt and survive in those conditions.” And on the other hand, incredibly damaging. “They use the coastline pretty heavily,” he said. “They’ll eat anything that turns up, scavenging things like dead whales and seals or even krill and squid.”

Mindful of the Department of Conservation’s long-held wish to eradicate the pigs, the Rare Breeds Conservation Society sent a team to retrieve some in 1999. Using dogs, they managed to catch 17. “Hunger appeared to be the pigs’ constant companion,” wrote team member Peter Jackson for New Zealand Geographic. “The suckling sows had only two or three teats producing milk, which told how few piglets survived.”

The team loaded the pigs on a boat and brought them back to the southern New Zealand town of Invercargill. There, the animals were put into a quarantine facility, intended to protect the country’s domestic pig herd from potential diseases.

Horn believes there are between 700 and 1,500 pigs on the island, with the population fluctuating widely.

Keeping the pigs in quarantine required money the Society didn’t have, so they prevailed upon Invercargill’s then-mayor, Tim Shadbolt, a colorful former left-wing activist, who dipped into his contingency fund for the approximately 2,300 in today’s New Zealand dollars, or $1,400, needed to feed them.

During the first year of quarantine, the pig population ballooned. “They dined on porridge and swedes and they became raging sexual beasts, producing larger litters than they did on the Auckland Islands,” Shadbolt recalled in a 2008 article in the Otago Daily Times. The pig’s food bill increased tenfold — an expenditure that whipped up a political storm in Invercargill, with councilors and constituents railing against what they characterized as a scandalous waste of public money. Shadbolt was unceremoniously stripped of his contingency fund.

The mayor, though, would be vindicated. These pigs from a previous century soon found an unlikely home in the futuristic world of xenotransplantation.


Globally, the demand for transplant organs is overwhelming. Every year, thousands of people die waiting for a new heart, liver, kidney, or lung that never arrives. In the United States alone, around 17 people on the organ waiting list die every day. For decades, xenotransplantation has been seen as a possibility to bridge this shortfall.

Since the 1960s, surgeons have transplanted chimpanzee and baboon parts into a small number of humans with life-threatening conditions, but these efforts have had little success. The biggest challenge is getting the human body’s immune system to accept the new organ.

The use of non-human primates for biomedical research is controversial, so over time, researchers looked to pigs. “Their organs, their tissues, and their physiology are sufficiently close to humans,” said Paul Tan, founder and CEO of New Zealand xenotransplantation research company NZeno. “Their cells function in a manner that is very close to humans. So their blood sugar levels and our blood sugar levels are pretty close.”

In the late 1980s, New Zealand pediatrician Bob Elliott and colleague David Collinson started a company called Diatranz to investigate whether pig islet cells could be used to treat Type-1 diabetes. For Collinson, the quest was personal. His son suffered from the disease.

Islet cells are found in the pancreas and produce insulin, but in Type-1 diabetes patients, are destroyed by the immune system. Trial transplants of human islet cells had met with mixed results, and in any case, with millions of Type-1 diabetes sufferers globally, there were nowhere near enough human donors to meet demand.

Diatranz aimed to surgically implant pig islet cells, encapsulated in a seaweed-derived polymer that shielded them from the human immune system, into the pancreases of diabetes patients. In the 1990s, though, the work stalled amid fears of disease.

Xenotransplantation, of both cells or organs, carries the risk of bacterial or viral infections crossing from the donor animal into humans. Pigs are not as closely related to humans as apes and baboons, a circumstance that makes transplanted pig parts less likely to spread disease to humans. Still, the risk persists.

While common diseases might be eliminated with medicines, a more serious risk was thought to come from viruses that essentially gatecrash the genetic material of the host animal. These are called retroviruses; they include HIV as well as viruses that cause certain cancers.

In the United States alone, around 17 people on the organ waiting list die every day. For decades, xenotransplantation has been seen as a possibility to bridge this shortfall.

Some retroviruses, called endogenous retroviruses, have, in the deep past, even insinuated themselves into the DNA of sperm and egg cells — they are therefore part of the animal’s genetic makeup, replicated in every cell in the body and passed down through generations. There is currently no medication to eliminate retroviruses.

The concern was that pig tissues could secrete infectious particles of a porcine endogenous retrovirus, or PERV, which could then infect human cells to create a new, transmissible human disease. In the worst-case scenario, it was feared, such an event could trigger a global pandemic.

In the late 1990s, a London-based research team confirmed that, in a laboratory setting at least, PERVs could infect human cells.

The discovery, for a time, “killed xenotransplantation,” said Björn Petersen, a xenotransplantation researcher with the Friedrich Loeffler Institute, the German government’s animal-disease research center. “Pharmaceutical companies withdrew their money from the research.”

Around the world, the hunt was on for pigs that were as disease-free as possible.


In 1998, Diatranz partner Olga Garkavenko turned on her radio and got wind of Invercargill’s new arrivals. She decided to investigate.

The company obtained tissue samples from the quarantined pigs for analysis. The islands’ harsh conditions, it seemed, had been tough on disease.

“They remained isolated and therefore they remained free of a lot of common infections that you have in pigs,” said Tan. “The pigs that were weak were probably wiped out. Only the fittest survived.”

The pigs also have an unusually low number of retrovirus copies in their genome. Petersen noted that the population is also completely free of a type of PERV called PERV-C, which may pose the biggest risk to human transplant recipients. This was possible “because they were isolated for a long time and they never had contact with other pigs.”

Joachim Denner, a xenotransplantation researcher from the Free University of Berlin, said the Auckland Island pigs had another major advantage over other pig breeds — their small stature. At around 90 pounds in weight, he said, “they are the right size for transplantation.” A domestic pig weighs 300 to 700 pounds, and its organs, he added, are too large.

Auckland Island pigs scour the coastline for food. Due to their smaller stature compared to other breeds, the pigs are better candidates for xenotransplantation.
Auckland Island pigs scour the coastline for food. Due to their smaller stature compared to other breeds, the pigs are better candidates for xenotransplantation.  Visual: New Zealand Department of Conservation

In 2004, Elliott, Tan, and others set up a company called Living Cell Technologies, or LCT, which absorbed Diatranz and took over the pigs’ care, building an expensive facility near Invercargill to keep them in medical-grade isolation while they were selectively bred for xenotransplantation.

The animals housed in quarantine were suddenly reputed to be worth hundreds of thousands of dollars each, much to then-Mayor Shadbolt’s barely-concealed glee.

The project brought jobs and millions of dollars of investment to Invercargill. “It has all come to fruition,” Shadbolt said in the 2008 Otago Daily Times article. “I rub it into those people who didn’t support me at every opportunity.”


By the 2010s, concerns around PERVs were lessening, as multiple clinical trials of cell transplants suggested not only that pig cells could be effective in treating diabetes, but also that PERVs weren’t passing to humans. New gene-editing technology also meant that retrovirus genes could be rendered non-functional before an animal was born.

With these advancements, the race to successfully implant pig organs in humans has gathered pace. Groups around the world now breed pigs for this purpose. It’s big business — a recent report estimated the global xenotransplantation market could be worth $24.5 billion by 2029.

In January 2022, a University of Maryland group, using a pig organ from the U.S. company Revivicor, conducted the first successful transplant of a pig heart into a living patient. The patient survived for two months. While the cause of his death is still being examined, evidence of a disease called porcine cytomegalovirus was found during the autopsy. The pig used in the transplant, said Tan, would have been rigorously screened for the virus, which, he added, shows the importance of breeding pigs that are genuinely free from such diseases.

Paul Tan now runs NZeno, which has taken over the breeding and keeping of the Auckland Island pigs. LCT, meanwhile, has switched its focus to Parkinson’s disease and recently began clinical trials of a treatment that involves inserting capsules containing pig brain cells into the human brain to repair nerve damage.

NZeno supplies pig cells to LCT and is also trying to establish itself as a major player in the organ game. “We like to think that our strain of pigs, derived from the Auckland Islands, further developed at Nzeno, would be the ideal pig strain for human organ xenotransplantation,” said Tan. Their cells, he noted, have already been used in humans for years, and have a very good track record of safety. The small number of retrovirus copies in the pigs’ genomes, he said, also require less gene editing compared to other breeds.

NZeno recently provided its pig cells to a team at Ludwig Maximilian University in Munich, which aims to have a genetically-modified pig ready for a pig-human heart transplant by 2025. NZeno is also working with another xenotransplantation group in China that aims to develop kidneys for transplant.

Petersen agreed that there is a solid rationale for minimizing gene editing. “The more genetic modifications you do,” he said, “the more side effects you can maybe expect.” But, he added, there may be cases in which it doesn’t make sense to prioritize the minimization of gene editing. For example, “if you want to have a universal donor” — an animal that can supply a variety of suitable organs or cells for human transplant — “then you need to have a pig with more genetic modifications right from the beginning.”

Denner said the Auckland Island pigs, which he describes as the most disease-free pigs in the world, may yet prove their true worth. But he cautioned against viewing them — or any pig — as a silver bullet. “All these studies have limitations,” he said. “The real effect of PERVs on humans, we will see when we perform the first transplants of organs.”


For now, wild Auckland Island pigs continue to run free in their storm-battered home, but the clock is ticking. Over the last five years, New Zealand’s Department of Conservation has been preparing for eradication.

Stephen Horn leads the team charged with this enormous task. Previous work attached GPS trackers to pigs, trying to learn their movements, and Horn’s team has trialed various methods of killing them. The plan is to wipe out the pigs using a combination of traps, poisoning, and hunters shooting from helicopters and on foot.

“The approach is really high intensity, as quickly as possible,” said Horn, “and try to keep the population as naive as possible.

“You need a suite of tools,” he continued, “because pigs are smart. Not every pig is going to be vulnerable to the same technique.”

Compounding the difficulty is the island’s size and isolation. It is several days’ dangerous sail from the mainland and, aside from a few uninhabitable hut shelters, the islands have no infrastructure to support human life. Once ashore, movement through the dense undergrowth and shoulder-high grasses is extraordinarily difficult.

Heart Disease photo
For now, the Auckland Island pigs continue to run free, but the clock is ticking: New Zealand’s Department of Conservation has been preparing for eradication. Visual: New Zealand Department of Conservation

“It’s rugged, remote, and massive,” said Horn. “It’s pretty overwhelming when you’re looking at it through a lens of animal pest control.”

Not everyone is thrilled at the prospect of the pigs’ demise. The animals are “very much part of our heritage,” said Willis of the Rare Breeds Conservation Society. The organization argues more effort should be made to preserve at least some of them. Perhaps the pigs could be fenced off, so as not to disrupt the entire island, said Willis. Or some could be relocated to another island, where they might not pose as much of a problem. As far as he is aware, however, these options are not being considered.

Paul Tan said he would also jump at the chance to retrieve more pigs.

The Department of Conservation, said Horn, has fielded inquiries about recovering pigs, but the logistics of retrieving them from the Auckland Islands, as well as the enormous costs involved in quarantine, are major hurdles to overcome.

Horn said that while staff are actively discussing options for retrieving pigs, their focus is eradication. With a plan in place, the department just needs to secure enough funding to make it happen, he said, “to undo some of the damage that was done by people, on what is an extremely fragile, but important place.”


Bill Morris is a documentary filmmaker, wildlife cameraman, and science journalist based in Dunedin, New Zealand. He is a regular contributor to New Zealand Geographic magazine and his work has also appeared on the BBC and Animal Planet.

This article was originally published on Undark. Read the original article.

Heart Disease photo

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What’s at the root of gray hairs? https://www.popsci.com/health/gray-hair-stem-cells/ Thu, 20 Apr 2023 19:00:00 +0000 https://www.popsci.com/?p=535572
Gray hair growing on a male's head.
Gray hair comes with aging and scientists may now know why. Deposit Photos

You can blame some of your gray hairs on faulty stem cells.

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Gray hair growing on a male's head.
Gray hair comes with aging and scientists may now know why. Deposit Photos

Aging has been said to be a “privilege denied to many”—and gray hair typically accompanies that privilege. Gray hair can also be caused by stress, but scientists might be closer to figuring out exactly why even the most colorful hair turns gray with age. A study published April 19 in the journal Nature found that certain stem cells have a unique ability to move between the growth compartments in hair follicles, but they get stuck and lose their ability to mature and maintain hair color as people age. 

[Related: We finally know why stress turns your hair white.]

The melanocyte stem cells (McSCs) in hair follicles are responsible for producing and maintaining the pigment in our hair. Every hair follicle stores immature melanocyte stem cells, and when they’re needed, the cells travel from one part of the follicle to another. When they reach other parts of the follicle, proteins turn them into more mature pigment-producing cells, and give hair its hue. Inside these follicle’s compartments, McSCs are exposed to different levels of maturity-influencing protein signals as a person ages. 

According to the study, which McSC cells from mice, as hair ages, sheds, and then repeatedly grows back, more McSCs get stuck in a stem cell compartment called the hair follicle bulge. While there, they stay put, unable to mature or be able to move between follicle compartments. They also do not travel back to their original location where WNT proteins would have prodded them to regenerate into pigment cells.

“Our study adds to our basic understanding of how melanocyte stem cells work to color hair,” study co-author and New York University computer engineer Qi Sun said in a statement. “The newfound mechanisms raise the possibility that the same fixed-positioning of melanocyte stem cells may exist in humans. If so, it presents a potential pathway for reversing or preventing the graying of human hair by helping jammed cells to move again between developing hair follicle compartments.”

To learn more about how stem cells behave during different phases of hair growth, the team tracked and took images of the individual cells in mouse fur. The stem cells actually traveled back and forth within the hair follicle and even transitioned into their mature, pigment-producing state and then out of it again as they moved.

As time continued, the McSCs couldn’t keep up this process, and a hair falling out and growing back takes its toll on the follicle. Eventually, the stem cells stopped making this journey through the follicle and stopped getting protein signals to make pigment. From then on, any new hair growth does not get the melanin needed to produce hair color. 

[Related: Alopecia patients finally have an FDA-approved hair-loss treatment.]

To explore this effect more, the ream plucked hair from mice to stimulate a faster growth cycle. The experiment led to a build up of McSCs stuck in storage that no longer produced melanin, and the fur turned from dark brown to a distinguished salt-and-pepper. 

“It is the loss of chameleon-like function in melanocyte stem cells that may be responsible for graying and loss of hair color,” co-author and NYU pharmacologist and cell biologist Mayumi Ito, said in a statement.  “These findings suggest that melanocyte stem cell motility and reversible differentiation are key to keeping hair healthy and colored.
Some next steps for the team include investigating how to restore motility in these stem cells so that they can move back to the compartments that produce pigment. Until then, consider joining the “gray hair revolution” of people embracing those beautiful gray strands.

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On 420, learn more about weed with these carefully cultivated science stories https://www.popsci.com/science/weed-science-stories/ Thu, 20 Apr 2023 13:08:19 +0000 https://www.popsci.com/?p=535481
Cannabis plant under purple weed grow light
Keep the weed growing to the experts. Deposit Photos

Light up your life with these highly educational articles on cannabis in its many forms.

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Cannabis plant under purple weed grow light
Keep the weed growing to the experts. Deposit Photos

Today is a very special holiday where a skunky smell permeates the air. If you’re celebrating 4/20, Popular Science has the perfect lineup of dope science stories to make you everyone’s favorite bud. Don’t puff puff pass on this one!

Essential cannabis accessories

First things first, everyone needs some cannabis supplies before lighting up. But with so many twists on glassware and other options, how do you decide? From vaporizers to grinders to pen batteries, PopSci’s roundup of essential cannabis accessories will walk you through the choices.

A step-by-step guide to rolling a joint

Rolling a joint can’t be that hard, right? Wrong. Thankfully, in honor of 4/20, our DIY step-by-step guide will explain both the art and the science of rolling a joint, with advice straight from some of New York City’s expert budtenders. It’s the perfect refresher for veterans and crash course for newbies, complete with photos, detailed instructions, and material recommendations.

Can CBD help you chill? Here’s what we know so far.

CBD, THC’s sister molecule, has been working its way into various products as part of a budding industry. CBD is legal in more US states than cannabis, and can be added to almost any product as long as it has less than 0.3 percent THC. It’s a great alternative for those looking for stress relief, or don’t want the psychoactive effects of cannabis itself. Still have some questions about CBD? It’s not a panacea, but it may be worth trying out.

Is growing weed sustainable? The answer is complicated.

Using cannabis products to ease climate anxiety might be a Catch-22. Researchers say it’s hard to measure the environmental impact of today’s celebrated plant: Grow operations across the US take up a lot of water, land, and energy. Here’s what we know about the sustainability of cannabis.

Can you overdose on weed?

All substances have their risks, what about weed? Well, thankfully its not possible to overdose in the traditional sense, but overdoing it does pose some safety threats. Before you celebrate 4/20, listen to this Ask Us Anything podcast on the side effects of weed to gain some insights on responsible consumption.

The tasty chemicals flavoring the edible cannabis boom

Cannabis may have a distinctive smell, but a little-known aspect to users and non-users alike is that each strain has a special chemical composition. Like wine with its various aromas (such as floral, fruity, or earthy) different strains of cannabis possess a signature scent and taste. What makes them unique? Terpenes, or “terps,” are aromatic compounds found in many herbs and flowers. There are hundreds of known kinds that yield diverse flavors and effects. PopSci reported a comprehensive overview on the science of terpenes, ending with a list of the most buyable varieties.

Is marijuana a performance-enhancing drug? The best evidence says no.

Unfortunately for many athletes, cannabis use still falls on the list of prohibited substances. These regulations are in place to prevent the use of performance-enhancing drugs and ensure fair competition, but does cannabis really belong on the same list as steroids? Learn why the scientific reasoning behind cannabis regulations in sports might be lacking.

Cannabis gets its high-inducing power from ancient viruses

The next time a friend thanks a higher power for cannabis, remind them to appreciate viruses for their genetic contributions. (At the very least, it was a joint effort.) The psychoactive and medicinal effects of cannabis probably evolved from ancient viruses Mapping the genome of the plant posed a challenge to researchers as an illicit substance, but as it slowly became legal in different states over the past two decades, they dove deep into its background. What better time than 4/20 to learn the evolutionary history of cannabis.

Why German scientists got cows stoned

Nobody wants animals to get high on our supply, but these German scientists did it on purpose with cows. Not to laugh at the animals’ “pronounced tongue play,” as researchers described: They wanted to test if leftover organic matter from the hemp industry could be fed to livestock, reducing waste and curbing methane emissions from regular hay and soy. The German study led to some especially silly bovine behavior and THC-spiked milk.

Does CBD show up on a drug test?

Using cannabis products might lead to a positive drug test that could cost you a job or other opportunities. For those that want the stress-reducing effects of cannabis, but have to keep off the grass, consider quality products with this CBD drug test and product guide.

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Parrots are deeply intelligent. But do we understand their emotions? https://www.popsci.com/environment/captive-parrot-ptsd/ Thu, 20 Apr 2023 10:00:00 +0000 https://www.popsci.com/?p=535420
White Moluccan cockatoo on a branch turning toward a person's hand. Reddish flames are behind the bird to symbolize past trauma. Illustrated.
Maybe Harpo found comfort by repeating the words that were once used against him. Isabel Seliger for Popular Science

The profound story of Harpo the cockatoo gives us insights on trauma among captive birds.

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White Moluccan cockatoo on a branch turning toward a person's hand. Reddish flames are behind the bird to symbolize past trauma. Illustrated.
Maybe Harpo found comfort by repeating the words that were once used against him. Isabel Seliger for Popular Science

How well do you know your pets? Pet Psychic takes some of the musings you’ve had about your BFFs (beast friends forever) and connects them to hard research and results from modern science.

ONE AFTERNOON several years ago, a Moluccan cockatoo named Harpo arrived at Midwest Avian Adoption & Rescue Services in St. Paul, Minnesota. As Galiena Cimperman sat quietly with him and scratched his head, the bird started to talk.

This was perfectly normal. Harpo, like others of his species and the parrot family to which it belongs, was a very vocal creature and gifted mimic. Cimperman, the sanctuary’s executive director, was accustomed to him keeping up a semicoherent monologue of under-his-breath babble. But a long while after their first meeting, he shared something unexpected.

“I hate this bird,” Harpo said, loudly and clearly. He repeated it twice more. “I hate this bird. I hate this bird.”

Harpo had certainly heard that insult before, likely in unpleasant circumstances. But what did the cockatoo mean by it? According to Cimperman, the words didn’t have the same significance for him that they would for us; Harpo was repeating the sounds, not using them as language. But that doesn’t mean the outburst was insignificant.

Cimperman believes the phrase reflected traumas the cockatoo experienced earlier in life and that uttering them was part of his recovery. “I’m hesitant to say, because I don’t have any scientific backing on this,” she explains, “but I think he was probably working through stuff.”

Her diagnosis of Harpo—and many other residents of MAARS, one of 100 or so sanctuaries in the US that provide lifetime homes to abused and abandoned parrots—indeed comes without a seal of scientific approval. Although there’s plenty of research on parrot memory, problem-solving, and communication (the cognitive sophistication of some species is likened to that of human children), the birds’ emotions are largely unstudied.

That makes the relationship between parrots and people all the more difficult. The birds’ intelligence, physiology, and social nature often makes it difficult for them to flourish in captivity—yet there are more than 50 million parrots in households and zoos worldwide. Many are ultimately dumped at overwhelmed rescue operations, where volunteers like Cimperman have to piece together their pasts to help them find solace in the present.

As for whether the animals’ suffering can lead to psychological trauma—defined as an ongoing emotional response to an intensely distressing event—there’s even less research on that than on their feelings. But between their emotions and their excellent long-term memories, they do possess the cognitive capacities necessary to experience extended trauma.

One of the only scientific papers about parrot trauma, in fact, emerged from a collaboration between MAARS caretakers and Gay Bradshaw, the psychologist and ecologist best known for identifying PTSD in orphaned elephants who witnessed their parents and elders being killed. Presented more than a decade ago at a conference of avian veterinarians, the paper describes how parrots at the sanctuary frequently meet the criteria for the disorder.

What Bradshaw learned is that the birds undergo intensely distressing experiences, beginning in most cases at birth. Unlike parrots in the wild, whose parents provide close, attentive care from hatching through fledging, commercially bred individuals often start life in isolation. They receive little attention except for intermittent tube feeding.

“I really think their whole lives are, in some form or another, traumatic,” Cimperman says. “The way people raise them is completely absent of everything they should have.” In a review of standard commercial breeding methods, bird vet Michelle Curtis Velasco likened them to the infamous Romanian orphanages where, in the near absence of human contact, infants went on to develop severe behavioral disorders.

At parrot sanctuaries, it’s important that the birds feel control over their own lives.

Then, at an age when their wild counterparts meet other young flock members while continuing to receive parental instruction, fledgling parrots enter a human home. They have evolved to live in large groups, but as pets, just one or a few often-absent people become their entire social world. These situations are intrinsically fraught; even well-meaning guardians may ignore or punish their parrots after tiring of unwittingly powerful bites and earsplitting cries for company. Sometimes keepers are not so well-meaning, and the situation devolves into full-blown abuse.

The birds are ill-equipped to cope, says Cimperman, and stress is magnified by helplessness and an inability to escape. Many parrots, especially the larger ones, either have their wings clipped to prevent flight or never learn to fly at all; they lack the sense of security that mobility provides.

Little wonder that some parrots arrive at MAARS with symptoms of severe psychological disturbance: tics like picking their feathers out and even wounding themselves, extreme aggression, hypersensitivity to everyday noises, repetitive movements, incessant screaming, constant agitation, catatonic unresponsiveness, and so on. In extreme cases, parrots have stayed in their cages for years, avoiding eye contact and trembling when humans approach.

When seen in people, those behaviors raise concerns about PTSD. “I know this hasn’t been borne out scientifically to the degree that it should be, but I don’t know what else it adds up to,” Cimperman says. So MAARS adapts insights on human PTSD into its treatment regime. New arrivals are initially kept separate from the flock; as they begin to acclimatize, grooming, eating, and showing curiosity about their surroundings, caretakers work with them to develop a sense of trust in humans.

It’s important that the birds feel control over their own lives, says Cimperman. “So much of a parrot’s life in captivity is without choice,” she says. “We try to give everyone a sense of free agency as much as possible, closer to what they would have in the wild.” Later they may be exposed to reminders of past trauma—the sight of a garbage bag, for example, for a bird delivered to the sanctuary inside one—as they learn to regulate their feelings. The process may take months or even years.

In Harpo’s case, the details of his early life are murky. He had one guardian before arriving at a sanctuary in Texas; there Harpo killed several birds and left volunteers with wounds requiring medical treatment, at which point MAARS took him in. “We couldn’t have him out for more than five minutes. He would just kind of implode and start flying at your face or attacking anything he could get his beak on,” Cimperman recalls.

By the time Harpo said, “I hate this bird,” she had worked with him for three years. He still had episodes when “he would just kind of blank out and kind of go into attack mode,” but he was improving. He felt safe around Cimperman, and she saw that utterance—delivered with the pinned-back feathers and slit-eyed glare that signify intensely negative feelings—as part of the process. To her, it signified a mental reenactment of his past. “I think they store a lot of stuff that’s happened to them. And to be able to move forward, there has to be some getting out of stuff,” she says.

Erin Colbert-White, a comparative psychologist at the University of Puget Sound in Washington who has studied how African grey parrots use words, says she’s open to the possibility that parrots experience PTSD. She cautions, however, that Harpo’s invective is difficult to parse as a recollection of his trauma because we don’t know the context in which he first heard the disparaging phrase. “It’s such a complex conclusion to draw that I would want to somehow be able to study it systematically. I’m not saying it’s not true. I would just have more questions. The scientist in me says, ‘Proceed with caution.’”

Colbert-White also warns that the expectation that another species will “experience psychological disorders in ways that humans do is a big assumption.” Rigorous, without-a-doubt scientific evidence may be unobtainable, though; it would require inflicting trauma on captive parrots in controlled conditions. “There’s no way to ethically reproduce these sorts of situations,” Colbert-White says.

Even granting that uncertainty, just the possibility that parrots experience psychological effects that resemble humans’ adds to the urgency of protecting them—not just in captivity, notes Cimperman, but also in the wild. Half of all parrot species are declining, and one-quarter are threatened with extinction, yet they receive relatively little conservation attention. Thriving populations are frequently persecuted for the wildlife trade or in the name of “pest management.”

By the end of Harpo’s life in 2021, nine years after his arrival at MAARS, he was one of the friendliest feathered guests there. He ran to greet people and was positively joyful. “I think who Harpo was and who he ended up being were completely different birds,” Cimperman says. “He was literally unrecognizable.” And whatever he’d meant when he said “I hate this bird,” he had stopped saying it.

We hope you enjoyed Brandon Keim’s column, Pet Psychic. Check back on PopSci+ in June for the next article.

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Can CBD help you chill? Here’s what we know so far. https://www.popsci.com/story/health/cbd-effects-pain-anxiety-evidence/ Tue, 29 Dec 2020 22:54:11 +0000 https://www.popsci.com/uncategorized/cbd-effects-pain-anxiety-evidence/
A CBD oil bottle with cannabis or hemp leaves
CBD comes from cannabis, which also contains the psychoactive chemical THC. Deposit Photos

The cannabis and hemp extract can be found in everything from lattes to kids’ vitamins. But experts are still trying to understand if it’s healthy.

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A CBD oil bottle with cannabis or hemp leaves
CBD comes from cannabis, which also contains the psychoactive chemical THC. Deposit Photos

If you’re reading this, you’re probably stressed. Never fear: We’ve dug through the evidence to reveal what science really says about finding zen—and holding onto it through tough times.

In 2013, Charlotte Figi made national news by becoming the youngest patient in Colorado to receive cannabidiol (CBD) therapy to soothe her seizures. The five-year-old had struggled with severe epilepsy since infancy, sometimes experiencing 50 or more episodes a day, with little relief from standard drugs and dietary tweaks. By the time her parents started consulting doctors about CBD extracts, she had difficulty walking, talking, and eating without help.

Figi’s neurologist put her on a low dose of a specially bred strain of medical cannabis, later dubbed “Charlotte’s Web.” The effects were almost immediate. The seizures slowed from daily to weekly events, and soon, the kid was living life almost normally. After close to two years of the oral treatment, the doctors decided to wean Figi off other epileptic medications.

Figi’s story represents one of the clearest, most well-documented cases of the healing potential of CBD. (The young pioneer died in 2020, due to complications of COVID-19.) Though people have used the plant-based chemical to treat migraines and other bodily aches for centuries, the science around its efficacy is still inconclusive because it’s tricky to study its direct effect on the nervous system. Regardless, the industry has boomed in the past decade. Today CBD can be found in a range of products—from lattes to bath bombs to dog treats—and is marketed as a cure-all for pain, anxiety, insomnia, and even AIDS.

So, what should a person who’s buying CBD expect? There’s plenty of information out there, but the bottom line is confusing. Here’s an overview of what medical experts say about the ingredient and whether it lives up to its hype.

What is CBD?

CBD is essentially cannabis, minus the strong psychoactive bits. The carbon-oxygen-hydrogen compound can be found in high concentrations in Cannabis sativa and less-potent hemp plants. Sometimes manufacturers mix it with traces of tetrahydrocannabinol (THC), the cannabis-based chemical that gets people high, but it generally doesn’t carry the same dopamine-heightening and possibly addictive properties.

Like THC, though, CBD works its “magic” by cozying up to the nervous system. From what molecular scientists know so far, it somehow changes proteins found all over the body that are responsible for managing pain, inflammation, mood, appetite, and even memory. It’s still unknown how extensively it affects that internal chemistry, especially when combined with other ingredients, says Johns Hopkins University food scientist Kantha Shelke.

Is CBD legal?

The Food and Drug Administration (FDA) recently updated its regulations to state that it supports further research on benefits, safety, and use of CBD products. For now, the extract is considered a controlled substance if it comes from cannabis plants. It’s treated more like a dietary supplement or food additive when harvested from hemp.

[Related: Cannabis poisoning is on the rise in pets]

That seems relatively straightforward, but throw local laws into the mix and the standards become a lot more unwieldy. CBD is legal to sell and buy in one form or another around the US, though it’s harder to hawk across state lines because of the federal regulations. In places where it’s lawful, the ingredient can be added to any product as long as it contains less than 0.3 percent THC and is marketed correctly. If it’s labeled as a drug it has to undergo clinical tests and win FDA approval before it’s available for public use. The agency has only approved one CBD medication so far: Epidolex, which is used to treat the same genetic syndrome that Charlotte Figi had.

At the beginning of 2023, the FDA announced that it would work with Congress on a new set of CBD regulations, citing potential long-term risks to people’s livers, the male reproductive system, livestock, and more. Once they are passed, the substance will be in a separate class from dietary supplements and food additives. In the meantime, the agency cautions against giving CBD products to children, pregnant and lactating people, and pets.

What are the proven benefits of CBD?

Some of the best research on CBD’s therapeutic effects comes from treating childhood epilepsy (thanks to the Figi family), schizophrenia, sleep deprivation, and anxiety disorders. The chemical has shown strong results in relieving all four of these conditions, with “a clear calming effect,” according to one 2019 analysis. That said, most of the studies exploring this connection don’t include a control group, or a baseline for comparison.

When it comes to looking at CBD for pain relief, the research is even more flimsy. Tests have shown that it can be effective against arthritis in rats, and that it might work as well as opioids for multiple sclerosis and cancer patients. But many of these treatments also included some amount of THC, so it’s hard to say if CBD was the primary cause of relief.

There’s also the question of which forms of CBD are safe enough for consumers but strong enough to make a difference. For neurological conditions like anxiety or apnea, the chemical needs to be absorbed into the bloodstream to have maximum impact. That means it needs to be ingested, inhaled, or rubbed in at high concentrations. But as health reporter Sarah Jacoby wrote in Self while vetting her own CBD buys, many of the proteins that trigger pain and inflammation are located between the skin and veins. So, any cream or gel that wants to counter aching joints and tight muscles needs to be able to get through the dermis but not as deep as the blood vessels. That’s a tall order for any drugstore formula.

Overall, doctors are reluctant to call CBD a pain panacea. But companies keep putting it in gels, goos, tinctures, massage oils, and roll-on creams, and people continue to snap them up. (One market report put CBD sales at nearly $5 billion sales in 2020.) It’s clear that the ingredient is somewhat beneficial to human health—science just needs to understand how much.

Does CBD have any bad effects?

Medical researchers haven’t pinpointed any deadly patterns with CBD use yet. A few case studies have mentioned respiratory failure, but in many of those instances, the patients also had THC in their system. People have complained about nausea and gastrointestinal issues after taking high concentrations of CBD. The Mayo Clinic also mentions fatigue, dizziness, and loss of appetite as possible complications.

[Related: Can you overdose on weed?]

There are concerns that CBD might interact negatively with other drugs, specifically blood thinners like warfarin. But there’s no specific guidance on which medications to avoid mixing with the extract.

How much CBD should people take?

Unfortunately, there’s no easy way to calculate safe and effective serving sizes for CBD. Dosing depends on body weight, desired effect, and the way a person is taking it. CBD products often come with suggestions, but those can be misleading, given that the FDA doesn’t test every supplement against its labels and claims. (The agency has issued warnings to dozens of companies who’ve listed incorrect information about CBD and THC levels in their products; see the full list here.)

“With CBD, dosage matters,” Shelke says, as over-indulgence has been associated with ill effects. But without a fundamental understanding of the chemistry of the ingredient, and how the cooking process changes it, it’s hard to come up with scientifically backed dosing recommendations. With the limited information available, Shelke advises to go the “less is better” route with any unregulated CBD products.

Why is CBD so hard to study?

Because CBD is one of hundreds of compounds in hemp and cannabis, it’s tricky to extract and standardize. If the chemical is tainted or alternated in any way during the process, it can have a different set of effects. The way it’s consumed also plays a big part in the reaction. As Figi’s neurologist wrote back in 2014, cooking or smoking CBD means adding heat, which could break down the chemical and make it less beneficial. Pills and edibles, on the other hand, need to be carefully engineered so that they don’t get neutralized by stomach acid.

All that variability, both in the plants and the products that are derived from them, makes CBD more challenging to test for medicinal purposes. It’s also often mixed with THC when treating chronic pain or life-threatening illnesses, so it take many extra layers of research to isolate the purely physical perks from the psychoactive ones.

Is CBD safe to cook with?

Plenty of food brands, restaurants, and cookbook authors are now folding CBD into their recipes. But does the ingredient have the same therapeutic effect when it’s baked in a brownie pan at 360 degrees Fahrenheit or seared in a skillet with sea bass and lemon rinds?

“There are many unanswered questions about the science, safety, quality, and physiological effects of CBD that need to be addressed before one can identify the effects of various chemical reactions on its efficacy,” Shelke says. Part of the issue with cooking with the extract is that the purity and the concentration is often unknown. This makes it even harder to know how it will interact with other ingredients, and whether that combination will help or harm a person. Bottom line: It’s better to avoid highly processed products or prepared meals with CBD, especially if you’re new to the compound.

What’s the best way to see if CBD works for me?

If you’re looking for a supplement to help you go to sleep at night, relieve a light migraine, or unwind after a stressful event, try a low-stakes gummy or topical oil. Be sure to choose a well-reviewed and reputable product, Shelke says: Just because it says it contains CBD doesn’t mean it will live up to its promise.

To treat chronic pain, depressive disorders, or other serious illnesses, get your doctor’s recommendations first. They can take stock of the latest research specific to your needs and also track how CBD works with other prescriptions you’re taking.

[Related on PopSci+: The tasty chemicals flavoring the edible cannabis boom]

As you head into the experience, manage your expectations. Like most wellness products that are backed by tepid evidence, the results can be hit or miss. Stay within the recommended doses on the products’ labels and report any unexpected side effects to your primary-care physician.

The future of CBD seems full of potential, but in present times, there are more questions than answers.

Update (April 19, 2023): This post has been updated with new regulatory information from the FDA.

The post Can CBD help you chill? Here’s what we know so far. appeared first on Popular Science.

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This is the safest way to sleep with your baby https://www.popsci.com/health/babies-safe-sleep/ Tue, 18 Apr 2023 13:00:00 +0000 https://www.popsci.com/?p=534684
Baby with brown eyes and brown hair laying on their back. The baby is sleeping in a crib, not a bed, to prevent SIDS.
There's an important difference between a crib mattress and any other mattress. Gustavo Cultivo/Unsplash

You and an infant can share a bedroom, but never a bed.

The post This is the safest way to sleep with your baby appeared first on Popular Science.

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Baby with brown eyes and brown hair laying on their back. The baby is sleeping in a crib, not a bed, to prevent SIDS.
There's an important difference between a crib mattress and any other mattress. Gustavo Cultivo/Unsplash

In early April, Cook Children’s Medical Center in Texas sounded the alarm on a possible surge in infant deaths. Since January 2022, the hospital reported 30 mortalities stemming from unsafe sleeping situations. And while the cause of death may not have been the same for every baby, most involved sharing a bed with a caregiver.

“We’re doing a better job at identifying what the causes are,” says Susan Katz, a nurse practitioner and the infant apnea program coordinator at Stony Brook Medicine in New York, about the report. In regards to bed-sharing, she and other experts say that though there are many reasons why parents might end up sleeping with their newborn, it’s never recommended. “The scream of a mom or dad who’s lost their baby because of something like bed-sharing outweigh any benefits,” adds Gina Posner, a pediatrician at MemorialCare Orange Coast Medical Center in California.

[Related: How to get your kids on a healthy sleep schedule]

About 3,500 babies in the US die each year from sleep-related incidents, including from suffocation and sudden infant death syndrome (SIDS). Bed-sharing increases the chance for these fatal events. And while the number of sleep-related infant deaths has gone down since the 1990s, reports like the one from Cook Children’s Medical Center are a reminder that there’s still work to do in preventing these accidents. 

Why is sleeping in a bed with a baby dangerous?

First off, babies need to lie on firm surfaces, like a crib pad, says Posner. A soft adult mattress can be harmful because it conforms to the shape of the baby’s head, creating pockets of space that can cover their nose and mouth if they turn over in their sleep. A 2019 study published in the journal Pediatrics reported 14 percent of SIDS cases were from suffocation. Of these, 69 percent of the suffocations were from regular mattresses.

Bed sharing also exposes infants to other soft materials like pillows and blankets that can easily smother children, explains Posner. What’s more, pillows that are slightly elevated can force a baby’s head down so their chin rests on their chest. This position can block the baby’s tiny airways and make it hard for them to breathe. The American Academy of Pediatrics warns that any surface inclining over 10 degrees is not safe for a baby.

Another danger is the adult itself. A lot of accidental deaths happen when a caregiver rolls over on a baby, pins the baby down under blankets, or traps the baby between a wall and a bed. “I’ve seen even the best of parents who are just exhausted accidentally suffocate their child,” says Posner.

Is there any way to make bed-sharing safer?

There are multiple reasons why people might want to sleep in the same bed as their child. For example, some caregivers find that infants sleep better when next to them. “Sometimes [the babies] really do,” explains Posner. “They were inside you for nine months and it can be a hard transition to be outside.” Other parents might do it for the convenience of breastfeeding and immediately getting to go back to sleep. For sleep-deprived adults, a few extra minutes of sleep matter.

But both Katz and Posner say there’s no way to keep your infant completely safe when bed-sharing and caution against it, at least until the child turns one. The American Academy of Pediatrics also doesn’t recommend bed-sharing with infants “under any circumstance,” and recommends other alternatives.

How to practice safe sleep

Instead of bed-sharing, Katz advises caregivers to keep the baby’s crib or bassinet in the room that they’re sleeping in. Room-sharing might make it easier to breastfeed; if you prefer to do it in bed, Katz says there should be another support person awake and keeping eyes on the baby to make sure no one accidentally falls asleep.

One downside to room-sharing is that babies—and by extension, caregivers—don’t sleep well. A 2017 study in the journal Pediatrics found that infants who slept in separate rooms from their parents before the age of four months rested longer than those who shared a room (and got fed more throughout the night). The solo-napping babies also slept up to 100 minutes longer at the age of nine months. 

[Related: Improving your baby’s bone health starts in the womb]

The idea of losing a few winks might make room-sharing an unappealing option. However, waking up from your baby’s cries could be a way of making sure they’re protected against SIDS. A 2014 study in the journal Acta Neuropathologica found that nearly 42 percent of infants who died from SIDS—which includes causes beyond bedsharing—had brain abnormalities that affected the hippocampus, an area in charge of controlling breathing and heart rate during sleep. Spending the night in the same room but in different sleeping areas gives adults the opportunity to check on babies and ensure there are no hazards nearby that would compromise their breathing. 

The post This is the safest way to sleep with your baby appeared first on Popular Science.

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The court ruling banning the abortion pill is based on bogus science https://www.popsci.com/health/mifepristone-abortion-court-decisions/ Tue, 18 Apr 2023 01:00:00 +0000 https://www.popsci.com/?p=534540
A goal of the Texas plaintiffs was to stop the practice of sending abortion medication by mail.
A goal of the Texas plaintiffs was to stop the practice of sending abortion medication by mail. Pexels

The legal and medical implications make clear just how much is at stake in these abortion-related decisions.

The post The court ruling banning the abortion pill is based on bogus science appeared first on Popular Science.

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A goal of the Texas plaintiffs was to stop the practice of sending abortion medication by mail.
A goal of the Texas plaintiffs was to stop the practice of sending abortion medication by mail. Pexels

This article was originally featured on The Conversation.

An early April 2023 decision by a U.S. district judge in Texas to reverse 23 years of approval of the abortion pill mifepristone has sparked explosive debate.

Mifepristone is a medicine that blocks the receptors for the hormone progesterone, which is needed for fetal development. It is part of a two-step medication abortion regimen along with misoprostol, a drug used to prevent stomach ulcers that also causes uterine contractions. Medication abortion with this two-step approach or a slightly less effective misoprostol-only regimen is now used in more than half of all abortions in the U.S.

The Food and Drug Administration approved mifepristone in the year 2000 for use in medication abortion up to seven weeks. Along with the approval, the FDA also required an in-person visit as an additional safety measure. In 2016 the FDA expanded its approval of mifepristone use for up to 10 weeks of pregnancy.

In January 2023, the FDA further modified its rules in light of many studies that show mifepristone is a very safe medication. It decided to not enforce the requirement for an in-person visit, allowing the drug to be offered by certified pharmacies with a prescription.

The Texas judgment by U.S. District Judge Matthew J. Kacsmaryk overturning the FDA’s approval would have taken this medication off the market altogether in the United States. The 5th U.S. Circuit Court of Appeals quickly responded, saying on April 12, 2023, that the plaintiffs could not challenge the original FDA approval of mifepristone because it is too late.

However, the 5th Circuit agreed with the plaintiffs that the FDA’s 2016 approval of mifepristone up to 10 weeks after pregnancy was invalid. In addition, drawing on an 1873 law, the Comstock Act, both the Texas district court and the appeals court said that mifepristone can no longer be sent through the mail.

In order to render these decisions, the Texas judge and the appellate court had to first determine that the groups that brought the case were harmed by the FDA’s original approval and thus had what is called, in legal terms, “standing” to be allowed to sue. The plaintiffs include a coalition of anti-abortion doctors’ associations that brought the lawsuit in Texas so that it would be assigned to this judge, who was an anti-abortion advocate before his judicial appointment.

This case, and another in which a federal judge from Washington made a different decision about mifepristone, are now headed to the Supreme Court. But regardless of how that court rules, we – a legal scholar and an academic obstetrician/gynecologist and complex family planning specialist – see multiple assertions about mifepristone in the decisions with potential ripple effects on reproductive health care and law.

The Texas ruling would affect abortion access throughout the U.S.

Both decisions stem from decades of judicial rulings that interpret medical science for legal ends. The 2022 Dobbs decision that overturned nearly 50 years of the constitutional right to an abortion opened the door for legal challenges to any and all abortions. Dobbs addressed medical care related to pregnancy and birth, but the case mainly focused on reinterpreting the legal history of abortion to justify overturning precedent.

While some states have further limited access to abortion in the wake of the Dobbs decision, they have not been able to successfully stop the distribution of medications that can induce abortions. In part, this is because both the FDA and the Department of Justice have allowed medication that induces abortion to be mailed from states where there are fewer legal restrictions.

The Texas case illustrates how judges apply their own reading of science to a thorny political question. Kacsmaryk’s reasoning echoes Justice Anthony Kennedy’s approach in a Supreme Court case known as the Carhart decision, which restricted doctors from performing a second-trimester abortion procedure.

In that 2007 case, Kennedy asserted that women experience psychological harms from having an abortion. Yet scientific studies show that the harm of denying an abortion and forcing women to birth are greater and longer lasting, with higher rates of death. Law influences public discourse, and these statements about psychological harms are now commonplace in anti-abortion communications. These arguments were central to the Texas judge’s critique of the FDA’s scientific process.

Assessing harms

Before asserting that the FDA’s scientific determination was inadequate, Kacsmaryk and the 5th Circuit appellate court had to decide whether the plaintiffs have standing to sue. The plaintiff doctors’ first standing argument includes the statement that they are harmed because they may, in the future, have to care for a woman who has an exceedingly rare complication from mifepristone prescribed by another doctor.

Potential harm does not align with long-standing principles related to judicial standing; the plaintiffs must show that the agency rule will harm them.

The decision on standing relies on a highly questionable interpretation of scientific evidence of harm. The 5th Circuit uses statistics about complications from medical abortions since 2000 to suggest that at least one doctor in the plaintiff’s associations, which they claim include approximately 8,200 medical professionals, will see a patient seeking emergency care for using mifepristone. Yet it cites no evidence – because there is none – that mifepristone alone causes complications. Further, it cites no evidence that access to mifepristone through the mail, or up to 10 weeks of pregnancy, increased the rate of complications.

The 5th Circuit that affirmed Kacsmaryk’s decision about standing claims this is a narrow decision about the harm to plaintiffs. The court said these doctors have standing because complications from medical abortion are statistically likely, that the FDA cut doctors out of the process of dispensing mifepristone, and that providing care to women who took mifepristone is emotionally draining for the doctors.

Unpacking the federal appeals court decision that partially blocks the Texas ruling.

Flawed arguments

The Supreme Court has recently struggled to balance the overall impacts – burdens and benefits – of various regulations, such as student debt relief and immigration policies.

In this case, and using the doctors’ own theory of harm, there are actually numerous benefits that the plaintiff doctors receive from having mifepristone available to pregnant people in Texas. Those who cannot access mifepristone will have to either use less effective medication regimens or will be forced to get surgical abortions at later gestational ages. Delays means the fetus continues to grow, a fact about abortion access restrictions that deeply troubled Justice Kennedy.

All the risks associated with medical abortion – and therefore the time and resources doctors must spend caring for patients – will be higher if pregnant people are compelled to have surgical abortions or to give birth.

Judge Kacsmaryk frames the decision as one designed to protect women and girls, yet mifepristone is a drug that has more benefits than just safe abortion. It has been shown in numerous studies to help women safely treat an incomplete miscarriage and is now used off label for this purpose. Studies have also shown mifepristone to be helpful with labor induction, increasing the safety of the delivery process for someone who does continue with a pregnancy. Ongoing research into other applications for mifepristone may be interrupted by these judges’ decisions that limit the ways the drug can be used.

Finally, it is difficult to see how the FDA’s approvals of other medications are not vulnerable. For example, COVID-19 vaccines do not require an in-person doctor’s visit. Doctors who have been vocally opposed to the COVID-19 vaccine can easily find information to support arguments that they will have to care for vaccine injuries.

Doctors opposed to vaccines and other medications could also claim that it is too emotionally draining to treat patients who need their care – and therefore prevent other doctors who do not find it too emotionally draining from doing that important work for people who need medical care.

The legal and medical implications make clear just how much is at stake in these abortion-related decisions.The Conversation

Jamie Rowen is an associate professor of legal studies and political science at UMass Amherst. Jamie Rowen receives funding from National Science Foundation and Humanity United. Tami S. Rowen is an associate professor of obstetrics, gynecology and gynecologic surgery at University of California, San Francisco.

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Amazfit Band 7 fitness & health tracker review: Back to basics https://www.popsci.com/gear/amazfit-band-7-fitness-health-tracker-review/ Mon, 17 Apr 2023 21:00:00 +0000 https://www.popsci.com/?p=534514
The Amazfit Band 7 is a minimal yet capable fitness watch.
The running stats displayed on the Band 7 help keep me and my pup, Athena, on target for our workouts. Abby Ferguson

The Amazfit Band 7 is a simple and budget-friendly fitness tracker that still offers plenty of health insights.

The post Amazfit Band 7 fitness & health tracker review: Back to basics appeared first on Popular Science.

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The Amazfit Band 7 is a minimal yet capable fitness watch.
The running stats displayed on the Band 7 help keep me and my pup, Athena, on target for our workouts. Abby Ferguson

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The rise of smartwatches has made health and fitness tracking seem inherently more expensive. Even fairly straightforward watches containing only the most basic sensors tend to be pricey. There used to be many budget options when “Fitbit” was synonymous with fitness tracker, but many seem to have disappeared as convergence devices have increased. Enter Amazfit. The company is relatively new (established in 2015) but already has a robust lineup of budget-friendly activity accessories. And with the Amazfit Band 7, the brand has a bracelet-style tracker that takes a step back from pricier smartwatches so you can track your steps (and other performance metrics) as you move toward your fitness goals. Let’s take a close look at the conveniences and compromises that accompany a $50 fitness watch.

Abby Ferguson

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The Amazfit Band 7’s design

While all of Amazfit’s watches are more affordable than most options, the Band 7 falls in Amazfit’s Essential Series lineup, which, as you might guess, is its lowest tier. The Band 7 follows in the footsteps of the Band 5 (there was no Band 6) but presents a larger, more rectangular display, better battery life, and some general software upgrades. There’s no built-in GPS, and there are minor usability issues, but the compromises are minimal and, for most, insignificant. The watch is surprisingly capable for such a low price, with a good amount of health data and tracking opportunities. What it is not, however, is flashy.

Minimal is the best word to use when describing the design of the Amazfit Band 7. It is a simple rectangular shape with no buttons or design flourishes whatsoever. The band is one seamless piece that secures the watch face, with no special design or color inserts. The stock models are available in beige, pink, or black (the color I received to review). Should you want something else, you can also buy $10 replacement straps in green, blue, pink, or orange. 

The watch strap connects with a snap button-type design. That makes it easier to put on, but I also had issues with the edge catching on things resulting in the band unsnapping and the watch coming loose on my wrist. The band is also fairly large. I have small wrists, yes, but I used the second to last hole. Amazfit lists the minimum wrist size as 6.5 inches. So if you have smaller wrists than that, you’ll likely want to stay away from the Band 7 unless you don’t mind wearing it higher on your arm. 

Although the band may be a bit long, the watch itself is really slim. It only measures 1.7 x 1 x 0.5 inches, so it looks great, even on my miniature wrists. And it’s low-profile enough that the watch face doesn’t get caught on long sleeves. 

The lack of buttons is either really great or really annoying, depending on your preferences. It was a bit of both for me. I like the sleek look of a button-free design. But there were definitely times when having a button would have been nice. For example, if the watch turns off—either because I turn it off or it goes to sleep after not being worn for a few days—you have to connect the watch to a charger to turn it back on because there’s no power button. I found this very annoying, especially if I wanted to pop out for a run or walk. 

Amazfit Band 7 smartwach
The snap-style band closure tends to catch on things and come undone.

Display

Despite the budget price, the watch features a rather nice display. It’s a 1.47-inch HD ​​AMOLED display with a resolution of 198×368, 282ppi, and very minimal bezels. I really like the narrow rectangular design, as it provides enough screen real estate to see things easily but doesn’t take up my entire wrist to do so. It just looks really nice to me. 

It’s a colorful display and is easy to see in most situations. You have to adjust brightness manually, though, which is tricky if the brightness is turned down and you are out in the sun. You can adjust that setting in the app, but that’s a bit of a pain if you are on a run, for example. The screen is topped with tempered glass and an anti-fingerprint coating. Tempered glass isn’t as durable as other options, such as Gorilla Glass. Yet I haven’t managed to scratch the Band 7 display despite scratching my more expensive, Gorilla Glass-topped Garmin Forerunner 955

As you may expect, since there are no buttons, the display is a touchscreen, so you can swipe and tap through menus and settings. It is plenty responsive; in fact, I had issues with it being too responsive. When I crossed my arms, there was enough pressure to activate the touchscreen and enter the menu to change the watch face. It got quite irritating. 

Sensors

Amazfit fitted the Band 7 with its ​​BioTracker 3.0 PPG biometric sensor. Put simply, PPG sensors use low infrared light to measure how much light is absorbed by blood vessels. This provides a constant measurement of heart rate and blood oxygen levels (SpO2). It can also use that data to calculate and track VO2 Max, stress levels, and sleep. You will have to turn on settings to automatically track SpO2, as it defaults to only manual measurement.

The watch also utilizes a geomagnetic sensor and a three-axis acceleration sensor. It connects to your smartphone via Bluetooth 5.2 BLE, and that’s the extent of its sensors and connectivity. 

One of the aforementioned compromises due to the budget price is the lack of GPS connectivity in the watch itself. Instead, it relies on tethered GPS, meaning you’ll need your phone for all GPS data. That leads to some accuracy issues compared to watches with built-in GPS, especially multi-band GPS like the Garmin Instinct 2S Solar. If you want your route tracked or need distance data, you must have your phone along. And even with your phone, distance and route information won’t be as accurate as watches with GPS. 

Setting up the Amazfit Band 7

Setting up the Amazfit Band 7 is mostly straightforward, albeit a bit tedious. Most of the setup process is done on your phone in the Zepp app (Amazfit is powered by Zepp Health’s health management platform). The initial pairing process with my Samsung Galaxy S22 was very easy, with a simple scan of a QR code on the watch using the app. 

From there, however, things get a little bit complicated and a lot annoying. You have to grant a lot of permissions, more than any other watch platform I’ve used before. It seemed to go on forever. I also had a really hard time finding some of the menus for permissions that the Zepp app specified. It mentioned menus that simply do not exist on my phone, even though it says it’s specific to the phone manufacturer. Then, if you want to get notifications on your watch, you have to go through each individual app that you want notifications from. Which, again, was a bit tedious. 

The Amazfit Band 7’s features

As a budget device, you’d expect the Band 7 to be extremely limited in functionality and abilities. And while it certainly doesn’t have as robust a feature set as a $500 watch, the watch is surprisingly feature-rich for $50. It won’t be a replacement for serious athletes that need highly accurate information and robust tools, but it’s more than capable for most people. 

Battery life

The battery life on the Band 7 is quite surprising, given the low price of the watch. The watch offers a 232 mAh rated capacity, and Amazfit promises up to 18 days of battery life with typical usage. It says heavy usage will result in up to 12 days of battery life. Of course, all this depends on your watch settings as well, as the always-on display and certain settings like stress measuring will eat away at battery life. 

In my testing, I got an average of 16 days of battery life. I typically do one dedicated workout (either a run or strength training session) a day with anywhere between 30 minutes to an hour of duration. And I generally track a few short walks per day on top of that because of my dog. I did not have the always-on display running because I wanted to save the battery more, which greatly affected how much battery life I could get.

When the battery did run out, I was able to charge the watch quickly. Amazfit claims that the theoretical charging duration is two hours, and I found that to be accurate. If I needed a quick top-off before a workout, 15 minutes of charging would give me enough juice to record an hour-long session. The charger uses a magnetic design. In line with the watch’s design, it’s a tiny charger, making it easier to bring along on trips than other watches I’ve used. 

Amazfit Band 7
The Band 7 is capable of tracking plenty of different workout types. Abby Ferguson

Activity tracking

The Amazfit Band 7 can track 120 different types of activities. That includes the basics like outdoor and indoor running, hiking, and cycling. But it also can track badminton, belly and square dancing, jumping rope, jiu-jitsu, and even kite-flying or swinging. Essentially, if there’s an activity you want to do, chances are there’s a unique profile for it on the Amazfit Band 7. 

Tracking is easy, though, by default, the workout widget (where all the activities are) is quite low in the list, so you’ll need to scroll a bit. I thought that was an odd default placement since that’s one of the main reasons to get a watch like this. But you can customize that placement in the Zepp app. Then, you simply tap on Workout and choose the type of workout you want. 

Before you start tracking, you can also adjust settings by tapping the ellipses above the “Go” button. For example, for outdoor running, you can set a workout goal (miles, time, or calories). You can set workout alerts for different metrics like high heart rate or minimum pace. And you can even set the watch up for interval training, which is a nice feature. 

Data collection and insights

The Band 7 is fairly limited in sensors, but it offers the most important ones for basic insights: a  PPG biometric sensor, a geomagnetic sensor, and a three-axis acceleration sensor. It uses these three sensors to collect and calculate heart rate, SpO2, VO2 Max, and stress levels. 

The watch can also track your sleep, breaking it down to give you insights into how long you slept, REM sleep, and how often you were awake during the night. While it doesn’t apply this information to your training, and it isn’t highly accurate, it can at least give you a rough idea of your sleep.

Your training information and data provide a few key insights: PAI and Training Status. PAI, or Personal Activity Intelligence, uses a simple 100-point scale to reflect how active you are, with the goal of keeping it at or above 100 to reduce your risk of disease. It is based on an algorithm that assesses your age, gender, resting heart rate, maximum heart rate, and accumulated heart rate over seven days. Because an algorithm powers it, it’s dynamic and based on you as an individual instead of using generalizations.

While Training Status and PAI are enough for most users, The Band 7 and Zepp app won’t provide the in-depth data and insights serious athletes want or need. For example, Garmin (what I’m most familiar with) provides training stats such as the training effect of each individual workout, power curves, race predictions, training readiness, and heart rate variability (HRV) information. Most of that isn’t relevant to those simply trying to stay active and healthy, but if you want focused training for performance reasons, the Amazfit Band 7 and companion app likely won’t cut it. 

Smartwatch features

On top of all the fitness tracking, the Band 7 provides some smartwatch functionality. It doesn’t provide cellular connectivity, and there is no microphone, which limits its capabilities, though that’s to be expected at this price point. But you can get notifications on the watch from your smartphone from just about any app you use. You can’t interact with those notifications in any way, but you can at least see them to know if it’s something important enough to pick up your phone.

Beyond notifications, the watch also provides access to weather information. And if you are playing music on your phone, you can control it from the watch. I really liked that feature while in the gym working out. If a song started in my UE Fits earbuds that I didn’t want, I could just hit next right on my wrist instead of needing to pick up my phone and sweatily navigate to Spotify. 

Zepp app

The Zepp app is clean and clutter-free, with three primary tabs containing settings and data that you may need. The Homepage of the app features data cards to give you snapshots of what you most want to keep track of. For example, it can show steps, sleep, workout history, exercise status, and more. You can customize this, both in terms of which cards are shown and their order, which is nice. 

The Health tab is also customizable, though with far fewer options. It primarily shows you a breakdown of your workouts and your target goals (which you can edit). Since all of this can be found on the Homepage, it’s a bit confusing that a separate tab is needed.

The third tab is your Profile, which gives you access to settings, goals, connected accounts, and more. It’s also where you access your devices to change device-specific settings.

The app runs very smoothly on my Samsung Galaxy, and it’s quick to sync the watch when I make changes via the app as well. It doesn’t provide as in-depth insights as the Garmin app and doesn’t offer the social component Garmin does, but Zepp works well and provides basic and necessary information. 

Garmin Forerunner 955 and Amazfit Band 7 watches
The distance data from the Band 7 isn’t very accurate since it relies on a connected phone’s GPS. Here you can see it compared to the Garmin Forerunner 955, which has multi-band GPS. Abby Ferguson

The Amazfit Band 7’s usability and accuracy 

Overall, the Amazfit Band 7 is straightforward to use. It has its quirks—such as a lack of buttons for input—that make getting used to it a little tricky at first. But most of the controls are intuitive and easy to figure out. The sensitive touchscreen can be a bit annoying but is small in the grand scheme of things. 

One aspect that I really love about the Amazfit Band 7 is that it provides help text on the watch itself for certain data sets and features. For example, under Workout Status, if you tap the “i” at the bottom of the screen, a rather thorough explanation of EPOC pops up. Since the budget-friendly watch is largely geared toward those who aren’t exercise experts, these terms may be completely new. Explaining what they mean and why they are important right on the watch is extremely helpful and valuable. 

I found the watch’s heart rate monitor to be very accurate, even compared to a dedicated heart rate monitor, which is typically more precise. Likewise, the calculated VO2 Max was in the range it should be for me, though I plan on getting a lab test done for a truly accurate comparison. 

I rarely find sleep tracking very accurate, and that was the case with the Amazfit Band 7. There were nights it seemed spot on, but most of the time, it seemed at least slightly off, and nights it was completely incorrect as well. It also tends to think I’m taking a nap if I take the watch off for more than a few minutes.

How the Amazfit Band 7 stacks up against the competition

There’s no shortage of fitness watches available, with even Amazfit’s own line of devices quite lengthy. I’ve also been using Amazfit’s T-Rex 2. At $200, the T-Rex 2 is still quite a bargain compared to the likes of a Garmin, though it’s four times more expensive than the Band 7. And in most ways, the price difference is noticeable. The T-Rex 2 is decidedly more aggressive looking and significantly larger. It’s much more rugged, having passed 15 Military-Standards Tests (MIL-STD-810G) to withstand harsh conditions. And it comes with more health data and built-in dual-band positioning. You get a lot more watch in the T-Rex 2, albeit in a very different style that isn’t for everyone.

Garmin’s fitness watches tend to be one of the gold standard options for athletes, and the prices certainly match that. The company has done a fantastic job of managing health and fitness data to provide useful and accurate information for training purposes. Amazfit does a nice job of providing useful insights, but it isn’t as thorough as Garmin, especially in the minimal Band 7 watch. Garmin’s watches offer more robust feature sets and data tracking than the Band 7, yet still offer battery life that’s nearly as much as the simpler Band 7.

Amazfit Band 7 and Amazfit T-Rex 2 watches on a wrist
The Band 7 is much more minimal than Amazfit’s dual-band positioning higher-end T-Rex 2. Abby Ferguson

So, who should buy the Amazfit Band 7?

I must admit that I was pleasantly surprised by the Amazfit Band 7. After exclusively using fairly expensive fitness watches for the past 10 years, I assumed that such a budget-level watch would be lacking and less impressive. But that was not the case. 

The Band 7 has some big wins, no matter what price point you are looking at. It sports a sleek design, lengthy battery life, accurate heart rate measurement, music controls, plenty of fitness-focused features, and a wide array of activity types. Of course, with the low price comes some disadvantages: No built-in GPS, a finicky touchscreen, and a cheap band enclosure design. It also doesn’t provide as in-depth training insights or data compared to more expensive watches. As a result, it isn’t great for serious, focused athletes looking for specific performance improvements. But it offers much more than the $50 price would lead you to believe. 

So who’s the Band 7 ideal for? It’s a fantastic choice for those looking for a simple device that can help encourage them to be more active. Not everyone needs access to race predictions and hyper-accurate pace and stride information. But the Amazfit Band 7 can help you learn more about exercise terms and support you in keeping tabs on your activity levels to work toward a healthier, more active lifestyle. And it can do this while functioning as a general smartwatch, making it even more well-rounded. 

The post Amazfit Band 7 fitness & health tracker review: Back to basics appeared first on Popular Science.

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This rechargeable battery is meant to be eaten https://www.popsci.com/technology/edible-battery-prototype/ Mon, 17 Apr 2023 18:00:00 +0000 https://www.popsci.com/?p=534669
Gloved hand holding up edible battery above its ingredients on table
Riboflavin and activated charcoal partially compose the digestible battery. IIT-Istituto Italiano di Tecnologia

The battery relies on chemical components often found in shiitake mushrooms, capers, and seaweed.

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Gloved hand holding up edible battery above its ingredients on table
Riboflavin and activated charcoal partially compose the digestible battery. IIT-Istituto Italiano di Tecnologia

Around 3,500 Americans ingest batteries every year, according to the National Capital Poison Center. It’s apparently such a perennial issue that there’s even a specific hotline number to call in the event of such an emergency (1-800-498-8666, just in case). And while it’s unlikely your wristwatch’s power source will ever be safe to eat, that doesn’t mean all batteries will remain inedible—in fact, some are being designed with digestion specifically in mind.

A team of researchers at the Italian Institute of Technology recently unveiled what is being billed as the world’s first fully rechargeable, edible battery. As detailed in a paper published with Advanced Materials, the new device utilizes riboflavin (often found in shiitake mushrooms) as its anode and quercetin (seen in capers) as the cathode. Activated charcoal amplified the electrical conductivity alongside a water-based electrolyte. Nori seaweed—most often seen in sushi—served as the short circuit prevention separator, while beeswax-encased electrodes and food-grade gold foil contacts also contributed to the design.

[Related: MasterChef inspired an edible medical sensor.]

“Edible electronic devices will have major implications for gastrointestinal tract monitoring, therapeutics, as well as rapid food quality monitoring,” reads the paper’s abstract, adding that although recent research proved the feasibility of edible sensors and circuits, “fully edible electronic devices edible power sources are [still] required, of which there have been very few examples.”

According to the team’s findings, their proof-of-concept battery was capable of producing 0.65 volts, which is safely low enough for the human body to handle. The ingestible could provide 48 μA of current for 12 minutes, or alternatively, a few microamps for over an hour. Such a power supply could provide enough energy for small electronics akin to edible pill-shaped modules and other gastrointestinal procedure alternatives. In a statement, researcher coordinator Mario Caironi explained that such a product could help power monitors for both human health conditions and food storage. Additionally, given their safety, more powerful iterations could be utilized within children’s toys, where ingestion risk is higher.

[Related: Watch this metallic material move like the T-1000 from ‘Terminator 2’.]

In the team’s statement, co-author Ivan Ilic also explained that despite the battery’s relatively low power, its digestibility provides a promising example of a battery that doesn’t use any toxic materials. “While our edible batteries won’t power electric cars, they are proof that batteries can be made from safer materials than current Li-ion batteries,” they said, adding that “We believe they will inspire other scientists to build safer batteries for a truly sustainable future.”

Moving forward, the team is already designing future iterations featuring greater capacities at smaller sizes in the hopes of soon powering edible, soft robots for use in medical procedures.

The post This rechargeable battery is meant to be eaten appeared first on Popular Science.

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The best hybrid smartwatches of 2023 https://www.popsci.com/gear/best-hybrid-smartwatches/ Thu, 11 Aug 2022 15:00:00 +0000 https://www.popsci.com/?p=461226
best hybrid smartwatches sliced header
Tony Ware

Get the best of both worlds with these timepieces.

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best hybrid smartwatches sliced header
Tony Ware

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Best overall The Withings ScanWatch is stylish, and comes with a full range of health-focused features. Withings ScanWatch
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The Withings ScanWatch is stylish and comes with a full range of health-focused features.

Best for iPhone Skagen Jorn 38MM Gen 6 Hybrid Smartwatch Skagen Jorn Hybrid HR
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The Skagen Jorn Hybrid is one of the most visually appealing in the space, and its e-ink display is a one-of-a-kind feature.

Best with heart rate monitor Garmin Vivomove hybrid smartwatch Garmin Vivomove HR
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The Garmin Vivomove HR is a sporty hybrid smartwatch with a nice array of features for fitness junkies.

Smartwatches are one of the most useful pieces of wearable tech out there. However, the chunky bodies and digital faces of the sensor-packed Apple Watches and Fitbits of the world don’t appeal to everyone’s sensibilities. So while the biggest tech companies build watches that emphasize the tech, many brands have integrated some of the simplest, most useful smartwatch features into conventional timepieces. The average hybrid smartwatch features analog hour and minute arms, with a small screen or screens underneath to show stats like heart rate and tracked steps. For many people, the best hybrid smartwatches provide a good balance between a watch that will give you the fitness tracking and heart rate monitor you desire without looking out of place in a professional workplace.

How we chose the best hybrid smartwatches

I’ve been writing about tech for nearly a decade for publications such as PC Gamer and Input, among others, so I know how to discern between the next big thing and the next big bust. I’m also a watch enthusiast who has owned more than my fair share of smart and traditional timepieces over the years. To determine these recommendations, I consulted technical specs and tests conducted by experts, as well as consumer reviews to find the best hybrid smartwatches for all kinds of people.

The best hybrid smartwatches: Reviews & Recommendations

Now that you know what to look for in a hybrid smartwatch, you’re ready to pick one for yourself. If you’d like a little help jumpstarting your search, we’ve selected the best hybrid smartwatches for all kinds of users. Whether you want to shell out a bundle for a high-end watch with all the bells and whistles or buy a cheaper model with just the essentials, we have you covered.

Best overall: Withings ScanWatch

Withings

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Buy it used or refurbished: eBay

Why it made the cut: The Withings ScanWatch offers everything you can hope for in a hybrid smartwatch.

Specs

  • Size: 38mm or 42mm
  • Heart monitor: Yes, with oxygen levels
  • Sleep tracking: Yes
  • Activity tracking: Yes, with altimeter
  • Water resistance: 50m
  • Battery life: 30 days
  • Other features: Sapphire glass

Pros

  • Great feature set
  • Water resistance
  • Comes in multiple sizes

Cons

  • A little expensive

French health tech manufacturer Withings specializes in devices that monitor your body, including smart scales, thermometers, and blood pressure monitors. Their flagship watch, the ScanWatch, integrates deep health-tracking functionality into a simple, elegant hybrid timepiece. Going beyond basic step and heart rate tracking, it features an altimeter to track vertical movements, such as climbing stairs, and a pulse oximeter for blood oxygen (SpO2) tracking. Its 30-day battery life makes it one of the longest-lasting watches. It’s also waterproof and certified for up to 50 meters (or 5 atmospheres) of water pressure. 

It also provides lots of room for you to pick a watch that fits your style. It comes in two sizes and Withings offers more colors and styles than many of its competitors. In plain black with metal hardware, it’s a simple and elegant everyday accessory.

All of that function pushes the ScanWatch’s price up higher than many of our other picks, but it offers a strong blend of style and tech substance.

Best for iPhone: Skagen Jorn Hybrid HR

Skagen

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Buy it used or refurbished: eBay

Why it made the cut: The Skagen Jorn is an elegant hybrid smartwatch with a unique e-ink display, and it has great app integration for your phone.

Specs

  • Size: 38mm or 42mm
  • Heart monitor: Yes
  • Sleep tracking: Yes
  • Activity tracking: Yes
  • Water resistance: “Water Resistant”
  • Battery life: 14 days+
  • Other features: E-ink display

Pros

  • Multiple size options
  • Stylish design
  • Decent features

Cons

  • E-ink display may not appeal to everyone
  • Interface can be confusing

Skagen is known for their fashion watches, and the Jorn brings a very appealing “Bauhaus”-like sensibility—a cleanly geometric German retro-modern aesthetic—to the hybrid smartwatch market. Its signature feature is a sharp e-ink display, akin to what you’d find in an Amazon Kindle Paperwhite or the classic Pebble Watch. It shows your steps, heart rate, and other stats with chronograph-like icons that perfectly match the watch’s look. The unique design and controls aren’t as intuitive as other watches, but it’s a small price to pay for such attention to detail.

If you’re a fan of buttons, the Jorn has three for you to play with rather than the traditional “hold/tap” design of the Apple Watch, and its app integration and customizability have received high marks from reviewers. 

As a whole, the Skagen Jorn is a strong hybrid smartwatch for those who care more about the watch and its aesthetics than smart features. However, it works very well for what it is.

Best heart rate monitor: Garmin Vivomove HR

Garmin

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Buy it used or refurbished: eBay

Why it made the cut: The Garmin Vivomove HR offers excellent fitness tracking and an appealing design.

Specs

  • Size: 40mm, 43mm
  • Heart monitor: Yes, with oxygen levels
  • Sleep tracking: Yes
  • Activity tracking: Yes
  • Water resistance: 50m
  • Battery life: 5 days (smart mode), 14+ days (watch only)
  • Other features: Stress tracking

Pros

  • Good fitness features
  • Many color options
  • Easy to read

Cons

  • Expensive
  • Short battery life for smart mode

Though it is not specifically a “fitness watch,” the Garmin Vivomove HR delivers more fitness-driven features than most hybrid smartwatches, making it a notable choice for people who specifically want one to discreetly monitor their heart. It has dedicated stress tracking and relaxation timers so you can track your vitals in any situation, as well as SpO2 tracking. It falters a bit on battery life compared to other hybrids, especially when you use the smart features, though.

The design of its face is a bit simple compared to our other picks, and it’s less customizable than most, but it does have that true “Bauhaus” look. While it comes in multiple sizes and many colors, we found that many styles and colors are much harder to come by in the 40mm “small/medium” size.

If you’re a fitness enthusiast, the Vivomove has the edge over competitors thanks to its stress monitor and relaxation timers. But its high price limits its appeal compared to other watches in the space.

Best for small wrists: Fossil Women’s Monroe Hybrid

Fossil

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Buy it used or refurbished: eBay

Why it made the cut: The Fossil Women’s Monroe packs a lot of punch into a watch that looks good on any wrist.

Specs

  • Size: 38mm
  • Heart monitor: Yes
  • Sleep tracking: Yes
  • Activity tracking: Yes
  • Water resistance: 30m
  • Battery life: 14+ days
  • Other features: None

Pros

  • Fits any wrist
  • The feminine silhouette isn’t common among smartwatches
  • Competitive feature-set

Cons

  • No signature feature

Look, there’s no delicate way to put this: The overwhelming majority of smartwatches out there feature masculine (or at least masculine-leaning) designs. Hybrid watches, in particular, are often based on larger “men’s” watches. If you’re looking for something feminine, rather than simply picking a smaller case size, Fossil’s Monroe is definitely the way to go. The mid-sized 38mm case will fit almost any wrist, unlike the 42mm (or even bigger) smartwatches out there.

It doesn’t skimp on the features either, with notification support, activity tracking, a heart rate monitor, and more. The only real downside to this hybrid smartwatch is that it lacks a unique tech-driven feature. The Monroe is purely a style play but, since feminine hybrid watches are fairly rare, that is a signature feature unto itself.

Best budget: Withings Steel HR

Withings

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Buy it used or refurbished: eBay

Why it made the cut: The Withings Steel HR is a fully featured hybrid smartwatch that offers 50m of water resistance for a cheap price tag.

Specs

  • Size: 36mm, 40mm
  • Heart monitor: Yes
  • Sleep tracking: Yes
  • Activity tracking: Yes, with multi-sport support
  • Water resistance: 50m
  • Battery life: 25 days
  • Other features: None

Pros

  • Competitive price
  • Visually appealing
  • Good battery life

Cons

  • Some may prefer a larger case size
  • Older model

The Withings Steel HR is an older, simpler hybrid smartwatch, but one that still holds up. For less than $200, the Steel HR offers only slightly less functionality than our top pick for $100 less. More importantly, the Steel is rated for 50m of water resistance, which means you can take it in the pool or the ocean without worrying about it. It offers great battery life—25 days—and features multi-sport tracking to record more accurate activity-specific health data.

Though many of the watches on this list feature a minimalist style, the Steel features what may be the simplest look. I quite like its two-dial configuration. However, with a 40mm case, it’s smaller than most of the picks on our list and may not be a great fit for people with very large wrists.

Things to consider before buying a hybrid smartwatch

Picking a hybrid smartwatch over a conventional smartwatch or fitness tracker is, more often than not, rooted in taste. You want some smart features, but not at the expense of how a classic wristwatch looks and feels on your wrist. In keeping with that, most hybrid smartwatches have a relatively standardized set of smart features, including step tracking, sleep tracking, and more. Some features, like surfacing notifications from your phone, aren’t on every model, though, so it does pay to think about how “smart” you want your watch to be.

It’s all about the features

Though hybrid smartwatches don’t vary as much in feature set and price range as other tech, you should keep in mind that they aren’t all identical. Most hybrid smartwatches offer some degree of fitness tracking, sleep tracking, and water resistance. Certain features—like GPS integration, altimeters, blood oxygen (SpO2) tracking, and 100-meter water resistance—tend to be reserved for more expensive models. 

High-end hybrids also tend to have better battery life, though even the least expensive of the bunch last longer than more tech-forward smartwatches like the Apple Watch Series 7 and Samsung Galaxy Watch4. The average battery life of a hybrid smartwatch is around two weeks, though some go as high as 25 to 30 days without a charge.

Aesthetics are everything

There are two main reasons to buy a hybrid smartwatch: less frequent charging and sheer aesthetics. As a watch enthusiast, I strongly prefer the round face and analog movement of a hybrid over the blocky silhouette of a Fitbit. As such, you should really consider the look and feel of the hybrid you want before you buy it. 

You should also measure your wrist before making any purchase. Most hybrid watches have a case diameter of 42mm, which is quite large on those of us with smaller wrists. If you have a wrist size of 6.5 inches or less, you will probably want to invest in a smaller 38mm model instead.

FAQs

Q: Can you buy refurbished smartwatches?

Absolutely, many of our recommended hybrid smartwatches can be purchased refurbished from Amazon, eBay, or other resellers for a reduced price. For example, you can buy a refurbished Garmin Vivomove for less than $100 right now. We’ve added a link to at least one used purchasing option for each watch on this list.

Q: Can you use a hybrid smartwatch without a phone?

Hybrid smartwatches can tell time perfectly fine without syncing to a smartphone, as they are watches first and foremost. Their smart features—heart rate monitoring, step tracking, and so on—require one, though.

Q: How do you charge a hybrid watch?

Most hybrid smartwatches charge via magnetic USB cables that you plug into a wall, similar to traditional smartwatch chargers.

Q: Can you text on a hybrid smartwatch?

Many hybrid smartwatches either display your texts or at least show you a notification when you receive one on your phone. Most, however, do not allow you to respond. If texting via your watch is a priority, you should consider buying an Apple or Android Wear watch.

Final thoughts on the best hybrid smartwatches

As with many products out there, these hybrid smartwatches ultimately have quite a lot in common with each other. Still, the devil is in the details. If you’re looking for top-of-the-line features, you may decide to go for a more traditional smartwatch instead. However, if aesthetics are what you’re looking for, all of these watches will have you well-covered. Besides, who wants to charge their watch every day, anyway?

Why trust us

Popular Science started writing about technology more than 150 years ago. There was no such thing as “gadget writing” when we published our first issue in 1872, but if there was, our mission to demystify the world of innovation for everyday readers means we would have been all over it. Here in the present, PopSci is fully committed to helping readers navigate the increasingly intimidating array of devices on the market right now.

Our writers and editors have combined decades of experience covering and reviewing consumer electronics. We each have our own obsessive specialties—from high-end audio to video games to cameras and beyond—but when we’re reviewing devices outside of our immediate wheelhouses, we do our best to seek out trustworthy voices and opinions to help guide people to the very best recommendations. We know we don’t know everything, but we’re excited to live through the analysis paralysis that internet shopping can spur so readers don’t have to.

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Food forests can bring climate resilience, better health, and tasty produce to city residents https://www.popsci.com/environment/food-forests-climate-change/ Mon, 17 Apr 2023 14:00:00 +0000 https://www.popsci.com/?p=534481
Food forests mimic the structure and function of a natural forest ecosystem.
Food forests mimic the structure and function of a natural forest ecosystem. DepositPhotos

Having an abundance of locally-sourced foods in the community is important on many levels.

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Food forests mimic the structure and function of a natural forest ecosystem.
Food forests mimic the structure and function of a natural forest ecosystem. DepositPhotos

In the United States, there are over 6,500 rural and urban areas where residents have limited access to stores that sell affordable, nutritious food. Living in these places, sometimes dubbed “food deserts”, can lead to poor diet and associated health risks. However, unlike deserts, the lack of access to healthy food in communities does not occur naturally. They developed over time as a result of racially discriminatory policies and systematic disinvestment.

Given the increase in food insecurity in urban areas, some cities have begun experiments with edible landscapes to address food insecurity. By working together to grow a “food forest,” community members can increase their access to local food sources.

Food forests, or edible forest gardens, are a type of agroforestry system that “mimic the structure and function of a natural forest ecosystem, but are designed to produce food, medicine, fiber, and other products for human use,” says Mikaela Schmitt-Harsh, an associate professor at James Madison University whose research focuses on the social-ecological dynamics of urban forests. 

[Related: How to eat sustainably without sacrificing your favorite foods.]

The first public food forest in the US—the Dr. George Washington Carver Edible Park in North Carolina—opened in 1997. As of 2018, there are more than 70 food forests in public spaces across the country.

Schmitt-Harsh says different layers of vegetation—like trees, shrubs, herbs, and ground covers—all work together to “create a sustainable and diverse food production system.” For example, a food forest could be composed of tall trees like chestnut or walnut as the canopy layer and apple or persimmon trees as the sub-canopy layer. Beneath them can lie currant bushes like elderberry or spicebush, along with edible herbs and mushrooms. Ground cover, medical roots, and climbing plants are also included. “You can swap out any of these selections for your favorite nut trees, fruit crops, and herbs to make your own system,” says Schmitt-Harsh.

Food forests may be grown on private properties, vacant lots, parks, or other open spaces in otherwise urban environments. This helps residents by forming a food production system within the community. The forests, which are typically at least 1/8 of an acre, can be critical in areas where local, fresh foods are inaccessible or unaffordable, says Sheila K. Schueller, ecosystem science and management lecturer at the University of Michigan.

Schueller says food forests don’t just give people access to fresh and nutritious fruits, nuts, and produce, but also empower neighborhoods by increasing food security and sovereignty and the sense of community. Moreover, connecting people with the source of their food may raise awareness about “the benefits of sustainable forms of agriculture and the value of local in-season foods over distantly-sourced or unsustainably-grown foods,” she adds.

Climate change mitigation and adaptation

The ecologically diverse system of food forests benefits the environment in so many ways, says Schueller. For instance, the structural complexity of the different layers can attract perching and nesting birds, while the variety of blooms expands the habitat of pollinators. Deeper root systems also improve water retention. Lastly, the vegetation provides shade and improves temperature regulation, which is ideal in hot cities or arid climates. All of these improve resilience in the face of changing climates and extreme weather events, says Schueller.

[Related: Paleo and keto diets aren’t great for you or the planet, study says.]

Food forests also help mitigate climate change by sequestering carbon from the atmosphere.

Since they have trees, shrubs, and perennial plants, Schueller says food forests can store more carbon in their biomass and the soil compared to other food systems or land use such as annually tilled crops or lawns.

“This increased vertical layering of plants means that more carbon is sequestered per area, and especially the woody vegetation stores more carbon long term,” she adds. “Food forests are not annually tilled like most crops and have deep root systems, so they can store a lot of carbon in the soil and below-ground vegetation.”

Having an abundance of locally-sourced foods in the community minimizes greenhouse gas (GHG) emissions as well, particularly those caused by transportation across the food chain. A 2021 Nature Food study previously estimated that food transportation contributed around 4.8 percent of the GHG emissions of the global food system, but newer research suggests it accounts for about 19 percent instead. In general, Schmitt-Harsh says food forests can reduce the food miles traveled, or the distance from where the food was grown to where it’s eaten.

The interest and advocacy for food forests have grown alongside other local food movements, like farmers’ markets and community-supported agriculture (CSA) programs. They are all experiencing an upward trend in urban and suburban landscapes as communities explore ways to bring food production closer to home, says Schmitt-Harsh. 

A 2017 Public Health Nutrition study on low-income adults’ perceptions of farmers’ markets and CSA programs found that residents of urban, affordable housing communities are motivated to eat healthily, but they cannot afford them. Accepting benefits like the Supplemental Nutrition Assistance Program (SNAP) would increase their access to healthy foods and reduce health risks.

“Some of the most successful community food forests are those that embrace a grassroots approach and engage multiple stakeholders in promoting community building and food literacy,” says Schmitt-Harsh. 
If you want to grow a food forest in your area, try getting in touch with potential stakeholders like local governments, community-based groups, academic institutions, and non-profit organizations that can mobilize community members to participate in civic activities. Who knows, there might be an organization near you already.

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Bears can count, take selfies, use tools, recognize supermodels, and even open car doors https://www.popsci.com/environment/are-bears-smart/ Sun, 16 Apr 2023 13:28:16 +0000 https://www.popsci.com/?p=534251
Black bear cub in a berry bush at Glacier National Park
A black bear cub foraging for berries. NPS/Tim Rains

Scientists studying bear intelligence want to know: What else can they learn?

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Black bear cub in a berry bush at Glacier National Park
A black bear cub foraging for berries. NPS/Tim Rains

Selfies occasionally go viral, but they’re not typically taken by an animal. So the fact that a black bear’s encounter with a motion-activated wildlife camera in Boulder, Colorado, in 2022 resulted in more than 400 of them—including an undeniably cute one with its tongue hanging out—is especially intriguing. Most creatures ignore camera traps. The question is: Why didn’t this bear?

​​It may be tempting to think of this selfie moment as an animal blunder, but this anecdote captures more than meets the eye. Research suggests bears, much like elephants and great apes, are more intelligent than previously assumed. The selfie bear is a unique reminder of a type of animal cognition scientists are just starting to understand. 

“Bears are probably more naturally curious about how things work than some other species,” says Jennifer Vonk, a psychology professor at Oakland University. 

Black bear, dubbed "selfie bear" looking directly into Colorado wildlife camera
One of selfie bear’s infamous wildlife camera shots. City of Boulder

Bears are generally impressive. They have an excellent sense of smell, seven times better than a bloodhound’s. Grizzly bears can run up to 35 miles per hour, beating the fastest human sprint by over 25 percent. Despite their bulk, bears are very dexterous—they can open screw-top jars, manipulate door latches, and even operate touchscreen computers with a talent that outpaces animals more closely related to people. 

Vonk discovered this when she and a colleague trained captive-bred black bears to select a larger or smaller set of dots that stayed in place or moved around the screen. Although the ability to count or distinguish between different quantities has been tested in many animals, scientists didn’t think ursines had this ability because they are a solitary, rather than social, species. The “social intelligence hypothesis” suggests social animals are likelier to be smarter than solitary species because interactive environments offer more cognitive challenges. 

[Related: Hibernating bears hold many secrets for better human health.]

The experiment proved otherwise. During the study, the size of the dots varied—in some trials, for example, the larger set of dots covered more area than the smaller set of dots. Conversely, the larger set could also cover a smaller area, which ultimately tested if black bears were making choices based on area or the number of dots. The animals performed above chance on all trials, showing they could use numbers to guide their choices. In other words, they could count. These results were published in the journal Animal Behavior

“I was surprised how quickly the bears took to responding on the computer because we were training animals that had never done any kind of experiments,” says Vonk. “On literally the first day we tested, the dominant male went right to the images that moved around the screen without making any errors. And with almost every task we gave him, he learned faster than the chimps and gorillas I was working with at the same time.”

While bears have one of the largest relative brain sizes of any carnivore, there’s surprisingly little research regarding their cognitive abilities. This oversight may be due to logistics more than anything else. Most cognitive research happens in a laboratory; the animals that do well in these environments are smaller creatures, like rats, mice, and pigeons. Facilities that allow controlled testing with bears are scarce. 

Captive black bear on a rock sticking out her tongue
Migwan the bear was able to communicate her snack preferences. Jennifer Vonk

Despite these challenges, Vonk’s lab at Oakland University has worked to fill this gap in our understanding of bears since 2012. Another study conducted by Vonk suggests bears also recognize images on computer screens as real objects: During it, a captive black bear named Migwan was able to show that she prefers grapes over beets. While bears can recognize features of real objects in their virtual images, the researchers emphasized this doesn’t necessarily mean bears fully grasp what pictures are. 

Another touchscreen study from the Vonk lab suggests bears can distinguish between different categories of things, such as animals versus non-animals. The bears were trained (with the help of a few treats) to choose between two rather odd and different groups: supermodels and Planet of the Apes characters. After that task was mastered, the bears were tested on more difficult subjects. For instance, the studied black bears could tell polar bears from other species of bears, primates from hoofed animals, or a chameleon from a car. They performed surprisingly well, even for the most abstract categories of distinguishing animals from non-animals.

Four captive black bears playing behind a fence
The clever black bears the Vonk lab studied. Jennifer Vonk

Other research suggests black bears aren’t the only intelligent bear. For example, in a study of tool use published in the Journal of Veterinary Behavior, brown bears had to manipulate logs and boxes to reach a tempting reward: glazed donuts. Six of the eight bears in the study successfully completed the pastry-acquiring task and usually did so out in less than two minutes, explains lead author Lynne Nelson, a professor of veterinary cardiology at Washington University. 

For decades, tool use was considered to be the defining characteristic of humans—something that proved how smart we are. The fact that bears can also use tools subsequently suggests some advanced intelligence.

Several factors may explain why bears are smart, though “more work needs to be done before we really know whether social structure or foraging ecology better predicts overall intelligence,” Vonk says. 

“I think people are only starting to recognize that it’s an interaction of all these things,” she adds.

For now, there are some promising theories. Overall most animals living in social groups, like primates, exhibit high levels of intelligence. Scientists hypothesize that social animals evolved to have mental abilities that help them cooperate and understand others’ intentions. But bears, generally, are solitary. Their brains are less of a response to their social situation and more of a response to the challenging environments that they live in. Their ability to make quick, adaptive responses to these conditions may explain why their brains are relatively large compared to their body weight—a proportion that suggests intelligence

Bear intelligence may also be the result of their early development; cubs start off life as curious little troublemakers. Gordon Burghardt, a professor of animal behavior at the University of Tennessee at Knoxville, experienced this firsthand when two rescued black bear cubs stayed in his house for several weeks. He describes the inquisitive youngsters opening kitchen cabinets and sliding glass doors, climbing into the shower, and running off with purses. The cubs were also fond of playing with each other, which he posits helps with their development. Play is often thought to facilitate learning and mental development, as well as being a method of exercise and stress relief. 

Black bears and brown bears are both generalists, showing great versatility in the food they eat, how they get it, and where they find it, Vonk explained. They hunt, scavenge, and also seek out plants, nuts, and fruit. Bears also adjust to a seasonally changing environment, gaining weight in the fall and hibernating in winter. This variable and unpredictable environment may have led to bears’ greater intelligence. 

“Bears live in a vast range of environments from the deserts to the tropics and the Arctic,” Nelson adds. “Animals must exhibit a certain level of intelligence to be able to earn a living almost anywhere on the earth.”

[Related: What an ancient jawbone reveals about polar bear evolution]

The giant mammals face considerable challenges because of people too: the development of their habitats, hunting, pollution, cars, and climate change all put them at risk. Studying bear intelligence, in turn, does more than explain a natural wonder—it increases the likelihood that they’ll survive. Some scientists argue that people are more likely to protect animals when they realize the species are intelligent. 

Bears, meanwhile, will continue to be as curious as ever. After the selfie black bear went viral, Canadian park rangers tweeted out their own celebrity: the selfie polar bear.

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Ghana is the first country to approve Oxford’s malaria vaccine https://www.popsci.com/health/ghana-malaria-vaccine-who/ Fri, 14 Apr 2023 20:00:00 +0000 https://www.popsci.com/?p=534217
Oxford malaria vaccine application kit
A health worker measures the dosage of malaria vaccine Mosquirix in western Kenya on September 13, 2019. BRIAN ONGORO/AFP via Getty Images

Malaria kills more than one thousand children every day and is the leading cause of child death in Africa.

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Oxford malaria vaccine application kit
A health worker measures the dosage of malaria vaccine Mosquirix in western Kenya on September 13, 2019. BRIAN ONGORO/AFP via Getty Images

Ghana is the first country to approve a malaria vaccine for young children, who have the highest risk of death from the disease. Some scientists have called the new vaccine a potential “game-changer” in the fight against the disease that is the leading cause of child death in Africa.

This new vaccine, called R21, has an efficacy rate of 77 percent, according to a September review in the journal The Lancet. One approved Malaria vaccine already exists, called Mosquirix, which has a 30 to 60 percent efficacy rate. 

Late stage testing is still underway in Burkina Faso, Kenya, Mali, and Tanzania. It’s unusual for a country to approve a vaccine before clinical trials are completed, according to WHO guidelines, and the World Health Organization has yet to approve it. 

Oxford researchers shared the mid-stage data with regulatory authorities in Ghana over the past six months and their new data suggests similar performance as in earlier trials, according to Oxford Professor and Chief investigator of the R21/Matrix-M programme, Adrian Hill. The results of R21’s final trials are expected to be published in the coming months. 

[Related: New four-dose malaria vaccine is up to 80 percent effective]

Oxford researchers shared the mid-stage data with regulatory authorities in Ghana over the past six months and their new data suggests similar performance as in earlier trials, according to Oxford Professor and Chief investigator of the R21/Matrix-M programme, Adrian Hill. The results of R21’s final trials are expected to be published in the coming months.

The R21 vaccine is designed to stop disease and death, not prevent transmission, although vaccines that prevent transmission between people are currently in the works at Oxford, Hill said in a press interview.

“The main idea now is to get R21 out there as soon as possible, and then add a transmission blocking vaccine,” Hill said. “That will allow us to use vaccination, not just for disease control, but for initial disease elimination, and then eventually global eradication.”

Ghana’s Food and Drug authority approved its use for children aged five months to three years, but rollout will be delayed until the WHO approves it. Once it is approved, Ghana’s drug regulator has a deal with the Serum Institute of India to produce up to 200 million doses of R21 a year. Each dose is expected to cost a couple dollars, per the BBC.

The mosquito-borne disease kills about 620,000 people globally each year, and 77 percent of those deaths are children. That translates to a death toll of over one thousand children each day, nearly one child lost per minute, according to UNICEF.

Malaria is a parasitic disease transmitted by mosquitoes, most often seen in tropical and subtropical climates. It is preventable and curable. Symptoms range from mild to life-threatening, including tissue inflammation in the brain, kidneys, and lungs. In extreme cases, leading to cerebral malaria, kidney failure, and acute respiratory distress syndrome. Children, pregnant women, and immunocompromised individuals are most at risk.

The parasite responsible for Malaria is the unicellular plasmodium. There are multiple plasmodium species known to cause the disease, each with its own unique characteristics. Unfortunately, the most common species in sub-saharan Africa, Plasmodium falciparum, is also the most deadly. 

Vaccinations are a relatively recent method of treatment for malaria. Since Mosquirix was introduced in 2019, 1.4 million children across Ghana, Kenya, and Malawi were vaccinated, resulting in a 10 percent drop in child mortality. A lack of funding and commercial potential has prevented drugmakers from producing adequate amounts of Mosquirix.

The release of the R21 vaccine “marks a culmination of 30 years of malaria vaccine research at Oxford with the design and provision of a high efficacy vaccine that can be supplied at adequate scale to the countries who need it most,” Hill said in a statement.

There are multiple reasons why a Malaria vaccine is hard to develop—including the complex life cycles of the parasite and its ability to evade immune responses. 

However, the biggest barrier is not biological, it’s financial. Malaria is most prevalent in sub-saharan Africa, making up 95 percent of all malaria cases and 96 percent of malaria deaths. This region is also home to low-income countries, which have limited resources for research funding and vaccine development

[Related: White House invests $5 billion in new COVID vaccines and treatments as national emergency ends]

“Malaria is a life-threatening disease that disproportionately affects the most vulnerable populations in our society and remains a leading cause of death in childhood,” Adar Poonawalla, CEO of the Serum Institute of India, said in a press release statement

“We remain steadfast in our commitment to scaling up production of the vaccine to meet the needs of countries with high malaria burden and to support global efforts towards saving lives,” he said.

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